JP2008544979A5 - - Google Patents
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- Publication number
- JP2008544979A5 JP2008544979A5 JP2008518998A JP2008518998A JP2008544979A5 JP 2008544979 A5 JP2008544979 A5 JP 2008544979A5 JP 2008518998 A JP2008518998 A JP 2008518998A JP 2008518998 A JP2008518998 A JP 2008518998A JP 2008544979 A5 JP2008544979 A5 JP 2008544979A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxazepan
- oxazolidine
- phenyl
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- -1 oxazepan-4-yl-phenyl Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 8
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 3
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 241000588621 Moraxella Species 0.000 claims 2
- 241000186367 Mycobacterium avium Species 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- FOCOZKMFTFOPCZ-UHFFFAOYSA-N 1,3-oxazolidine-5-carboxamide Chemical compound NC(=O)C1CNCO1 FOCOZKMFTFOPCZ-UHFFFAOYSA-N 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241001112695 Clostridiales Species 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000588655 Moraxella catarrhalis Species 0.000 claims 1
- OIBLANUWJYFXGT-UHFFFAOYSA-N N-methyl-1,3-oxazolidine-5-carboxamide Chemical compound CNC(=O)C1CNCO1 OIBLANUWJYFXGT-UHFFFAOYSA-N 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 208000009361 bacterial endocarditis Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 208000011323 eye infectious disease Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000007119 infective endocarditis Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 150000003852 triazoles Chemical group 0.000 claims 1
- 0 Cc1c(*)c(N(CC(*)O2)C2=O)cc(*)c1N1C(CC2)[C@@]2CO[C@@]2C1C2 Chemical compound Cc1c(*)c(N(CC(*)O2)C2=O)cc(*)c1N1C(CC2)[C@@]2CO[C@@]2C1C2 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69486205P | 2005-06-29 | 2005-06-29 | |
| PCT/IB2006/001730 WO2007000644A1 (en) | 2005-06-29 | 2006-06-20 | Homomorpholine oxazolidinones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008544979A JP2008544979A (ja) | 2008-12-11 |
| JP2008544979A5 true JP2008544979A5 (https=) | 2009-07-30 |
Family
ID=37101665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518998A Withdrawn JP2008544979A (ja) | 2005-06-29 | 2006-06-20 | 抗菌剤としてのホモモルホリンオキサゾリジノン |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1899331B1 (https=) |
| JP (1) | JP2008544979A (https=) |
| AT (1) | ATE449773T1 (https=) |
| CA (1) | CA2610978A1 (https=) |
| DE (1) | DE602006010702D1 (https=) |
| DK (1) | DK1899331T3 (https=) |
| ES (1) | ES2335307T3 (https=) |
| WO (1) | WO2007000644A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080110877A (ko) | 2006-03-31 | 2008-12-19 | 재단법인 이쯔우 연구소 | 헤테로환을 갖는 신규 화합물 |
| US8178683B2 (en) | 2007-08-06 | 2012-05-15 | Micurx Pharmaceuticals, Inc. | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections |
| WO2009044777A1 (ja) * | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| CN105612166B (zh) | 2014-02-21 | 2019-02-19 | 上海盟科药业有限公司 | 治疗用水溶性(o-羰基)氨基磷酸酯前药 |
| EP3307268B1 (en) | 2015-07-17 | 2021-09-01 | The Global Alliance for TB Drug Development, Inc. | Substituted phenyloxazolidinones for antimicrobial therapy |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK283420B6 (sk) | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| BR9509673A (pt) | 1994-11-15 | 1997-09-30 | Upjohn Co | Compostos e uso dos mesmos |
| BR9813985A (pt) | 1997-11-12 | 2000-09-26 | Upjohn Co | Derivados de oxazolidinona e composições farmacêuticas |
| JP2000204084A (ja) | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| AU764980B2 (en) | 1998-11-27 | 2003-09-04 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| HUP0203869A2 (hu) | 1999-12-21 | 2003-07-28 | Pharmacia & Upjohn Co. | Szulfoximin funkcionalitással rendelkező oxazolidinok és alkalmazásuk mikrobaellenes szerként, a vegyületeket tartalmazó gyógyszerkészítmények |
