IN2012DN02358A - - Google Patents

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Publication number
IN2012DN02358A
IN2012DN02358A IN2358DEN2012A IN2012DN02358A IN 2012DN02358 A IN2012DN02358 A IN 2012DN02358A IN 2358DEN2012 A IN2358DEN2012 A IN 2358DEN2012A IN 2012DN02358 A IN2012DN02358 A IN 2012DN02358A
Authority
IN
India
Prior art keywords
silk
active agents
microparticles
present
compositions
Prior art date
Application number
Other languages
English (en)
Inventor
Xiaoqin Wang
David L Kaplan
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of IN2012DN02358A publication Critical patent/IN2012DN02358A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5052Proteins, e.g. albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
IN2358DEN2012 2009-09-29 2010-09-29 IN2012DN02358A (cg-RX-API-DMAC10.html)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24667609P 2009-09-29 2009-09-29
PCT/US2010/050698 WO2011041395A2 (en) 2009-09-29 2010-09-29 Silk nanospheres and microspheres and methods of making same

Publications (1)

Publication Number Publication Date
IN2012DN02358A true IN2012DN02358A (cg-RX-API-DMAC10.html) 2015-08-21

Family

ID=43826861

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2358DEN2012 IN2012DN02358A (cg-RX-API-DMAC10.html) 2009-09-29 2010-09-29

Country Status (7)

