BR112016013754A2 - Recaptação de serotonina-norepinefrina inibidores (irsns) e combinações dos ligantes do receptor sigma - Google Patents

Recaptação de serotonina-norepinefrina inibidores (irsns) e combinações dos ligantes do receptor sigma

Info

Publication number
BR112016013754A2
BR112016013754A2 BR112016013754A BR112016013754A BR112016013754A2 BR 112016013754 A2 BR112016013754 A2 BR 112016013754A2 BR 112016013754 A BR112016013754 A BR 112016013754A BR 112016013754 A BR112016013754 A BR 112016013754A BR 112016013754 A2 BR112016013754 A2 BR 112016013754A2
Authority
BR
Brazil
Prior art keywords
serotonin
norepinephrine reuptake
snris
receptor ligand
reuptake inhibitors
Prior art date
Application number
BR112016013754A
Other languages
English (en)
Inventor
Zamanillo-Castanedo Daniel
Portillo-Salido Enrique
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of BR112016013754A2 publication Critical patent/BR112016013754A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

RECAPTAÇÃO DE SEROTONINA-NOREPINEFRINA INIBIDORES (IRSNs) E COMBINAÇÕES DOS LIGANTES DO RECEPTOR SIGMA. A invenção refere-se a uma combinação sinérgica que compreende um ligante sigma de fórmula geral (I), e um Inibidor de Recaptação de Serotonina-Norepinefrina (IRSN), um medicamento compreendendo referida combinação de substância ativa, e o uso da referida combinação de substância ativa para a fabricação de um medicamento, em particular para a profilaxia e/ou tratamento da dor.
BR112016013754A 2013-12-17 2014-12-16 Recaptação de serotonina-norepinefrina inibidores (irsns) e combinações dos ligantes do receptor sigma BR112016013754A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13382518 2013-12-17
PCT/EP2014/077996 WO2015091508A1 (en) 2013-12-17 2014-12-16 SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS

Publications (1)

Publication Number Publication Date
BR112016013754A2 true BR112016013754A2 (pt) 2017-08-08

Family

ID=49885115

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016013754A BR112016013754A2 (pt) 2013-12-17 2014-12-16 Recaptação de serotonina-norepinefrina inibidores (irsns) e combinações dos ligantes do receptor sigma

Country Status (17)

Country Link
US (1) US9931346B2 (pt)
EP (1) EP3082782A1 (pt)
JP (1) JP2016540771A (pt)
KR (1) KR20160097366A (pt)
CN (1) CN105873578A (pt)
AR (1) AR101638A1 (pt)
AU (1) AU2014364647A1 (pt)
BR (1) BR112016013754A2 (pt)
CA (1) CA2933511A1 (pt)
IL (1) IL245953A0 (pt)
MA (1) MA39147B1 (pt)
MX (1) MX2016007285A (pt)
PH (1) PH12016501096A1 (pt)
SG (1) SG11201604480PA (pt)
TN (1) TN2016000228A1 (pt)
TW (1) TW201607538A (pt)
WO (1) WO2015091508A1 (pt)

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CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

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PH12016501096A1 (en) 2016-07-11
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AU2014364647A1 (en) 2016-06-23
CA2933511A1 (en) 2015-06-25
US20160310500A1 (en) 2016-10-27
MX2016007285A (es) 2016-08-04
SG11201604480PA (en) 2016-07-28
US9931346B2 (en) 2018-04-03
TN2016000228A1 (en) 2017-10-06
AR101638A1 (es) 2017-01-04
WO2015091508A1 (en) 2015-06-25
KR20160097366A (ko) 2016-08-17

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