JP2001518922A - アリール−またはヘテロアリール−スルホンアミドで置換されたヒドロキサム酸誘導体、その製法およびその医薬としての使用 - Google Patents
アリール−またはヘテロアリール−スルホンアミドで置換されたヒドロキサム酸誘導体、その製法およびその医薬としての使用Info
- Publication number
- JP2001518922A JP2001518922A JP54489898A JP54489898A JP2001518922A JP 2001518922 A JP2001518922 A JP 2001518922A JP 54489898 A JP54489898 A JP 54489898A JP 54489898 A JP54489898 A JP 54489898A JP 2001518922 A JP2001518922 A JP 2001518922A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- hydroxy
- treating
- tnf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9706255.8 | 1997-03-26 | ||
| GBGB9706255.8A GB9706255D0 (en) | 1997-03-26 | 1997-03-26 | Novel compounds |
| PCT/EP1998/001766 WO1998042659A2 (en) | 1997-03-26 | 1998-03-16 | Aryl- or heteroarylsulfonamide substituted hydroxamic acid derivates, process for their preparation and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001518922A true JP2001518922A (ja) | 2001-10-16 |
Family
ID=10809882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54489898A Pending JP2001518922A (ja) | 1997-03-26 | 1998-03-16 | アリール−またはヘテロアリール−スルホンアミドで置換されたヒドロキサム酸誘導体、その製法およびその医薬としての使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6242467B1 (hu) |
| EP (1) | EP0973732A2 (hu) |
| JP (1) | JP2001518922A (hu) |
| KR (1) | KR20010005627A (hu) |
| CN (1) | CN1251091A (hu) |
| AR (1) | AR012294A1 (hu) |
| AU (1) | AU7210598A (hu) |
| BR (1) | BR9808366A (hu) |
| CA (1) | CA2285439A1 (hu) |
| CO (1) | CO4950563A1 (hu) |
| GB (1) | GB9706255D0 (hu) |
| HU (1) | HUP0003021A3 (hu) |
| IL (1) | IL131751A0 (hu) |
| NO (1) | NO994671D0 (hu) |
| PL (1) | PL336039A1 (hu) |
| TR (1) | TR199902357T2 (hu) |
| WO (1) | WO1998042659A2 (hu) |
| ZA (1) | ZA982517B (hu) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011528013A (ja) * | 2008-07-14 | 2011-11-10 | ノバルティス アーゲー | ヒドロキサム酸系の選択的ｍｍｐ−１２およびｍｍｐ−１３阻害剤 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5904697A (en) * | 1995-02-24 | 1999-05-18 | Heartport, Inc. | Devices and methods for performing a vascular anastomosis |
| EP1009737A2 (en) * | 1997-07-31 | 2000-06-21 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
| US6403632B1 (en) * | 2000-03-01 | 2002-06-11 | Bristol Myers Squibb Pharma Co | Lactam metalloprotease inhibitors |
| US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
| US6762178B2 (en) | 1999-01-27 | 2004-07-13 | Wyeth Holdings Corporation | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
| US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
| US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
| CN1178915C (zh) | 1999-01-27 | 2004-12-08 | 惠氏控股有限公司 | 含有炔基的异羟肟酸衍生物、其制备及其作为基质金属蛋白酶抑制剂/TNF-α转变酶抑制剂的用途 |
| US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
| US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
| WO2000051975A1 (en) | 1999-03-03 | 2000-09-08 | The Procter & Gamble Company | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
| CA2366954A1 (en) | 1999-03-03 | 2000-09-08 | The Procter & Gamble Company | Dihetero-substituted metalloprotease inhibitors |