| AU2001253113B2 (en) | 2000-04-20 | 2005-02-03 | Pharmacia & Upjohn Company | Use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis |
| ES2245698T3 (es) | 2000-06-30 | 2006-01-16 | PHARMACIA & UPJOHN COMPANY LLC | Composiciones para el tratamiento de infecciones bacterianas que contienen un compuesto de oxazolidinona, sulbactam y ampicilina. |
| GB0017225D0 (en) | 2000-07-14 | 2000-08-30 | Really Useful Products Limited | Container |
| DE10034627A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Aryl-substituierte Oxazolidinone mit Cytokin inhibitorischer Wirkung |
| BR0112826A (pt) | 2000-07-17 | 2003-06-24 | Ranbaxy Lab Ltd | Derivados da oxazolidinona como antimicrobianos |
| WO2002016960A1 (en) | 2000-08-24 | 2002-02-28 | Sirf Technology, Inc. | Apparatus for reducing auto-correlation or cross-correlation in weak cdma signals |
| PE20020578A1 (es) | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
| WO2002072066A1 (en) | 2001-02-05 | 2002-09-19 | Pharmacia & Upjohn Company | Composition for rectal delivery of an oxazolidinone antibacterial drug |
| DE10105989A1 (de) | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| ES2268011T3 (es) | 2001-04-07 | 2007-03-16 | Astrazeneca Ab | Oxazolidinonas que contienen un grupo sulfonimida como antibioticos. |
| GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| US6956040B2 (en) | 2001-07-16 | 2005-10-18 | Ranbaxy Laboratories Limited | Oxazolidinone piperazinyl derivatives as potential antimicrobials |
| EP1409464A4 (en) | 2001-07-16 | 2005-11-02 | Ranbaxy Lab Ltd | OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS |
| TW200302095A (en) | 2002-01-25 | 2003-08-01 | Upjohn Co | Oxazolidinone cotherapy |
| BR0307898A (pt) | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio |
| EP1476135A1 (en) | 2002-02-22 | 2004-11-17 | Pharmacia Corporation | Ophthalmic formulation with gum system |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| JP2005524661A (ja) | 2002-02-28 | 2005-08-18 | アストラゼネカ アクチボラグ | ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用 |
| IL163643A0 (en) | 2002-02-28 | 2005-12-18 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their forpreparation, and pharmaceutical compositions containing them |
| BR0308806A (pt) | 2002-03-29 | 2005-01-04 | Upjohn Co | Uso de oxazolidinonas para tratar infecções do tipo pé diabético |
| WO2003093247A2 (en) | 2002-04-30 | 2003-11-13 | Orchid Chemicals & Pharmaceuticals Ltd | Antibacterial agents |
| TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| WO2004009587A1 (en) | 2002-07-22 | 2004-01-29 | Orchid Chemicals & Pharmaceuticals Ltd | Oxazolidinone derivatives as antibacterial agents |
| MXPA05001199A (es) | 2002-07-29 | 2005-05-16 | Ranbaxy Lab Ltd | Derivados de oxazolidinona como antimicrobianos. |
| EP1578734A1 (en) | 2002-08-22 | 2005-09-28 | Orchid Chemicals and Pharmaceuticals Ltd | Novel antibacterial agents |
-
2006
- 2006-06-20 WO PCT/IB2006/001730 patent/WO2007000644A1/en not_active Ceased
- 2006-06-20 DE DE602006010702T patent/DE602006010702D1/de active Active
- 2006-06-20 ES ES06779767T patent/ES2335307T3/es active Active
- 2006-06-20 CA CA002610978A patent/CA2610978A1/en not_active Abandoned
- 2006-06-20 DK DK06779767.0T patent/DK1899331T3/da active
- 2006-06-20 EP EP06779767A patent/EP1899331B1/en not_active Not-in-force
- 2006-06-20 AT AT06779767T patent/ATE449773T1/de not_active IP Right Cessation
- 2006-06-20 JP JP2008518998A patent/JP2008544979A/ja not_active Withdrawn
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