JP2001526211A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001526211A5 JP2001526211A5 JP2000525083A JP2000525083A JP2001526211A5 JP 2001526211 A5 JP2001526211 A5 JP 2001526211A5 JP 2000525083 A JP2000525083 A JP 2000525083A JP 2000525083 A JP2000525083 A JP 2000525083A JP 2001526211 A5 JP2001526211 A5 JP 2001526211A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- form according
- core material
- hydrophilic
- atpase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 description 21
- 229940121819 ATPase inhibitor Drugs 0.000 description 11
- 239000000362 adenosine triphosphatase inhibitor Substances 0.000 description 11
- 239000011162 core material Substances 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 150000001447 alkali salts Chemical group 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 230000002209 hydrophobic effect Effects 0.000 description 6
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 229960000381 omeprazole Drugs 0.000 description 5
- 238000013265 extended release Methods 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical group 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000009858 acid secretion Effects 0.000 description 2
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000002702 enteric coating Substances 0.000 description 2
- 238000009505 enteric coating Methods 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 229920001600 hydrophobic polymer Polymers 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 159000000003 magnesium salts Chemical group 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008203 oral pharmaceutical composition Substances 0.000 description 2
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229940082483 carnauba wax Drugs 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 125000004438 haloalkoxy group Chemical group 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229960003174 lansoprazole Drugs 0.000 description 1
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000002829 nitrogen Chemical group 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 125000005968 oxazolinyl group Chemical group 0.000 description 1
- 229960005019 pantoprazole Drugs 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000002071 phenylalkoxy group Chemical group 0.000 description 1
- -1 piperidino, morpholino Chemical group 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704869A SE9704869D0 (sv) | 1997-12-22 | 1997-12-22 | New pharmaceutical formulaton II |
| SE9704869-8 | 1997-12-22 | ||
| PCT/SE1998/002368 WO1999032091A1 (en) | 1997-12-22 | 1998-12-17 | Oral pharmaceutical extended release dosage form |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001526211A JP2001526211A (ja) | 2001-12-18 |
| JP2001526211A5 true JP2001526211A5 (enExample) | 2006-02-16 |
| JP4865945B2 JP4865945B2 (ja) | 2012-02-01 |
Family
ID=20409571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525083A Expired - Fee Related JP4865945B2 (ja) | 1997-12-22 | 1998-12-17 | 経口の延長放出性医薬品剤形 |
Country Status (38)
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE286394T1 (de) * | 1995-09-21 | 2005-01-15 | Pharma Pass Ii Llc | Ein säurelabile omeprazol enthaltende arzneizusammensetzung und verfahren zu deren herstellung |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| ATE500815T1 (de) | 1997-12-08 | 2011-03-15 | Dietrich Rango | Neue suppositoriumsform mit säureempfindlichem wirkstoff |
| FR2774288B1 (fr) * | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques |
| ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
| FR2793688B1 (fr) | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
