JP2005521527A - 物質を皮内に供給する方法およびデバイス - Google Patents
物質を皮内に供給する方法およびデバイス Download PDFInfo
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- JP2005521527A JP2005521527A JP2003581835A JP2003581835A JP2005521527A JP 2005521527 A JP2005521527 A JP 2005521527A JP 2003581835 A JP2003581835 A JP 2003581835A JP 2003581835 A JP2003581835 A JP 2003581835A JP 2005521527 A JP2005521527 A JP 2005521527A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
Abstract
Description
Claims (45)
- 患者に物質を供給する皮内供給デバイスであって、
患者に供給するための物質を受け入れるような寸法を有する内部空洞を有するハウジングと、
前記空洞に流体的に連通する皮膚貫入デバイスと、
患者に充分な量の物質を供給したことを示すインジケータと、
を具えた皮内供給デバイス。 - 前記インジケータが、充分な量の物質が供給された位置まで可動の少なくとも1つの部分を持つ指標部材を具え、該指標部材が前記位置にあることによって、充分な量の物質が供給されたことを示すようにした請求項1の皮内供給デバイス。
- 前記指標部材の可動部分が前記位置にある場合に、前記可動部分が前記皮内供給デバイスの外部から視認可能である請求項2の皮内供給デバイス。
- 前記可動部分が前記位置に向けて弾性的に付勢されている請求項2の皮内供給デバイス。
- 前記指標部材が前記位置から膨張可能な弾性部材を具え、該膨張可能な弾性部材の弾性が前記可動部分を前記位置に向けて付勢している請求項4の皮内供給デバイス。
- 前記膨張可能な弾性部材の弾性が、充分な量の物質が供給されるまで前記空洞内の物質に対して供給圧力を発生させる手段を具えている請求項5の皮内供給デバイス。
- 前記膨張可能な部材が、加圧下で前記空洞に物質を導入することによって膨張可能である請求項6の皮内供給デバイス。
- 供給されるべき充分な量の物質が一つのまとまった容積を形成し、前記指標部材が一つのまとまった容積を通って移動し、前記指標部材が通る当該容積が、供給されるべき前記物質の容積に少なくとも等しい請求項2の皮内供給デバイス。
- 前記ハウジングが、前記物質を前記空洞に入れる入口をさらに具えている請求項1の皮内供給デバイス。
- 前記入口を通じて前記空洞から前記物質が出て行くことを防ぐために、前記入口に接続された逆止弁をさらに具えている請求項9の皮内供給デバイス。
- 前記膨張可能な弾性部材が、前記ハウジングと一体化されている請求項5の皮内供給デバイス。
- 前記膨張可能な弾性部材がエラストマー材料で作られている請求項11の皮内供給デバイス。
- 前記ハウジングが天壁を具え、前記膨張可能な弾性部材が該天壁に接続されている請求項5の皮内供給デバイス。
- 前記天壁が開口部を具え、前記膨張可能な弾性部材が該開口部を閉鎖している請求項13の皮内供給デバイス。
- 前記膨張可能な弾性部材がダイアフラムである請求項5の皮内供給デバイス。
- 前記ダイアフラムがエラストマー材料で作られている請求項15の皮内供給デバイス。
- 前記膨張可能な弾性部材が前記ハウジングの天壁を形成している請求項15の皮内供給デバイス。
- 物質を前記空洞に入れる入口をさらに具えている請求項17の皮内供給デバイス。
- 前記デバイスを前記皮膚の表面に取り付ける取付け機構をさらに具えている請求項1の皮内供給デバイス。
- 前記取付け機構が、前記デバイスを前記皮膚に取り外し可能に接合する接着部を具えている請求項13の皮内供給デバイス。
- 前記皮膚貫入デバイスが、約50ミクロンないし約1500ミクロンの長さの皮膚貫入部材を具えている請求項1の皮内供給デバイス。
- 前記皮膚貫入デバイスが、複数の前記皮膚貫入部材を具えている請求項21の皮内供給デバイス。
- 前記皮膚貫入デバイスが、約30ゲージないし約50ゲージの針である請求項21の皮内供給デバイス。
- 前記皮膚貫入デバイスが、約500ミクロンないし約1000ミクロンの長さを有する皮膚貫入部材を具えている請求項1の皮内供給デバイス。
- 前記皮膚貫入デバイスが、複数の前記皮膚貫入部材を具えている請求項24の皮内供給デバイス。
- 前記皮膚貫入部材が、約30ゲージないし約50ゲージの針である請求項24の皮内供給デバイス。
- 前記膨脹可能な弾性部材が、患者に供給されるべき物質を受容する寸法を有する内部空洞の少なくとも一部を具えている請求項5の皮内供給デバイス。
- 前記ハウジングが、実質的に非膨脹性の材料で作られた実質的に非膨脹の部分を有する請求項27の皮内供給デバイス。
- 前記実質的に非膨脹の部分が、前記物質を前記空洞に供給するための入口を具えている請求項28の皮内供給デバイス。
- 前記入口に接続された逆止弁をさらに具え、物質が前記入口を通じて前記空洞から出て行くことを防ぐようにした請求項29の皮内供給デバイス。
- 前記ハウジングに連結された可撓性の接着剤コート部材をさらに具え、前記デバイスが前記患者の皮膚に接着により取り付けられるようにした請求項1の皮内供給デバイス。
- 前記接着剤コート部材が帯である請求項31の皮内供給デバイス。
- 前記皮膚貫入部材が、前記物質を前記患者に供給するための前記空洞に流体的に連通する軸方向通路を有する針である請求項1の皮内供給デバイス。
- 前記物質を物質源から前記空洞まで液密に移動させる手段をさらに具えている請求項1の皮内供給デバイス。
- 前記移動手段が、前記ハウジングに入口開口部を具えるとともに、前記液体源を前記ハウジングに取り外し可能に連結する機構を具えている請求項34の皮内供給デバイス。
- 前記液体源が単位用量薬剤供給デバイスである請求項34の皮内供給デバイス。
- 前記膨脹可能な弾性ダイアフラムが、前記ハウジングの外壁を形成している請求項34の皮内供給デバイス。
- 前記外壁が皮膚貫入デバイスの末端に有る請求項37の皮内供給デバイス。
- 前記ハウジングが底を有し、該底に前記皮膚貫入デバイスが連結されている請求項1の皮内供給デバイス。
