JP2008544979A5 - - Google Patents
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- Publication number
- JP2008544979A5 JP2008544979A5 JP2008518998A JP2008518998A JP2008544979A5 JP 2008544979 A5 JP2008544979 A5 JP 2008544979A5 JP 2008518998 A JP2008518998 A JP 2008518998A JP 2008518998 A JP2008518998 A JP 2008518998A JP 2008544979 A5 JP2008544979 A5 JP 2008544979A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxazepan
- oxazolidine
- phenyl
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- -1 oxazepan-4-yl-phenyl Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 8
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 3
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 241000588621 Moraxella Species 0.000 claims 2
- 241000186367 Mycobacterium avium Species 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- FOCOZKMFTFOPCZ-UHFFFAOYSA-N 1,3-oxazolidine-5-carboxamide Chemical compound NC(=O)C1CNCO1 FOCOZKMFTFOPCZ-UHFFFAOYSA-N 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241001112695 Clostridiales Species 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000588655 Moraxella catarrhalis Species 0.000 claims 1
- OIBLANUWJYFXGT-UHFFFAOYSA-N N-methyl-1,3-oxazolidine-5-carboxamide Chemical compound CNC(=O)C1CNCO1 OIBLANUWJYFXGT-UHFFFAOYSA-N 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 208000009361 bacterial endocarditis Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 208000011323 eye infectious disease Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000007119 infective endocarditis Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 150000003852 triazoles Chemical group 0.000 claims 1
- 0 Cc1c(*)c(N(CC(*)O2)C2=O)cc(*)c1N1C(CC2)[C@@]2CO[C@@]2C1C2 Chemical compound Cc1c(*)c(N(CC(*)O2)C2=O)cc(*)c1N1C(CC2)[C@@]2CO[C@@]2C1C2 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69486205P | 2005-06-29 | 2005-06-29 | |
| PCT/IB2006/001730 WO2007000644A1 (en) | 2005-06-29 | 2006-06-20 | Homomorpholine oxazolidinones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008544979A JP2008544979A (ja) | 2008-12-11 |
| JP2008544979A5 true JP2008544979A5 (https=) | 2009-07-30 |
Family
ID=37101665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518998A Withdrawn JP2008544979A (ja) | 2005-06-29 | 2006-06-20 | 抗菌剤としてのホモモルホリンオキサゾリジノン |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1899331B1 (https=) |
| JP (1) | JP2008544979A (https=) |
| AT (1) | ATE449773T1 (https=) |
| CA (1) | CA2610978A1 (https=) |
| DE (1) | DE602006010702D1 (https=) |
| DK (1) | DK1899331T3 (https=) |
| ES (1) | ES2335307T3 (https=) |
| WO (1) | WO2007000644A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080110877A (ko) | 2006-03-31 | 2008-12-19 | 재단법인 이쯔우 연구소 | 헤테로환을 갖는 신규 화합물 |
| JP5455906B2 (ja) | 2007-08-06 | 2014-03-26 | ミクウルク ファーマシューティカルズ，インコーポレイテッド | 細菌感染症治療のための抗微生物性オルト−フルオロフェニルオキサゾリジノン |
| CN101883768A (zh) | 2007-10-02 | 2010-11-10 | 财团法人乙卯研究所 | 具有7元杂环的噁唑烷酮衍生物 |
| US9382276B2 (en) | 2014-02-21 | 2016-07-05 | Micurx Pharmaceuticals, Inc. | Water-soluble O-carbonyl phosphoramidate prodrugs for therapeutic administration |
| EA202190167A1 (ru) * | 2015-07-17 | 2021-07-30 | Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. | Замещенные фенилоксазолидиноны для антимикробной терапии |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK283420B6 (sk) | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| PT792273E (pt) | 1994-11-15 | 2003-06-30 | Upjohn Co | Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas |
| US5998406A (en) | 1997-11-12 | 1999-12-07 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions |
