JP2005531603A5 - - Google Patents
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- Publication number
- JP2005531603A5 JP2005531603A5 JP2004509701A JP2004509701A JP2005531603A5 JP 2005531603 A5 JP2005531603 A5 JP 2005531603A5 JP 2004509701 A JP2004509701 A JP 2004509701A JP 2004509701 A JP2004509701 A JP 2004509701A JP 2005531603 A5 JP2005531603 A5 JP 2005531603A5
- Authority
- JP
- Japan
- Prior art keywords
- alkenyl
- alkyl
- optionally substituted
- compound
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000000304 alkynyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- -1 heterocyclo Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 206010005940 Bone and joint infections Diseases 0.000 claims 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 241000588655 Moraxella catarrhalis Species 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010062255 Soft tissue infection Diseases 0.000 claims 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000000676 alkoxyimino group Chemical group 0.000 claims 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960003276 erythromycin Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
- IUEQMQXAVZARKU-UHFFFAOYSA-N c1ccnc(-c2cnccn2)c1 Chemical compound c1ccnc(-c2cnccn2)c1 IUEQMQXAVZARKU-UHFFFAOYSA-N 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N c1ccnnc1 Chemical compound c1ccnnc1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N c1cncnc1 Chemical compound c1cncnc1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38448302P | 2002-05-31 | 2002-05-31 | |
| PCT/US2003/016617 WO2003102010A1 (en) | 2002-05-31 | 2003-05-28 | 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531603A JP2005531603A (ja) | 2005-10-20 |
| JP2005531603A5 true JP2005531603A5 (https=) | 2006-06-29 |
Family
ID=29712041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004509701A Pending JP2005531603A (ja) | 2002-05-31 | 2003-05-28 | ３−デスクラジノシル−６−ｏ−カルバモイルおよび６−ｏ−カルボノイルマクロライド抗菌剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6825172B2 (https=) |
| EP (1) | EP1513856A1 (https=) |
| JP (1) | JP2005531603A (https=) |
| CN (1) | CN1671726A (https=) |
| AU (1) | AU2003234650A1 (https=) |
| CA (1) | CA2487918A1 (https=) |
| WO (1) | WO2003102010A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100695322B1 (ko) | 2005-02-23 | 2007-03-15 | (주)에스.앤.디 | 메밀등겨로부터 수용성섬유소 및 파고피리톨의 저온 및 연속추출 방법 |
| US20090075916A1 (en) * | 2005-11-23 | 2009-03-19 | Upadhyay Dilip J | Use of Macrolide Derivatives for Treating Acne |
| US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
| EP2871188B1 (en) * | 2012-07-06 | 2017-04-19 | Godo Shusei Co., Ltd. | Method for separating cyclic macrolide compound |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8521402D0 (en) | 1985-08-28 | 1985-10-02 | Beecham Group Plc | Chemical compounds |
| IL114589A (en) | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| KR19990067492A (ko) * | 1995-11-08 | 1999-08-25 | 스티븐 에프. 웨인스톡 | 트리사이클릭 에리트로마이신 유도체 |
| US6274715B1 (en) * | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
| DE69733723T2 (de) | 1996-09-04 | 2006-04-20 | Abbott Laboratories, Abbott Park | 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| AU720921B2 (en) | 1996-11-27 | 2000-06-15 | Taisho Pharmaceutical Co., Ltd. | Erythromycin A derivatives |
| US6037137A (en) * | 1997-02-20 | 2000-03-14 | Oncoimmunin, Inc. | Fluorogenic peptides for the detection of protease activity |
| ZA987689B (en) * | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
| ZA989835B (en) * | 1997-10-29 | 1999-05-05 | Taisho Pharmaceutical Co Ltd | Erythromycin a derivatives |
| WO1999021870A1 (en) | 1997-10-29 | 1999-05-06 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a 11, 12-carbamate derivatives |
| US6169168B1 (en) | 1997-10-29 | 2001-01-02 | Taisho Pharmaceuticals Co., Ltd. | Erythromycin A derivatives |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| US6020521A (en) | 1998-08-26 | 2000-02-01 | Abbott Laboratories | Macrolide LHRH antagonists |
| ID30547A (id) | 1999-04-16 | 2001-12-20 | Kosan Biosciences Inc | Zat anti-infeksi makrolida |
| IL145976A0 (en) | 1999-04-16 | 2002-07-25 | Ortho Mcneil Pharm Inc | Ketolide antibacterials |
| GB9910079D0 (en) | 1999-05-01 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
| US6420535B1 (en) * | 1999-06-07 | 2002-07-16 | Abbott Laboratories | 6-O-carbamate ketolide derivatives |
| ATE250076T1 (de) | 1999-06-07 | 2003-10-15 | Abbott Lab | 6-o-carbamat ketolide derivate |
| WO2001010880A1 (fr) | 1999-08-06 | 2001-02-15 | Taisho Pharmaceutical Co., Ltd. | Derives d'erythromycine a |
| WO2001010878A1 (fr) | 1999-08-06 | 2001-02-15 | Taisho Pharmaceutical Co., Ltd. | Derives d'erythromycine a |
| US6498146B1 (en) * | 1999-10-28 | 2002-12-24 | Pfizer Inc | Erythromycin derivatives |
| EP1146051A3 (en) | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Erythromycin A derivatives |
| US20020115621A1 (en) | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| JP2002173498A (ja) | 2000-09-27 | 2002-06-21 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
| US6472372B1 (en) * | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| NZ533282A (en) * | 2001-12-05 | 2006-09-29 | Ortho Mcneil Pharm Inc | 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials |
-
2003
- 2003-05-28 US US10/447,058 patent/US6825172B2/en not_active Expired - Lifetime
- 2003-05-28 CN CNA038177595A patent/CN1671726A/zh active Pending
- 2003-05-28 CA CA002487918A patent/CA2487918A1/en not_active Abandoned
- 2003-05-28 AU AU2003234650A patent/AU2003234650A1/en not_active Abandoned
- 2003-05-28 EP EP03729151A patent/EP1513856A1/en not_active Withdrawn
- 2003-05-28 WO PCT/US2003/016617 patent/WO2003102010A1/en not_active Ceased
- 2003-05-28 JP JP2004509701A patent/JP2005531603A/ja active Pending
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