JP2001519794A - テトラアザ大環状体の製造方法 - Google Patents
テトラアザ大環状体の製造方法Info
- Publication number
- JP2001519794A JP2001519794A JP54234498A JP54234498A JP2001519794A JP 2001519794 A JP2001519794 A JP 2001519794A JP 54234498 A JP54234498 A JP 54234498A JP 54234498 A JP54234498 A JP 54234498A JP 2001519794 A JP2001519794 A JP 2001519794A
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- JP
- Japan
- Prior art keywords
- compound
- formula
- per mole
- ratio
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 150000002678 macrocyclic compounds Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 9
- 239000002168 alkylating agent Substances 0.000 claims description 9
- 229940100198 alkylating agent Drugs 0.000 claims description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000002585 base Substances 0.000 claims description 5
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical class O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000003880 polar aprotic solvent Substances 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 4
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims description 3
- 150000008041 alkali metal carbonates Chemical class 0.000 claims description 3
- -1 alkaline earth metal carbonates Chemical class 0.000 claims description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 2
- NYYDZOSYLUOKEM-UHFFFAOYSA-N oxaldehyde;hydrate Chemical compound O.O=CC=O NYYDZOSYLUOKEM-UHFFFAOYSA-N 0.000 claims description 2
- 229920000768 polyamine Polymers 0.000 claims description 2
- 239000003021 water soluble solvent Substances 0.000 claims description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 16
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 10
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- PAAZPARNPHGIKF-UHFFFAOYSA-N 1,2-dibromoethane Chemical compound BrCCBr PAAZPARNPHGIKF-UHFFFAOYSA-N 0.000 description 7
- 239000003054 catalyst Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 239000000543 intermediate Substances 0.000 description 6
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 description 3
- 125000004054 acenaphthylenyl group Chemical group C1(=CC2=CC=CC3=CC=CC1=C23)* 0.000 description 3
- HXGDTGSAIMULJN-UHFFFAOYSA-N acetnaphthylene Natural products C1=CC(C=C2)=C3C2=CC=CC3=C1 HXGDTGSAIMULJN-UHFFFAOYSA-N 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000007086 side reaction Methods 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229940015043 glyoxal Drugs 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- XJFQPBHOGJVOHU-UHFFFAOYSA-N n'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;hydrate Chemical compound O.NCCNCCNCCN XJFQPBHOGJVOHU-UHFFFAOYSA-N 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- APQIUTYORBAGEZ-UHFFFAOYSA-N 1,1-dibromoethane Chemical compound CC(Br)Br APQIUTYORBAGEZ-UHFFFAOYSA-N 0.000 description 1
- 150000000921 Gadolinium Chemical class 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- DDTBPAQBQHZRDW-UHFFFAOYSA-N cyclododecane Chemical compound C1CCCCCCCCCCC1 DDTBPAQBQHZRDW-UHFFFAOYSA-N 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- FJBFPHVGVWTDIP-UHFFFAOYSA-N dibromomethane Chemical compound BrCBr FJBFPHVGVWTDIP-UHFFFAOYSA-N 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- RYHQMKVRYNEBNJ-BMWGJIJESA-K gadoterate meglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 RYHQMKVRYNEBNJ-BMWGJIJESA-K 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229910003480 inorganic solid Inorganic materials 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 125000004957 naphthylene group Chemical group 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000005956 quaternization reaction Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000000956 solid--liquid extraction Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式(I): (式中、n、p、およびqは独立に0または1であることができる)で示される 化合物の製造方法であって、 反応式: に従う下記の工程: 上記式において、 工程a):式(III)のポリアミンと、Yが−OH(グリオキサールヒドラート )または[−SO3 -Na+](Bertagniniの塩)である式(IV)のグリオキサール 誘導体とを、水中もしくは水溶性溶媒中、またはそれらの混合液中で、温度0〜 50℃において、水酸化カルシウムの化学量論量またはわずかな過剰量の存在下 で縮合させて、式(V)の化合物とし; 工程b):式(V)の化合物と、アルキル化剤X−CH2−(CH2)q−CH2− X(式中、qは、先の定義と同じであり、Xは、ClまたはBrである)とを、 化合物(V)のモルあたり後者が1〜5モルの比率で、極性非プロトン溶媒中に おいて、アルカリまたはアルカリ土類金属の炭酸塩から選択された塩基を、化合 物(V)のモルあたり5〜10モルの比率で存在させ、NaZ(式中、Zは、I またはBrであり、XおよびZが同時にはBrでない)を触媒として、化合物( V)のモルあたり0.1〜2モルの比率で添加し、温度25〜150℃において 縮合させて、式(I)の化合物にすること: を含む製造方法。 