- 前記表示部材が、患者に供給するために物質を受け入れるような寸法を有する前記内部空洞の少なくとも一部を具えている請求項1の皮内供給デバイス。
- 患者に物質を供給する皮内供給デバイスであって、
患者に供給するための物質を受け入れるような寸法を有する内部空洞を有するハウジングと、
前記空洞に流体的に連通する皮膚貫入デバイスと、
患者に充分な量の物質を供給したことを示す手段と、
を具えた皮内供給デバイス。 - 患者の皮内に物質を供給する方法であって、
内部空洞を具えたハウジングと前記空洞に流体的に連通する皮膚貫入デバイスとを有する供給デバイスを設けて、前記ハウジングを加圧して前記空洞内に供給圧力を維持し、
前記供給デバイスを患者の皮膚の上の目標領域に位置決めし、充分な力を付与して前記皮膚貫入デバイスを前記患者の皮膚に貫入させ、
物質を前記ハウジングの前記空洞に加圧下で導入し、
該導入圧力を使用して前記供給圧力を前記空洞内に発生させ、
前記物質を前記患者に供給する方法。 - 前記デバイスを設ける工程において、約50ミクロンないし約1500ミクロンの長さを有する少なくとも一本のマイクロ針を具えた皮膚貫入デバイスを設け、前記貫入の工程において、前記マイクロ針を前記皮膚に貫入する請求項42の方法。
- 前記デバイスを設ける工程において、膨脹可能な弾性部材を供給デバイスに設け、前記導入の工程において、前記膨脹可能な弾性部材を膨脹させるのに充分な力で前記空洞に前記物質を導入して前記空洞内に前記供給圧力を発生させ、そして前記物質を前記患者に供給する請求項42の方法。
- 前記膨脹可能な弾性部材がエラストマー材料で作られたダイアフラムである請求項44の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/112,933 US7115108B2 (en) | 2002-04-02 | 2002-04-02 | Method and device for intradermally delivering a substance |
PCT/US2003/009709 WO2003084598A1 (en) | 2002-04-02 | 2003-03-31 | Method and device for intradermally delivering a substance |
Publications (1)
Publication Number | Publication Date |
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JP2005521527A true JP2005521527A (ja) | 2005-07-21 |
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Application Number | Title | Priority Date | Filing Date |
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JP2003581835A Pending JP2005521527A (ja) | 2002-04-02 | 2003-03-31 | 物質を皮内に供給する方法およびデバイス |
Country Status (7)
Country | Link |
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US (3) | US7115108B2 (ja) |
EP (2) | EP1490145B1 (ja) |
JP (1) | JP2005521527A (ja) |
AU (1) | AU2003218457A1 (ja) |
CA (1) | CA2480479A1 (ja) |
ES (2) | ES2762899T3 (ja) |
WO (1) | WO2003084598A1 (ja) |
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JP2012010830A (ja) * | 2010-06-30 | 2012-01-19 | Yoshino Kogyosho Co Ltd | 投薬デバイス |
JP2012100783A (ja) * | 2010-11-08 | 2012-05-31 | Nanbu Plastics Co Ltd | 薬液供給装置 |
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JPWO2018110510A1 (ja) * | 2016-12-12 | 2019-10-24 | 株式会社 メドレックス | マイクロニードル貼付剤 |
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JP7116430B2 (ja) | 2016-12-12 | 2022-08-10 | 株式会社 メドレックス | マイクロニードル貼付剤 |
Also Published As
Publication number | Publication date |
---|---|
EP3167929A1 (en) | 2017-05-17 |
US7410476B2 (en) | 2008-08-12 |
WO2003084598A1 (en) | 2003-10-16 |
US20030187394A1 (en) | 2003-10-02 |
AU2003218457A1 (en) | 2003-10-20 |
CA2480479A1 (en) | 2003-10-16 |
US7115108B2 (en) | 2006-10-03 |
ES2616865T3 (es) | 2017-06-14 |
US20050245877A1 (en) | 2005-11-03 |
ES2762899T3 (es) | 2020-05-26 |
EP1490145B1 (en) | 2016-11-30 |
EP1490145A1 (en) | 2004-12-29 |
US20080287871A1 (en) | 2008-11-20 |
EP3167929B1 (en) | 2019-10-02 |
US7896837B2 (en) | 2011-03-01 |
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