JP2001522849A5 - - Google Patents
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- Publication number
- JP2001522849A5 JP2001522849A5 JP2000520440A JP2000520440A JP2001522849A5 JP 2001522849 A5 JP2001522849 A5 JP 2001522849A5 JP 2000520440 A JP2000520440 A JP 2000520440A JP 2000520440 A JP2000520440 A JP 2000520440A JP 2001522849 A5 JP2001522849 A5 JP 2001522849A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxo
- compound according
- methyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 description 10
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 1
- -1 1,2,3,4,6,7-hexahydro-4- Methyl-5-oxo-1,4-diazepin-1-yl Chemical group 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- 0 Cc1cc(N(C[C@](C*)O2)C2=O)cc(*)c1N(CC1)CCN(*)C1=O Chemical compound Cc1cc(N(C[C@](C*)O2)C2=O)cc(*)c1N(CC1)CCN(*)C1=O 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- TUROGGJOBCYLHI-AWEZNQCLSA-N n-[[(5s)-3-[3-fluoro-4-(4-methyl-5-oxo-1,4-diazepan-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound C1CC(=O)N(C)CCN1C1=CC=C(N2C(O[C@@H](CNC(C)=O)C2)=O)C=C1F TUROGGJOBCYLHI-AWEZNQCLSA-N 0.000 description 1
- KTLHCJNSFNSLOZ-ZDUSSCGKSA-N n-[[(5s)-3-[3-fluoro-4-(5-oxo-1,4-diazepan-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCC(=O)NCC1 KTLHCJNSFNSLOZ-ZDUSSCGKSA-N 0.000 description 1
- IEEKDTALXZSEBL-ZDUSSCGKSA-N n-[[(5s)-3-[3-fluoro-4-(5-oxo-1,4-diazepan-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]ethanethioamide Chemical compound O=C1O[C@@H](CNC(=S)C)CN1C(C=C1F)=CC=C1N1CCC(=O)NCC1 IEEKDTALXZSEBL-ZDUSSCGKSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6537697P | 1997-11-12 | 1997-11-12 | |
| US60/065,376 | 1997-11-12 | ||
| PCT/US1998/022639 WO1999024428A1 (en) | 1997-11-12 | 1998-10-30 | Oxazolidinone derivatives and pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001522849A JP2001522849A (ja) | 2001-11-20 |
| JP2001522849A5 true JP2001522849A5 (https=) | 2006-01-05 |
Family
ID=22062294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520440A Withdrawn JP2001522849A (ja) | 1997-11-12 | 1998-10-30 | オキサゾリジノン誘導体および医薬組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5998406A (https=) |
| EP (1) | EP1030852B1 (https=) |
| JP (1) | JP2001522849A (https=) |
| KR (1) | KR20010031953A (https=) |
| CN (1) | CN1154644C (https=) |
| AT (1) | ATE250054T1 (https=) |
| AU (1) | AU739055B2 (https=) |
| BR (1) | BR9813985A (https=) |
| CA (1) | CA2303959A1 (https=) |
| DE (1) | DE69818294T2 (https=) |
| DK (1) | DK1030852T3 (https=) |
| ES (1) | ES2207010T3 (https=) |
| HU (1) | HUP0100470A3 (https=) |
| IL (1) | IL136062A (https=) |
| NO (1) | NO317291B1 (https=) |
| NZ (1) | NZ504503A (https=) |
| PT (1) | PT1030852E (https=) |
| RU (1) | RU2215740C2 (https=) |
| SK (1) | SK284577B6 (https=) |
| TR (1) | TR200001330T2 (https=) |
| WO (1) | WO1999024428A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| KR100355345B1 (ko) * | 2000-01-21 | 2002-10-12 | 한국과학기술연구원 | 티오펜환을 함유한 신규한 옥사졸리디논 유도체, 그의 제조방법 및 조성물 |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| ES2258234T3 (es) | 2002-08-12 | 2006-08-16 | PHARMACIA & UPJOHN COMPANY LLC | N-aril-2-oxazolidinonas y sus derivados. |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| BRPI0413838A (pt) * | 2003-08-25 | 2006-10-24 | Warner Lambert Co | compostos de ariloxazolidinona antimicrobianos |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| EP1819699A2 (en) * | 2004-11-29 | 2007-08-22 | Pharmacia & Upjohn Company LLC | Diazepine oxazolidinones as antibacterial agents |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) * | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| WO2007000644A1 (en) | 2005-06-29 | 2007-01-04 | Pharmacia & Upjohn Company Llc | Homomorpholine oxazolidinones as antibacterial agents |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| US8188270B2 (en) | 2005-10-04 | 2012-05-29 | Bayer Schering Pharma Aktiengesellschaft | Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| KR20080110877A (ko) | 2006-03-31 | 2008-12-19 | 재단법인 이쯔우 연구소 | 헤테로환을 갖는 신규 화합물 |
| WO2009044777A1 (ja) * | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| WO2012059823A1 (en) | 2010-11-03 | 2012-05-10 | Wockhardt Limited | Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl] - 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester |
| WO2015173664A1 (en) | 2014-05-14 | 2015-11-19 | Wockhardt Limited | Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| CA1320730C (en) * | 1987-10-16 | 1993-07-27 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
| EP0316594B1 (en) * | 1987-10-21 | 1993-09-29 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| AU617871B2 (en) * | 1988-09-15 | 1991-12-05 | Pharmacia & Upjohn Company | In position 3 substituted-5-beta-amidomethyl-oxazolidin-2- ones |
| ATE146783T1 (de) * | 1991-11-01 | 1997-01-15 | Upjohn Co | Substituierte aryl- und heteroaryl- phenyloxazolidinone |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| EP0730591B1 (en) * | 1993-11-22 | 1999-07-14 | PHARMACIA & UPJOHN COMPANY | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
| JPH0873455A (ja) * | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
-
1998
- 1998-10-30 BR BR9813985-1A patent/BR9813985A/pt not_active IP Right Cessation
- 1998-10-30 TR TR2000/01330T patent/TR200001330T2/xx unknown
- 1998-10-30 ES ES98956200T patent/ES2207010T3/es not_active Expired - Lifetime
- 1998-10-30 RU RU2000114891/04A patent/RU2215740C2/ru not_active IP Right Cessation
- 1998-10-30 HU HU0100470A patent/HUP0100470A3/hu unknown
- 1998-10-30 DE DE69818294T patent/DE69818294T2/de not_active Expired - Fee Related
- 1998-10-30 EP EP98956200A patent/EP1030852B1/en not_active Expired - Lifetime
- 1998-10-30 WO PCT/US1998/022639 patent/WO1999024428A1/en not_active Ceased
- 1998-10-30 SK SK618-2000A patent/SK284577B6/sk unknown
- 1998-10-30 DK DK98956200T patent/DK1030852T3/da active
- 1998-10-30 PT PT98956200T patent/PT1030852E/pt unknown
- 1998-10-30 CN CNB988093952A patent/CN1154644C/zh not_active Expired - Fee Related
- 1998-10-30 CA CA002303959A patent/CA2303959A1/en not_active Abandoned
- 1998-10-30 US US09/183,432 patent/US5998406A/en not_active Expired - Fee Related
- 1998-10-30 NZ NZ504503A patent/NZ504503A/xx unknown
- 1998-10-30 JP JP2000520440A patent/JP2001522849A/ja not_active Withdrawn
- 1998-10-30 KR KR1020007005061A patent/KR20010031953A/ko not_active Ceased
- 1998-10-30 AT AT98956200T patent/ATE250054T1/de not_active IP Right Cessation
- 1998-10-30 AU AU12778/99A patent/AU739055B2/en not_active Ceased
- 1998-10-30 IL IL13606298A patent/IL136062A/en not_active IP Right Cessation
-
2000
- 2000-05-11 NO NO20002434A patent/NO317291B1/no unknown
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