2.式(I)の化合物において、n、pおよびqが0である、請求項1記載の方 法。 3.化合物のXがClであり、そしてZがBrである、請求項1または2記載の 方法。 4.極性非プロトン溶媒が、ジメチルアセトアミド、ジメチルホルムアミド、ジ メチルスルホキシド、N−メチルピロリドンから選択され、アルカリ金属炭酸塩 から選択された塩基が、化合物(V)のモルあたり少なくとも塩基2モルの比率 、アルキル化剤が、化合物(V)のモルあたり1〜5モルの比率で存在し、温度 が50〜80℃の範囲であり、そして反応時間が2〜5時間の範囲である、請求 項3記載の方法。 5.XがClであり、そしてZがIである、請求項1または2記載の方法。 6.極性非プロトン溶媒が、ジメチルアセトアミド、ジメチルホルムアミド、ジ メチルスルホキシド、N−メチルピロリドンから選択され、アルカリ金属炭酸塩 から選択された塩基が、化合物(V)のモルあたり少なくとも2モルの比率、ア ルキル化剤が化合物のモルあたり1〜5モルの比率で存在し、温度が30〜50 ℃の範囲であり、そして反応時間が5〜15時間の範囲である、請求項5記載の 方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI000783A IT1290457B1 (it) | 1997-04-04 | 1997-04-04 | Processo per la preparazione di tetraazamacrocicli |
IT97A000783 | 1997-04-04 | ||
PCT/EP1998/001882 WO1998045296A1 (en) | 1997-04-04 | 1998-04-01 | A process for the preparation of tetraazamacrocycles |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001519794A true JP2001519794A (ja) | 2001-10-23 |
JP4320060B2 JP4320060B2 (ja) | 2009-08-26 |
Family
ID=11376764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54234498A Expired - Lifetime JP4320060B2 (ja) | 1997-04-04 | 1998-04-01 | テトラアザ大環状体の製造方法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6150520A (ja) |
EP (1) | EP0973776B1 (ja) |
JP (1) | JP4320060B2 (ja) |
CN (1) | CN1101817C (ja) |
AU (1) | AU6832098A (ja) |
DE (1) | DE69806368T2 (ja) |
ES (1) | ES2178830T3 (ja) |
IT (1) | IT1290457B1 (ja) |
NO (1) | NO311940B1 (ja) |
WO (1) | WO1998045296A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1297035B1 (it) | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
DE19856481C1 (de) * | 1998-12-02 | 2000-07-06 | Schering Ag | Verfahren zur Herstellung von Cyclen |
WO2006039505A2 (en) | 2004-09-30 | 2006-04-13 | Molecular Devices Corporation | Luminescent lanthanide complexes |
US11473032B2 (en) | 2010-02-02 | 2022-10-18 | Fuchs Petrolub Se | Constant velocity joint having a boot |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3485818A (en) * | 1968-04-05 | 1969-12-23 | Jerome B Thompson | 1,4,7,10-tetraazacyclododecene and 1,4,7,10,13 - pentaazacyclopentadecene and process for their manufacture |
US3932451A (en) * | 1973-11-27 | 1976-01-13 | E. I. Du Pont De Nemours & Company | 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids |
DE4229979A1 (de) * | 1992-09-08 | 1994-03-10 | Hoechst Ag | Neue Fulleren-Derivate, Verfahren zur Herstellung und deren Verwendung |
GB9504922D0 (en) * | 1995-03-10 | 1995-04-26 | Nycomed As | Process |
IT1284046B1 (it) * | 1996-06-21 | 1998-05-08 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
-
1997
- 1997-04-04 IT IT97MI000783A patent/IT1290457B1/it active IP Right Grant
-
1998
- 1998-04-01 JP JP54234498A patent/JP4320060B2/ja not_active Expired - Lifetime
- 1998-04-01 EP EP98913744A patent/EP0973776B1/en not_active Expired - Lifetime
- 1998-04-01 US US09/367,221 patent/US6150520A/en not_active Expired - Lifetime
- 1998-04-01 ES ES98913744T patent/ES2178830T3/es not_active Expired - Lifetime
- 1998-04-01 AU AU68320/98A patent/AU6832098A/en not_active Abandoned
- 1998-04-01 DE DE69806368T patent/DE69806368T2/de not_active Expired - Lifetime
- 1998-04-01 WO PCT/EP1998/001882 patent/WO1998045296A1/en active IP Right Grant
- 1998-04-01 CN CN98803622A patent/CN1101817C/zh not_active Expired - Lifetime
-
1999
- 1999-09-29 NO NO19994749A patent/NO311940B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO311940B1 (no) | 2002-02-18 |
WO1998045296A1 (en) | 1998-10-15 |
CN1101817C (zh) | 2003-02-19 |
NO994749D0 (no) | 1999-09-29 |
EP0973776A1 (en) | 2000-01-26 |
DE69806368T2 (de) | 2003-04-03 |
ES2178830T3 (es) | 2003-01-01 |
DE69806368D1 (de) | 2002-08-08 |
AU6832098A (en) | 1998-10-30 |
CN1251104A (zh) | 2000-04-19 |
EP0973776B1 (en) | 2002-07-03 |
JP4320060B2 (ja) | 2009-08-26 |
ITMI970783A1 (it) | 1998-10-04 |
IT1290457B1 (it) | 1998-12-03 |
US6150520A (en) | 2000-11-21 |
NO994749L (no) | 1999-09-29 |
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