JP2001149485A - 物質の経皮投与の方法及び装置 - Google Patents

物質の経皮投与の方法及び装置

Info

Publication number
JP2001149485A
JP2001149485A JP2000287878A JP2000287878A JP2001149485A JP 2001149485 A JP2001149485 A JP 2001149485A JP 2000287878 A JP2000287878 A JP 2000287878A JP 2000287878 A JP2000287878 A JP 2000287878A JP 2001149485 A JP2001149485 A JP 2001149485A
Authority
JP
Japan
Prior art keywords
skin
substance
patient
microneedle
microneedles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000287878A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001149485A5 (enExample
Inventor
Zeil B Rosenberg
ジール・ビー・ローゼンバーグ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of JP2001149485A publication Critical patent/JP2001149485A/ja
Publication of JP2001149485A5 publication Critical patent/JP2001149485A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000287878A 1999-09-22 2000-09-22 物質の経皮投与の方法及び装置 Pending JP2001149485A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/401,452 US6623457B1 (en) 1999-09-22 1999-09-22 Method and apparatus for the transdermal administration of a substance
US09/401452 1999-09-22

Publications (2)

Publication Number Publication Date
JP2001149485A true JP2001149485A (ja) 2001-06-05
JP2001149485A5 JP2001149485A5 (enExample) 2007-11-08

Family

ID=23587826

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000287878A Pending JP2001149485A (ja) 1999-09-22 2000-09-22 物質の経皮投与の方法及び装置

Country Status (9)

Country Link
US (4) US6623457B1 (enExample)
EP (1) EP1086718B1 (enExample)
JP (1) JP2001149485A (enExample)
AT (1) ATE346644T1 (enExample)
AU (1) AU778234B2 (enExample)
CA (1) CA2315469C (enExample)
DE (1) DE60032082T2 (enExample)
ES (1) ES2273639T3 (enExample)
SG (1) SG92728A1 (enExample)

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005021678A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベースの製造方法及び経皮投薬用パッドベース、並びに注射針
JP2005521527A (ja) * 2002-04-02 2005-07-21 ベクトン・ディキンソン・アンド・カンパニー 物質を皮内に供給する方法およびデバイス
JP2006526475A (ja) * 2003-06-02 2006-11-24 ベクトン・ディキンソン・アンド・カンパニー カートリッジ付きの医薬マイクロデバイス給送システム
JP2007508914A (ja) * 2003-10-24 2007-04-12 アルザ・コーポレーシヨン 経皮薬剤送達を促進するための装置及び方法
JP2007516781A (ja) * 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー 医療用具および該医療用具を含むキット
JP2007535346A (ja) * 2004-03-24 2007-12-06 コリウム インターナショナル, インコーポレイテッド 経皮送達デバイス
WO2008015782A1 (en) * 2006-07-31 2008-02-07 Hamamatsu Foundation For Science And Technology Promotion Microneedle patch and process for producing the same
JP2008529750A (ja) * 2005-02-16 2008-08-07 アルザ コーポレイション 生体適合性が改善されたマイクロプロジェクションアレイ
JP2008543528A (ja) * 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
JP2009078074A (ja) * 2007-09-27 2009-04-16 Toppan Printing Co Ltd マイクロニードル製造方法
WO2009130926A1 (ja) * 2008-04-22 2009-10-29 南部化成株式会社 経皮投薬方法、ニードル形成体及び経皮投薬装置
WO2010055622A1 (ja) * 2008-11-17 2010-05-20 Inaba Yoichi 爪白癬用簡易治療具
WO2012057270A1 (ja) * 2010-10-27 2012-05-03 Asti株式会社 マイクロニードルアレイ装着用治具とマイクロニードルアレイ装置
US8251958B2 (en) 2001-01-12 2012-08-28 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
JP2013505057A (ja) * 2009-09-17 2013-02-14 ジップライン メディカル, インコーポレイテッド 迅速閉鎖の外科的閉鎖デバイス
WO2013171907A1 (ja) * 2012-05-18 2013-11-21 大勝 明 注射針、および、キット製剤
WO2014003002A1 (ja) * 2012-06-27 2014-01-03 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
US8702726B2 (en) 2000-10-16 2014-04-22 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
JP2014147837A (ja) * 2012-06-27 2014-08-21 Kosumedei Seiyaku Kk マイクロニードルパッチの保護離型シート
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP2015515474A (ja) * 2012-04-03 2015-05-28 セラジェクト, インコーポレイテッド ワクチンの経頬送達のための溶解性微小針アレイ
US9050086B2 (en) 2011-11-01 2015-06-09 Zipline Medical, Inc. Surgical incision and closure apparatus
US9089328B2 (en) 2011-11-01 2015-07-28 Zipline Medical, Inc. Surgical incision and closure apparatus
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
JP2016067618A (ja) * 2014-09-30 2016-05-09 日本写真印刷株式会社 マイクロニードルシートの梱包体及びその製造方法
US9561034B2 (en) 2011-11-01 2017-02-07 Zipline Medical, Inc. Surgical incision and closure apparatus
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US10010710B2 (en) 2009-09-17 2018-07-03 Zipline Medical, Inc. Rapid closing surgical closure device
US10123801B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Means to prevent wound dressings from adhering to closure device
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
WO2019059265A1 (ja) * 2017-09-20 2019-03-28 シンクランド株式会社 マイクロニードルの製造方法及びマイクロニードル
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP2020513899A (ja) * 2016-12-22 2020-05-21 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドJohnson & Johnson Consumer Inc. マイクロニードルアレイ及び製造方法及び使用方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10888269B2 (en) 2014-01-05 2021-01-12 Zipline Medical, Inc. Instrumented wound closure device
US10918332B2 (en) 2016-10-31 2021-02-16 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
US11051988B2 (en) 2010-06-14 2021-07-06 Zipline Medical, Inc. Methods and apparatus for inhibiting scar formation
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
JP2021529760A (ja) * 2018-06-29 2021-11-04 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドJohnson & Johnson Consumer Inc. 活性物質の送達のための三次元マイクロ流体デバイス
KR20220147288A (ko) * 2021-04-27 2022-11-03 주식회사 이엘컴퍼니 마이크로 니들을 이용한 문신 패치
US11849415B2 (en) 2018-07-27 2023-12-19 Mclaren Applied Technologies Limited Time synchronisation
JP2024505198A (ja) * 2021-01-22 2024-02-05 ソレント・セラピューティクス・インコーポレイテッド コロナウイルスワクチンのマイクロリットルスケールのリンパ送達のためのデバイス
US11898874B2 (en) 2019-10-18 2024-02-13 Mclaren Applied Technologies Limited Gyroscope bias estimation
US12171432B2 (en) 2011-11-01 2024-12-24 Zipline Medical, Inc. Closure apparatuses and methods for ulcers and irregular skin defects