| GB9922825D0 (en) * | 1999-09-25 | 1999-11-24 | Smithkline Beecham Biolog | Medical use |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| US20030134880A1 (en) * | 2000-02-24 | 2003-07-17 | Gordon Bruton | Novel cd23 inhibitors |
| CN1440400A (zh) * | 2000-05-25 | 2003-09-03 | 史密斯克莱·比奇曼公司 | 二环基或杂二环基甲磺酰氨基－取代的n－羟基甲酰胺化合物 |
| MXPA04000134A (es) | 2001-06-26 | 2005-06-06 | Abgenix Inc | Anticuerpos para ligandos de osteoprotegerina. |
| JP2005507937A (ja) | 2001-11-01 | 2005-03-24 | ワイス・ホールディングズ・コーポレイション | マトリックスメタロプロテイナーゼおよびｔａｃｅ阻害剤としてのアレンアリールスルホンアミドヒドロキサム酸 |
| GB0128376D0 (en) * | 2001-11-27 | 2002-01-16 | Smithkline Beecham Plc | Novel compounds |
| DE60233688D1 (de) * | 2001-12-27 | 2009-10-22 | Lg Electronics Inc | Waschmaschine |
| ES2323527T3 (es) | 2002-05-29 | 2009-07-20 | MERCK & CO., INC. | Compuestos utiles en el tratamiento del carbunco y en la inhibicion del factor letal. |
| WO2005021489A2 (en) | 2002-12-23 | 2005-03-10 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors |
| EP1747212A4 (en) | 2004-05-11 | 2009-03-25 | Merck & Co Inc | PROCESS FOR PRODUCING N-SULFINATED AMINO ACID DERIVATIVES |
| USD810196S1 (en) * | 2015-04-14 | 2018-02-13 | Marcia D. Fackler | Sunglass book cover |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| CA2193691A1 (en) * | 1994-06-22 | 1995-12-28 | Andrew Miller | Metalloproteinase inhibitors |
| GB9414157D0 (en) | 1994-07-13 | 1994-08-31 | Smithkline Beecham Plc | Medical use |
| KR19990036271A (ko) * | 1995-08-08 | 1999-05-25 | 토마스 네프 | 콜라겐 과다생산과 연관된 질환의 치료에 이용되는 ｃ-프로테나제 저해물질 |
| DK0757984T3 (da) | 1995-08-08 | 2003-03-03 | Ono Pharmaceutical Co | Hydroxamsyrederivater, der kan anvendes til inhibering af gelatinase |
| DE69707865T2 (de) | 1996-05-17 | 2002-05-02 | Warner-Lambert Co., Morris Plains | Biphenylsulfonamid matrix metalloproteinase inhibitoren |
| NZ333063A (en) * | 1996-09-04 | 2000-12-22 | Warner Lambert Co | Dibenzofuran sulfonamide derivatives as matrix metalloproteinase inhibitors |
-
1997
- 1997-03-26 GB GBGB9706255.8A patent/GB9706255D0/en active Pending
-
1998
- 1998-03-16 CA CA002285439A patent/CA2285439A1/en not_active Abandoned
- 1998-03-16 TR TR1999/02357T patent/TR199902357T2/xx unknown
- 1998-03-16 IL IL13175198A patent/IL131751A0/xx unknown
- 1998-03-16 BR BR9808366-0A patent/BR9808366A/pt not_active Application Discontinuation
- 1998-03-16 US US09/381,405 patent/US6242467B1/en not_active Expired - Fee Related
- 1998-03-16 AU AU72105/98A patent/AU7210598A/en not_active Abandoned
- 1998-03-16 KR KR1019997008694A patent/KR20010005627A/ko not_active Application Discontinuation
- 1998-03-16 PL PL98336039A patent/PL336039A1/xx unknown
- 1998-03-16 HU HU0003021A patent/HUP0003021A3/hu unknown
- 1998-03-16 JP JP54489898A patent/JP2001518922A/ja active Pending
- 1998-03-16 CN CN98803639A patent/CN1251091A/zh active Pending
- 1998-03-16 WO PCT/EP1998/001766 patent/WO1998042659A2/en not_active Application Discontinuation
