CY1119505T1 - ΚΑΜΣΥΛΙΚΟ ΑΛΑΣ (1r,1'R,4R)-4-MEΘOΞY-5"-MEΘYΛ-6'-[5-(ΠΡΟΠ-1-ΥΝ-1-ΥΛ)ΠΥΡΙΔΙΝ-3-ΥΛ]-3Ή-ΔΙΣΠΙΡΟ[ΚΥΚΛΟΕΞΑΝ-1,2',-ΙΝΔΕΝ-1'2'-ΙΜΙΔΑΖΟΛ]-4"-ΑΜΙΝΗΣ ΚΑΙ ΚΡΥΣΤΑΛΛΙΚΕΣ ΜΟΡΦΕΣ ΑΥΤΟΥ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΤΩΝ ΠΑΘΟΛΟΓΙΩΝ ΠΟΥ ΣΧΕΤΙΖΟΝΤΑΙ ΜΕ Α[ΒΕΤΑ], ΟΠΩΣ Π.Χ., Η ΝΟΣΟΣ ALZHEIMER - Google Patents
ΚΑΜΣΥΛΙΚΟ ΑΛΑΣ (1r,1'R,4R)-4-MEΘOΞY-5"-MEΘYΛ-6'-[5-(ΠΡΟΠ-1-ΥΝ-1-ΥΛ)ΠΥΡΙΔΙΝ-3-ΥΛ]-3Ή-ΔΙΣΠΙΡΟ[ΚΥΚΛΟΕΞΑΝ-1,2',-ΙΝΔΕΝ-1'2'-ΙΜΙΔΑΖΟΛ]-4"-ΑΜΙΝΗΣ ΚΑΙ ΚΡΥΣΤΑΛΛΙΚΕΣ ΜΟΡΦΕΣ ΑΥΤΟΥ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΤΩΝ ΠΑΘΟΛΟΓΙΩΝ ΠΟΥ ΣΧΕΤΙΖΟΝΤΑΙ ΜΕ Α[ΒΕΤΑ], ΟΠΩΣ Π.Χ., Η ΝΟΣΟΣ ALZHEIMERInfo
- Publication number
- CY1119505T1 CY1119505T1 CY20171100314T CY171100314T CY1119505T1 CY 1119505 T1 CY1119505 T1 CY 1119505T1 CY 20171100314 T CY20171100314 T CY 20171100314T CY 171100314 T CY171100314 T CY 171100314T CY 1119505 T1 CY1119505 T1 CY 1119505T1
- Authority
- CY
- Cyprus
- Prior art keywords
- salt
- inden
- pyridin
- methoxy
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Ένα καμσυλικό άλας (1r,1'R,4R)-4-μεθοξυ-5''-μεθυλ-6'-[5-(προπ-1-υν-1-υλ) πυριδιν-3-υλ]-3Ή-δισπιρο[κυκλοεξαν-1,2'-ινδεν-1'2'-ιμιδαζολ]-4"-αμίνης, φαρμακευτικές συνθέσεις που περιέχουν το άλας και θεραπευτικές χρήσεις του άλατος για τη θεραπεία των παθολογιών που σχετίζονται με Αβ όπως Νόσος Alzheimer, σύνδρομο Down, β-αμυλοειδική αγγειοπάθεια και καταστάσεων, όπως άνοια, συμπεριλαμβανομένης άνοιας μικτής αγγειακής και εκφυλιστικής προέλευσης, προ-γεροντικής άνοιας, γεροντικής άνοιας και άνοιας που συνδέεται με τη νόσο Parkinson, προϊούσας υπερπυρηνικής παράλυσης ή φλοιοβασικής εκφύλισης.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662592P | 2012-06-21 | 2012-06-21 | |
| PCT/GB2013/051606 WO2013190302A1 (en) | 2012-06-21 | 2013-06-20 | Camsylate salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119505T1 true CY1119505T1 (el) | 2018-03-07 |
Family
ID=48746084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100314T CY1119505T1 (el) | 2012-06-21 | 2017-03-13 | ΚΑΜΣΥΛΙΚΟ ΑΛΑΣ (1r,1'R,4R)-4-MEΘOΞY-5"-MEΘYΛ-6'-[5-(ΠΡΟΠ-1-ΥΝ-1-ΥΛ)ΠΥΡΙΔΙΝ-3-ΥΛ]-3Ή-ΔΙΣΠΙΡΟ[ΚΥΚΛΟΕΞΑΝ-1,2',-ΙΝΔΕΝ-1'2'-ΙΜΙΔΑΖΟΛ]-4"-ΑΜΙΝΗΣ ΚΑΙ ΚΡΥΣΤΑΛΛΙΚΕΣ ΜΟΡΦΕΣ ΑΥΤΟΥ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΤΩΝ ΠΑΘΟΛΟΓΙΩΝ ΠΟΥ ΣΧΕΤΙΖΟΝΤΑΙ ΜΕ Α[ΒΕΤΑ], ΟΠΩΣ Π.Χ., Η ΝΟΣΟΣ ALZHEIMER |
Country Status (42)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8415483B2 (en) | 2010-12-22 | 2013-04-09 | Astrazeneca Ab | Compounds and their use as BACE inhibitors |
| US9650336B2 (en) | 2011-10-10 | 2017-05-16 | Astrazeneca Ab | Mono-fluoro beta-secretase inhibitors |
| US9000184B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors |
| US9000185B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cycloalkyl ether compounds and their use as BACE inhibitors |
| US9000183B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors |
| US9000182B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | 2H-imidazol-4-amine compounds and their use as BACE inhibitors |
| TW201629025A (zh) | 2014-10-07 | 2016-08-16 | 阿斯特捷利康公司 | 化合物及其作為ｂａｃｅ抑制劑之用途 |
| JP6546410B2 (ja) * | 2015-02-23 | 2019-07-17 | ローム株式会社 | 電力供給装置、ａｃアダプタ、ａｃチャージャ、電子機器および電力供給システム |
| TW201742625A (zh) | 2016-03-15 | 2017-12-16 | 阿斯特捷利康公司 | 組合療法 |
| TW201740944A (zh) * | 2016-03-15 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
| US20220175749A1 (en) * | 2019-03-14 | 2022-06-09 | Astrazeneca Ab | Lanabecestat for weight loss |
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| KR100452491B1 (ko) * | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