| US7029701B2 (en) * | 2000-09-11 | 2006-04-18 | Andrx Pharmaceuticals, Llc | Composition for the treatment and prevention of ischemic events |
| WO2002032427A1 (en) * | 2000-10-20 | 2002-04-25 | Galephar M/F | Stable oral formulation containing benzimidazole derivative |
| WO2002045694A1 (en) * | 2000-12-07 | 2002-06-13 | Altana Pharma Ag | Rapidly disintegrating tablet comprising an acid-labile active ingredient |
| JP4848101B2 (ja) * | 2001-08-17 | 2011-12-28 | 株式会社フジモト・コーポレーション | 徐放性マイクロペレット |
| JP4732696B2 (ja) | 2002-04-09 | 2011-07-27 | フラメル・テクノロジー | 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤 |
| TW200410955A (en) | 2002-07-29 | 2004-07-01 | Altana Pharma Ag | Novel salt of (S)-PANTOPRAZOLE |
| MXPA05003162A (es) | 2002-09-26 | 2005-07-05 | Yamanouchi Pharma Co Ltd | Agentes mejoradores de absorbibilidad de droga. |
| US8697094B2 (en) | 2002-10-16 | 2014-04-15 | Takeda Pharmaceutical Company Limited | Stable solid preparations |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| JP4493970B2 (ja) * | 2002-10-16 | 2010-06-30 | 武田薬品工業株式会社 | 持続性製剤 |
| CA2519208A1 (en) | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Controlled release composition |
| JP4933033B2 (ja) * | 2003-03-17 | 2012-05-16 | 武田薬品工業株式会社 | 放出制御組成物 |
| CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| WO2005012289A1 (en) * | 2003-07-17 | 2005-02-10 | Altana Pharma Ag | Novel salt of (r) - pantoprazole |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
| FR2861990B1 (fr) * | 2003-11-10 | 2006-02-10 | Nouveaux Produits Pharma | Comprimes faiblement doses a reseau de polymeres |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2469427A1 (en) * | 2004-06-01 | 2005-12-01 | Pharmascience Inc. | Dry mixed dosage form containing benzimidazole derivatives |
| US8461187B2 (en) | 2004-06-16 | 2013-06-11 | Takeda Pharmaceuticals U.S.A., Inc. | Multiple PPI dosage form |
| US20090124702A1 (en) * | 2005-01-25 | 2009-05-14 | Pechetti Siva Satya Krishna Babu | Pharmaceutical Compositions of Metformin |
| KR100591142B1 (ko) * | 2005-11-04 | 2006-06-20 | 지엘팜텍 주식회사 | 파록세틴을 활성물질로 함유하는 장용성 서방형 정제 |
| DE102005060393A1 (de) * | 2005-12-16 | 2007-06-21 | Add Advanced Drug Delivery Technologies Ltd. | Orales Präparat mit kontrollierter Freisetzung |
| CN101389316A (zh) * | 2005-12-28 | 2009-03-18 | 武田药品工业株式会社 | 控制释放固体制剂 |
| US20100297226A1 (en) * | 2006-06-01 | 2010-11-25 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| WO2008094877A2 (en) * | 2007-01-30 | 2008-08-07 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
| US8679541B2 (en) * | 2007-03-14 | 2014-03-25 | Particle Dynamics International, Llc | Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals |
| RU2010119041A (ru) * | 2007-10-12 | 2011-11-20 | Такеда Фармасьютикалз Норт Америка, Инк. (Us) | Способы лечения нарушений желудочно-кишечного тракта, независимого от потребления пищи |
| US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
| US8945622B2 (en) | 2009-03-09 | 2015-02-03 | Council Of Scientific And Industrial Research | Sustained release composition of therapeutic agent |
| US20140127296A1 (en) * | 2012-11-05 | 2014-05-08 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
| HRP20191559T1 (hr) | 2013-02-13 | 2019-11-29 | Redhill Biopharma Ltd | Farmaceutski pripravci za liječenje infekcije bakterijom helicobacter pylori |
| CN104721185A (zh) * | 2013-12-21 | 2015-06-24 | 辰欣药业股份有限公司 | 一种提高埃索美拉唑钠稳定性的方法 |
| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| WO2017145146A1 (en) | 2016-02-25 | 2017-08-31 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| US10729735B1 (en) | 2016-09-14 | 2020-08-04 | Phoenix Biotechnology, Inc. | Method and compostitions for treating coronavirus infection |