Families Citing this family (273)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6641591B1 (en) 1999-08-26 2003-11-04 John H. Shadduck Instruments and techniques for controlled removal of epidermal layers
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) * 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2736501A (en) * 1999-12-30 2001-07-16 Redeon, Inc. Stacked microneedle systems
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
WO2001093930A1 (en) * 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
WO2002028471A1 (de) 2000-10-05 2002-04-11 Thomas Marsoner Medizinische injektionseinrichtung
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
AU2002237703A1 (en) * 2000-11-09 2002-06-18 Biovalve Technologies, Inc. Microneedle adapter
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US20040071734A1 (en) * 2001-02-23 2004-04-15 Nathalie Garcon Novel vaccine
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
EP1381423A1 (en) * 2001-04-13 2004-01-21 Becton, Dickinson and Company Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7963935B2 (en) * 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
AU2007203302B2 (en) * 2001-04-20 2010-07-01 Alza Corporation Microprojection array immunization patch and method
GB2386072A (en) * 2001-04-27 2003-09-10 Becton Dickinson Co Novel vaccine
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
CA2451816A1 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
PT1465535E (pt) * 2001-12-20 2008-02-08 Alza Corp Microprojecções que perfuram a pele tendo controlo de profundidade de perfuração
ITTO20011228A1 (it) 2001-12-28 2003-06-28 Cane Srl Contenitore per ago monouso.
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
BR0311443A (pt) 2002-05-06 2005-03-22 Becton Dickinson Co Método e dispositivo para controlar farmacocinética de droga
WO2004009172A1 (en) 2002-07-19 2004-01-29 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
CA2497086A1 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
WO2004033021A1 (en) * 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
AU2004238257A1 (en) * 2003-05-06 2004-11-25 Becton, Dickinson And Company A method for altering insulin pharmacokinetics
EP1632263A4 (en) * 2003-06-10 2008-04-30 Medrx Co Ltd METHOD FOR THE PRODUCTION OF A REFERENCE BASIS FOR TRANSDERMAL MEDICINAL ADMINISTRATION, BASIC BASIS FOR TRANSDERMAL ADMINISTRATIVE ADMINISTRATION AND NEEDLE
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
WO2005004842A2 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
EP1648363B1 (en) 2003-07-03 2019-03-06 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
US7766902B2 (en) 2003-08-13 2010-08-03 Wisconsin Alumni Research Foundation Microfluidic device for drug delivery
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
KR101114710B1 (ko) 2004-03-26 2012-02-29 우노메디컬 에이/에스 주사세트
US20050251095A1 (en) * 2004-05-07 2005-11-10 Giap Brandon C Improved medication injection device
EP1744683B1 (en) 2004-05-13 2016-03-16 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
EP1773444B1 (en) * 2004-06-10 2017-09-20 3M Innovative Properties Company Patch application device and kit
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
ES2463818T3 (es) 2004-08-16 2014-05-29 Functional Microstructures Limited Dispositivo que se aplicará a una barrera biológica
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
AU2005306372B2 (en) 2004-11-18 2011-01-06 Kindeva Drug Delivery L.P. Method of contact coating a microneedle array
EP1833547A1 (en) 2004-11-18 2007-09-19 3M Innovative Properties Company Low-profile microneedle array applicator
KR101224257B1 (ko) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006057619A1 (en) * 2004-11-26 2006-06-01 Agency For Science, Technology And Research Method and apparatus for forming microstructures
KR20070086306A (ko) 2004-12-10 2007-08-27 우노메디컬 에이/에스 주입기
WO2006064270A1 (en) * 2004-12-17 2006-06-22 Functional Microstructures Limited Microneedle device for transdermal transport of fluid
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
EP1871457B1 (en) 2005-04-11 2012-05-02 Infotonics Technology Center, Inc. Blood monitoring systems and methods thereof
WO2006115502A1 (en) * 2005-04-25 2006-11-02 Giap, Brandon, C. Improved medication injection device
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
AU2006261898B2 (en) * 2005-06-27 2011-11-03 3M Innovative Properties Company Microneedle array applicator device
