IN2014DN10088A - - Google Patents

Info

Publication number
IN2014DN10088A
IN2014DN10088A IN10088DEN2014A IN2014DN10088A IN 2014DN10088 A IN2014DN10088 A IN 2014DN10088A IN 10088DEN2014 A IN10088DEN2014 A IN 10088DEN2014A IN 2014DN10088 A IN2014DN10088 A IN 2014DN10088A
Authority
IN
India
Prior art keywords
dementia
salt
disease
senile dementia
senile
Prior art date
Application number
Other languages
English (en)
Inventor
Martin Hans Bohlin
Craig Robert Stewart
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IN2014DN10088A publication Critical patent/IN2014DN10088A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IN10088DEN2014 2012-06-21 2013-06-20 IN2014DN10088A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261662592P 2012-06-21 2012-06-21
PCT/GB2013/051606 WO2013190302A1 (en) 2012-06-21 2013-06-20 Camsylate salt

Publications (1)

Publication Number Publication Date
IN2014DN10088A true IN2014DN10088A (ko) 2015-08-21

Family

ID=48746084

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10088DEN2014 IN2014DN10088A (ko) 2012-06-21 2013-06-20

Country Status (42)

Country Link
US (1) US10548882B2 (ko)
EP (2) EP3064494A1 (ko)
JP (2) JP2015520221A (ko)
KR (1) KR102123708B1 (ko)
CN (2) CN106279102A (ko)
AP (2) AP2014008137A0 (ko)
AR (2) AR091495A1 (ko)
AU (2) AU2013279109B2 (ko)
BR (2) BR122016014302B1 (ko)
CA (1) CA2875589C (ko)
CL (1) CL2014003374A1 (ko)
CO (1) CO7151486A2 (ko)
CR (2) CR20140571A (ko)
CY (1) CY1119505T1 (ko)
DK (1) DK2864316T3 (ko)
DO (1) DOP2014000268A (ko)
EC (1) ECSP14032215A (ko)
ES (1) ES2618939T3 (ko)
HK (1) HK1206349A1 (ko)
HR (1) HRP20170359T1 (ko)
HU (1) HUE033376T2 (ko)
IL (1) IL236131A0 (ko)
IN (1) IN2014DN10088A (ko)
LT (1) LT2864316T (ko)
MA (2) MA39259B1 (ko)
ME (1) ME02633B (ko)
MX (1) MX354214B (ko)
NI (1) NI201400146A (ko)
NZ (2) NZ702742A (ko)
PE (1) PE20150670A1 (ko)
PH (2) PH12014502803A1 (ko)
PL (1) PL2864316T3 (ko)
PT (1) PT2864316T (ko)
RS (1) RS55815B1 (ko)
RU (1) RU2638175C2 (ko)
SG (1) SG11201407934UA (ko)
SI (1) SI2864316T1 (ko)
TN (1) TN2014000491A1 (ko)
TW (2) TWI588140B (ko)
UA (1) UA114196C2 (ko)
WO (1) WO2013190302A1 (ko)
ZA (1) ZA201500408B (ko)

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US8415483B2 (en) 2010-12-22 2013-04-09 Astrazeneca Ab Compounds and their use as BACE inhibitors
US9650336B2 (en) 2011-10-10 2017-05-16 Astrazeneca Ab Mono-fluoro beta-secretase inhibitors
US9000182B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab 2H-imidazol-4-amine compounds and their use as BACE inhibitors
US9000185B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cycloalkyl ether compounds and their use as BACE inhibitors
US9000183B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors
US9000184B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
AR102202A1 (es) 2014-10-07 2017-02-08 Astrazeneca Ab Compuestos de oxazol y su uso como inhibidores de bace de oxazol
JP6546410B2 (ja) * 2015-02-23 2019-07-17 ローム株式会社 電力供給装置、acアダプタ、acチャージャ、電子機器および電力供給システム
EP3429620A1 (en) 2016-03-15 2019-01-23 AstraZeneca AB Combination of a bace inhibitor and an antibody or antigen-binding fragment for the treatment of a disorder associated with the accumulation of amyloid beta
TW201740944A (zh) 2016-03-15 2017-12-01 美國禮來大藥廠 組合療法
BR112021017960A2 (pt) 2019-03-14 2021-11-23 Astrazeneca Ab Lanabecestate para perda de peso