| US11878011B2 (en) | 2020-05-07 | 2024-01-23 | Redhill Biopharma Ltd. | Method for eradicating Helicobacter pylori infection in patients regardless of body mass index |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| AU4640985A (en) * | 1984-08-31 | 1986-03-06 | Nippon Chemiphar Co. Ltd. | Benzimidazole derivatives |
| SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
| US5229181A (en) * | 1990-10-30 | 1993-07-20 | Amber Technologies | Tubular knit cleanroom wiper |
| TW209174B (enExample) | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
| IT1251153B (it) | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
| US5178867A (en) * | 1991-08-19 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug in short-time period |
| KR100355130B1 (ko) * | 1992-09-18 | 2003-01-30 | 야마노우치세이야쿠 가부시키가이샤 | 하이드로겔서방성정제 |
| JPH06199657A (ja) * | 1992-12-10 | 1994-07-19 | Sumitomo Pharmaceut Co Ltd | 徐放性製剤 |
| SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| JPH07330629A (ja) * | 1994-06-02 | 1995-12-19 | Nippon Shokubai Co Ltd | 徐放性製剤 |
| DK1078628T3 (da) * | 1994-07-08 | 2009-02-23 | Astrazeneca Ab | Tabletteret flerenhedsdoseringsform |
| BR9508261A (pt) * | 1994-07-08 | 1997-12-23 | Astra Ab | Formulação oral entericamente revestida uso da mesma processo para preparer a formulação inibir a secreção de ácido gástrico em mamíferos e no ser humano e tratar doenças relacionadas ao ácido gástrico em maníferos e no ser humano e pacote de empola de pressão transversal |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
| US6132768A (en) | 1995-07-05 | 2000-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors |
| SE9600071D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
| AU3290397A (en) * | 1996-06-10 | 1998-01-07 | Depomed, Inc. | Gastric-retentive oral controlled drug delivery system with enhanced retention properties |
| SE9602442D0 (sv) * | 1996-06-20 | 1996-06-20 | Astra Ab | Administration of pharmaceuticals |
| DE19626045C2 (de) * | 1996-06-28 | 1998-12-03 | Klinge Co Chem Pharm Fab | Stabile Arzneiform zur oralen Verabreichung, welche Omeprazol als aktiven Wirkstoff enthält, sowie Verfahren zur Herstellung derselben |
| US7016717B2 (en) * | 2002-07-05 | 2006-03-21 | The Regents Of The University Of California | Near-infrared spectroscopic tissue imaging for medical applications |
| ITPD20050230A1 (it) * | 2005-07-28 | 2007-01-29 | Marcato Spa | Macchina ad uso domestico per la estrusione di paste alimentari fresche |
-
1997
- 1997-12-22 SE SE9704869A patent/SE9704869D0/xx unknown
-
1998
- 1998-12-08 ZA ZA9811239A patent/ZA9811239B/xx unknown
- 1998-12-09 AR ARP980106244A patent/AR017201A1/es not_active Application Discontinuation
- 1998-12-09 TW TW087120440A patent/TWI249410B/zh not_active IP Right Cessation
- 1998-12-11 MA MA25383A patent/MA26576A1/fr unknown
- 1998-12-16 DZ DZ980295A patent/DZ2685A1/xx active
- 1998-12-16 TN TNTNSN98229A patent/TNSN98229A1/fr unknown
- 1998-12-17 US US09/555,744 patent/US6605303B1/en not_active Expired - Lifetime
- 1998-12-17 TR TR2000/01981T patent/TR200001981T2/xx unknown
- 1998-12-17 CA CA002315261A patent/CA2315261C/en not_active Expired - Fee Related
- 1998-12-17 BR BR9814378-6A patent/BR9814378A/pt not_active Application Discontinuation
- 1998-12-17 JP JP2000525083A patent/JP4865945B2/ja not_active Expired - Fee Related
- 1998-12-17 PL PL98341428A patent/PL193776B1/pl unknown
- 1998-12-17 EP EP98964631A patent/EP1043976B1/en not_active Expired - Lifetime
- 1998-12-17 SK SK807-2000A patent/SK284988B6/sk unknown