DE602006016123D1 (de) 2005-06-28 2010-09-23 Unomedical As Verpackung für infusionssatz und verfahren zum anwenden eines infusionssatzes
WO2007008824A2 (en) * 2005-07-11 2007-01-18 Infotonics Technology Center, Inc. Minimally invasive allergy testing system
EP1928537B1 (en) * 2005-09-02 2015-01-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
PT1762259E (pt) 2005-09-12 2010-12-10 Unomedical As Insersor para um conjunto de infusão com uma primeira e uma segunda unidades de mola
GB0520757D0 (en) * 2005-10-12 2005-11-23 Vuppalapati Gunasekar Delivery device
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US20090247953A1 (en) * 2005-12-08 2009-10-01 Nanopass Technologies Ltd. Microneedle adaptor for dosed drug delivery devices
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
AU2006329075A1 (en) 2005-12-23 2007-06-28 Unomedical A/S Injection device
US8048089B2 (en) 2005-12-30 2011-11-01 Edge Systems Corporation Apparatus and methods for treating the skin
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
WO2011053607A1 (en) 2009-10-26 2011-05-05 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
EP1988958B2 (en) 2006-02-28 2016-03-16 Unomedical A/S Inserter for infusion part
US8343116B2 (en) 2008-01-04 2013-01-01 Edge Systems Corporation Apparatus and method for treating the skin
US9566088B2 (en) 2006-03-29 2017-02-14 Edge Systems Llc Devices, systems and methods for treating the skin
US10172644B2 (en) 2006-03-29 2019-01-08 Edge Systems Llc Devices, systems and methods for treating the skin
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20070265570A1 (en) * 2006-04-27 2007-11-15 Gerut Zachary E Device and method for treating skin prior to performing surgery
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US20070276425A1 (en) * 2006-05-29 2007-11-29 Stanley Kim Painless Blood Sampling Lancet with Bundled Multiple Thin Needles
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
AU2007256561B2 (en) 2006-06-07 2012-07-19 Unomedical A/S Inserter for transcutaneous sensor
EP2026861A1 (en) 2006-06-09 2009-02-25 Unomedical A/S Mounting pad
US8012566B2 (en) * 2006-07-12 2011-09-06 Hewlett-Packard Development Company, L.P. Microneedles formed by electroplating and selectively releasing temperature sensitive layers
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
US20080015516A1 (en) * 2006-07-12 2008-01-17 Nanopass Technologies Ltd. Microneedle Devices With Controlled Uncapping
KR100886633B1 (ko) * 2006-07-14 2009-03-04 호남석유화학 주식회사 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치
CA2658577A1 (en) 2006-08-02 2008-02-07 Unomedical A/S Cannula and delivery device
WO2008042902A2 (en) 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
US20080114340A1 (en) * 2006-11-01 2008-05-15 Biotex, Inc. System and method for reducing photon scatter in dermal tissue
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US8523926B2 (en) * 2007-01-19 2013-09-03 Joseph Neev Devices and methods for generation of subsurface microdisruptions for biomedical applications
US10588694B1 (en) 2007-01-19 2020-03-17 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for biomedical applications
ES2391599T3 (es) * 2007-06-14 2012-11-28 Crucell Switzerland Ag Vacuna intradérmica contra la gripe
JP2010530266A (ja) 2007-06-20 2010-09-09 ウノメディカル アクティーゼルスカブ カテーテル並びにカテーテルの製造方法及び装置
CN101808685A (zh) 2007-07-03 2010-08-18 优诺医疗有限公司 具有双稳平衡状态的插入器
US20090041810A1 (en) * 2007-07-09 2009-02-12 Andrianov Alexander K Immunostimulating polyphosphazene compounds for intradermal immunization
DK2173410T3 (da) 2007-07-10 2011-06-06 Unomedical As Inserter med to fjedre
CA2694952A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
CA2694210C (en) * 2007-07-21 2016-11-08 Stanley Kim Lancet system
US8328720B2 (en) 2007-08-10 2012-12-11 Infotonics Technology Center, Inc. MEMS interstitial prothrombin time test
CN101808588B (zh) * 2007-09-28 2012-12-19 贝尔法斯特女王大学 递送装置及方法
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2009097451A1 (en) 2008-01-29 2009-08-06 Edge Systems Corporation Apparatus and method for treating the skin
US8814836B2 (en) 2008-01-29 2014-08-26 Edge Systems Llc Devices, systems and methods for treating the skin using time-release substances
KR20100123711A (ko) 2008-02-13 2010-11-24 우노메디컬 에이/에스 캐뉼라부와 유체 통로 사이의 밀봉부
WO2009103759A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
US9408971B2 (en) * 2008-03-31 2016-08-09 Covidien Lp Self-capping syringe assembly with one-way valve
US10543123B2 (en) 2008-04-28 2020-01-28 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for opthalmic surgery and opthalmic applications
