JP2000513237A - ベクロメタゾンジプロピオネート用計量投与用吸入器 - Google Patents
ベクロメタゾンジプロピオネート用計量投与用吸入器Info
- Publication number
- JP2000513237A JP2000513237A JP08531181A JP53118196A JP2000513237A JP 2000513237 A JP2000513237 A JP 2000513237A JP 08531181 A JP08531181 A JP 08531181A JP 53118196 A JP53118196 A JP 53118196A JP 2000513237 A JP2000513237 A JP 2000513237A
- Authority
- JP
- Japan
- Prior art keywords
- inhaler
- fluorocarbon
- propellant
- drug
- inhaler according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 229950000210 beclometasone dipropionate Drugs 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 239000003380 propellant Substances 0.000 claims abstract description 32
- 229920002313 fluoropolymer Polymers 0.000 claims abstract description 31
- 239000003814 drug Substances 0.000 claims abstract description 28
- 229940079593 drug Drugs 0.000 claims abstract description 26
- 238000009472 formulation Methods 0.000 claims abstract description 21
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 11
- 239000012453 solvate Substances 0.000 claims abstract description 11
- 239000013543 active substance Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000013583 drug formulation Substances 0.000 claims description 22
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 15
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- 239000000956 alloy Substances 0.000 claims description 5
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 4
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- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 3
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 3
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- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical group FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims description 2
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- 238000011065 in-situ storage Methods 0.000 description 2
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- 150000002739 metals Chemical class 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229960004398 nedocromil Drugs 0.000 description 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
- 229920006120 non-fluorinated polymer Polymers 0.000 description 1
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- 229920001778 nylon Polymers 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 description 1
- 229960000797 oxitropium Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
- 229960004448 pentamidine Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
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- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- TWHXWYVOWJCXSI-UHFFFAOYSA-N phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O TWHXWYVOWJCXSI-UHFFFAOYSA-N 0.000 description 1
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- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 229960002720 reproterol Drugs 0.000 description 1
- WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 description 1
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- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
- B65D83/752—Aerosol containers not provided for in groups B65D83/16 - B65D83/74 characterised by the use of specific products or propellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0222—Materials for reducing friction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mechanical Engineering (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 一以上のフルオロカーボンポリマーおよびこれに組み合わせてもよい一 以上の非フルオロカーボンポリマーで内面の一部またはすべてが被覆された計量 投与用吸入器であって、ベクロメタゾンジプロピオネートまたはその生理学上許 容される溶媒和物と、フルオロカーボン噴射剤と、場合によっては一以上の他の 薬学上活性な薬剤または一以上の賦形剤とを組み合わせて含んでなる吸入薬剤配 合物を投与するための計量投与用吸入器。 2. 薬剤配合物を含有する請求項1に記載の吸入器。 3. 薬剤配合物が界面活性剤をさらに含む、請求項2に記載の吸入器。 4. 薬剤配合物が極性補助溶媒をさらに含む、請求項2または3に記載の吸 入器。 5. 薬剤配合物が、噴射剤の重量を基準にして0.01〜5%w/wの極性 補助溶媒を含んでなり、界面活性剤を実質的に含まない、請求項2に記載の吸入 器。 6. 極性補助溶媒がエタノールである請求項4または5に記載の吸入器。 7. 薬剤配合物がベクロメタゾンジプロピオネートまたはその生理学上許容 される溶媒和物をサルメテロールまたはサルブタモールまたはそれらの生理学上 許容される塩と組み合わせて含んでなる、請求項2〜6のいずれか一項に記載の 吸入器。 