SK284988B6 - Orálna farmaceutická dávková forma s predĺženým uvoľňovaním - Google Patents
Orálna farmaceutická dávková forma s predĺženým uvoľňovaním Download PDFInfo
- Publication number
- SK284988B6 SK284988B6 SK807-2000A SK8072000A SK284988B6 SK 284988 B6 SK284988 B6 SK 284988B6 SK 8072000 A SK8072000 A SK 8072000A SK 284988 B6 SK284988 B6 SK 284988B6
- Authority
- SK
- Slovakia
- Prior art keywords
- dosage form
- atpase inhibitor
- core material
- matrix
- hydrophilic
- Prior art date
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- 239000002552 dosage form Substances 0.000 title claims abstract description 63
- 238000013265 extended release Methods 0.000 title abstract description 4
- 239000011159 matrix material Substances 0.000 claims abstract description 54
- 239000011162 core material Substances 0.000 claims abstract description 48
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 24
- 239000000362 adenosine triphosphatase inhibitor Substances 0.000 claims abstract description 23
- 229940121819 ATPase inhibitor Drugs 0.000 claims abstract description 22
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims description 49
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- 229960000381 omeprazole Drugs 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 25
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- 239000002702 enteric coating Substances 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 20
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 17
- 238000013268 sustained release Methods 0.000 claims description 16
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- 230000002035 prolonged effect Effects 0.000 claims description 15
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- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
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- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims description 11
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- 229940045902 sodium stearyl fumarate Drugs 0.000 claims description 11
- 239000000654 additive Substances 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 claims description 10
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
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- 239000011777 magnesium Substances 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- -1 omeprazole alkaline salt Chemical class 0.000 claims description 6
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 5
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 2
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- 229960003174 lansoprazole Drugs 0.000 claims description 2
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704869A SE9704869D0 (sv) | 1997-12-22 | 1997-12-22 | New pharmaceutical formulaton II |
| PCT/SE1998/002368 WO1999032091A1 (en) | 1997-12-22 | 1998-12-17 | Oral pharmaceutical extended release dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK8072000A3 SK8072000A3 (en) | 2001-01-18 |
| SK284988B6 true SK284988B6 (sk) | 2006-04-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK807-2000A SK284988B6 (sk) | 1997-12-22 | 1998-12-17 | Orálna farmaceutická dávková forma s predĺženým uvoľňovaním |
Country Status (38)
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6998796A (en) * | 1995-09-21 | 1997-04-28 | Pharma Pass Llc | Novel composition containing an acid-labile benzimidazole and process for its preparation |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| ES2216351T3 (es) | 1997-12-08 | 2004-10-16 | Altana Pharma Ag | Nueva forma de supositorio que comprende un compuesto activo labil o acidos. |
| FR2774288B1 (fr) * | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques |
| ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
| FR2793688B1 (fr) | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
| US7029701B2 (en) * | 2000-09-11 | 2006-04-18 | Andrx Pharmaceuticals, Llc | Composition for the treatment and prevention of ischemic events |
| WO2002032427A1 (en) * | 2000-10-20 | 2002-04-25 | Galephar M/F | Stable oral formulation containing benzimidazole derivative |
| AU2002221939A1 (en) * | 2000-12-07 | 2002-06-18 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Rapidly disintegrating tablet comprising an acid-labile active ingredient |
| JP4848101B2 (ja) * | 2001-08-17 | 2011-12-28 | 株式会社フジモト・コーポレーション | 徐放性マイクロペレット |
| PT1492511E (pt) | 2002-04-09 | 2009-04-09 | Flamel Tech Sa | Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s) |
| TW200410955A (en) | 2002-07-29 | 2004-07-01 | Altana Pharma Ag | Novel salt of (S)-PANTOPRAZOLE |
| CN1681534A (zh) * | 2002-09-26 | 2005-10-12 | 山之内制药株式会社 | 药物吸收性改善剂 |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| JP4493970B2 (ja) * | 2002-10-16 | 2010-06-30 | 武田薬品工業株式会社 | 持続性製剤 |
| CA2771725C (en) | 2002-10-16 | 2015-08-18 | Takeda Pharmaceutical Company Limited | Solid preparation comprising a non-toxic base and a proton pump inhibitor |
| JP4933033B2 (ja) * | 2003-03-17 | 2012-05-16 | 武田薬品工業株式会社 | 放出制御組成物 |
| CA2519208A1 (en) | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Controlled release composition |
| CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| WO2005012289A1 (en) * | 2003-07-17 | 2005-02-10 | Altana Pharma Ag | Novel salt of (r) - pantoprazole |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| TWI372066B (en) | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
| FR2861990B1 (fr) * | 2003-11-10 | 2006-02-10 | Nouveaux Produits Pharma | Comprimes faiblement doses a reseau de polymeres |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2469427A1 (en) * | 2004-06-01 | 2005-12-01 | Pharmascience Inc. | Dry mixed dosage form containing benzimidazole derivatives |
