IN2014KN02324A - - Google Patents

Info

Publication number
IN2014KN02324A
IN2014KN02324A IN2324KON2014A IN2014KN02324A IN 2014KN02324 A IN2014KN02324 A IN 2014KN02324A IN 2324KON2014 A IN2324KON2014 A IN 2324KON2014A IN 2014KN02324 A IN2014KN02324 A IN 2014KN02324A
Authority
IN
India
Prior art keywords
masp
inhibitory agent
subject
amount
mas
Prior art date
Application number
Other languages
English (en)
Inventor
Hans-Wilhelm Schwaeble
Gregory A Demopulos
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of IN2014KN02324A publication Critical patent/IN2014KN02324A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
IN2324KON2014 2012-04-06 2013-04-05 IN2014KN02324A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261621461P 2012-04-06 2012-04-06
PCT/US2013/035488 WO2013180834A2 (en) 2012-04-06 2013-04-05 Compositions and methods of inhibting masp-1 and/or masp-3 for the treatment of paroxysmal nocturnal hemoglobinuria

Publications (1)

Publication Number Publication Date
IN2014KN02324A true IN2014KN02324A (he) 2015-05-01

Family

ID=49325295

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2324KON2014 IN2014KN02324A (he) 2012-04-06 2013-04-05

Country Status (29)

Country Link
US (3) US20130273053A1 (he)
EP (2) EP3366307B1 (he)
JP (3) JP6366571B2 (he)
KR (2) KR102142508B1 (he)
CN (1) CN104661676A (he)
AU (3) AU2013267909B2 (he)
BR (1) BR112014024793A2 (he)
CA (2) CA3087933A1 (he)
CL (1) CL2014002694A1 (he)
CY (1) CY1120736T1 (he)
DK (2) DK2833907T3 (he)
ES (2) ES2670668T3 (he)
HK (1) HK1206996A1 (he)
HR (1) HRP20180671T1 (he)
HU (1) HUE036930T2 (he)
IL (2) IL234991B (he)
IN (1) IN2014KN02324A (he)
LT (1) LT2833907T (he)
MX (2) MX357540B (he)
NO (1) NO2881536T3 (he)
NZ (2) NZ781091A (he)
PL (2) PL3366307T3 (he)
PT (1) PT2833907T (he)
RS (1) RS57266B1 (he)
RU (2) RU2018114903A (he)
SI (1) SI2833907T1 (he)
TR (1) TR201806939T4 (he)
WO (1) WO2013180834A2 (he)
ZA (1) ZA201408100B (he)

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CA3131223C (en) * 2011-05-04 2024-01-30 Omeros Corporation Compositions for inhibiting masp-2 dependent complement activation
EP3058951A1 (en) * 2012-06-18 2016-08-24 Omeros Corporation Compositions and methods of inhibiting masp-1 and/or masp-2 and/or masp-3 for the treatment of various diseases and disorders
CA2906096C (en) 2013-03-15 2022-03-15 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
JOP20170154B1 (ar) * 2016-08-01 2023-03-28 Omeros Corp تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة
WO2018097307A1 (ja) * 2016-11-28 2018-05-31 中外製薬株式会社 抗原結合ドメインおよび運搬部分を含むポリペプチド
TW202235438A (zh) 2016-11-28 2022-09-16 日商中外製藥股份有限公司 能夠調節配體結合活性的配體結合分子
US11827717B2 (en) 2017-04-03 2023-11-28 Chugai Seiyaku Kabushiki Kaisha Anti-MASP-1 antibodies and methods of use
WO2019107380A1 (ja) 2017-11-28 2019-06-06 中外製薬株式会社 抗原結合ドメインおよび運搬部分を含むポリペプチド
BR112020024148A2 (pt) * 2018-05-29 2021-03-30 Omeros Corporation Compostos, composição farmacêutica, e, métodos para identificação de uma pequena molécula capaz de inibir masp-2 e para o tratamento de uma doença ou transtorno associado a masp-2
WO2019230867A1 (en) 2018-05-30 2019-12-05 Chugai Seiyaku Kabushiki Kaisha Polypeptide comprising aggrecan binding domain and carrying moiety
MX2022001268A (es) * 2019-07-31 2022-02-22 Biocryst Pharm Inc Regimenes de dosificacion para inhibidores orales del factor d del complemento.
WO2021113698A1 (en) 2019-12-04 2021-06-10 Omeros Corporation Masp-2 inhibitors and methods of use
JP2023504543A (ja) 2019-12-04 2023-02-03 オメロス コーポレーション Masp-2阻害剤および使用方法
CA3159176A1 (en) 2019-12-04 2021-06-10 Neil S. Cutshall Masp-2 inhibitors and methods of use
CN114295594B (zh) * 2021-12-06 2023-09-19 贵州理工学院 一种基于分子信标筛选三螺旋DNA嵌入剂的“turn on”型荧光传感器

