IN2015DN00544A - - Google Patents

Info

Publication number
IN2015DN00544A
IN2015DN00544A IN544DEN2015A IN2015DN00544A IN 2015DN00544 A IN2015DN00544 A IN 2015DN00544A IN 544DEN2015 A IN544DEN2015 A IN 544DEN2015A IN 2015DN00544 A IN2015DN00544 A IN 2015DN00544A
Authority
IN
India
Prior art keywords
relates
present
glucagon analogues
hypoglycaemia
treatment
Prior art date
Application number
Other languages
English (en)
Inventor
Ditte Riber
Lise Giehm
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Publication of IN2015DN00544A publication Critical patent/IN2015DN00544A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
IN544DEN2015 2012-07-23 2013-07-23 IN2015DN00544A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261674706P 2012-07-23 2012-07-23
US201361785611P 2013-03-14 2013-03-14
DKPA201300360 2013-06-14
PCT/EP2013/065519 WO2014016300A1 (fr) 2012-07-23 2013-07-23 Analogues du glucagon

Publications (1)

Publication Number Publication Date
IN2015DN00544A true IN2015DN00544A (fr) 2015-06-26

Family

ID=49996630

Family Applications (1)

Application Number Title Priority Date Filing Date
IN544DEN2015 IN2015DN00544A (fr) 2012-07-23 2013-07-23

Country Status (25)

Country Link
US (3) US10442847B2 (fr)
EP (1) EP2875043B1 (fr)
JP (3) JP6534927B2 (fr)
KR (1) KR102129235B1 (fr)
CN (2) CN104662038B (fr)
AR (1) AR091866A1 (fr)
AU (1) AU2013295035B2 (fr)
BR (1) BR112015001451B1 (fr)
CA (1) CA2878991C (fr)
DK (1) DK2875043T3 (fr)
EA (1) EA033399B1 (fr)
ES (1) ES2620111T3 (fr)
HK (1) HK1210787A1 (fr)
IL (1) IL236554B (fr)
IN (1) IN2015DN00544A (fr)
MX (1) MX356957B (fr)
MY (1) MY170671A (fr)
NZ (1) NZ704043A (fr)
PH (1) PH12015500115A1 (fr)
PL (1) PL2875043T3 (fr)
SG (1) SG11201500375PA (fr)
TW (1) TWI642682B (fr)
UA (1) UA117103C2 (fr)
WO (1) WO2014016300A1 (fr)
ZA (1) ZA201702364B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ597981A (en) 2009-07-13 2014-02-28 Zealand Pharma As Acylated glucagon analogues
NZ702333A (en) 2012-05-03 2017-06-30 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods
BR112015001451B1 (pt) * 2012-07-23 2022-03-29 Zealand Pharma A/S Composto, construção de ácido nucleico, vetor de expressão, célula hospedeira, composição farmacêutica, utilização de um composto ou de seu sal ou solvato farmaceuticamente aceitável
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
ES2653765T3 (es) 2012-12-21 2018-02-08 Sanofi Agonistas duales de GLP1/GIP o trigonales de GLP1/GIP/glucagón
MY176022A (en) 2013-10-17 2020-07-21 Boehringer Ingelheim Int Acylated glucagon analogues
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
AU2014345570B2 (en) 2013-11-06 2019-01-24 Zealand Pharma A/S Glucagon-GLP-1-GIP triple agonist compounds
EP3065767B1 (fr) 2013-11-06 2020-12-30 Zealand Pharma A/S Composés agonistes doubles gip-glp-1 et procédés
EP3080149A1 (fr) 2013-12-13 2016-10-19 Sanofi Agonistes mixtes des récepteurs du glp-1/glucagon
WO2015086730A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine 4 non acylés
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/gip受體促效劑
WO2015086728A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine 4 en tant qu'agonistes mixtes des récepteurs glp-1/gip
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
EP3151852A1 (fr) 2014-06-04 2017-04-12 Novo Nordisk A/S Co-agonistes de récepteur du glucagon/glp-1 à usage médical
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
EP3212218B1 (fr) 2014-10-29 2021-06-30 Zealand Pharma A/S Composés agonistes de gip et procédés associés
CA2980978A1 (fr) 2015-04-16 2016-10-20 Zealand Pharma A/S Analogue acyle du glucagon
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
GB201710822D0 (en) * 2017-07-05 2017-08-16 Zealand Pharma As Methods and medical uses relating to the treatment of hypoglycaemia
AU2018301715A1 (en) 2017-07-14 2020-01-30 Xeris Pharmaceuticals, Inc. Methods for treating congenital hyperinsulinism
JP7444786B2 (ja) 2018-01-23 2024-03-06 ゼリス ファーマシューティカルズ インコーポレイテッド 低用量の安定なグルカゴンを使用する肥満治療手術後の低血糖症の処置
AU2021236878A1 (en) 2020-03-16 2022-09-29 Zealand Pharma A/S Liquid formulations of glucagon analogues
EP4357358A1 (fr) * 2021-06-18 2024-04-24 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Analogue du glucagon et son utilisation médicale
CN113501871B (zh) * 2021-07-21 2022-10-28 汉肽生物医药集团有限公司 一种固液相结合制备达西高血糖素的方法