| WO2002098462A1 (fr) | 2001-06-01 | 2002-12-12 | Ono Pharmaceutical Co., Ltd. | Remedes contenant un inhibiteur d'aldose reductase en tant qu'agent actif destines a des troubles de demyelinisation ou des troubles associes a la demyelinisation |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| ES2332184T3 (es) | 2004-03-22 | 2010-01-28 | ELI LILLY & COMPANY | Derivados de piridilo y su uso como antagonistas del receptor mglu5. |
| CA2609582A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| US20090176850A1 (en) | 2005-11-21 | 2009-07-09 | Astrazeneca Ab | Novel 2-Amino-Imidazole-4-One Compounds And Their Use In The Manufacture Of A Medicament To Be Used In The Treatment Of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration And Dementia |
| TW200734311A (en) * | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
| CA2633992A1 (en) | 2005-12-21 | 2007-07-05 | Boehringer Ingelheim International Gmbh | Pyrimidine derivatives useful as inhibitors of pkc-theta |
| WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| EP2644600B1 (en) | 2006-06-12 | 2017-01-11 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
| WO2008076043A1 (en) | 2006-12-20 | 2008-06-26 | Astrazeneca Ab | Novel 2-amino-5,5-diaryl-imidazol-4-ones |
| WO2008092877A2 (en) | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | 8-oxa-1, 4-diazaspiro [4,5] dec-3-en-1-yl and 1,4, 8-triazaspiro [4,5] dec- 3-en-1-yl acetamides as glyti transporter inhibitors in treatment of neurological and neuropsychiatric disorders |
| RU2009144998A (ru) | 2007-05-07 | 2011-06-20 | Шеринг Корпорейшн (US) | Модуляторы гамма-секретазы |
| WO2009100169A1 (en) | 2008-02-06 | 2009-08-13 | Glaxo Group Limited | Dual pharmacophores - pde4-muscarinic antagonistics |
| FR2929943B1 (fr) * | 2008-04-15 | 2010-09-24 | Inst Rech Developpement Ird | Sels de quinoleines 2-substituees |
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| UY32751A (es) | 2009-07-02 | 2011-01-31 | Astrazeneca Ab | Imidazoles sustituidos y uso de los mismos |
| WO2011106414A1 (en) | 2010-02-24 | 2011-09-01 | Dillard Lawrence W | Inhibitors of beta-secretase |
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| WO2012071458A1 (en) | 2010-11-22 | 2012-05-31 | Array Biopharma Inc. | Heterocyclic inhibitors of beta - secretase for the treatment of neurodegenerative diseases |
| US8415483B2 (en) | 2010-12-22 | 2013-04-09 | Astrazeneca Ab | Compounds and their use as BACE inhibitors |
| US9650336B2 (en) | 2011-10-10 | 2017-05-16 | Astrazeneca Ab | Mono-fluoro beta-secretase inhibitors |
| US9000183B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors |
| US9000182B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | 2H-imidazol-4-amine compounds and their use as BACE inhibitors |
| US9000185B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cycloalkyl ether compounds and their use as BACE inhibitors |
| US9000184B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors |
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2013
- 2013-06-13 US US13/916,754 patent/US10548882B2/en active Active
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- 2013-06-20 RU RU2014148305A patent/RU2638175C2/ru active
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- 2013-06-20 LT LTEP13733415.7T patent/LT2864316T/lt unknown
- 2013-06-20 AP AP2014008137A patent/AP2014008137A0/xx unknown
- 2013-06-20 CN CN201380033030.6A patent/CN104411697B/zh active Active
- 2013-06-20 DK DK13733415.7T patent/DK2864316T3/en active
- 2013-06-20 WO PCT/GB2013/051606 patent/WO2013190302A1/en active Application Filing
- 2013-06-20 CN CN201610570484.2A patent/CN106279102A/zh active Pending
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2015
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2016
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2017
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2018
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