IN2012DN00801A - - Google Patents

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Publication number
IN2012DN00801A
IN2012DN00801A IN801DEN2012A IN2012DN00801A IN 2012DN00801 A IN2012DN00801 A IN 2012DN00801A IN 801DEN2012 A IN801DEN2012 A IN 801DEN2012A IN 2012DN00801 A IN2012DN00801 A IN 2012DN00801A
Authority
IN
India
Prior art keywords
adamts
expression
methods
useful
proteins
Prior art date
Application number
Other languages
English (en)
Inventor
Grillberger Leopold
Spenger Alexandra
Hasslacher Meinhard
Grillberger Rana
Reiter Manfred
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of IN2012DN00801A publication Critical patent/IN2012DN00801A/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0681Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0686Kidney cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/12Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14Calcium; Ca chelators; Calcitonin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • C12N2500/22Zinc; Zn chelators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95Protein-free medium and culture conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/99Serum-free medium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
IN801DEN2012 2009-07-31 2010-07-30 IN2012DN00801A (enEXAMPLES)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23047709P 2009-07-31 2009-07-31
PCT/US2010/044020 WO2011014838A1 (en) 2009-07-31 2010-07-30 Cell culture medium for adamts protein expression

Publications (1)

Publication Number Publication Date
IN2012DN00801A true IN2012DN00801A (enEXAMPLES) 2015-06-26

Family

ID=42668009

Family Applications (1)

Application Number Title Priority Date Filing Date
IN801DEN2012 IN2012DN00801A (enEXAMPLES) 2009-07-31 2010-07-30

Country Status (21)

Country Link
US (7) US8313926B2 (enEXAMPLES)
EP (1) EP2459702B1 (enEXAMPLES)
JP (5) JP5451884B2 (enEXAMPLES)
KR (5) KR101808496B1 (enEXAMPLES)
CN (2) CN104962539B (enEXAMPLES)
AU (1) AU2010278751B2 (enEXAMPLES)
BR (2) BR112012002151B1 (enEXAMPLES)
CA (1) CA2769361A1 (enEXAMPLES)
CO (1) CO6501191A2 (enEXAMPLES)
EA (1) EA023193B1 (enEXAMPLES)
ES (1) ES2583258T3 (enEXAMPLES)
HR (1) HRP20160783T1 (enEXAMPLES)
HU (1) HUE029110T2 (enEXAMPLES)
IN (1) IN2012DN00801A (enEXAMPLES)
MX (2) MX2012001261A (enEXAMPLES)
NZ (1) NZ597727A (enEXAMPLES)
PL (1) PL2459702T3 (enEXAMPLES)
PT (1) PT2459702T (enEXAMPLES)
SG (1) SG178194A1 (enEXAMPLES)
SI (1) SI2459702T1 (enEXAMPLES)
WO (1) WO2011014838A1 (enEXAMPLES)

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PL3152317T3 (pl) 2014-06-04 2019-08-30 Amgen Inc. Sposoby zbierania hodowli ssaczych komórek
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JP2021515584A (ja) * 2018-03-16 2021-06-24 ジェンザイム・コーポレーション 産生バイオリアクターにおける細胞生存度を改善するための方法
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JP2022548197A (ja) 2019-12-06 2022-11-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗vegfタンパク質組成物及びその製造方法
CA3173709A1 (en) 2020-04-02 2021-10-07 Friedmund BACHMANN Adamts13 variant, compositions, and uses thereof
KR20230008830A (ko) 2020-05-08 2023-01-16 리제너론 파마슈티칼스 인코포레이티드 Vegf 트랩 및 미니-트랩 및 안구 장애 및 암의 치료 방법
JP2023526546A (ja) 2020-05-22 2023-06-21 武田薬品工業株式会社 コロナウイルス疾患の合併症の治療及び診断のための、adamts13組成物及び方法
WO2021246557A1 (ko) * 2020-06-05 2021-12-09 주식회사 프로앱텍 특정한 갯수의 알부민이 연결된 요산산화효소-알부민 복합체 및 이의 제조 방법
CN111808822B (zh) * 2020-07-02 2024-01-12 北京百普赛斯生物科技股份有限公司 细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法

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Also Published As

Publication number Publication date
US20200308566A1 (en) 2020-10-01
PL2459702T3 (pl) 2016-12-30
KR20120046301A (ko) 2012-05-09
BR112012002151B1 (pt) 2021-07-06
US8759026B2 (en) 2014-06-24
US10724024B2 (en) 2020-07-28
KR20170081747A (ko) 2017-07-12
JP6883071B2 (ja) 2021-06-09
KR20150044981A (ko) 2015-04-27
US20130071906A1 (en) 2013-03-21
HRP20160783T1 (hr) 2016-08-12
EP2459702B1 (en) 2016-05-04
KR101573972B1 (ko) 2015-12-02
ES2583258T3 (es) 2016-09-20
EP2459702A1 (en) 2012-06-06
JP2018093881A (ja) 2018-06-21
US9127265B2 (en) 2015-09-08
JP2019201661A (ja) 2019-11-28
US20150329848A1 (en) 2015-11-19
US11254921B2 (en) 2022-02-22
WO2011014838A1 (en) 2011-02-03
JP2013500724A (ja) 2013-01-10
CN102549145B (zh) 2015-05-20
JP2014061005A (ja) 2014-04-10
PT2459702T (pt) 2016-08-02
AU2010278751B2 (en) 2014-05-15
KR101912552B1 (ko) 2018-10-26
US20140329294A1 (en) 2014-11-06
JP7083059B2 (ja) 2022-06-09
BR112012002151A2 (pt) 2020-03-03
EA023193B1 (ru) 2016-05-31
US9441216B2 (en) 2016-09-13
SI2459702T1 (sl) 2016-11-30
JP5936232B2 (ja) 2016-06-22
MX2012001261A (es) 2012-05-22
EA201270224A1 (ru) 2012-09-28
BR122021005965B1 (pt) 2022-01-25
JP2021112210A (ja) 2021-08-05
HUE029110T2 (en) 2017-02-28
KR101574056B1 (ko) 2015-12-02
SG178194A1 (en) 2012-03-29
KR20150138425A (ko) 2015-12-09
JP2016144471A (ja) 2016-08-12
KR101808496B1 (ko) 2017-12-12
CN104962539B (zh) 2019-09-17
JP6567707B2 (ja) 2019-08-28
JP5451884B2 (ja) 2014-03-26
US10072254B2 (en) 2018-09-11
US8313926B2 (en) 2012-11-20
HK1171790A1 (zh) 2013-04-05
AU2010278751A1 (en) 2012-02-09
CN104962539A (zh) 2015-10-07
KR20170140411A (ko) 2017-12-20
JP6511007B2 (ja) 2019-05-08
US20110086413A1 (en) 2011-04-14
US20170051270A1 (en) 2017-02-23
KR101756354B1 (ko) 2017-07-26
CO6501191A2 (es) 2012-08-15
US20190071660A1 (en) 2019-03-07
NZ597727A (en) 2013-08-30
CA2769361A1 (en) 2011-02-03
MX344970B (es) 2017-01-12
CN102549145A (zh) 2012-07-04

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