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288627A (en) 1980-02-12 1981-09-08 Phillips Petroleum Company Oxidation of thiols employing cobalt molybdate/triethylamine catalyst
NZ202757A (en) 1981-12-23 1985-11-08 Novo Industri As Peptides and medicaments
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
EP0512042B1 (fr) 1990-01-24 1998-04-08 BUCKLEY, Douglas I. Analogues de glp-1 utiles dans le traitement du diabete
ATE118545T1 (de) 1990-05-09 1995-03-15 Novo Nordisk As Eine ein endoglucanase enzym enthaltende zellulasezubereitung.
DK36392D0 (da) 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
US5846747A (en) 1992-03-25 1998-12-08 Novo Nordisk A/S Method for detecting glucagon-like peptide-1 antagonists and agonists
DK39892D0 (da) 1992-03-25 1992-03-25 Bernard Thorens Peptid
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
AU7531094A (en) 1993-08-24 1995-03-21 Novo Nordisk A/S Protracted glp-1
EP0717635B1 (fr) 1993-09-07 2000-11-15 Amylin Pharmaceuticals, Inc. Procedes de regulation de la motilite gastro-intestinale
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5523449A (en) 1995-05-17 1996-06-04 Bayer Corporation Process for preparing phosphorodichlorido-dithioates by reacting alkylmercaptans with phosphorus trichloride in the presence of sulfur
ATE316100T1 (de) 1996-06-05 2006-02-15 Roche Diagnostics Gmbh Exendin-analoga, verfahren zu deren herstellung und diese enthaltende arzneimittel
US6110703A (en) 1996-07-05 2000-08-29 Novo Nordisk A/S Method for the production of polypeptides
ATE417622T1 (de) 1996-08-08 2009-01-15 Amylin Pharmaceuticals Inc Regulation gastrointestinaler beweglichkeit
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6384016B1 (en) 1998-03-13 2002-05-07 Novo Nordisk A/S Stabilized aqueous peptide solutions
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
BRPI9711437B8 (pt) 1996-08-30 2021-05-25 Novo Nordisk As derivados de glp-1
DK0929567T3 (da) 1996-09-09 2005-06-27 Zealand Pharma As Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese
KR20000036015A (ko) 1996-09-09 2000-06-26 스타이니스 에바 알파-히드록시산 링커를 함유하는 펩티드 프로드럭
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
WO1998022577A1 (fr) 1996-11-15 1998-05-28 Maria Grazia Masucci Proteines de fusion a demi-vie allongee
AU739020B2 (en) 1997-01-07 2001-10-04 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the reduction of food intake
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
US6410511B2 (en) 1997-01-08 2002-06-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
WO1998035033A1 (fr) 1997-02-05 1998-08-13 1149336 Ontario Inc. Polynucleotides codant la proexendine, et procedes et utilisations correspondants
US5846937A (en) 1997-03-03 1998-12-08 1149336 Ontario Inc. Method of using exendin and GLP-1 to affect the central nervous system
KR20010012321A (ko) 1997-05-07 2001-02-15 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 신규의 시스테인 유도체, 이의 제조 방법 및 이를 함유한약제
PT1019077E (pt) 1997-08-08 2008-02-21 Amylin Pharmaceuticals Inc Novos compostos agonistas de exendina
US7157555B1 (en) 1997-08-08 2007-01-02 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
US7223725B1 (en) 1997-11-14 2007-05-29 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