- 1998-12-17 WO PCT/SE1998/002368 patent/WO1999032091A1/en not_active Ceased
- 1998-12-17 KR KR1020067016717A patent/KR20060097069A/ko not_active Withdrawn
- 1998-12-17 CN CNB988136163A patent/CN1171582C/zh not_active Expired - Fee Related
- 1998-12-17 KR KR1020007006908A patent/KR100755154B1/ko not_active Expired - Fee Related
- 1998-12-17 ES ES98964631T patent/ES2252875T3/es not_active Expired - Lifetime
- 1998-12-17 AT AT98964631T patent/ATE312602T1/de not_active IP Right Cessation
- 1998-12-17 HR HR20000380A patent/HRP20000380B1/xx not_active IP Right Cessation
- 1998-12-17 RU RU2000116011/14A patent/RU2214232C2/ru not_active IP Right Cessation
- 1998-12-17 EE EEP200000383A patent/EE04901B1/xx not_active IP Right Cessation
- 1998-12-17 HU HU0101437A patent/HUP0101437A3/hu unknown
- 1998-12-17 NZ NZ505127A patent/NZ505127A/xx unknown
- 1998-12-17 DE DE69832816T patent/DE69832816T2/de not_active Expired - Lifetime
- 1998-12-17 AU AU19912/99A patent/AU759634B2/en not_active Ceased
- 1998-12-17 IL IL13682798A patent/IL136827A0/xx not_active IP Right Cessation
- 1998-12-17 DK DK98964631T patent/DK1043976T3/da active
- 1998-12-17 UA UA2000063360A patent/UA69397C2/uk unknown
- 1998-12-17 CZ CZ20002314A patent/CZ299228B6/cs not_active IP Right Cessation
- 1998-12-17 YU YU36700A patent/YU36700A/sh unknown
- 1998-12-21 MY MYPI98005796A patent/MY126555A/en unknown
-
1999
- 1999-02-17 SA SA99191077A patent/SA99191077B1/ar unknown
-
2000
- 2000-06-08 IS IS5524A patent/IS5524A/is unknown
- 2000-06-15 IL IL136827A patent/IL136827A/en unknown
- 2000-06-21 NO NO20003218A patent/NO20003218L/no not_active Application Discontinuation
- 2000-07-17 BG BG104620A patent/BG65028B1/bg unknown
-
2006
- 2006-03-13 CY CY20061100346T patent/CY1106072T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2000116011A (ru) | Пероральная фармацевтическая лекарственная форма с продолжительным высвобождением | |
| CA2315261C (en) | Oral pharmaceutical extended release dosage form | |
| US6610323B1 (en) | Oral pharmaceutical pulsed release dosage form | |
| KR100740218B1 (ko) | 벤즈이미다졸 유도체의 경구 투여용 약학적 제형 및 그제조방법 | |
| CN1236770C (zh) | 胃酸分泌抑制组合物 | |
| EP1607088B1 (en) | Controlled release composition | |
| RU96107040A (ru) | Многоединичный фармацевтический препарат, содержащий ингибитор протонного насоса | |
| CN1134668A (zh) | 含有质子泵抑制剂的多单元药物制剂 | |
| RU96120189A (ru) | Новые фармацевтические препараты и способы их получения | |
| JP2004508396A (ja) | 非ステロイド性抗炎症薬およびプロトンポンプ阻害薬を含有する医薬製剤 | |
| JP2004155773A (ja) | 安定な固形製剤 | |
| JP2000512993A (ja) | Ｈ▲上＋▼，ｋ▲上＋▼−ａｔｐアーゼ阻害剤の投与計画 | |
| JPWO2007074910A1 (ja) | 放出制御固形製剤 | |
| EP3377046A1 (en) | Pharmaceutical composition containing a non-steroidal antiinflammatory drug and a proton pump inhibitor | |
| WO2000028975A2 (en) | Improved chemical process and pharmaceutical formulation | |
| EA012261B1 (ru) | Лекарственные формы, содержащие ингибитор протонного насоса и прокинетический агент | |
| JP2014508187A (ja) | 選択的セロトニン再取り込み阻害薬の放出制御医薬組成物 | |
| WO2009137648A1 (en) | Multilayer proton pump inhibitor tablets | |
| WO2004034973A2 (en) | Method of treating snoring and other obstructive breathing disorders | |
| TH59041A (th) | รูปแบบขนาดสารทางเภสัชศาสตร์ที่มีการปลดปล่อยนานสำหรับให้ทางปาก | |
| WO2006111853A2 (en) | Stable solid dosage forms of acid labile drug | |
| JP2005522462A (ja) | 気道疾患の治療のためのプロトンポンプ阻害剤の使用 | |
| CH699302A1 (de) | Orale pharmazeutische Formulierung für Omeprazol enthaltend eine spezifische Trennschicht. | |
| MXPA00005896A (en) | Oral pharmaceutical extended release dosage form | |
| HK1017991B (en) | Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a nsaid |