AU2010278751B2 - Cell culture medium for ADAMTS protein expression - Google Patents

Cell culture medium for ADAMTS protein expression Download PDF

Info

Publication number
AU2010278751B2
AU2010278751B2 AU2010278751A AU2010278751A AU2010278751B2 AU 2010278751 B2 AU2010278751 B2 AU 2010278751B2 AU 2010278751 A AU2010278751 A AU 2010278751A AU 2010278751 A AU2010278751 A AU 2010278751A AU 2010278751 B2 AU2010278751 B2 AU 2010278751B2
Authority
AU
Australia
Prior art keywords
adamts
protein
culture
culture medium
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2010278751A
Other languages
English (en)
Other versions
AU2010278751A1 (en
Inventor
Leopold Grillberger
Rana Grillberger
Meinhard Hasslacher
Manfred Reiter
Alexandra Spenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of AU2010278751A1 publication Critical patent/AU2010278751A1/en
Priority to AU2014202427A priority Critical patent/AU2014202427B2/en
Application granted granted Critical
Publication of AU2010278751B2 publication Critical patent/AU2010278751B2/en
Priority to AU2015202142A priority patent/AU2015202142B2/en
Assigned to Baxalta GmbH, BAXALTA INCORPORATED reassignment Baxalta GmbH Request for Assignment Assignors: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
Priority to AU2017261523A priority patent/AU2017261523B2/en
Priority to AU2019279943A priority patent/AU2019279943B2/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: Baxalta GmbH, BAXALTA INCORPORATED
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/22—Zinc; Zn chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
AU2010278751A 2009-07-31 2010-07-30 Cell culture medium for ADAMTS protein expression Active AU2010278751B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2014202427A AU2014202427B2 (en) 2009-07-31 2014-05-05 Cell culture medium for adamts protein expression
AU2015202142A AU2015202142B2 (en) 2009-07-31 2015-04-27 Cell culture medium for adamts protein expression
AU2017261523A AU2017261523B2 (en) 2009-07-31 2017-11-15 Cell culture medium for adamts protein expression
AU2019279943A AU2019279943B2 (en) 2009-07-31 2019-12-10 Cell culture medium for adamts protein expression

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23047709P 2009-07-31 2009-07-31
US61/230,477 2009-07-31
PCT/US2010/044020 WO2011014838A1 (en) 2009-07-31 2010-07-30 Cell culture medium for adamts protein expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014202427A Division AU2014202427B2 (en) 2009-07-31 2014-05-05 Cell culture medium for adamts protein expression

Publications (2)

Publication Number Publication Date
AU2010278751A1 AU2010278751A1 (en) 2012-02-09
AU2010278751B2 true AU2010278751B2 (en) 2014-05-15

Family

ID=42668009

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010278751A Active AU2010278751B2 (en) 2009-07-31 2010-07-30 Cell culture medium for ADAMTS protein expression

Country Status (21)

