BR112014024793A2 - método de inibição da ativação do complemento dependente de masp-3, e, composição farmacêutica. - Google Patents
método de inibição da ativação do complemento dependente de masp-3, e, composição farmacêutica.Info
- Publication number
- BR112014024793A2 BR112014024793A2 BR112014024793A BR112014024793A BR112014024793A2 BR 112014024793 A2 BR112014024793 A2 BR 112014024793A2 BR 112014024793 A BR112014024793 A BR 112014024793A BR 112014024793 A BR112014024793 A BR 112014024793A BR 112014024793 A2 BR112014024793 A2 BR 112014024793A2
- Authority
- BR
- Brazil
- Prior art keywords
- masp
- inhibiting agent
- complement activation
- dependent complement
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
método de inibição da ativação do complemento dependente de masp-3, e, composição farmacêutica em um aspecto, a invenção fornece métodos e composições para inibir a ativação do complemento dependente de masp-3 em um indivíduo sofrendo de hemoglobinúria paroxística noturna pela administração ao indivíduo de uma composição que compreende uma quantidade de um agente inibidor da masp-3 em uma quantidade eficaz para inibir a ativação do complemento dependente de masp-3. em outro aspecto, a invenção fornece métodos e composições para aumentar a sobrevivência das hemácias em um indivíduo que sofre de hemoglobinúria paroxística noturna pela administração ao indivíduo de uma composição que compreende uma quantidade de pelo menos um de um agente inibidor da masp-1 e/ou um agente inibidor da masp-3 eficaz para aumentar a sobrevivência das hemácias. em algumas modalidades, é administrado ao indivíduo um agente inibidor da masp-2 e um agente inibidor da masp-1, um agente inibidor da masp-2 e um agente inibidor da masp-3, um agente inibidor da masp-3 e um agente inibidor da masp-1 ou um agente inibidor da masp-1, um agente inibidor da masp-2 e um agente inibidor da masp-3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261621461P | 2012-04-06 | 2012-04-06 | |
PCT/US2013/035488 WO2013180834A2 (en) | 2012-04-06 | 2013-04-05 | Compositions and methods of inhibting masp-1 and/or masp-3 for the treatment of paroxysmal nocturnal hemoglobinuria |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014024793A2 true BR112014024793A2 (pt) | 2019-08-27 |
Family
ID=49325295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014024793A BR112014024793A2 (pt) | 2012-04-06 | 2013-04-05 | método de inibição da ativação do complemento dependente de masp-3, e, composição farmacêutica. |
Country Status (29)
Country | Link |
---|---|
US (3) | US20130273053A1 (pt) |
EP (2) | EP2833907B1 (pt) |
JP (3) | JP6366571B2 (pt) |
KR (2) | KR102142508B1 (pt) |
CN (1) | CN104661676A (pt) |
AU (3) | AU2013267909B2 (pt) |
BR (1) | BR112014024793A2 (pt) |
CA (2) | CA3087933A1 (pt) |
CL (1) | CL2014002694A1 (pt) |
CY (1) | CY1120736T1 (pt) |
DK (2) | DK3366307T3 (pt) |
ES (2) | ES2670668T3 (pt) |
HK (1) | HK1206996A1 (pt) |
HR (1) | HRP20180671T1 (pt) |
HU (1) | HUE036930T2 (pt) |
IL (2) | IL234991B (pt) |
IN (1) | IN2014KN02324A (pt) |
LT (1) | LT2833907T (pt) |
MX (2) | MX357540B (pt) |
NO (1) | NO2881536T3 (pt) |
NZ (2) | NZ781091A (pt) |
PL (2) | PL3366307T3 (pt) |
PT (1) | PT2833907T (pt) |
RS (1) | RS57266B1 (pt) |
RU (2) | RU2655299C2 (pt) |
SI (1) | SI2833907T1 (pt) |
TR (1) | TR201806939T4 (pt) |
WO (1) | WO2013180834A2 (pt) |
ZA (1) | ZA201408100B (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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HUE049154T2 (hu) * | 2011-05-04 | 2020-09-28 | Omeros Corp | Készítmények a MASP-2-függõ komplement-aktiválás gátlására |
RU2709351C2 (ru) * | 2012-06-18 | 2019-12-17 | Омерос Корпорейшн | Композиции и способы ингибирования masp-1, и/или masp-2, и/или masp-3 для лечения различных заболеваний и нарушений |
US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
WO2014144542A2 (en) * | 2013-03-15 | 2014-09-18 | Omeros Corporation | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
JOP20170154B1 (ar) * | 2016-08-01 | 2023-03-28 | Omeros Corp | تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة |
CN110177875B (zh) * | 2016-11-28 | 2023-11-28 | 中外制药株式会社 | 包含抗原结合结构域和运送部分的多肽 |
WO2018186322A1 (en) * | 2017-04-03 | 2018-10-11 | Chugai Seiyaku Kabushiki Kaisha | Anti-masp-1 antibodies and methods of use |
KR20210016545A (ko) * | 2018-05-29 | 2021-02-16 | 오메로스 코포레이션 | Masp-2 억제제 및 사용 방법 |
MX2022001268A (es) * | 2019-07-31 | 2022-02-22 | Biocryst Pharm Inc | Regimenes de dosificacion para inhibidores orales del factor d del complemento. |
AU2020398241A1 (en) | 2019-12-04 | 2022-06-30 | Omeros Corporation | MASP-2 inhibitors and methods of use |
CN114295594B (zh) * | 2021-12-06 | 2023-09-19 | 贵州理工学院 | 一种基于分子信标筛选三螺旋DNA嵌入剂的“turn on”型荧光传感器 |
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2013
- 2013-04-05 ES ES13798222.9T patent/ES2670668T3/es active Active
- 2013-04-05 KR KR1020147030787A patent/KR102142508B1/ko active IP Right Grant
- 2013-04-05 EP EP13798222.9A patent/EP2833907B1/en active Active
- 2013-04-05 JP JP2015504751A patent/JP6366571B2/ja active Active
- 2013-04-05 TR TR2018/06939T patent/TR201806939T4/tr unknown
- 2013-04-05 IN IN2324KON2014 patent/IN2014KN02324A/en unknown
- 2013-04-05 LT LTEP13798222.9T patent/LT2833907T/lt unknown
- 2013-04-05 DK DK18158799.9T patent/DK3366307T3/da active
- 2013-04-05 AU AU2013267909A patent/AU2013267909B2/en active Active
- 2013-04-05 EP EP18158799.9A patent/EP3366307B1/en active Active
- 2013-04-05 NZ NZ781091A patent/NZ781091A/en unknown
- 2013-04-05 RU RU2014144621A patent/RU2655299C2/ru active
- 2013-04-05 CA CA3087933A patent/CA3087933A1/en active Pending
- 2013-04-05 KR KR1020207022397A patent/KR102318623B1/ko active IP Right Grant
- 2013-04-05 PL PL18158799T patent/PL3366307T3/pl unknown
- 2013-04-05 PT PT137982229T patent/PT2833907T/pt unknown
- 2013-04-05 HU HUE13798222A patent/HUE036930T2/hu unknown
- 2013-04-05 PL PL13798222T patent/PL2833907T3/pl unknown
- 2013-04-05 DK DK13798222.9T patent/DK2833907T3/en active
- 2013-04-05 BR BR112014024793A patent/BR112014024793A2/pt not_active Application Discontinuation
- 2013-04-05 MX MX2014012045A patent/MX357540B/es active IP Right Grant
- 2013-04-05 WO PCT/US2013/035488 patent/WO2013180834A2/en active Application Filing
- 2013-04-05 SI SI201331032T patent/SI2833907T1/en unknown
- 2013-04-05 CN CN201380029994.3A patent/CN104661676A/zh active Pending
- 2013-04-05 RS RS20180586A patent/RS57266B1/sr unknown
- 2013-04-05 CA CA2869326A patent/CA2869326C/en active Active
- 2013-04-05 NZ NZ629675A patent/NZ629675A/en unknown
- 2013-04-05 RU RU2018114903A patent/RU2018114903A/ru unknown
- 2013-04-05 US US13/857,391 patent/US20130273053A1/en not_active Abandoned
- 2013-04-05 ES ES18158799T patent/ES2894944T3/es active Active
- 2013-04-05 MX MX2018008658A patent/MX2018008658A/es unknown
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2014
- 2014-10-05 IL IL234991A patent/IL234991B/en active IP Right Grant
- 2014-10-06 CL CL2014002694A patent/CL2014002694A1/es unknown
- 2014-11-05 ZA ZA2014/08100A patent/ZA201408100B/en unknown
- 2014-12-04 NO NO14196403A patent/NO2881536T3/no unknown
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2015
- 2015-08-10 HK HK15107717.0A patent/HK1206996A1/xx unknown
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2018
- 2018-01-31 AU AU2018200721A patent/AU2018200721B2/en active Active
- 2018-04-26 HR HRP20180671TT patent/HRP20180671T1/hr unknown
- 2018-05-23 CY CY181100540T patent/CY1120736T1/el unknown
- 2018-07-03 JP JP2018126460A patent/JP6815355B2/ja active Active
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2019
- 2019-02-26 US US16/285,741 patent/US20190382505A1/en not_active Abandoned
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2020
- 2020-05-17 IL IL274721A patent/IL274721B/en unknown
- 2020-06-22 AU AU2020204163A patent/AU2020204163A1/en not_active Abandoned
- 2020-09-17 JP JP2020156216A patent/JP2021001199A/ja active Pending
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2021
- 2021-10-11 US US17/498,521 patent/US20220242972A1/en active Pending
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