JP2003518106A5 - - Google Patents
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- Publication number
- JP2003518106A5 JP2003518106A5 JP2001547075A JP2001547075A JP2003518106A5 JP 2003518106 A5 JP2003518106 A5 JP 2003518106A5 JP 2001547075 A JP2001547075 A JP 2001547075A JP 2001547075 A JP2001547075 A JP 2001547075A JP 2003518106 A5 JP2003518106 A5 JP 2003518106A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- pharmaceutically acceptable
- embedded image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 36
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 18
- 125000000217 alkyl group Chemical group 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
- -1 benzyloxyacetyl Chemical group 0.000 description 7
- 239000000203 mixture Substances 0.000 description 5
- 125000002877 alkyl aryl group Chemical group 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 0 CC1CCN(*)CC1 Chemical compound CC1CCN(*)CC1 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 206010005940 Bone and joint infections Diseases 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000003106 haloaryl group Chemical group 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17292399P | 1999-12-21 | 1999-12-21 | |
| US60/172,923 | 1999-12-21 | ||
| PCT/US2000/033835 WO2001046164A1 (en) | 1999-12-21 | 2000-12-14 | Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003518106A JP2003518106A (ja) | 2003-06-03 |
| JP2003518106A5 true JP2003518106A5 (https=) | 2008-02-14 |
Family
ID=22629768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001547075A Pending JP2003518106A (ja) | 1999-12-21 | 2000-12-14 | 抗菌薬としてのピペリジニルオキシおよびピロリジニルオキシフェニルオキサゾリジノン類 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6518285B2 (https=) |
| EP (1) | EP1246810B1 (https=) |
| JP (1) | JP2003518106A (https=) |
| CN (1) | CN1227238C (https=) |
| AR (1) | AR029420A1 (https=) |
| AT (1) | ATE326452T1 (https=) |
| AU (1) | AU784314B2 (https=) |
| CA (1) | CA2395204C (https=) |
| CO (1) | CO5280081A1 (https=) |
| CY (1) | CY1106124T1 (https=) |
| DE (1) | DE60028085T2 (https=) |
| DK (1) | DK1246810T3 (https=) |
| ES (1) | ES2265365T3 (https=) |
| MX (1) | MXPA02006323A (https=) |
| MY (1) | MY127677A (https=) |
| PT (1) | PT1246810E (https=) |
| WO (1) | WO2001046164A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| US6940748B2 (en) | 2002-05-16 | 2005-09-06 | Micron Technology, Inc. | Stacked 1T-nMTJ MRAM structure |
| AU2003202753A1 (en) * | 2003-02-07 | 2004-08-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| NZ543757A (en) | 2003-04-30 | 2009-02-28 | Morphochem Ag Komb Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| AU2004299278C9 (en) | 2003-12-18 | 2013-10-24 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| AU2006296004B2 (en) | 2005-09-27 | 2011-11-17 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
| JP5209254B2 (ja) * | 2007-08-30 | 2013-06-12 | 日本曹達株式会社 | 置換フェノキシアザビシクロオクタン誘導体の製造方法 |
| CN108785728A (zh) * | 2017-05-05 | 2018-11-13 | 国家纳米科学中心 | 含药物中间体修饰的纳米金的抗菌敷料、其制备方法及应用 |
| CN109503569B (zh) * | 2019-01-03 | 2021-01-15 | 山东大学 | 噻唑类衍生物及其制备方法和应用 |
| EP4416140A1 (en) * | 2021-10-12 | 2024-08-21 | F. Hoffmann-La Roche AG | Sulfonylpiperazinyl compounds for treatment of bacterial infections |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705799A (en) | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| HU196771B (en) * | 1983-06-07 | 1989-01-30 | Du Pont | Process for production of intermediers of derivatives of oxo-oxazolidinil-benzol having antibacterial effect |
| ES8506659A1 (es) | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
| ATE146783T1 (de) | 1991-11-01 | 1997-01-15 | Upjohn Co | Substituierte aryl- und heteroaryl- phenyloxazolidinone |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| BR9509673A (pt) | 1994-11-15 | 1997-09-30 | Upjohn Co | Compostos e uso dos mesmos |
| US6124334A (en) | 1995-02-03 | 2000-09-26 | Pharmacia & Upjohn Company | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
| DK0807112T3 (da) | 1995-02-03 | 2001-12-17 | Upjohn Co | Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon |
| HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| NZ306310A (en) | 1995-05-11 | 2001-05-25 | Upjohn Co | Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones |
| US5883093A (en) | 1995-09-12 | 1999-03-16 | Pharmacia & Upjohn Company | Phenyloxazolidinone antimicrobials |
| DE19601264A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| ES2166073T3 (es) | 1996-04-11 | 2002-04-01 | Upjohn Co | Procedimiento para preparar oxazolidinonas. |
| CN1138765C (zh) | 1997-05-30 | 2004-02-18 | 法玛西雅厄普约翰美国公司 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| WO1999012914A1 (en) | 1997-09-11 | 1999-03-18 | Hokuriku Seiyaku Co., Ltd. | Thiourea derivatives |
| JPH11322729A (ja) | 1998-03-09 | 1999-11-24 | Hokuriku Seiyaku Co Ltd | ジチオカルバミド酸誘導体 |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
-
2000
- 2000-12-05 US US09/729,342 patent/US6518285B2/en not_active Expired - Lifetime
- 2000-12-14 CN CNB008189803A patent/CN1227238C/zh not_active Expired - Fee Related
- 2000-12-14 JP JP2001547075A patent/JP2003518106A/ja active Pending
- 2000-12-14 DE DE60028085T patent/DE60028085T2/de not_active Expired - Fee Related
- 2000-12-14 AT AT00986365T patent/ATE326452T1/de not_active IP Right Cessation
- 2000-12-14 MX MXPA02006323A patent/MXPA02006323A/es active IP Right Grant
- 2000-12-14 ES ES00986365T patent/ES2265365T3/es not_active Expired - Lifetime
- 2000-12-14 EP EP00986365A patent/EP1246810B1/en not_active Expired - Lifetime
- 2000-12-14 AU AU22617/01A patent/AU784314B2/en not_active Ceased
- 2000-12-14 DK DK00986365T patent/DK1246810T3/da active
- 2000-12-14 WO PCT/US2000/033835 patent/WO2001046164A1/en not_active Ceased
- 2000-12-14 PT PT00986365T patent/PT1246810E/pt unknown
- 2000-12-14 CA CA002395204A patent/CA2395204C/en not_active Expired - Fee Related
- 2000-12-20 MY MYPI20006020A patent/MY127677A/en unknown
- 2000-12-20 AR ARP000106796A patent/AR029420A1/es unknown
- 2000-12-21 CO CO00097143A patent/CO5280081A1/es not_active Application Discontinuation
-
2006
- 2006-07-21 CY CY20061101016T patent/CY1106124T1/el unknown
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