JP5476062B2 (ja) * 2008-07-25 2014-04-23 南部化成株式会社 経皮投薬デバイス
US8986250B2 (en) 2008-08-01 2015-03-24 Wisconsin Alumni Research Foundation Drug delivery platform utilizing hydrogel pumping mechanism
US8795259B2 (en) 2008-08-01 2014-08-05 Wisconsin Alumni Research Foundation Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow
US8545856B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8784384B2 (en) * 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Frozen compositions and array devices thereof
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US8551506B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8221480B2 (en) 2008-10-31 2012-07-17 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8563012B2 (en) 2008-10-31 2013-10-22 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8256233B2 (en) 2008-10-31 2012-09-04 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
KR20190064676A (ko) * 2008-11-18 2019-06-10 쓰리엠 이노베이티브 프로퍼티즈 컴파니 중공 마이크로니들 어레이
EP2384217B1 (en) 2008-12-22 2021-01-27 Unomedical A/S Medical device comprising adhesive pad
FI20095433A0 (fi) * 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
KR20120054598A (ko) 2009-07-30 2012-05-30 우노메디컬 에이/에스 수평방향 이동부를 구비한 삽입장치
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
EP2461853B1 (en) 2009-08-07 2016-03-30 Unomedical A/S Delivery device with sensor and one or more cannulas
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8409147B2 (en) * 2009-08-22 2013-04-02 Joseph Wayne Kraft Rapid local anesthesia linear injection device
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
DE102009046581A1 (de) * 2009-11-10 2011-05-12 Robert Bosch Gmbh Herstellungsverfahren für eine poröse Mikronadelanordnung und entsprechende poröse Mikronadelanordnung und entsprechender Substratverbund
EP2512509A2 (en) 2009-12-16 2012-10-24 ChronTech Pharma AB Injection needle and device
CA2689400C (en) * 2009-12-30 2023-01-10 Kenneth W. Adams Therapeutic agent delivery apparatus and process
US8328757B2 (en) * 2010-01-08 2012-12-11 Wisconsin Alumni Research Foundation Bladder arrangement for microneedle-based drug delivery device
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
US9327105B2 (en) 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
EP2552513B1 (en) 2010-03-30 2014-03-19 Unomedical A/S Medical device
US8439945B2 (en) 2010-05-03 2013-05-14 Zipline Medical, Inc. Methods for biopsying tissue
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
CN103429606A (zh) 2010-10-01 2013-12-04 现代治疗公司 设计核酸及其使用方法
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
EP2643449A2 (en) * 2010-11-23 2013-10-02 The Regents of the University of California Low-pressure biolistic barrels
US10244981B2 (en) 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
EP2720740A1 (en) 2011-06-15 2014-04-23 ChronTech Pharma AB Injection needle and device
CN103764668B (zh) 2011-07-09 2016-08-17 加利福尼亚大学董事会 白血病干细胞靶向配体及应用方法
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9700245B2 (en) 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
KR20190099538A (ko) 2011-10-03 2019-08-27 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도
US11197689B2 (en) 2011-10-05 2021-12-14 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2578190A1 (en) * 2011-10-07 2013-04-10 Sanofi-Aventis Deutschland GmbH Intraocular injection device
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US8323313B1 (en) 2011-11-01 2012-12-04 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
EP4144378A1 (en) 2011-12-16 2023-03-08 ModernaTX, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013138118A1 (en) 2012-03-14 2013-09-19 The Regents Of The University Of California Treatment of inflammatory disorders in non-human mammals
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AU2013243954A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
KR200466758Y1 (ko) 2012-06-01 2013-05-07 인싸이토(주) 경피내 주사기 모듈
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
DK2922554T3 (en) 2012-11-26 2022-05-23 Modernatx Inc Terminalt modificeret rna
US10179239B2 (en) 2013-01-15 2019-01-15 Itrace Biomedical Inc. Personalized pain management treatments
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
WO2014126101A1 (ja) * 2013-02-13 2014-08-21 久光製薬株式会社 マイクロニードル・アレイ
WO2014132239A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
JP6522523B2 (ja) 2013-02-28 2019-05-29 ソレント・セラピューティクス・インコーポレイテッド 経皮的薬物送達装置