BR9814189A (pt) 1997-11-14 2000-10-03 Amylin Pharmaceuticals Inc "compostos agonistas da exendina"
US7220721B1 (en) 1997-11-14 2007-05-22 Amylin Pharmaceuticals, Inc. Exendin agonist peptides
MXPA00004670A (es) 1997-11-14 2003-07-14 Amylin Pharmaceuticals Inc Compuestos agonistas de exendina novedosos.
WO1999029336A1 (fr) 1997-12-05 1999-06-17 Eli Lilly And Company Formulations de glp-1
US6703359B1 (en) 1998-02-13 2004-03-09 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and GLP-1
JP4677095B2 (ja) 1998-02-13 2011-04-27 アミリン・ファーマシューティカルズ,インコーポレイテッド エキセンジンおよびglp−1の変力および利尿効果
WO1999043708A1 (fr) 1998-02-27 1999-09-02 Novo Nordisk A/S Derives de gpl-1 et de l'extendine au profil d'action etendu
AU2610899A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S N-terminally modified glp-1 derivatives
NZ506839A (en) 1998-03-09 2003-05-30 Zealand Pharma As Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
WO1999049788A1 (fr) 1998-03-30 1999-10-07 Focus Surgery, Inc. Systeme d'ablation
SE9802080D0 (sv) 1998-06-11 1998-06-11 Hellstroem Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein
ES2553108T3 (es) 1998-08-10 2015-12-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diferenciación de células no productoras de insulina en células productoras de insulina mediante GLP-1 o exendina-4 y utilizaciones de las mismas
DE69926007T2 (de) 1998-10-07 2005-12-29 Medical College Of Georgia Research Institute, Inc. Glukose-abhängiges, insulinotropisches peptid für die verwendung als osteotropes hormon
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
NZ527241A (en) 1998-12-07 2004-12-24 Sod Conseils Rech Applic Analogues of GLP-1
US7399489B2 (en) 1999-01-14 2008-07-15 Amylin Pharmaceuticals, Inc. Exendin analog formulations
KR20070051948A (ko) 1999-01-14 2007-05-18 아밀린 파마슈티칼스, 인크. 글루카곤 억제용 제약학적 조성물
CN100356978C (zh) 1999-01-14 2007-12-26 安米林药品公司 新型exendin激动剂制剂及其给药方法
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
EP1956000B1 (fr) 1999-03-17 2016-10-05 Novo Nordisk A/S Agents d'acylation utilisés dans l'acylation de peptides
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
US6271241B1 (en) 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US6924264B1 (en) 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
EP1175443A1 (fr) 1999-04-30 2002-01-30 Amylin Pharmaceuticals, Inc. Exendines modifiees et agonistes de l'exendine
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
ATE252601T1 (de) 1999-05-17 2003-11-15 Conjuchem Inc Lang wirkende insulinotrope peptide
US6506724B1 (en) 1999-06-01 2003-01-14 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
US6344180B1 (en) 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
EP1076066A1 (fr) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides abaissant le taux de glucose sanguin
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
MXPA02006118A (es) 2000-10-20 2004-08-23 Amylin Pharmaceuticals Inc Tratamiento de la invernacion del miocardio y cardiopatia diabetica con un peptido glp-1.
GB0121709D0 (en) 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
AU2002346491A1 (en) 2001-12-19 2003-07-09 Eli Lilly And Company Crystalline compositions for controlling blood glucose
IL161848A0 (en) 2001-12-20 2005-11-20 Lilly Co Eli Insulin moldecule having protracted time action