| JP2000204084A (ja) | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| HK1040707A1 (zh) | 1998-11-27 | 2002-06-21 | 法玛西雅厄普约翰美国公司 | 具有硫代羰基官能團的噁唑烷酮抗菌劑 |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| SK7572002A3 (en) | 1999-12-21 | 2002-12-03 | Upjohn Co | Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents |
| AU5311301A (en) | 2000-04-20 | 2001-11-07 | Upjohn Co | Use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis |
| AU2001272961A1 (en) | 2000-06-30 | 2002-01-14 | Pharmacia & Upjohn Company | Compositions for treating bacterial infections containing oxazolidinone compound, sulbactam and an ampicillin |
| GB0017225D0 (en) | 2000-07-14 | 2000-08-30 | Really Useful Products Limited | Container |
| HUP0302918A2 (hu) | 2000-07-17 | 2003-12-29 | Ranbaxy Laboratories Limited | Mikrobaellenes oxazolidinonszármazékok és a vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| DE10034627A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Aryl-substituierte Oxazolidinone mit Cytokin inhibitorischer Wirkung |
| WO2003008389A1 (en) | 2001-07-16 | 2003-01-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as potential antimicrobials |
| US6466161B2 (en) | 2000-08-24 | 2002-10-15 | Sirf Technology, Inc. | Location services system that reduces auto-correlation or cross-correlation in weak signals |
| PE20020578A1 (es) | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
| EP1365739A1 (en) | 2001-02-05 | 2003-12-03 | Pharmacia & Upjohn Company | Composition for rectal delivery of an oxazolidinone antibacterial drug |
| DE10105989A1 (de) | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE60212959T2 (de) | 2001-04-07 | 2007-02-15 | Astrazeneca Ab | Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika |
| GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| US6956040B2 (en) | 2001-07-16 | 2005-10-18 | Ranbaxy Laboratories Limited | Oxazolidinone piperazinyl derivatives as potential antimicrobials |
| TW200302095A (en) | 2002-01-25 | 2003-08-01 | Upjohn Co | Oxazolidinone cotherapy |
| BR0307898A (pt) | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio |
| MXPA04008171A (es) | 2002-02-22 | 2004-11-26 | Pharmacia Corp | Formulacion oftalmica con sistema de goma. |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| CN1653064A (zh) | 2002-02-28 | 2005-08-10 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物 |
| CN1649866A (zh) | 2002-02-28 | 2005-08-03 | 阿斯特拉曾尼卡有限公司 | 3－环状基－5－(含氮5－元环)甲基－噁唑烷酮衍生物及其作为抗菌药物的用途 |
| EP1490059A1 (en) | 2002-03-29 | 2004-12-29 | Pharmacia & Upjohn Company LLC | Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections |
| AU2003224345A1 (en) | 2002-04-30 | 2003-11-17 | Orchid Chemicals & Pharmaceuticals | Antibacterial agents |
| TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| WO2004009587A1 (en) | 2002-07-22 | 2004-01-29 | Orchid Chemicals & Pharmaceuticals Ltd | Oxazolidinone derivatives as antibacterial agents |
| BR0215921A (pt) | 2002-07-29 | 2005-09-13 | Ranbaxy Lab Ltd | Derivados de oxazolidinona utilizáveis como antimicrobianos e processo de sua preparação |
| US7217726B2 (en) | 2002-08-22 | 2007-05-15 | Orchid Chemicals & Pharmaceuticals Limited | Antibacterial agents |
-
2006
- 2006-06-20 DE DE602006010702T patent/DE602006010702D1/de active Active
- 2006-06-20 WO PCT/IB2006/001730 patent/WO2007000644A1/en not_active Ceased
- 2006-06-20 AT AT06779767T patent/ATE449773T1/de not_active IP Right Cessation
- 2006-06-20 ES ES06779767T patent/ES2335307T3/es active Active
- 2006-06-20 EP EP06779767A patent/EP1899331B1/en not_active Not-in-force
- 2006-06-20 JP JP2008518998A patent/JP2008544979A/ja not_active Withdrawn
- 2006-06-20 CA CA002610978A patent/CA2610978A1/en not_active Abandoned
- 2006-06-20 DK DK06779767.0T patent/DK1899331T3/da active
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