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3903704B1 (en) 2013-03-15 2022-11-02 HydraFacial LLC Devices and systems for treating the skin
US10238812B2 (en) 2013-03-15 2019-03-26 Edge Systems Llc Skin treatment systems and methods using needles
CA2903583C (en) 2013-03-15 2021-12-28 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
ES2897659T3 (es) 2013-09-03 2022-03-02 Georgia Tech Res Inst Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
US20160279401A1 (en) * 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
EP3132822B1 (en) * 2014-04-14 2018-10-31 Toppan Printing Co., Ltd. Injection device
MX384280B (es) 2014-04-30 2025-03-14 Vivasor Inc Metodo y aparato de administracion transdermica de medicamentos.
MX376608B (es) 2014-04-30 2025-03-04 Vivasor Inc Porcion del receptaculo de un aparato y metodo de administracion transdermica de medicamentos.
RU2633324C1 (ru) 2014-04-30 2017-10-11 Кимберли-Кларк Ворлдвайд, Инк. Контроллер в виде части устройства и способ трансдермальной доставки лекарств
KR101724655B1 (ko) * 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
US9987427B1 (en) * 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
US9907941B2 (en) 2014-07-21 2018-03-06 The Cleveland Clinic Foundation Convection enhanced delivery device and system
US9968765B2 (en) 2014-07-21 2018-05-15 The Cleveland Clinic Foundation Convection enhanced delivery device and system
KR101636775B1 (ko) * 2014-08-19 2016-07-08 아주대학교산학협력단 부위마취 장치 및 방법
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
EP4324414A3 (en) 2014-12-23 2024-05-01 HydraFacial LLC Devices and methods for treating the skin using a rollerball or a wicking member
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
CN104922791B (zh) * 2015-05-26 2018-10-26 上海交通大学 无创针灸贴片及其制备方法
KR20240014104A (ko) 2015-07-08 2024-01-31 하이드라페이셜 엘엘씨 모발 성장을 촉진하기 위한 디바이스, 시스템 및 방법
JP2019513070A (ja) 2016-03-01 2019-05-23 キトテック メディカル, インコーポレイテッド 創傷閉鎖のための微細構造に基づくシステム、装置および方法
BR112019012924A2 (pt) * 2016-12-22 2019-12-10 Ohio State Innovation Foundation microestruturas interpenetrantes para liberação de carga com base em nanocanal
US12415058B2 (en) 2016-12-22 2025-09-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery
JP2020507422A (ja) 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドAllergan,Incorporated 活性成分を含むマイクロニードルアレイ
CN109394236B (zh) * 2017-08-17 2022-04-01 李泉 一种采血装置及其控制设备
WO2019033362A1 (zh) * 2017-08-17 2019-02-21 深圳华迈兴微医疗科技有限公司 一种采血装置及其控制设备
TWI666036B (zh) * 2017-10-27 2019-07-21 研能科技股份有限公司 穿戴式人體胰島素注入供液裝置
TWI657842B (zh) * 2017-10-27 2019-05-01 研能科技股份有限公司 人體胰島素注入之供液裝置
US20220362532A1 (en) * 2019-10-24 2022-11-17 Janine HOPKINS Applicator device and methods of use
US11291474B2 (en) 2020-01-06 2022-04-05 Ed F. Nicolas Skin treatment tool applicator tip
US11986613B2 (en) 2020-02-19 2024-05-21 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
EP4117768A4 (en) * 2020-04-09 2024-04-24 Carnegie Mellon University HYBRID MICRONEEDLE ARRANGEMENTS
EP4149594B1 (en) * 2020-05-11 2025-08-13 Evjensvold, Laila Rigmor Injection device with multiple cannulas
CN112869871B (zh) * 2021-01-11 2022-10-14 杭州维纳安可医疗科技有限责任公司 消融装置及其控制方法、装置、系统、存储介质
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12029562B2 (en) 2021-04-14 2024-07-09 Satio, Inc. Dermal patch system
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11510602B1 (en) 2021-11-08 2022-11-29 Satio, Inc. Dermal patch for collecting a physiological sample
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US20220355045A1 (en) * 2021-05-04 2022-11-10 Michael Berry Hair growth applicator and method of use
USD1065551S1 (en) 2021-09-10 2025-03-04 Hydrafacial Llc Skin treatment device
USD1016615S1 (en) 2021-09-10 2024-03-05 Hydrafacial Llc Container for a skin treatment device
USD1042807S1 (en) 2021-10-11 2024-09-17 Hydrafacial Llc Skin treatment tip
US11957346B2 (en) 2022-02-18 2024-04-16 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
US20250205217A1 (en) 2022-04-01 2025-06-26 The Regents Of The University Of California Methods of improving cancer immunotherapy
CA3249491A1 (en) 2022-04-29 2023-11-02 Colgate-Palmolive Company PERSONAL CARE COMPOSITIONS
CN116020046A (zh) * 2022-09-09 2023-04-28 中山大学附属第一医院 一种微针阵列透皮递送系统及使用方法
CN115845241A (zh) * 2022-12-30 2023-03-28 首都医科大学附属北京安贞医院 一种微针透皮给药装置及其制备方法
USD1084369S1 (en) 2023-02-10 2025-07-15 Hydrafacial Llc Skin treatment tip
WO2025217124A1 (en) 2024-04-09 2025-10-16 Beth Israel Deaconess Medical Center, Inc. An inhibitor of soluble epoxide hydrolase for use in the treatment of cancer cachexia