Country Link
US (2) US8715740B2 (cg-RX-API-DMAC10.html)
EP (1) EP2483199B1 (cg-RX-API-DMAC10.html)
JP (1) JP5730317B2 (cg-RX-API-DMAC10.html)
CA (1) CA2774643A1 (cg-RX-API-DMAC10.html)
IL (1) IL218654A (cg-RX-API-DMAC10.html)
IN (1) IN2012DN02358A (cg-RX-API-DMAC10.html)
WO (1) WO2011041395A2 (cg-RX-API-DMAC10.html)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6092337A (ja) * 1983-10-26 1985-05-23 Sekisui Plastics Co Ltd 発泡フエノ−ル樹脂成形物の製造方法
WO2005122285A2 (en) 2004-06-04 2005-12-22 The Board Of Trustees Of The University Of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
US9969134B2 (en) 2006-11-03 2018-05-15 Trustees Of Tufts College Nanopatterned biopolymer optical device and method of manufacturing the same
CA2704304C (en) 2006-11-03 2015-01-13 Trustees Of Trufts College Biopolymer optical waveguide and method of manufacturing the same
WO2008127402A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
JP5646492B2 (ja) 2008-10-07 2014-12-24 エムシー10 インコーポレイテッドMc10,Inc. 伸縮可能な集積回路およびセンサアレイを有する装置
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US8389862B2 (en) 2008-10-07 2013-03-05 Mc10, Inc. Extremely stretchable electronics
WO2011038401A2 (en) 2009-09-28 2011-03-31 Trustees Of Tufts College Drawn silk egel fibers and methods of making same
IN2012DN02358A (cg-RX-API-DMAC10.html) 2009-09-29 2015-08-21 Tufts College
US9723122B2 (en) 2009-10-01 2017-08-01 Mc10, Inc. Protective cases with integrated electronics
EP2513953B1 (en) 2009-12-16 2017-10-18 The Board of Trustees of the University of Illionis Electrophysiology using conformal electronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
WO2011115643A1 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The University Of Illinois Implantable biomedical devices on bioresorbable substrates
JP2013542181A (ja) 2010-09-03 2013-11-21 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ プラズモンナノ粒子ドープ絹材料
CA2833879C (en) 2011-04-21 2023-03-14 David L. Kaplan Compositions and methods for stabilization of active agents
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
JP2014523633A (ja) 2011-05-27 2014-09-11 エムシー10 インコーポレイテッド 電子的、光学的、且つ/又は機械的装置及びシステム並びにこれらの装置及びシステムを製造する方法
EP2713863B1 (en) 2011-06-03 2020-01-15 The Board of Trustees of the University of Illionis Conformable actively multiplexed high-density surface electrode array for brain interfacing
CN102344686A (zh) * 2011-08-02 2012-02-08 北京汇亨创管理咨询有限公司 一种以聚乙烯醇为稳定剂的丝素蛋白纳米颗粒的制备方法
US9691873B2 (en) 2011-12-01 2017-06-27 The Board Of Trustees Of The University Of Illinois Transient devices designed to undergo programmable transformations
EP2811987B1 (en) 2012-02-06 2021-01-20 Children's Medical Center Corporation Multi-layer biomaterial for tissue regeneration and wound healing
JP2015510818A (ja) 2012-03-20 2015-04-13 トラスティーズ オブ タフツ カレッジ 薬物送達のための絹リザーバー
WO2013149181A1 (en) 2012-03-30 2013-10-03 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces
WO2013152265A1 (en) 2012-04-06 2013-10-10 Trustees Of Tufts College Methods of producing and using silk microfibers
WO2014021954A2 (en) * 2012-04-13 2014-02-06 Trustees Of Tufts College Magneto-sensitive silk fibroin-based materials
US20150056294A1 (en) * 2012-04-13 2015-02-26 Trustees Of Tufts College Methods and compositions for preparing a silk microsphere
EP2841108A4 (en) * 2012-04-25 2015-11-25 Tufts College SILK MICRO BEADS AND METHOD OF SURFACE LUBRICATION
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
EP2872115A4 (en) * 2012-07-13 2016-04-06 Univ Tufts Encapsulation of immiscible phases in silk fibroin biomaterials
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
KR102774944B1 (ko) 2013-03-15 2025-02-27 트러스티즈 오브 터프츠 칼리지 저분자량 실크 조성물 및 안정화 실크 조성물
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
WO2014176458A2 (en) 2013-04-24 2014-10-30 Trustees Of Tufts College Bioresorbable biopolymer anastomosis devices