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KR100452491B1 (ko) * 2001-03-29 2004-10-12 한미약품 주식회사 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
WO2002098462A1 (fr) 2001-06-01 2002-12-12 Ono Pharmaceutical Co., Ltd. Remedes contenant un inhibiteur d'aldose reductase en tant qu'agent actif destines a des troubles de demyelinisation ou des troubles associes a la demyelinisation
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
WO2005094822A1 (en) 2004-03-22 2005-10-13 Eli Lilly And Company Pyridyl derivatives and their use as mglu5 receptor antagonists
KR20080029965A (ko) 2005-06-14 2008-04-03 쉐링 코포레이션 아스파르틸 프로테아제 억제제
EP1954682A4 (en) 2005-11-21 2011-11-09 Astrazeneca Ab NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT FOR USE IN THE TREATMENT OF COGNITIVE DEFICIENCY, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA
TW200734311A (en) * 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
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WO2007100536A1 (en) 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
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MX2011009571A (es) 2009-03-13 2011-10-19 Boehringer Ingelheim Int Inhibidores de beta-secretasa.
TW201103893A (en) 2009-07-02 2011-02-01 Astrazeneca Ab New compounds
UY32751A (es) 2009-07-02 2011-01-31 Astrazeneca Ab Imidazoles sustituidos y uso de los mismos
JP5828848B2 (ja) 2010-02-24 2015-12-09 ヴァイティー ファーマシューティカルズ,インコーポレイテッド ベータセクレターゼインヒビター
WO2011123674A1 (en) 2010-03-31 2011-10-06 Array Biopharma Inc. Compounds for treating neurodegenerative diseases
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EP2601197B1 (en) 2010-08-05 2014-06-25 Amgen Inc. Amino-iso-indole, amino-aza-iso-indole, amino-dihydroisoquinoline and amino-benzoxazine compounds as beta-secretase modulators and methods of use
TW201219400A (en) 2010-09-24 2012-05-16 Array Biopharma Inc Compounds for treating neurodegenerative diseases
US20120157448A1 (en) 2010-11-22 2012-06-21 Adam Cook Compounds for treating neurodegenerative diseases
US8415483B2 (en) 2010-12-22 2013-04-09 Astrazeneca Ab Compounds and their use as BACE inhibitors
US9650336B2 (en) 2011-10-10 2017-05-16 Astrazeneca Ab Mono-fluoro beta-secretase inhibitors
US9000185B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cycloalkyl ether compounds and their use as BACE inhibitors
US9000182B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab 2H-imidazol-4-amine compounds and their use as BACE inhibitors
US9000183B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors
US9000184B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors

Also Published As

Publication number Publication date
WO2013190302A1 (en) 2013-12-27
CO7151486A2 (es) 2014-12-29
KR20150023388A (ko) 2015-03-05
EP2864316B1 (en) 2016-12-14
ZA201500408B (en) 2016-10-26
UA114196C2 (uk) 2017-05-10
TW201730177A (zh) 2017-09-01
CL2014003374A1 (es) 2015-02-27
HK1206349A1 (zh) 2016-01-08
TWI588140B (zh) 2017-06-21
US20140031379A1 (en) 2014-01-30
PH12016500498A1 (en) 2017-04-10
ME02633B (me) 2017-06-20
TW201406745A (zh) 2014-02-16
ECSP14032215A (es) 2015-12-31
CN106279102A (zh) 2017-01-04
RU2014148305A (ru) 2016-08-10
NZ702742A (en) 2016-12-23
AR091495A1 (es) 2015-02-11
AU2017254965A1 (en) 2017-11-23
AU2013279109A1 (en) 2015-01-15
CA2875589A1 (en) 2013-12-27
SG11201407934UA (en) 2015-01-29
BR122016014302A2 (pt) 2019-08-27
BR122016014302B1 (pt) 2022-08-23
RS55815B1 (sr) 2017-08-31
MA39259A1 (fr) 2017-12-29
MX354214B (es) 2018-02-19
NI201400146A (es) 2016-09-21
AR105176A2 (es) 2017-09-13
US10548882B2 (en) 2020-02-04
MA37666B1 (fr) 2016-12-30
KR102123708B1 (ko) 2020-06-16
ES2618939T3 (es) 2017-06-22
PT2864316T (pt) 2017-02-24
IL236131A0 (en) 2015-02-01
TN2014000491A1 (en) 2016-03-30
CA2875589C (en) 2020-08-25
EP3064494A1 (en) 2016-09-07
MA37666A1 (fr) 2016-04-29
JP2015520221A (ja) 2015-07-16
NZ727045A (en) 2018-06-29
AU2017254965B2 (en) 2019-05-09
BR112014031531B1 (pt) 2022-08-02
MX2014014709A (es) 2015-03-04
AP2014008137A0 (en) 2014-12-31
PL2864316T3 (pl) 2017-09-29
TWI639591B (zh) 2018-11-01
EP2864316A1 (en) 2015-04-29
RU2638175C2 (ru) 2017-12-12
DK2864316T3 (en) 2017-03-20
JP6509393B2 (ja) 2019-05-08
CR20160202A (es) 2016-07-26
AP2017009693A0 (en) 2017-01-31
AU2013279109B2 (en) 2017-08-31
HRP20170359T1 (hr) 2017-05-05
CY1119505T1 (el) 2018-03-07
DOP2014000268A (es) 2015-04-15
JP2018104448A (ja) 2018-07-05
BR112014031531A2 (pt) 2017-06-27
PE20150670A1 (es) 2015-06-03
CN104411697A (zh) 2015-03-11
PH12014502803B1 (en) 2015-02-23
HUE033376T2 (en) 2017-11-28
LT2864316T (lt) 2017-03-27
CR20140571A (es) 2015-02-04
MA39259B1 (fr) 2018-09-28
PH12014502803A1 (en) 2015-02-23
SI2864316T1 (sl) 2017-04-26
CN104411697B (zh) 2016-08-10

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