Country Link
US (7) US8313926B2 (enEXAMPLES)
EP (1) EP2459702B1 (enEXAMPLES)
JP (5) JP5451884B2 (enEXAMPLES)
KR (5) KR101912552B1 (enEXAMPLES)
CN (2) CN104962539B (enEXAMPLES)
AU (1) AU2010278751B2 (enEXAMPLES)
BR (2) BR122021005965B1 (enEXAMPLES)
CA (1) CA2769361A1 (enEXAMPLES)
CO (1) CO6501191A2 (enEXAMPLES)
EA (1) EA023193B1 (enEXAMPLES)
ES (1) ES2583258T3 (enEXAMPLES)
HR (1) HRP20160783T1 (enEXAMPLES)
HU (1) HUE029110T2 (enEXAMPLES)
IN (1) IN2012DN00801A (enEXAMPLES)
MX (2) MX2012001261A (enEXAMPLES)
NZ (1) NZ597727A (enEXAMPLES)
PL (1) PL2459702T3 (enEXAMPLES)
PT (1) PT2459702T (enEXAMPLES)
SG (1) SG178194A1 (enEXAMPLES)
SI (1) SI2459702T1 (enEXAMPLES)
WO (1) WO2011014838A1 (enEXAMPLES)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2769361A1 (en) * 2009-07-31 2011-02-03 Baxter International Inc. Cell culture medium for adamts protein expression
DK3064508T4 (da) 2010-07-08 2023-04-11 Takeda Pharmaceuticals Co Fremgangsmåde til fremstilling af rekombinant vwf med høj molekylevægt i cellekultur
KR101857380B1 (ko) 2011-07-01 2018-05-11 암젠 인크 포유동물 세포 배양
EP2906683B1 (en) 2012-10-15 2017-05-31 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
US9611455B2 (en) 2013-03-13 2017-04-04 Merck Sharp & Dohme Corp. Adapted lepidopteran insect cells for the production of recombinant proteins
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
AR095196A1 (es) * 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
CA2926517C (en) * 2013-10-14 2021-03-23 Ares Trading S.A. New medium for high performance mammalian fed-batch cultures
ES2709994T3 (es) 2014-06-04 2019-04-22 Amgen Inc Métodos de recolección en cultivos de células de mamífero
KR101867134B1 (ko) * 2015-03-23 2018-06-12 한양대학교 산학협력단 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법
MX2017014595A (es) * 2015-05-22 2018-03-21 Dupont Nutrition Biosci Aps Acetolactato-descarboxilasa.
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
KR102537083B1 (ko) 2016-08-04 2023-05-25 다케다 파머수티컬 컴패니 리미티드 겸상적혈구병, 급성 폐 손상 및/또는 급성 호흡 곤란 증후군에서 혈관폐색 위기의 치료, 개선, 및/또는 예방을 위한 adamts13의 용도
AU2017391164B2 (en) * 2016-11-04 2024-01-04 Takeda Pharmaceutical Company Limited Adeno-associated virus purification methods
SG11201912548XA (en) * 2017-07-06 2020-01-30 Regeneron Pharma Cell culture process for making a glycoprotein
CA3094076A1 (en) * 2018-03-16 2019-09-19 Genzyme Corporation Methods for improving cell viability in a production bioreactor
CA3103443A1 (en) * 2018-06-18 2019-12-26 Synthetic Biologics, Inc. Methods of making alkaline phosphatase agents
WO2021067668A1 (en) 2019-10-04 2021-04-08 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
TW202128991A (zh) 2019-12-06 2021-08-01 美商再生元醫藥公司 抗ｖｅｇｆ蛋白組成物及其製備方法
AU2021248679A1 (en) 2020-04-02 2022-10-27 Takeda Pharmaceutical Company Limited ADAMTS13 variant, compositions, and uses thereof
EP4146686A2 (en) 2020-05-08 2023-03-15 Regeneron Pharmaceuticals, Inc. Vegf traps and mini-traps and methods for treating ocular disorders and cancer
EP4153215A1 (en) 2020-05-22 2023-03-29 Takeda Pharmaceutical Company Limited Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease
US20230020297A1 (en) * 2020-06-05 2023-01-19 Proabtech Co., Ltd. Uox-albumin conjugate with certain numbers of albumin conjugated thereto, and manufacturing method thereof
CN111808822B (zh) * 2020-07-02 2024-01-12 北京百普赛斯生物科技股份有限公司 细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
CZ280901B6 (cs) 1988-10-06 1996-05-15 Hideaki Yamada Způsob kultivace bakterií
JPH0753104B2 (ja) * 1989-02-28 1995-06-07 秀明 山田 細菌の培養法
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
EP2290053A1 (en) 1994-11-10 2011-03-02 Baxter Healthcare S.A. Method for producing Influenza virus in protein-free cell culture medium
EP0811056B1 (en) 1995-02-23 2000-05-31 Quest International B.V. Peptides for tissue and cell culture media
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
EP2243827B2 (en) 1996-08-30 2017-11-22 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
IT1285158B1 (it) * 1996-09-17 1998-06-03 Angeletti P Ist Richerche Bio Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il
AU735469B2 (en) 1996-10-07 2001-07-12 Ascend Performance Materials Llc Process for the hydroxylation of benzene
US6103529A (en) 1996-10-10 2000-08-15 Life Technologies, Inc. Animal cell culture media comprising peptides derived from rice
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6406909B1 (en) 1998-07-10 2002-06-18 Chugai Seiyaku Kabushiki Kaisha Serum-free medium for culturing animal cells
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
JP4723862B2 (ja) 2002-12-23 2011-07-13 フジフィルム マニュファクチャリング ユーロプ ビー．ブイ． 細胞培養支持体を被覆する方法
EP1737953A2 (en) * 2004-04-16 2007-01-03 Wyeth a Corporation of the State of Delaware Adamts-8 proteins and uses thereof
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
JP2007174948A (ja) * 2005-12-27 2007-07-12 Noritsu Koki Co Ltd 酵素水製造装置
JP4880997B2 (ja) * 2005-12-28 2012-02-22 アルフレッサファーマ株式会社 Ａｄａｍｔｓ１３の安定化方法
EP3653699A1 (en) * 2006-01-04 2020-05-20 Baxalta Incorporated Oligopeptide-free cell culture media
WO2008077217A2 (en) * 2006-12-22 2008-07-03 Springer Carrier Ltda. Fresh air command lever for an air conditioning unit
US20090067805A1 (en) 2007-09-10 2009-03-12 Victor Company Of Japan, Limited Recording and reproducing device
US9359629B2 (en) 2007-12-27 2016-06-07 Baxalta Incorporated Cell culture processes
CA2769361A1 (en) * 2009-07-31 2011-02-03 Baxter International Inc. Cell culture medium for adamts protein expression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PLAIMAUER et al (2002) Blood, vol. 100, pps 3626-3632 *
ZUQUELLI et al (2006) Latin American Applied Research, vol. 36, pps 321-327 *