EP3016634A2 (en) * 2013-07-05 2016-05-11 Therakine Biodelivery GmbH Drug-delivery composition for topical applications and injections and ophtalmic formulations, method for manufacturing thereof, and methods for delivery a drug-delivery composition
US10080644B2 (en) 2013-07-19 2018-09-25 National University Of Singapore Tissue interface augmentation device for ligament/tendon reconstruction
EP3049068A1 (en) * 2013-09-27 2016-08-03 Tufts University Synthesis of silk fibroin micro- and submicron spheres using a co-flow method
WO2015048527A1 (en) 2013-09-27 2015-04-02 Tufts University Optically transparent silk hydrogels
KR20210153142A (ko) * 2013-09-30 2021-12-16 실크 테라퓨틱스, 인코퍼레이티드 실크 단백질 단편 조성물 및 이로부터 제작된 물품
JP6135486B2 (ja) * 2013-12-06 2017-05-31 豊田合成株式会社 樹脂成形体
AU2015358537B2 (en) 2014-12-02 2021-08-19 Evolved By Nature, Inc. Silk performance apparel and products and methods of preparing the same
WO2016115159A1 (en) * 2015-01-12 2016-07-21 Silk Therapeutics, Inc. Preserved silk protein fragment compositions and articles
BR112017025609A2 (pt) 2015-06-01 2018-08-07 The Board Of Trustees Of The University Of Illinois sistemas eletrônicos miniaturizados com potência sem fio e capacidades de comunicação de campo próximo
AU2016270805A1 (en) 2015-06-01 2017-12-14 The Board Of Trustees Of The University Of Illinois Alternative approach to UV sensing
EA201890289A1 (ru) 2015-07-14 2018-08-31 Силк Терапьютикс, Инк. Одежда и продукты с характеристиками шелка и способы их приготовления
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
CN105297289B (zh) * 2015-12-07 2017-10-31 清华大学深圳研究生院 一种丝素蛋白储能调温纤维膜制备方法
CN105963275B (zh) * 2016-05-31 2019-05-17 中国医学科学院生物医学工程研究所 壳层可控的丝素蛋白微囊及制备方法
US11413319B2 (en) 2016-06-23 2022-08-16 Phagelux (Canada) Inc. Microencapsulation of bacteriophages and related products
WO2017221201A1 (en) 2016-06-23 2017-12-28 Phagelux (Canada) Inc. Microencapsulation of bacteriophages and related products
WO2018026853A1 (en) 2016-08-01 2018-02-08 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
WO2018081815A2 (en) 2016-10-31 2018-05-03 Sofregen Medical, Inc. Compositions comprising silk fibroin particles and uses thereof
KR101957013B1 (ko) * 2017-04-04 2019-03-11 서울대학교산학협력단 골 형성 단백질을 포함하는 약물 전달체 및 그 제조 방법
WO2019067745A1 (en) 2017-09-27 2019-04-04 Silk, Inc. SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR
US11794161B1 (en) 2018-11-21 2023-10-24 Trucapsol, Llc Reduced permeability microcapsules
US11571674B1 (en) 2019-03-28 2023-02-07 Trucapsol Llc Environmentally biodegradable microcapsules
US11542392B1 (en) 2019-04-18 2023-01-03 Trucapsol Llc Multifunctional particle additive for enhancement of toughness and degradation in biodegradable polymers
CN110327307B (zh) * 2019-06-26 2020-06-23 浙江大学 一种丝素载药纳米微囊的制备方法及产品
CN110483830B (zh) * 2019-07-31 2021-08-17 武汉纺织大学 超轻高弹丝素微纳米纤维气凝胶及其制备方法与应用
EP4045124A4 (en) 2019-10-15 2024-01-24 Sofregen Medical, Inc. DISPENSING DEVICES FOR DISPENSING AND METHOD FOR DISPENSING COMPOSITIONS
US11465117B2 (en) 2020-01-30 2022-10-11 Trucapsol Llc Environmentally biodegradable microcapsules
CN111454468B (zh) * 2020-03-27 2021-04-20 西安交通大学 一种形状可控的智能响应微球及其制备方法
EP4188417A4 (en) * 2020-07-28 2024-08-21 University of Georgia Research Foundation, Inc. ANTIMICROBIAL SILK NANOPARTICLES AND METHODS FOR THE PRODUCTION AND USE THEREOF
US12302933B2 (en) 2021-06-25 2025-05-20 Trucapsol Llc Flavor delivery system
US12187829B2 (en) 2021-08-12 2025-01-07 Trucapsol Llc Environmentally biodegradable microcapsules
US11878280B2 (en) 2022-04-19 2024-01-23 Trucapsol Llc Microcapsules comprising natural materials
CN115414533B (zh) * 2022-09-20 2024-02-23 中国人民解放军总医院第一医学中心 一种模拟膀胱壁生理结构的组织工程支架及其制备方法
US11904288B1 (en) 2023-02-13 2024-02-20 Trucapsol Llc Environmentally biodegradable microcapsules
US11969491B1 (en) 2023-02-22 2024-04-30 Trucapsol Llc pH triggered release particle