| EP1768668A2 (en) | 2004-06-16 | 2007-04-04 | Tap Pharmaceutical Products, Inc. | Multiple ppi dosage form |
| WO2006082523A2 (en) * | 2005-01-25 | 2006-08-10 | Aurobindo Pharma Limited | Pharmaceutical sustained release composition of metformin |
| KR100591142B1 (ko) * | 2005-11-04 | 2006-06-20 | 지엘팜텍 주식회사 | 파록세틴을 활성물질로 함유하는 장용성 서방형 정제 |
| DE102005060393A1 (de) * | 2005-12-16 | 2007-06-21 | Add Advanced Drug Delivery Technologies Ltd. | Orales Präparat mit kontrollierter Freisetzung |
| SG184754A1 (en) * | 2005-12-28 | 2012-10-30 | Takeda Pharmaceutical | Controlled release solid preparation |
| EP2026768B1 (en) * | 2006-06-01 | 2018-02-28 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| US20080181932A1 (en) * | 2007-01-30 | 2008-07-31 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
| WO2008112388A1 (en) | 2007-03-14 | 2008-09-18 | Drugtech Corporation | Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals |
| EP2203068A4 (en) * | 2007-10-12 | 2012-08-22 | Takeda Pharmaceuticals Usa Inc | METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES INDEPENDENT FROM FOOD STORAGE |
| US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
| JP5592902B2 (ja) | 2009-03-09 | 2014-09-17 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 治療薬の徐放性組成物 |
| US20140127296A1 (en) * | 2012-11-05 | 2014-05-08 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
| SI2956149T1 (sl) | 2013-02-13 | 2019-11-29 | Redhill Biopharma Ltd | Farmacevtske kombinacije za zdravljenje okužbe z bakterijo helicobacter pylori |
| CN104721185A (zh) * | 2013-12-21 | 2015-06-24 | 辰欣药业股份有限公司 | 一种提高埃索美拉唑钠稳定性的方法 |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| WO2017145146A1 (en) | 2016-02-25 | 2017-08-31 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| US10729735B1 (en) | 2016-09-14 | 2020-08-04 | Phoenix Biotechnology, Inc. | Method and compostitions for treating coronavirus infection |
| US11878011B2 (en) | 2020-05-07 | 2024-01-23 | Redhill Biopharma Ltd. | Method for eradicating Helicobacter pylori infection in patients regardless of body mass index |
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| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
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| IT1251153B (it) | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
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| US6132768A (en) | 1995-07-05 | 2000-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors |
| SE9600071D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
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-
1997
- 1997-12-22 SE SE9704869A patent/SE9704869D0/xx unknown
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1998
- 1998-12-08 ZA ZA9811239A patent/ZA9811239B/xx unknown
- 1998-12-09 TW TW087120440A patent/TWI249410B/zh not_active IP Right Cessation
- 1998-12-09 AR ARP980106244A patent/AR017201A1/es not_active Application Discontinuation
- 1998-12-11 MA MA25383A patent/MA26576A1/fr unknown
- 1998-12-16 DZ DZ980295A patent/DZ2685A1/xx active
- 1998-12-16 TN TNTNSN98229A patent/TNSN98229A1/fr unknown
- 1998-12-17 CZ CZ20002314A patent/CZ299228B6/cs not_active IP Right Cessation
- 1998-12-17 HU HU0101437A patent/HUP0101437A3/hu unknown
- 1998-12-17 BR BR9814378-6A patent/BR9814378A/pt not_active Application Discontinuation
- 1998-12-17 KR KR1020007006908A patent/KR100755154B1/ko not_active Expired - Fee Related
- 1998-12-17 UA UA2000063360A patent/UA69397C2/uk unknown
- 1998-12-17 CA CA002315261A patent/CA2315261C/en not_active Expired - Fee Related
- 1998-12-17 EE EEP200000383A patent/EE04901B1/xx not_active IP Right Cessation
- 1998-12-17 AT AT98964631T patent/ATE312602T1/de not_active IP Right Cessation
- 1998-12-17 NZ NZ505127A patent/NZ505127A/xx unknown
- 1998-12-17 PL PL98341428A patent/PL193776B1/pl unknown
- 1998-12-17 JP JP2000525083A patent/JP4865945B2/ja not_active Expired - Fee Related
- 1998-12-17 YU YU36700A patent/YU36700A/sh unknown
- 1998-12-17 WO PCT/SE1998/002368 patent/WO1999032091A1/en not_active Ceased
- 1998-12-17 AU AU19912/99A patent/AU759634B2/en not_active Ceased
- 1998-12-17 DE DE69832816T patent/DE69832816T2/de not_active Expired - Lifetime
- 1998-12-17 KR KR1020067016717A patent/KR20060097069A/ko not_active Withdrawn
- 1998-12-17 US US09/555,744 patent/US6605303B1/en not_active Expired - Lifetime
- 1998-12-17 RU RU2000116011/14A patent/RU2214232C2/ru not_active IP Right Cessation
- 1998-12-17 SK SK807-2000A patent/SK284988B6/sk unknown
- 1998-12-17 IL IL13682798A patent/IL136827A0/xx not_active IP Right Cessation
- 1998-12-17 CN CNB988136163A patent/CN1171582C/zh not_active Expired - Fee Related
- 1998-12-17 TR TR2000/01981T patent/TR200001981T2/xx unknown
- 1998-12-17 ES ES98964631T patent/ES2252875T3/es not_active Expired - Lifetime
- 1998-12-17 DK DK98964631T patent/DK1043976T3/da active
- 1998-12-17 EP EP98964631A patent/EP1043976B1/en not_active Expired - Lifetime
- 1998-12-17 HR HR20000380A patent/HRP20000380B1/xx not_active IP Right Cessation
- 1998-12-21 MY MYPI98005796A patent/MY126555A/en unknown
-
1999
- 1999-02-17 SA SA99191077A patent/SA99191077B1/ar unknown
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2000
- 2000-06-08 IS IS5524A patent/IS5524A/is unknown
- 2000-06-15 IL IL136827A patent/IL136827A/en unknown
- 2000-06-21 NO NO20003218A patent/NO20003218L/no not_active Application Discontinuation
- 2000-07-17 BG BG104620A patent/BG65028B1/bg unknown
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2006
- 2006-03-13 CY CY20061100346T patent/CY1106072T1/el unknown
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