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Also Published As

Publication number Publication date
KR102318623B1 (ko) 2021-11-02
CN104661676A (zh) 2015-05-27
HUE036930T2 (hu) 2018-08-28
NZ629675A (en) 2017-02-24
EP3366307B1 (en) 2021-07-28
RU2018114903A3 (he) 2021-08-12
NZ781091A (en) 2022-04-29
IL234991B (he) 2020-06-30
US20220242972A1 (en) 2022-08-04
CA3087933A1 (en) 2013-12-05
MX357540B (es) 2018-07-13
US20130273053A1 (en) 2013-10-17
PT2833907T (pt) 2018-05-29
JP2015514117A (ja) 2015-05-18
RU2655299C2 (ru) 2018-05-24
KR20150003785A (ko) 2015-01-09
ES2894944T3 (es) 2022-02-16
BR112014024793A2 (pt) 2019-08-27
CA2869326A1 (en) 2013-12-05
RU2014144621A (ru) 2016-05-27
EP2833907A4 (en) 2016-03-16
PL3366307T3 (pl) 2022-03-07
MX2014012045A (es) 2015-05-15
TR201806939T4 (tr) 2018-06-21
NO2881536T3 (he) 2018-06-30
JP6366571B2 (ja) 2018-08-01
EP2833907A2 (en) 2015-02-11
CL2014002694A1 (es) 2015-08-28
HK1206996A1 (en) 2016-01-22
AU2018200721B2 (en) 2020-03-26
ES2670668T3 (es) 2018-05-31
ZA201408100B (en) 2022-05-25
KR102142508B1 (ko) 2020-08-10
JP2018162307A (ja) 2018-10-18
AU2013267909A1 (en) 2014-11-27
HRP20180671T1 (hr) 2018-07-13
RU2018114903A (ru) 2019-03-04
KR20200097808A (ko) 2020-08-19
MX2018008658A (es) 2021-10-19
WO2013180834A3 (en) 2014-04-03
AU2013267909B2 (en) 2018-03-01
NZ727063A (en) 2021-10-29
WO2013180834A2 (en) 2013-12-05
LT2833907T (lt) 2018-06-11
RS57266B1 (sr) 2018-08-31
IL274721A (he) 2020-07-30
DK2833907T3 (en) 2018-05-28
SI2833907T1 (en) 2018-07-31
US20190382505A1 (en) 2019-12-19
CY1120736T1 (el) 2019-12-11
IL234991A0 (he) 2014-12-31
PL2833907T3 (pl) 2018-08-31
IL274721B (he) 2022-04-01
EP3366307A1 (en) 2018-08-29
JP6815355B2 (ja) 2021-01-20
DK3366307T3 (da) 2021-11-01
EP2833907B1 (en) 2018-02-28
JP2021001199A (ja) 2021-01-07
CA2869326C (en) 2021-09-21
AU2020204163A1 (en) 2020-07-09
AU2018200721A1 (en) 2018-02-22

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