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1699012A (en) * 1927-11-22 1929-01-15 Joseph S Naylor Stock and poultry marker
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
FR1584474A (enExample) 1968-02-20 1969-12-26
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2513467C3 (de) * 1975-03-26 1979-10-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Gerät zur Infusion von Flüssigkeiten in den menschlichen oder tierischen Körper
IT1202218B (it) * 1985-05-21 1989-02-02 Mario Aluigi Piastre di derivazione multi-aghi per uso mesoterapico e relative custodie salva punte
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
WO1995023005A1 (en) * 1994-02-28 1995-08-31 Novo Nordisk A/S Needle unit
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
ZA975326B (en) * 1996-06-18 1998-01-14 Alza Corp Device and method for enhancing transdermal flux of agents being delivered or sampled.
AU3880697A (en) 1996-07-03 1998-01-21 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
CA2241615A1 (en) 1997-06-26 1998-12-26 An-Go-Gen Inc. Catheters
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002532165A (ja) * 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
EP1187653B1 (en) * 1999-06-04 2010-03-31 Georgia Tech Research Corporation Devices for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance

Cited By (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8702726B2 (en) 2000-10-16 2014-04-22 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US8251958B2 (en) 2001-01-12 2012-08-28 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
JP2005521527A (ja) * 2002-04-02 2005-07-21 ベクトン・ディキンソン・アンド・カンパニー 物質を皮内に供給する方法およびデバイス
JP4842807B2 (ja) * 2003-06-02 2011-12-21 ベクトン・ディキンソン・アンド・カンパニー カートリッジ付きの医薬マイクロデバイス給送システム
JP2006526475A (ja) * 2003-06-02 2006-11-24 ベクトン・ディキンソン・アンド・カンパニー カートリッジ付きの医薬マイクロデバイス給送システム
JP2005021678A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベースの製造方法及び経皮投薬用パッドベース、並びに注射針
JP2007508914A (ja) * 2003-10-24 2007-04-12 アルザ・コーポレーシヨン 経皮薬剤送達を促進するための装置及び方法
JP2007516781A (ja) * 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー 医療用具および該医療用具を含むキット
JP2007535346A (ja) * 2004-03-24 2007-12-06 コリウム インターナショナル, インコーポレイテッド 経皮送達デバイス
JP2008529750A (ja) * 2005-02-16 2008-08-07 アルザ コーポレイション 生体適合性が改善されたマイクロプロジェクションアレイ
JP2008543528A (ja) * 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
WO2008015782A1 (en) * 2006-07-31 2008-02-07 Hamamatsu Foundation For Science And Technology Promotion Microneedle patch and process for producing the same
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US10238848B2 (en) 2007-04-16 2019-03-26 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP2009078074A (ja) * 2007-09-27 2009-04-16 Toppan Printing Co Ltd マイクロニードル製造方法
WO2009130926A1 (ja) * 2008-04-22 2009-10-29 南部化成株式会社 経皮投薬方法、ニードル形成体及び経皮投薬装置
JP2010184102A (ja) * 2008-04-22 2010-08-26 Nanbu Plastics Co Ltd 経皮投薬装置及びその装置に使用するニードル形成体
WO2010055622A1 (ja) * 2008-11-17 2010-05-20 Inaba Yoichi 爪白癬用簡易治療具
US10159825B2 (en) 2009-09-17 2018-12-25 Zipline Medical, Inc. Rapid closing surgical closure device
US10010710B2 (en) 2009-09-17 2018-07-03 Zipline Medical, Inc. Rapid closing surgical closure device
US9179914B2 (en) 2009-09-17 2015-11-10 Zipline Medical, Inc. Rapid closing surgical closure device
JP2013505057A (ja) * 2009-09-17 2013-02-14 ジップライン メディカル, インコーポレイテッド 迅速閉鎖の外科的閉鎖デバイス
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US11419816B2 (en) 2010-05-04 2022-08-23 Corium, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US11051988B2 (en) 2010-06-14 2021-07-06 Zipline Medical, Inc. Methods and apparatus for inhibiting scar formation
WO2012057270A1 (ja) * 2010-10-27 2012-05-03 Asti株式会社 マイクロニードルアレイ装着用治具とマイクロニードルアレイ装置
US10441767B2 (en) 2010-10-27 2019-10-15 Asti Corporation Jig for microneedle array placement and microneedle array device
US9554799B2 (en) 2011-11-01 2017-01-31 Zipline Medical, Inc. Surgical incision and closure apparatus
US9642621B2 (en) 2011-11-01 2017-05-09 ZipLine Medical, Inc Surgical incision and closure apparatus
US9554800B2 (en) 2011-11-01 2017-01-31 Zipline Medical, Inc. Surgical incision and closure apparatus
