JP2003518106A - 抗菌薬としてのピペリジニルオキシおよびピロリジニルオキシフェニルオキサゾリジノン類 - Google Patents

抗菌薬としてのピペリジニルオキシおよびピロリジニルオキシフェニルオキサゾリジノン類

Info

Publication number
JP2003518106A
JP2003518106A JP2001547075A JP2001547075A JP2003518106A JP 2003518106 A JP2003518106 A JP 2003518106A JP 2001547075 A JP2001547075 A JP 2001547075A JP 2001547075 A JP2001547075 A JP 2001547075A JP 2003518106 A JP2003518106 A JP 2003518106A
Authority
JP
Japan
Prior art keywords
oxy
compound
mmol
oxo
piperidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001547075A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003518106A5 (https=
Inventor
ウエイドナー−ウエルズ，マイケル
ボグズ，クリステイン
フラスタ，デニス
ネルソン，エリン
Original Assignee
オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド filed Critical オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド
Publication of JP2003518106A publication Critical patent/JP2003518106A/ja
Publication of JP2003518106A5 publication Critical patent/JP2003518106A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2001547075A 1999-12-21 2000-12-14 抗菌薬としてのピペリジニルオキシおよびピロリジニルオキシフェニルオキサゾリジノン類 Pending JP2003518106A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17292399P 1999-12-21 1999-12-21
US60/172,923 1999-12-21
PCT/US2000/033835 WO2001046164A1 (en) 1999-12-21 2000-12-14 Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials

Publications (2)

Publication Number Publication Date
JP2003518106A true JP2003518106A (ja) 2003-06-03
JP2003518106A5 JP2003518106A5 (https=) 2008-02-14

Family

ID=22629768

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001547075A Pending JP2003518106A (ja) 1999-12-21 2000-12-14 抗菌薬としてのピペリジニルオキシおよびピロリジニルオキシフェニルオキサゾリジノン類

Country Status (17)

Country Link
US (1) US6518285B2 (https=)
EP (1) EP1246810B1 (https=)
JP (1) JP2003518106A (https=)
CN (1) CN1227238C (https=)
AR (1) AR029420A1 (https=)
AT (1) ATE326452T1 (https=)
AU (1) AU784314B2 (https=)
CA (1) CA2395204C (https=)
CO (1) CO5280081A1 (https=)
CY (1) CY1106124T1 (https=)
DE (1) DE60028085T2 (https=)
DK (1) DK1246810T3 (https=)
ES (1) ES2265365T3 (https=)
MX (1) MXPA02006323A (https=)
MY (1) MY127677A (https=)
PT (1) PT1246810E (https=)
WO (1) WO2001046164A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504262A (ja) * 2003-09-03 2007-03-01 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー オキサゾリジノン‐キノロンハイブリッド調製用中間体
JP2008513506A (ja) * 2004-09-20 2008-05-01 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
JP2009057299A (ja) * 2007-08-30 2009-03-19 Nippon Soda Co Ltd 置換フェノキシアザビシクロオクタン誘導体およびその製造方法
JP5114202B2 (ja) * 2005-09-27 2013-01-09 塩野義製薬株式会社 Ｐｇｄ２受容体アンタゴニスト活性を有するスルホンアミド誘導体
JP2024538778A (ja) * 2021-10-12 2024-10-23 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の処置のためのスルホニルピペラジニル化合物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US6940748B2 (en) 2002-05-16 2005-09-06 Micron Technology, Inc. Stacked 1T-nMTJ MRAM structure
AU2003202753A1 (en) * 2003-02-07 2004-08-30 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
NZ543757A (en) 2003-04-30 2009-02-28 Morphochem Ag Komb Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
AU2004299278C9 (en) 2003-12-18 2013-10-24 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051091A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2006343359A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN108785728A (zh) * 2017-05-05 2018-11-13 国家纳米科学中心 含药物中间体修饰的纳米金的抗菌敷料、其制备方法及应用
CN109503569B (zh) * 2019-01-03 2021-01-15 山东大学 噻唑类衍生物及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608277A (ja) * 1983-06-07 1985-01-17 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー アミノメチルオキソオキサゾリジニルベンゼン誘導体
JPS61134379A (ja) * 1984-12-05 1986-06-21 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー アミノメチルオキソオキサゾリジニルベンゼン誘導体
JPH08301869A (ja) * 1995-04-21 1996-11-19 Bayer Ag ヘテロ原子−含有ベンゾシクロペンタン−オキサゾリジノン
JPH09502436A (ja) * 1993-09-09 1997-03-11 ジ・アップジョン・カンパニー 置換オキサジンおよびチアジンオキサゾリジノン抗微生物剤
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
ATE146783T1 (de) 1991-11-01 1997-01-15 Upjohn Co Substituierte aryl- und heteroaryl- phenyloxazolidinone
BR9509673A (pt) 1994-11-15 1997-09-30 Upjohn Co Compostos e uso dos mesmos
US6124334A (en) 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
DK0807112T3 (da) 1995-02-03 2001-12-17 Upjohn Co Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon
NZ306310A (en) 1995-05-11 2001-05-25 Upjohn Co Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
US5883093A (en) 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
ES2166073T3 (es) 1996-04-11 2002-04-01 Upjohn Co Procedimiento para preparar oxazolidinonas.
CN1138765C (zh) 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
WO1999012914A1 (en) 1997-09-11 1999-03-18 Hokuriku Seiyaku Co., Ltd. Thiourea derivatives
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608277A (ja) * 1983-06-07 1985-01-17 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー アミノメチルオキソオキサゾリジニルベンゼン誘導体
JPS61134379A (ja) * 1984-12-05 1986-06-21 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー アミノメチルオキソオキサゾリジニルベンゼン誘導体
JPH09502436A (ja) * 1993-09-09 1997-03-11 ジ・アップジョン・カンパニー 置換オキサジンおよびチアジンオキサゾリジノン抗微生物剤
JPH08301869A (ja) * 1995-04-21 1996-11-19 Bayer Ag ヘテロ原子−含有ベンゾシクロペンタン−オキサゾリジノン
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504262A (ja) * 2003-09-03 2007-03-01 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー オキサゾリジノン‐キノロンハイブリッド調製用中間体
JP2008513506A (ja) * 2004-09-20 2008-05-01 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
JP2013014623A (ja) * 2004-09-20 2013-01-24 Xenon Pharmaceuticals Inc ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
JP5114202B2 (ja) * 2005-09-27 2013-01-09 塩野義製薬株式会社 Ｐｇｄ２受容体アンタゴニスト活性を有するスルホンアミド誘導体
JP2009057299A (ja) * 2007-08-30 2009-03-19 Nippon Soda Co Ltd 置換フェノキシアザビシクロオクタン誘導体およびその製造方法
JP2024538778A (ja) * 2021-10-12 2024-10-23 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の処置のためのスルホニルピペラジニル化合物