8. 薬剤配合物が、 (a)ベクロメタゾンジプロピオネート一水和物(実質的にすべての前記一水 和物の粒度は20ミクロンより小さい)、 (b)一水和物に関連する結晶化水に加えて、配合物の重量に対し少なくとも 0.15重量%の水、および (c)フルオロカーボンの噴射剤、 を含んでなる請求項2に記載の吸入器。 9. 配合物が、噴射剤を基準にして0.05〜3%w/wの極性補助溶媒を さらに含む、請求項8に記載の吸入器。 10. 極性補助溶媒がエタノールである、請求項9に記載の吸入器。 11. 薬剤配合物がベクロメタゾンジプロピオネートまたはその生理学上許 容される溶媒和物と、場合によって組み合わせてもよい一以上の他の薬学上活性 な薬剤、フルオロカーボンの噴射剤および噴射剤を基準にして0.01〜5%w /wの極性補助溶媒とから本質的に成り、前記配合物が界面活性剤を実質的に含 まない、請求項2に記載の吸入器。 12. フルオロカーボンの噴射剤が1,1,1,2−テトラフルオロエタン または1,1,1,2,3,3,3−ヘプタフルオロ−n−プロパンまたはそれ らの混合物である、請求項2〜11のいずれか一項に記載の吸入器。 13. フルオロカーボンの噴射剤が1,1,1,2−テトラフルオロエタン である、請求項12に記載の吸入器。 14. 金属の内面の一部分またはすべてが被覆された金属から作られた缶か らなる、請求項1〜13のいずれか一項に記載の吸入器。 15. 金属がアルミニウムまたはその合金である、請求項14に記載の吸入 器。 16. フルオロカーボンのポリマーがペルフルオロカーボンのポリマーであ る、請求項1〜15のいずれか一項に記載の吸入器。 17. フルオロカーボンのポリマーがPTFE、PFA、FEPおよびそれ らの混合物から選択される、請求項16に記載の吸入器。 18. フルオロカーボンのポリマーをポリアミドイミドおよびポリエーテル スルホンと組み合わせる、請求項1〜17のいずれか一項に記載の吸入器。 19. 実質的に楕円状の基部を含む、請求項1〜18のいずれか一項に記載 の吸入器。 20. 薬剤配合物の経口または経鼻吸入のための適当な流路装置に装着され た、請求項1〜19のいずれか一項に記載の計量投与用吸入器を含んでなる計量 投与用吸入器装置。 21. 請求項20に記載の計量投与用吸入器装置の呼吸器疾患の治療への使 用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42228095A | 1995-04-14 | 1995-04-14 | |
US08/422,280 | 1995-04-14 | ||
PCT/US1996/005009 WO1996032345A1 (en) | 1995-04-14 | 1996-04-11 | Metered dose inhaler for beclomethasone dipropionate |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000513237A true JP2000513237A (ja) | 2000-10-10 |
JP3573213B2 JP3573213B2 (ja) | 2004-10-06 |
Family
ID=23674168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53118196A Expired - Fee Related JP3573213B2 (ja) | 1995-04-14 | 1996-04-11 | ベクロメタゾンジプロピオネート用計量投与用吸入器 |
Country Status (26)
Country | Link |
---|---|
US (3) | US6149892A (ja) |
EP (1) | EP0820414B1 (ja) |
JP (1) | JP3573213B2 (ja) |
KR (1) | KR19980703850A (ja) |
CN (1) | CN1186473A (ja) |
AP (1) | AP835A (ja) |
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1996
- 1996-04-11 NZ NZ306281A patent/NZ306281A/xx unknown
- 1996-04-11 PL PL96322781A patent/PL180880B1/pl unknown
- 1996-04-11 US US08/945,141 patent/US6149892A/en not_active Expired - Fee Related
- 1996-04-11 CZ CZ973261A patent/CZ326197A3/cs unknown
- 1996-04-11 GE GEAP19963926A patent/GEP20002266B/en unknown
- 1996-04-11 ES ES96911713T patent/ES2214536T3/es not_active Expired - Lifetime
- 1996-04-11 WO PCT/US1996/005009 patent/WO1996032345A1/en not_active Application Discontinuation
- 1996-04-11 AP APAP/P/1997/001112A patent/AP835A/en active
- 1996-04-11 BR BR9604979A patent/BR9604979A/pt not_active Application Discontinuation
- 1996-04-11 EA EA199700230A patent/EA000889B1/ru not_active IP Right Cessation
- 1996-04-11 AU AU54812/96A patent/AU718851B2/en not_active Ceased
- 1996-04-11 TR TR97/01170T patent/TR199701170T1/xx unknown
- 1996-04-11 CA CA002218179A patent/CA2218179A1/en not_active Abandoned
- 1996-04-11 EP EP96911713A patent/EP0820414B1/en not_active Revoked
- 1996-04-11 AT AT96911713T patent/ATE258813T1/de not_active IP Right Cessation
- 1996-04-11 CN CN96194409A patent/CN1186473A/zh active Pending
- 1996-04-11 HU HU9800641A patent/HUP9800641A3/hu unknown
- 1996-04-11 DE DE1996631476 patent/DE69631476T2/de not_active Revoked
- 1996-04-11 EE EE9700372A patent/EE9700372A/xx unknown
- 1996-04-11 SK SK1391-97A patent/SK139197A3/sk unknown
- 1996-04-11 KR KR1019970707250A patent/KR19980703850A/ko not_active Application Discontinuation
- 1996-04-11 JP JP53118196A patent/JP3573213B2/ja not_active Expired - Fee Related
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1997
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- 1997-10-13 NO NO974738A patent/NO974738L/no not_active Application Discontinuation
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2000
- 2000-02-18 US US09/506,834 patent/US6511652B1/en not_active Expired - Fee Related
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009136695A (ja) * | 1998-02-23 | 2009-06-25 | Glaxo Group Ltd | 薬剤分配装置 |
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