DK1525219T3 (da) 2002-07-04 2009-09-07 Zealand Pharma As GLP-1 og fremgangsm der til behandling af diabetes
CA2500295A1 (fr) 2002-10-02 2004-04-29 Zealand Pharma A/S Composes d'exendine-4 stabilises
US7192922B2 (en) 2002-11-19 2007-03-20 Allegheny-Singer Research Institute Method of treating left ventricular dysfunction
GB0300571D0 (en) 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
WO2004096854A2 (fr) 2003-04-29 2004-11-11 Eli Lilly And Company Analogues de l'insuline ayant une action prolongee
AU2004243531B2 (en) * 2003-06-03 2009-11-05 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
US7623530B2 (en) 2003-11-20 2009-11-24 Nokia Corporation Indication of service flow termination by network control to policy decision function
CA2554458A1 (fr) 2004-01-30 2005-08-11 Waratah Pharmaceuticals, Inc. Utilisation d'un agoniste de glp-1 associe a des composes gastriniques
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
ES2458991T3 (es) 2004-11-12 2014-05-07 Novo Nordisk A/S Formulaciones estables de péptidos insulinotrópicos
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
EP1883419A4 (fr) 2005-05-06 2010-08-04 Bayer Pharmaceuticals Corp Agonistes vis-a-vis du recepteur peptidique de type glucagon 1 (glp-1) et procedes pharmacologiques d'utilisation
AU2006258841B2 (en) 2005-06-13 2012-05-03 Imperial Innovations Limited Oxyntomodulin analogues and their effects on feeding behaviour
US20090202497A1 (en) 2005-08-23 2009-08-13 The General Hospital Corporation Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes
EP2570133B1 (fr) * 2005-11-07 2016-03-23 Indiana University Research and Technology Corporation Analogues du glucagon dotés de stabilité et solubilité physiologiques
WO2007081824A2 (fr) 2006-01-06 2007-07-19 Case Western Reserve University Protéines résistantes à la fibrillation
WO2007095737A1 (fr) 2006-02-21 2007-08-30 Waratah Pharmaceuticals Inc. Polythérapie pour le traitement du diabète, comprenant un agoniste d'exendine et un composé de gastrine
US7928058B2 (en) 2006-02-22 2011-04-19 Merck Sharp & Dohme Corp. Pharmaceutical composition comprising oxyntomodulin derivatives and a method for reducing body weight using the composition
USRE47123E1 (en) 2006-07-18 2018-11-13 Sanofi EPHA2 receptor antagonist antibodies
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
EP2074140B8 (fr) 2006-10-04 2015-10-28 Case Western Reserve University Insuline et analogues de l'insuline résistants à la fibrillation
US8642727B2 (en) 2006-11-08 2014-02-04 Zealand Pharma A/S Selective glucagon-like-peptide-2 (GLP-2) analogues
WO2008071010A1 (fr) 2006-12-12 2008-06-19 Waratah Pharmaceuticals Inc. Polythérapies impliquant des facteurs de régulation de croissance/des hormones sélectionnés pour le diabète et les maladies apparentées
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
US8669228B2 (en) * 2007-01-05 2014-03-11 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological pH buffers
KR20150116465A (ko) 2007-02-15 2015-10-15 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 글루카곤/glp-1 수용체 공동-항진물질
EP2025684A1 (fr) 2007-08-15 2009-02-18 Zealand Pharma A/S Analogues du glucagon
ATE520714T1 (de) 2007-06-15 2011-09-15 Zealand Pharma As Glucagonanaloga