Also Published As

Publication number Publication date
AU784314B2 (en) 2006-03-09
EP1246810B1 (en) 2006-05-17
AU2261701A (en) 2001-07-03
CA2395204A1 (en) 2001-06-28
CN1434810A (zh) 2003-08-06
US6518285B2 (en) 2003-02-11
MY127677A (en) 2006-12-29
PT1246810E (pt) 2006-08-31
CA2395204C (en) 2008-02-05
DE60028085D1 (de) 2006-06-22
AR029420A1 (es) 2003-06-25
EP1246810A1 (en) 2002-10-09
MXPA02006323A (es) 2003-09-22
CO5280081A1 (es) 2003-05-30
CY1106124T1 (el) 2011-06-08
US20020103377A1 (en) 2002-08-01
ATE326452T1 (de) 2006-06-15
CN1227238C (zh) 2005-11-16
DK1246810T3 (da) 2006-09-18
DE60028085T2 (de) 2006-12-07
WO2001046164A1 (en) 2001-06-28
ES2265365T3 (es) 2007-02-16

Similar Documents

Publication Publication Date Title
JP2003518106A (ja) 抗菌薬としてのピペリジニルオキシおよびピロリジニルオキシフェニルオキサゾリジノン類
KR100882377B1 (ko) 치환된 이속사졸 및 항생제로서의 이들의 용도
JP2006519247A (ja) 抗生物質として有用なヒドロキシメチル置換ジヒドロイソオキサゾール誘導体
HUP9901979A2 (hu) 4 és 8 Közötti gyűrűtagszámú heterociklushoz szén-szén kötéssel kapcsolódó fenil-oxazolidin-származékok és az ezeket tartalmazó gyógyszerkészítmények
JPH09505582A (ja) 置換−ヒドロキシアセチルピペラジンフェニルオキサゾリジノンのエステル
JPH11514662A (ja) 抗生物質であるオキサゾリジノン誘導体
JPH11506430A (ja) スピロ環式および二環式ジアジニル−およびカルバジニル−オキサゾリジノン
JP2004518677A (ja) 抗菌性キノロン誘導体および細菌感染を治療するためのその使用
KR20020067557A (ko) 설폭시민 관능기를 가지는 옥사졸리디논 및항미생물제로서의 그의 용도
JP2007500707A (ja) ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法
KR20040030712A (ko) 항균제로서 옥사졸리디논의 신규 유도체
JP4917432B2 (ja) インビボ効力が改良された抗菌活性を有する置換ピペリジノフェニルオキサゾリジノン化合物
WO2002064574A2 (en) Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
KR20020062332A (ko) 히드록시아세틸피페라진 치환체를 갖는 옥사졸리디논의벤조산 에스테르
EP1904489B1 (en) Process for the synthesis of triazoles
KR20110092309A (ko) 신규 항균제
MXPA06013539A (es) 3-[4-(6-{4, 5-dihidroisoxasol- 3-il} piridin-3-il) -3-fenil]-5-(1h-1, 2, 3-triazol-1 -ilmetil)-1, 3-oxazolidin- 2-onas como agentes antibacterianos.
JPWO1998002431A1 (ja) シス置換アミノシクロプロパン誘導体
EP1565461A2 (en) Antibacterial substituted cyanomethyl(ene)piperidinophenyl oxazolidinones, process for their preparation, and pharmaceutical compositions containing them
ES2381155T3 (es) 3-cianopirrolidinil-fenil-oxazolidinonas como agentes antibacterianos
AU2009265791A1 (en) 3-(n-heterocyclyl)-pyrrolidinyl-phenyl-Oxazolidinones as antibacterial agents
WO2009077485A2 (en) 1(2)h-tetrazol-5-yl-phenyl-oxazolidinones as antibacterial agents
TW202423920A (zh) 用於治療哺乳動物感染之新穎化合物
HK1159606A (en) 3-(n-heterocyclyl)-pyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
WO2007004032A1 (en) Oxazolidiones containing cyclobutane as antibacterial agents

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071214

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20080427

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110104

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110719