US11439395B2 (en) 2011-11-01 2022-09-13 Zipline Medical, Inc. Surgical incision and closure apparatus
US9561034B2 (en) 2011-11-01 2017-02-07 Zipline Medical, Inc. Surgical incision and closure apparatus
US12171432B2 (en) 2011-11-01 2024-12-24 Zipline Medical, Inc. Closure apparatuses and methods for ulcers and irregular skin defects
US9642622B2 (en) 2011-11-01 2017-05-09 Zipline Medical, Inc. Surgical incision and closure apparatus
US9474529B2 (en) 2011-11-01 2016-10-25 Zipline Medical, Inc. Surgical incision and closure apparatus
US9089328B2 (en) 2011-11-01 2015-07-28 Zipline Medical, Inc. Surgical incision and closure apparatus
US10456136B2 (en) 2011-11-01 2019-10-29 Zipline Medical, Inc. Surgical incision and closure apparatus
US9050086B2 (en) 2011-11-01 2015-06-09 Zipline Medical, Inc. Surgical incision and closure apparatus
US10123801B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Means to prevent wound dressings from adhering to closure device
US10123800B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
JP2015515474A (ja) * 2012-04-03 2015-05-28 セラジェクト, インコーポレイテッド ワクチンの経頬送達のための溶解性微小針アレイ
WO2013171907A1 (ja) * 2012-05-18 2013-11-21 大勝 明 注射針、および、キット製剤
JP2014028108A (ja) * 2012-06-27 2014-02-13 Kosumedei Seiyaku Kk マイクロニードルパッチの保護離型シート
US11998712B2 (en) 2012-06-27 2024-06-04 Cosmed Pharmaceutical Co., Ltd. Protective release sheet for microneedle patch
JP2014147837A (ja) * 2012-06-27 2014-08-21 Kosumedei Seiyaku Kk マイクロニードルパッチの保護離型シート
JP2019115718A (ja) * 2012-06-27 2019-07-18 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
AU2013281871B2 (en) * 2012-06-27 2017-04-13 Cosmed Pharmaceutical Co., Ltd. Protective release sheet for microneedle patch
JP2020192411A (ja) * 2012-06-27 2020-12-03 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
US10821275B2 (en) 2012-06-27 2020-11-03 Cosmed Pharmaceutical Co., Ltd. Protective release sheet for microneedle patch
JP2017127752A (ja) * 2012-06-27 2017-07-27 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
WO2014003002A1 (ja) * 2012-06-27 2014-01-03 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
US11110259B2 (en) 2013-03-12 2021-09-07 Corium, Inc. Microprojection applicators and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US11565097B2 (en) 2013-03-15 2023-01-31 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
US10888269B2 (en) 2014-01-05 2021-01-12 Zipline Medical, Inc. Instrumented wound closure device
US11844625B2 (en) 2014-01-05 2023-12-19 Zipline Medical, Inc. Instrumented wound closure device
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP2016067618A (ja) * 2014-09-30 2016-05-09 日本写真印刷株式会社 マイクロニードルシートの梱包体及びその製造方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11033270B2 (en) 2015-08-07 2021-06-15 Zipline Medical, Inc. Means to prevent wound dressings from adhering to closure device
US10918332B2 (en) 2016-10-31 2021-02-16 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
US11337649B2 (en) 2016-10-31 2022-05-24 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
US11992334B2 (en) 2016-10-31 2024-05-28 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
JP2020513899A (ja) * 2016-12-22 2020-05-21 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドJohnson & Johnson Consumer Inc. マイクロニードルアレイ及び製造方法及び使用方法
JP2023086967A (ja) * 2016-12-22 2023-06-22 ジョンソン アンド ジョンソン コンシューマー インコーポレイテッド マイクロニードルアレイ
WO2019059265A1 (ja) * 2017-09-20 2019-03-28 シンクランド株式会社 マイクロニードルの製造方法及びマイクロニードル
JP2021529760A (ja) * 2018-06-29 2021-11-04 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドJohnson & Johnson Consumer Inc. 活性物質の送達のための三次元マイクロ流体デバイス
JP7616745B2 (ja) 2018-06-29 2025-01-17 ジョンソン アンド ジョンソン コンシューマー インク. 活性物質の送達のための三次元マイクロ流体デバイス
US11849415B2 (en) 2018-07-27 2023-12-19 Mclaren Applied Technologies Limited Time synchronisation
US11898874B2 (en) 2019-10-18 2024-02-13 Mclaren Applied Technologies Limited Gyroscope bias estimation
JP2024505198A (ja) * 2021-01-22 2024-02-05 ソレント・セラピューティクス・インコーポレイテッド コロナウイルスワクチンのマイクロリットルスケールのリンパ送達のためのデバイス
KR102577073B1 (ko) * 2021-04-27 2023-09-11 주식회사 이엘홀딩스 마이크로 니들을 이용한 문신 패치
KR20220147288A (ko) * 2021-04-27 2022-11-03 주식회사 이엘컴퍼니 마이크로 니들을 이용한 문신 패치