FR2917552B1 (fr) 2007-06-15 2009-08-28 Sagem Defense Securite Procede de regulation de la gigue de transmission au sein d'un terminal de reception
ES2632504T3 (es) 2007-11-20 2017-09-13 Ambrx, Inc. Polipéptidos de insulina modificados y sus usos
GB2455553B (en) 2007-12-14 2012-10-24 Nuaire Ltd Motor mounting assembly for an axial fan
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
CN102007143B (zh) 2008-01-09 2015-08-26 塞诺菲-安万特德国有限公司 具有超延迟时效特征的新型胰岛素衍生物
AU2009203810B2 (en) 2008-01-09 2013-07-25 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
BRPI0911571A2 (pt) 2008-04-22 2018-04-03 Univ Case Western Reserve método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
BRPI0915282A2 (pt) 2008-06-17 2017-02-07 Univ Indiana Res & Tech Corp agonistas mistos baseados no gip para o tratamento de distúrbios metabólicos e obesidade
KR20110039230A (ko) * 2008-06-17 2011-04-15 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 생리학적 pH 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체
JP5775450B2 (ja) 2008-06-17 2015-09-09 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation グルカゴン/glp−1受容体コアゴニスト
PL219335B1 (pl) 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
EP2982687A1 (fr) 2008-07-31 2016-02-10 Case Western Reserve University Insuline stabilisée par un halogène
WO2010016940A2 (fr) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Analogues de polypeptide insulinotrope glucose-dépendant
EP2340049B1 (fr) 2008-09-12 2015-11-11 Novo Nordisk A/S Procédé d'acylation d'un peptide ou d'une protéine
CN102282167B (zh) 2008-12-15 2014-08-13 西兰制药公司 胰高血糖素类似物
CA2747112A1 (fr) 2008-12-15 2010-06-24 Zealand Pharma A/S Analogues du glucagon
NZ593813A (en) * 2008-12-15 2013-02-22 Zealand Pharma As Glucagon analogues
ES2439499T3 (es) 2008-12-15 2014-01-23 Zealand Pharma A/S Análogos de glucagón
US8481485B2 (en) 2008-12-19 2013-07-09 Indiana University Research And Technology Corporation Insulin analogs
CA2744558A1 (fr) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Promedicaments insuliniques a base d'amide
WO2010096052A1 (fr) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Analogues d'oxyntomoduline
WO2010107487A2 (fr) 2009-03-18 2010-09-23 Wu Nian Conjugués lipide-médicament pour administration de médicaments
CN101519446A (zh) 2009-03-31 2009-09-02 上海一就生物医药有限公司 一种重组人胰岛素及其类似物的制备方法
JP5383905B2 (ja) 2009-05-08 2014-01-08 ジェネンテック, インコーポレイテッド ヒト化抗egfl7抗体とその使用方法
IN2012DN00377A (fr) 2009-06-16 2015-08-21 Univ Indiana Res & Tech Corp
NZ597981A (en) 2009-07-13 2014-02-28 Zealand Pharma As Acylated glucagon analogues
EP2513141B1 (fr) 2009-12-16 2017-03-01 Novo Nordisk A/S Analogues et dérivés de glp-1
WO2011084808A2 (fr) 2009-12-21 2011-07-14 Amunix Operating Inc. Compositions de polypeptides bifonctionnels et procédés pour le traitement de maladies métaboliques et cardiovasculaires
KR20120128129A (ko) 2010-01-20 2012-11-26 질랜드 파마 에이/에스 심장 병태의 치료
EP2528618A4 (fr) 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp Conjugués d'antagoniste du glucagon et d'agoniste du gip et compositions pour le traitement de troubles métaboliques et de l'obésité
AR080592A1 (es) 2010-03-26 2012-04-18 Lilly Co Eli Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
