CN1227238C - 作为抗菌剂的哌啶氧基和吡咯烷氧基苯基噁唑烷酮 - Google Patents

作为抗菌剂的哌啶氧基和吡咯烷氧基苯基噁唑烷酮 Download PDF

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Publication number
CN1227238C
CN1227238C CNB008189803A CN00818980A CN1227238C CN 1227238 C CN1227238 C CN 1227238C CN B008189803 A CNB008189803 A CN B008189803A CN 00818980 A CN00818980 A CN 00818980A CN 1227238 C CN1227238 C CN 1227238C
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CN
China
Prior art keywords
compound
phenyl
oxo
mmol
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB008189803A
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English (en)
Chinese (zh)
Other versions
CN1434810A (zh
Inventor
M·维德纳－维尔斯
C·波格斯
D·拉斯塔
E·内尔森
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3 Dimensional Pharmaceuticals Inc
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3 Dimensional Pharmaceuticals Inc
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Publication date
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Publication of CN1434810A publication Critical patent/CN1434810A/zh
Application granted granted Critical
Publication of CN1227238C publication Critical patent/CN1227238C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CNB008189803A 1999-12-21 2000-12-14 作为抗菌剂的哌啶氧基和吡咯烷氧基苯基噁唑烷酮 Expired - Fee Related CN1227238C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17292399P 1999-12-21 1999-12-21
US60/172,923 1999-12-21

Publications (2)

Publication Number Publication Date
CN1434810A CN1434810A (zh) 2003-08-06
CN1227238C true CN1227238C (zh) 2005-11-16

Family

ID=22629768

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008189803A Expired - Fee Related CN1227238C (zh) 1999-12-21 2000-12-14 作为抗菌剂的哌啶氧基和吡咯烷氧基苯基噁唑烷酮

Country Status (17)

Country Link
US (1) US6518285B2 (https=)
EP (1) EP1246810B1 (https=)
JP (1) JP2003518106A (https=)
CN (1) CN1227238C (https=)
AR (1) AR029420A1 (https=)
AT (1) ATE326452T1 (https=)
AU (1) AU784314B2 (https=)
CA (1) CA2395204C (https=)
CO (1) CO5280081A1 (https=)
CY (1) CY1106124T1 (https=)
DE (1) DE60028085T2 (https=)
DK (1) DK1246810T3 (https=)
ES (1) ES2265365T3 (https=)
MX (1) MXPA02006323A (https=)
MY (1) MY127677A (https=)
PT (1) PT1246810E (https=)
WO (1) WO2001046164A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US6940748B2 (en) 2002-05-16 2005-09-06 Micron Technology, Inc. Stacked 1T-nMTJ MRAM structure
AU2003202753A1 (en) * 2003-02-07 2004-08-30 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
NZ543757A (en) 2003-04-30 2009-02-28 Morphochem Ag Komb Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
AU2004299278C9 (en) 2003-12-18 2013-10-24 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051091A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
AU2006343359A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
AU2006296004B2 (en) 2005-09-27 2011-11-17 Shionogi & Co., Ltd. Sulfonamide derivative having PGD2 receptor antagonistic activity
JP5209254B2 (ja) * 2007-08-30 2013-06-12 日本曹達株式会社 置換フェノキシアザビシクロオクタン誘導体の製造方法
CN108785728A (zh) * 2017-05-05 2018-11-13 国家纳米科学中心 含药物中间体修饰的纳米金的抗菌敷料、其制备方法及应用
CN109503569B (zh) * 2019-01-03 2021-01-15 山东大学 噻唑类衍生物及其制备方法和应用
EP4416140A1 (en) * 2021-10-12 2024-08-21 F. Hoffmann-La Roche AG Sulfonylpiperazinyl compounds for treatment of bacterial infections

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
HU196771B (en) * 1983-06-07 1989-01-30 Du Pont Process for production of intermediers of derivatives of oxo-oxazolidinil-benzol having antibacterial effect
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
ATE146783T1 (de) 1991-11-01 1997-01-15 Upjohn Co Substituierte aryl- und heteroaryl- phenyloxazolidinone
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
BR9509673A (pt) 1994-11-15 1997-09-30 Upjohn Co Compostos e uso dos mesmos
US6124334A (en) 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
DK0807112T3 (da) 1995-02-03 2001-12-17 Upjohn Co Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
NZ306310A (en) 1995-05-11 2001-05-25 Upjohn Co Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
US5883093A (en) 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
ES2166073T3 (es) 1996-04-11 2002-04-01 Upjohn Co Procedimiento para preparar oxazolidinonas.
CN1138765C (zh) 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
WO1999012914A1 (en) 1997-09-11 1999-03-18 Hokuriku Seiyaku Co., Ltd. Thiourea derivatives
JPH11322729A (ja) 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体

Also Published As

Publication number Publication date
AU784314B2 (en) 2006-03-09
EP1246810B1 (en) 2006-05-17
AU2261701A (en) 2001-07-03
CA2395204A1 (en) 2001-06-28
CN1434810A (zh) 2003-08-06
US6518285B2 (en) 2003-02-11
MY127677A (en) 2006-12-29
PT1246810E (pt) 2006-08-31
CA2395204C (en) 2008-02-05
DE60028085D1 (de) 2006-06-22
AR029420A1 (es) 2003-06-25
EP1246810A1 (en) 2002-10-09
MXPA02006323A (es) 2003-09-22
CO5280081A1 (es) 2003-05-30
CY1106124T1 (el) 2011-06-08
US20020103377A1 (en) 2002-08-01
ATE326452T1 (de) 2006-06-15
JP2003518106A (ja) 2003-06-03
DK1246810T3 (da) 2006-09-18
DE60028085T2 (de) 2006-12-07
WO2001046164A1 (en) 2001-06-28
ES2265365T3 (es) 2007-02-16

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PB01 Publication
C10 Entry into substantive examination
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20051116

Termination date: 20100114