Also Published As

Publication number Publication date
US6623457B1 (en) 2003-09-23
ATE346644T1 (de) 2006-12-15
EP1086718A1 (en) 2001-03-28
EP1086718B1 (en) 2006-11-29
DE60032082D1 (de) 2007-01-11
AU5352800A (en) 2001-03-29
DE60032082T2 (de) 2007-06-21
CA2315469A1 (en) 2001-03-22
US20060047243A1 (en) 2006-03-02
US20030199812A1 (en) 2003-10-23
ES2273639T3 (es) 2007-05-16
SG92728A1 (en) 2002-11-19
CA2315469C (en) 2009-04-21
AU778234B2 (en) 2004-11-25
US6960193B2 (en) 2005-11-01
US20080287864A1 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
JP2001149485A (ja) 物質の経皮投与の方法及び装置
JP4892166B2 (ja) 微小器具及びその製造方法
US7083592B2 (en) Device and method for delivering withdrawing a substance through the skin
JP4917540B2 (ja) 被膜を含む物質の供給方法および装置
EP1301236B1 (en) Delivery device with microneedles for the transdermal administration of a substance
EP1757240B1 (en) Valved intradermal delivery device
KR101615592B1 (ko) 역 작동기를 포함하는 마이크로니들 주사 장치
US6689100B2 (en) Microdevice and method of delivering or withdrawing a substance through the skin of an animal
AU2004245051B2 (en) Medicament microdevice delivery system with a cartridge

Legal Events

Date Code Title Description
A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070919

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070919

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20080418

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080425

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080725

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080730

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080825

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090213