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE380083A (cg-RX-API-DMAC10.html) 1929-12-23
US3424164A (en) 1966-05-20 1969-01-28 Ethicon Inc Silk suture
JPS5838449B2 (ja) 1979-04-17 1983-08-23 カネボウ株式会社 微粉末状絹フィプロインの製造法
JPS56166235A (en) 1980-05-24 1981-12-21 Kanebo Ltd Hydrophilic porous body and its preparation
JPS5838449A (ja) 1981-08-31 1983-03-05 Matsushita Electronics Corp 高圧ナトリウムランプ装置
JPS60142259A (ja) 1983-12-29 1985-07-27 Kanebo Ltd 固定化抗体
JPS60259677A (ja) 1984-05-31 1985-12-21 水島 繁三郎 動物蛋白吸着再生繊維からなる原糸、織物、編物及びその製造方法
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
JPS63190604A (ja) 1987-02-03 1988-08-08 Agency Of Ind Science & Technol 新規の水−アルコ−ル分離膜
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
JPH0694518B2 (ja) 1987-11-02 1994-11-24 工業技術院長 絹フィブロイン多孔質体の製造方法
GB8800078D0 (en) 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
JPH0669485B2 (ja) * 1988-10-19 1994-09-07 住江織物株式会社 シルクフィブロイン含有成形物
US5290494A (en) 1990-03-05 1994-03-01 Board Of Regents, The University Of Texas System Process of making a resorbable implantation device
US5989894A (en) 1990-04-20 1999-11-23 University Of Wyoming Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA
JPH04263611A (ja) 1991-02-16 1992-09-18 Pola Chem Ind Inc 水不溶性固形フィブロイン成形物及びその製造法
JPH06346314A (ja) 1993-06-02 1994-12-20 Toyobo Co Ltd 再生絹フィブロイン繊維およびその製造方法
JPH08295697A (ja) 1995-04-26 1996-11-12 Kanebo Ltd 高濃度絹フィブロイン水溶液の製造方法
JPH1036676A (ja) 1996-07-26 1998-02-10 Kanebo Ltd タンパク質水溶液の濃縮方法
WO1998057676A1 (en) 1997-06-18 1998-12-23 Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forestry And Fisheries Wound covering material containing silk fibroin and silk sericin as the main components and process for producing the same
EP1006945A1 (en) 1997-07-01 2000-06-14 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
US6123819A (en) 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
US5994099A (en) 1997-12-31 1999-11-30 The University Of Wyoming Extremely elastic spider silk protein and DNA coding therefor
US6110590A (en) 1998-04-15 2000-08-29 The University Of Akron Synthetically spun silk nanofibers and a process for making the same
US6196358B1 (en) 1998-07-08 2001-03-06 Shimano Inc. Detachable fluid cooling system for bicycle disc brake
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20030007991A1 (en) 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US6592623B1 (en) 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
JP3151665B2 (ja) 1999-03-23 2001-04-03 農林水産省蚕糸・昆虫農業技術研究所長 生体高分子/ポリアリルアミン複合体およびその製造方法
WO2001036531A1 (fr) 1999-11-15 2001-05-25 Zaidan-Houjin Ueda Sen-I Kagaku Shinkoukai Materiau polymere moleculairement composite en fibroine/cellulose et procede de production de ce materiau
CA2398635A1 (en) 2000-02-03 2001-08-09 Nexia Biotechnologies, Inc. Surgical sutures containing spider silk
IT1316885B1 (it) 2000-10-02 2003-05-13 Consorzio Per Gli Studi Uni Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta.
JP2002128691A (ja) 2000-10-24 2002-05-09 National Institute Of Agrobiological Sciences セリシン含有素材、その製造方法およびその使用方法
JPWO2002072931A1 (ja) 2001-03-14 2004-07-02 東京農工大学長 絹及び絹様材料の繊維及びフィルムの製造方法
ITVR20010098A1 (it) 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
WO2003038033A2 (en) 2001-10-02 2003-05-08 Northwestern University Protein and peptide nanoarrays
GB0126118D0 (en) 2001-10-31 2002-01-02 Vollrath Friedrich W L Precursor feedstock for forming filaments
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
DE10297527B4 (de) 2001-12-07 2013-10-31 Lumileds Lighting U.S., Llc Kompaktes Beleuchtungssystem und Anzeigeeinrichtung
JP3803962B2 (ja) 2001-12-28 2006-08-02 独立行政法人科学技術振興機構 絹タンパク質フィルムとその製造方法
US7057023B2 (en) 2002-01-11 2006-06-06 Nexia Biotechnologies Inc. Methods and apparatus for spinning spider silk protein
JP3772207B2 (ja) * 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
EP1558444B1 (en) 2002-06-24 2016-09-21 Tufts University Silk biomaterials and methods of use thereof
CN1732014B (zh) 2002-11-01 2013-05-22 塔夫茨大学理事会 模板天然丝近晶状凝胶
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
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WO2005000483A1 (en) 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
US8178656B2 (en) 2004-06-11 2012-05-15 Trustees Of Tufts College Silk-based drug delivery system
WO2006076711A2 (en) 2005-01-14 2006-07-20 Trustees Of Tufts College Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials
US9290579B2 (en) 2005-04-20 2016-03-22 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds
EP1915436B1 (en) 2005-08-02 2011-09-28 Trustees Of Tufts College Methods for stepwise deposition of silk fibroin coatings
GB0516846D0 (en) 2005-08-17 2005-09-21 Knight David P Meniscal repair device
DE102005043609A1 (de) * 2005-09-13 2007-03-22 Technische Universität München Verfahren und Vorrichtung zur Herstellung eines Fadens aus Seidenproteinen
US20100028451A1 (en) 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
US20110121485A1 (en) 2006-10-30 2011-05-26 Spintec Engineering Gmbh Method and apparatus for the manufacture of a fiber
US20100068740A1 (en) 2006-11-03 2010-03-18 Trustees Of Tufts College Microfluidic device with a cylindrical microchannel and a method for fabricating same
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WO2008127402A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
US9102916B2 (en) 2007-02-27 2015-08-11 Trustees Of Tufts College Tissue-engineered silk organs
PL2211876T3 (pl) 2007-05-29 2015-05-29 Tufts College Sposób żelowania fibroiny jedwabiu z użyciem sonikacji
US9808557B2 (en) 2007-08-10 2017-11-07 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
WO2009061823A1 (en) 2007-11-05 2009-05-14 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
EP2249886A4 (en) 2008-02-07 2013-05-22 Tufts College 3-DIMENSIONAL SILK HYDROXYLAPATITE COMPOSITIONS
US8206774B2 (en) 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
WO2009126689A2 (en) 2008-04-08 2009-10-15 Trustees Of Tufts College System and method for making biomaterial structures
MX341351B (es) 2008-05-15 2016-08-17 Tufts College Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia.
US20090297588A1 (en) 2008-05-28 2009-12-03 Spin'tec Engineering Gmbh Antibiotic dressing for the treatment of infected wounds
JP2011525254A (ja) 2008-06-18 2011-09-15 トラスティーズ オブ タフツ カレッジ 食用のホログラフィック絹製品
GB2461125A (en) 2008-06-25 2009-12-30 Spintec Engineering Gmbh A silk membrane for bone graft material
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
GB2464348A (en) 2008-10-17 2010-04-21 Spintec Engineering Gmbh Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties
EP2253336A1 (en) 2009-05-15 2010-11-24 Spintec Engineering GmbH A silk medical device with antimicrobial properties and a method of manufacture thereof
EP2451953A4 (en) 2009-07-10 2013-07-03 Tufts College GEN-MANIPULATED SILK PROTEIN-BASED NUCLEIC ACID DELIVERY SYSTEMS
IN2012DN02358A (cg-RX-API-DMAC10.html) 2009-09-29 2015-08-21 Tufts College

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