MX2013014630A - Leucotoxina e/d como agente anti-inflamatorio novedoso y microbicida. - Google Patents

Leucotoxina e/d como agente anti-inflamatorio novedoso y microbicida.

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Publication number
MX2013014630A
MX2013014630A MX2013014630A MX2013014630A MX2013014630A MX 2013014630 A MX2013014630 A MX 2013014630A MX 2013014630 A MX2013014630 A MX 2013014630A MX 2013014630 A MX2013014630 A MX 2013014630A MX 2013014630 A MX2013014630 A MX 2013014630A
Authority
MX
Mexico
Prior art keywords
leukotoxin
microbicide
inflammatory agent
new anti
subject
Prior art date
Application number
MX2013014630A
Other languages
English (en)
Other versions
MX343589B (es
Inventor
Victor J Torres
Derya Unutmaz
Francis Alonzo Iii
Original Assignee
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York filed Critical Univ New York
Publication of MX2013014630A publication Critical patent/MX2013014630A/es
Publication of MX343589B publication Critical patent/MX343589B/es

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

La presente invención se refiere a métodos para prevenir o tratar la infección por el virus de inmunodeficiencia humana (VIH), afecciones inflamatorias y la enfermedad de injerto contra huésped (GVHD) en un sujeto. Las composiciones terapéuticas de la presente invención comprenden proteínas o polipéptidos de leucocidina E (LuKe) y/o D. La invención también referida a métodos para tratar infección por Staphylococcus aureus administrando una composición que comprende un antagonista de CCR5 o cualquier molécula que bloquea la interacción de LuKe/D con células CCR5' en una cantidad eficaz para tratar la infección por S. aureus en el sujeto.
MX2013014630A 2011-06-19 2012-06-19 Leucotoxina e/d como agente anti-inflamatorio novedoso y microbicida. MX343589B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161498606P 2011-06-19 2011-06-19
PCT/US2012/043182 WO2012177660A2 (en) 2011-06-19 2012-06-19 Leukotoxin e/d as a new anti-inflammatory agent and microbicide

Publications (2)

Publication Number Publication Date
MX2013014630A true MX2013014630A (es) 2014-05-14
MX343589B MX343589B (es) 2016-11-11

Family

ID=47423178

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014630A MX343589B (es) 2011-06-19 2012-06-19 Leucotoxina e/d como agente anti-inflamatorio novedoso y microbicida.

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US (3) US8846609B2 (es)
EP (2) EP2720754B1 (es)
JP (1) JP6093760B2 (es)
KR (1) KR20140071318A (es)
CN (1) CN103764228B (es)
AU (1) AU2012273125B2 (es)
BR (1) BR112013032911A2 (es)
CA (1) CA2839558A1 (es)
CL (1) CL2013003651A1 (es)
ES (1) ES2609817T3 (es)
MX (1) MX343589B (es)
MY (1) MY165115A (es)
RU (1) RU2609650C2 (es)
WO (1) WO2012177660A2 (es)

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Publication number Publication date
WO2012177660A2 (en) 2012-12-27
AU2012273125B2 (en) 2017-05-25
US20150056163A1 (en) 2015-02-26
ES2609817T3 (es) 2017-04-24
MY165115A (en) 2018-02-28
WO2012177660A3 (en) 2013-02-21
EP3135339A1 (en) 2017-03-01
RU2609650C2 (ru) 2017-02-02
BR112013032911A2 (pt) 2017-01-24
NZ619942A (en) 2016-02-26
MX343589B (es) 2016-11-11
US20130039885A1 (en) 2013-02-14
JP2014520150A (ja) 2014-08-21
EP2720754B1 (en) 2016-10-19
US20170224768A1 (en) 2017-08-10
AU2012273125A1 (en) 2014-01-16
JP6093760B2 (ja) 2017-03-08
EP2720754A4 (en) 2015-04-29
KR20140071318A (ko) 2014-06-11
CN103764228B (zh) 2017-09-08
CN103764228A (zh) 2014-04-30
US9480726B2 (en) 2016-11-01
CA2839558A1 (en) 2012-12-27
EP2720754A2 (en) 2014-04-23
RU2014101489A (ru) 2015-07-27
CL2013003651A1 (es) 2014-09-26
US8846609B2 (en) 2014-09-30

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