CA2792663A1 (fr) * 2010-03-26 2011-09-29 Novo Nordisk A/S Nouveaux analogues du glucagon
WO2011117417A1 (fr) * 2010-03-26 2011-09-29 Novo Nordisk A/S Nouveaux analogues de glucagon
SG185066A1 (en) 2010-04-27 2012-12-28 Zhejiang Beta Pharma Inc Glucagon-like peptide-1 analogue and use thereof
EA023925B1 (ru) 2010-04-27 2016-07-29 Зилэнд Фарма А/С Пептидные конъюгаты агонистов рецептора glp-1 и их применение
AR081975A1 (es) 2010-06-23 2012-10-31 Zealand Pharma As Analogos de glucagon
NZ604208A (en) 2010-06-24 2014-10-31 Zealand Pharma As Glucagon analogues
WO2011163473A1 (fr) * 2010-06-25 2011-12-29 Indiana University Research And Technology Corporation Analogues du glucagon présentant une solubilité et une stabilité améliorées dans des tampons à ph physiologique
WO2012062804A1 (fr) 2010-11-09 2012-05-18 Novo Nordisk A/S Dérivés de glp-1 à double acylation présentant un lieur
WO2012098462A1 (fr) 2011-01-20 2012-07-26 Zealand Pharma A/S Combinaison d'analogues du glucagon acylé à des analogues d'insuline
AU2012234276A1 (en) 2011-03-28 2013-08-29 Novo Nordisk A/S Novel glucagon analogues
KR101972836B1 (ko) 2011-04-12 2019-04-29 노보 노르디스크 에이/에스 이중 아실화된 glp-1 유도체
WO2012150503A2 (fr) 2011-05-03 2012-11-08 Zealand Pharma A/S Composés sélectifs de la signalisation d'agoniste mixte glu-glp-1
EP2707713A2 (fr) 2011-05-10 2014-03-19 Zealand Pharma A/S Composés sélectifs pour une signalisation d'agonistes doubles de glu-glp1
JP5914641B2 (ja) 2011-06-10 2016-05-11 ベイジン・ハンミ・ファーマシューティカル・カンパニー・リミテッドBeijing Hanmi Pharmaceutical Co., Ltd. グルコース依存性インスリン分泌刺激ポリペプチドのアナログ、医薬組成物及びその使用
AU2012311484B2 (en) 2011-09-23 2017-04-13 Novo Nordisk A/S Novel glucagon analogues
AP2014007797A0 (en) 2011-12-23 2014-07-31 Boehringer Ingelheim Int Glucagon analogues
WO2013098408A1 (fr) * 2011-12-30 2013-07-04 Zealand Pharma A/S Conjugués peptidiques agonistes des récepteurs de la cck et du glucagon
NZ702333A (en) 2012-05-03 2017-06-30 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods
EP2844670B1 (fr) 2012-05-03 2017-12-06 Zealand Pharma A/S Analogues du glucagon-like peptide 2 (glp-2)
BR112015001451B1 (pt) 2012-07-23 2022-03-29 Zealand Pharma A/S Composto, construção de ácido nucleico, vetor de expressão, célula hospedeira, composição farmacêutica, utilização de um composto ou de seu sal ou solvato farmaceuticamente aceitável
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
MY176022A (en) 2013-10-17 2020-07-21 Boehringer Ingelheim Int Acylated glucagon analogues
EP3065767B1 (fr) 2013-11-06 2020-12-30 Zealand Pharma A/S Composés agonistes doubles gip-glp-1 et procédés
JP2017509603A (ja) 2014-02-18 2017-04-06 ノヴォ ノルディスク アー/エス 安定なグルカゴン類似体及び低血糖症の処置のための使用
CA2980978A1 (fr) 2015-04-16 2016-10-20 Zealand Pharma A/S Analogue acyle du glucagon

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IL236554A0 (en) 2015-02-26
US11795204B2 (en) 2023-10-24
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MY170671A (en) 2019-08-26
SG11201500375PA (en) 2015-02-27
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CA2878991A1 (fr) 2014-01-30
KR20150032912A (ko) 2015-03-30
WO2014016300A1 (fr) 2014-01-30
DK2875043T3 (en) 2017-03-27
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PH12015500115B1 (en) 2015-03-30
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