JP2005503416A5 - - Google Patents
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- Publication number
- JP2005503416A5 JP2005503416A5 JP2003528832A JP2003528832A JP2005503416A5 JP 2005503416 A5 JP2005503416 A5 JP 2005503416A5 JP 2003528832 A JP2003528832 A JP 2003528832A JP 2003528832 A JP2003528832 A JP 2003528832A JP 2005503416 A5 JP2005503416 A5 JP 2005503416A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- aryl
- compound
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 17
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- -1 substituted Chemical class 0.000 description 11
- 125000001072 heteroaryl group Chemical group 0.000 description 10
- 125000000217 alkyl group Chemical group 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
- 125000000304 alkynyl group Chemical group 0.000 description 8
- 125000003342 alkenyl group Chemical group 0.000 description 7
- 125000003118 aryl group Chemical group 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 5
- 125000001424 substituent group Chemical group 0.000 description 5
- 125000003107 substituted aryl group Chemical group 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 1
- 206010005940 Bone and joint infections Diseases 0.000 description 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 description 1
- UGSIWFDLFHIUMC-IPWFJVSNSA-N CC[C@H]([C@](C)(C(CC=O)C(C)C([C@H](C)C[C@](C)(C([C@@H](C)C([C@H]1C)=O)/C=[O]/[C@@H]([C@@H]2O)O[C@H](C)C[C@@H]2N(C)C)OC(NCCCc(nc2)c[n]2C2=CN=CCN2C)=O)=O)O)OC1=O Chemical compound CC[C@H]([C@](C)(C(CC=O)C(C)C([C@H](C)C[C@](C)(C([C@@H](C)C([C@H]1C)=O)/C=[O]/[C@@H]([C@@H]2O)O[C@H](C)C[C@@H]2N(C)C)OC(NCCCc(nc2)c[n]2C2=CN=CCN2C)=O)=O)O)OC1=O UGSIWFDLFHIUMC-IPWFJVSNSA-N 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32276201P | 2001-09-17 | 2001-09-17 | |
| PCT/US2002/029314 WO2003024986A1 (en) | 2001-09-17 | 2002-09-16 | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503416A JP2005503416A (ja) | 2005-02-03 |
| JP2005503416A5 true JP2005503416A5 (https=) | 2006-01-05 |
Family
ID=23256294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528832A Pending JP2005503416A (ja) | 2001-09-17 | 2002-09-16 | ６−ｏ−カルバメート−１１，１２−ラクト−ケトライド抗菌剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6713455B2 (https=) |
| EP (1) | EP1430068A1 (https=) |
| JP (1) | JP2005503416A (https=) |
| CN (1) | CN1589277A (https=) |
| CA (1) | CA2460947A1 (https=) |
| WO (1) | WO2003024986A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1492874A (zh) * | 2000-12-21 | 2004-04-28 | 大环内酯 | |
| US6995143B2 (en) * | 2002-02-28 | 2006-02-07 | Basilea Pharmaceutica Ag | Macrolides with antibacterial activity |
| US6727229B2 (en) | 2002-08-19 | 2004-04-27 | Enanta Pharmaceuticals, Inc. | 11,12-substituted lactone ketolide derivatives having antibacterial activity |
| US6720308B1 (en) | 2002-11-07 | 2004-04-13 | Enanta Pharmaceuticals, Inc. | Anhydrolide derivatives having antibacterial activity |
| US6790835B1 (en) | 2003-06-05 | 2004-09-14 | Enanta Pharmaceuticals, Inc. | Bicyclic macrolide derivatives |
| US6716820B1 (en) | 2003-06-05 | 2004-04-06 | Enanta Pharmaceuticals, Inc. | 6-O-substituted bicyclic macrolides |
| US6774115B1 (en) | 2003-06-05 | 2004-08-10 | Enanta Pharmaceuticals, Inc. | 6-O-substituted bicyclic ketolides |
| US6765016B1 (en) | 2003-06-05 | 2004-07-20 | Enanta Pharmaceuticals, Inc. | Bicyclic ketolide derivatives |
| US20080027012A1 (en) * | 2006-07-24 | 2008-01-31 | Heejin Kim | Bridged carbamate macrolides |
| DK2049556T3 (da) | 2006-08-09 | 2013-08-12 | Basilea Pharmaceutica Ag | Nye makrolider anvendelige mod inflammatoriske og allergiske sygdomme |
| WO2009106419A1 (en) | 2008-02-08 | 2009-09-03 | Basilea Pharmaceutica Ag | New macrolides and their use |
| WO2012002577A1 (ja) | 2010-06-30 | 2012-01-05 | 富士フイルム株式会社 | 新規なニコチンアミド誘導体またはその塩 |
| WO2012052412A1 (de) | 2010-10-22 | 2012-04-26 | Bayer Cropscience Ag | Neue heterocylische verbindungen als schädlingsbekämpfungsmittel |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8521402D0 (en) | 1985-08-28 | 1985-10-02 | Beecham Group Plc | Chemical compounds |
| IL114589A (en) | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| US5559256A (en) | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| US5703106A (en) | 1994-03-28 | 1997-12-30 | Japat Ltd. | Antagonists of endothelin receptors |
| KR19990067492A (ko) | 1995-11-08 | 1999-08-25 | 스티븐 에프. 웨인스톡 | 트리사이클릭 에리트로마이신 유도체 |
| CA2249650A1 (en) | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| DE69733723T2 (de) | 1996-09-04 | 2006-04-20 | Abbott Laboratories, Abbott Park | 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| UA59384C2 (uk) | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
| AU7937998A (en) | 1997-07-08 | 1999-02-08 | Sankyo Company Limited | Antifungal triazole compounds |
| AR015986A1 (es) | 1997-10-29 | 2001-05-30 | Abbott Lab | Derivados de eritromicina puenteados en 6,11, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procedimientospara su preparacion |
| CO4990960A1 (es) | 1997-10-29 | 2000-12-26 | Abbott Lab | Derivados de cetolidos 2-halo-6-o sustituidos |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| IL145976A0 (en) | 1999-04-16 | 2002-07-25 | Ortho Mcneil Pharm Inc | Ketolide antibacterials |
| ID30547A (id) | 1999-04-16 | 2001-12-20 | Kosan Biosciences Inc | Zat anti-infeksi makrolida |
| ATE250076T1 (de) | 1999-06-07 | 2003-10-15 | Abbott Lab | 6-o-carbamat ketolide derivate |
| EP1114826A3 (en) | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| BR0113472A (pt) * | 2000-08-22 | 2003-07-01 | Basilea Pharmaceutica Ag | Macrolìdeos com atividade antibacteriana |
| GB0031312D0 (en) * | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Macrolides |
-
2002
- 2002-09-16 WO PCT/US2002/029314 patent/WO2003024986A1/en not_active Ceased
- 2002-09-16 EP EP02761677A patent/EP1430068A1/en not_active Withdrawn
- 2002-09-16 JP JP2003528832A patent/JP2005503416A/ja active Pending
- 2002-09-16 US US10/244,184 patent/US6713455B2/en not_active Expired - Lifetime
- 2002-09-16 CA CA002460947A patent/CA2460947A1/en not_active Abandoned
- 2002-09-16 CN CNA028227999A patent/CN1589277A/zh active Pending
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