Also Published As

Publication number Publication date
KR101808496B1 (ko) 2017-12-12
US11254921B2 (en) 2022-02-22
KR20120046301A (ko) 2012-05-09
KR20150044981A (ko) 2015-04-27
US9127265B2 (en) 2015-09-08
JP5451884B2 (ja) 2014-03-26
CA2769361A1 (en) 2011-02-03
AU2010278751A1 (en) 2012-02-09
CO6501191A2 (es) 2012-08-15
PL2459702T3 (pl) 2016-12-30
JP6567707B2 (ja) 2019-08-28
EA023193B1 (ru) 2016-05-31
CN104962539B (zh) 2019-09-17
CN104962539A (zh) 2015-10-07
HRP20160783T1 (hr) 2016-08-12
JP6883071B2 (ja) 2021-06-09
WO2011014838A1 (en) 2011-02-03
PT2459702T (pt) 2016-08-02
IN2012DN00801A (enEXAMPLES) 2015-06-26
KR101573972B1 (ko) 2015-12-02
CN102549145B (zh) 2015-05-20
JP2014061005A (ja) 2014-04-10
US20110086413A1 (en) 2011-04-14
KR20150138425A (ko) 2015-12-09
US20170051270A1 (en) 2017-02-23
US10072254B2 (en) 2018-09-11
JP2019201661A (ja) 2019-11-28
HK1171790A1 (zh) 2013-04-05
ES2583258T3 (es) 2016-09-20
KR101912552B1 (ko) 2018-10-26
JP5936232B2 (ja) 2016-06-22
MX2012001261A (es) 2012-05-22
EP2459702A1 (en) 2012-06-06
MX344970B (es) 2017-01-12
US20130071906A1 (en) 2013-03-21
SG178194A1 (en) 2012-03-29
JP2018093881A (ja) 2018-06-21
EA201270224A1 (ru) 2012-09-28
JP6511007B2 (ja) 2019-05-08
BR112012002151A2 (pt) 2020-03-03
CN102549145A (zh) 2012-07-04
SI2459702T1 (sl) 2016-11-30
US10724024B2 (en) 2020-07-28
US20190071660A1 (en) 2019-03-07
US20200308566A1 (en) 2020-10-01
JP2021112210A (ja) 2021-08-05
KR101574056B1 (ko) 2015-12-02
KR20170140411A (ko) 2017-12-20
KR20170081747A (ko) 2017-07-12
HUE029110T2 (en) 2017-02-28
EP2459702B1 (en) 2016-05-04
US20150329848A1 (en) 2015-11-19
US8759026B2 (en) 2014-06-24
BR122021005965B1 (pt) 2022-01-25
BR112012002151B1 (pt) 2021-07-06
JP2016144471A (ja) 2016-08-12
JP2013500724A (ja) 2013-01-10
US9441216B2 (en) 2016-09-13
JP7083059B2 (ja) 2022-06-09
KR101756354B1 (ko) 2017-07-26
NZ597727A (en) 2013-08-30
US8313926B2 (en) 2012-11-20
US20140329294A1 (en) 2014-11-06

Similar Documents

Publication Publication Date Title
US11254921B2 (en) ADAMTS13 protein cell culture supernatant
AU2017261523B2 (en) Cell culture medium for adamts protein expression
AU2019279943B2 (en) Cell culture medium for adamts protein expression
HK1171790B (en) Cell culture medium for adamts protein expression

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: BAXALTA GMBH; BAXALTA INCORPORATED

Free format text: FORMER OWNER WAS: BAXTER HEALTHCARE S.A.; BAXTER INTERNATIONAL INC.

PC Assignment registered

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Free format text: FORMER OWNER(S): BAXALTA INCORPORATED; BAXALTA GMBH