- 1998-03-16 EP EP98919153A patent/EP0973732A2/en not_active Withdrawn
- 1998-03-24 AR ARP980101342A patent/AR012294A1/es unknown
- 1998-03-25 ZA ZA9802517A patent/ZA982517B/xx unknown
- 1998-03-26 CO CO98016978A patent/CO4950563A1/es unknown
-
1999
- 1999-09-24 NO NO994671A patent/NO994671D0/no not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011528013A (ja) * | 2008-07-14 | 2011-11-10 | ノバルティス アーゲー | ヒドロキサム酸系の選択的ｍｍｐ−１２およびｍｍｐ−１３阻害剤 |
| JP2015091824A (ja) * | 2008-07-14 | 2015-05-14 | ノバルティス アーゲー | ヒドロキサム酸系の選択的ｍｍｐ−１２およびｍｍｐ−１３阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998042659A2 (en) | 1998-10-01 |
| PL336039A1 (en) | 2000-06-05 |
| EP0973732A2 (en) | 2000-01-26 |
| ZA982517B (en) | 1999-09-27 |
| KR20010005627A (ko) | 2001-01-15 |
| HUP0003021A2 (hu) | 2002-01-28 |
| BR9808366A (pt) | 2000-05-23 |
| WO1998042659A3 (en) | 1999-02-25 |
| NO994671L (no) | 1999-09-24 |
| TR199902357T2 (xx) | 2000-05-22 |
| CA2285439A1 (en) | 1998-10-01 |
| HUP0003021A3 (en) | 2002-02-28 |
| IL131751A0 (en) | 2001-03-19 |
| GB9706255D0 (en) | 1997-05-14 |
| AU7210598A (en) | 1998-10-20 |
| NO994671D0 (no) | 1999-09-24 |
| AR012294A1 (es) | 2000-10-18 |
| CO4950563A1 (es) | 2000-09-01 |
| CN1251091A (zh) | 2000-04-19 |
| US6242467B1 (en) | 2001-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001518922A (ja) | アリール−またはヘテロアリール−スルホンアミドで置換されたヒドロキサム酸誘導体、その製法およびその医薬としての使用 | |
| JP2768554B2 (ja) | 金属タンパク質加水分解酵素阻害剤であるヒドロキサム酸誘導体 | |
| US7589126B2 (en) | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | |
| JP2001513767A (ja) | メタロプロテアーゼ阻害剤としての逆ヒドロキサメート誘導体 | |
| EP0856315B1 (en) | Protein-farnesyltransferase inhibitors in combination with hmgcoa-reductase-inhibitors for the treatment of aids | |
| JP2000510473A (ja) | ｓ―ＣＤ２３生成およびＴＮＦ分泌の阻害剤 | |
| JP2000514043A (ja) | マトリックスメタロプロテイナーゼ・インヒビター | |
| US20030195191A1 (en) | N-sulfonyl hydroxamic acid derivatives as inhibitors of cd23 | |
| JPH10502656A (ja) | ヒトｓ−ｃｄ２３の阻害剤の使用 | |
| JP3922431B2 (ja) | 可溶性ヒトｃｄ２３形成阻害剤としてのヒドロキサム酸誘導体 | |
| JP2000503312A (ja) | ヒドロキサム酸を基礎とするコラゲナーゼ阻害剤 | |
| JPH08231505A (ja) | インドール含有スルホンアミド誘導体 | |
| ES2222711T3 (es) | Derivados de acido hidroxamico como inhibidores de la produccion de cd23 humano y de la liberacion de tnf. | |
| KR20060023544A (ko) | 벤즈아미드 니트릴 유도체 | |
| US20030199571A1 (en) | (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives | |
| JP2000510138A (ja) | ヒドロキサム酸をベースとするｃｄ２３およびｔｎｆ形成の阻害剤 | |
| JPH10147564A (ja) | ペプチジルアルデヒド誘導体およびその用途 | |
| RU2451013C2 (ru) | Винилогические производные кислот как ингибиторы химазы | |
| US20030207923A1 (en) | 2,'3-Amino-4-(n-hydroxyamino)-succinylamino-acetamides for use as cd23 formation inhibitors | |
| CZ341799A3 (cs) | Deriváty hydroxamové kyseliny substituované aryl- nebo heteroarylsulfonamidem, způsob jejich přípravy a jejich použití jako léčivých přípravků | |
| JPH08500115A (ja) | 高血圧治療のためのピペラジニル−末端基またはピペラジニルアルキルアミノ−末端基を有するエチニルアラニンアミノジオール化合物 | |
| JP2001523666A (ja) | 金属タンパク質分解酵素阻害剤 |