IL97867A - Process for making indolones and intermediates used in it - Google Patents
Process for making indolones and intermediates used in itInfo
- Publication number
- IL97867A IL97867A IL9786791A IL9786791A IL97867A IL 97867 A IL97867 A IL 97867A IL 9786791 A IL9786791 A IL 9786791A IL 9786791 A IL9786791 A IL 9786791A IL 97867 A IL97867 A IL 97867A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- water
- equiv
- compound
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/40—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups and esterified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11102991A IL111029A (en) | 1990-04-17 | 1991-04-16 | Esters of 4-hydroxyalkyl-indoline-2-helium |
IL11102891A IL111028A (en) | 1990-04-17 | 1991-04-16 | 4-Hydroxyalkyl- Indole-2-Onim |
IL11103091A IL111030A (en) | 1990-04-17 | 1991-04-16 | Phenyl-alkyl alcohol esters are converted to position 2 |
IL11102994A IL111029A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
IL11102894A IL111028A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
IL11103094A IL111030A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909008605A GB9008605D0 (en) | 1990-04-17 | 1990-04-17 | Process |
Publications (2)
Publication Number | Publication Date |
---|---|
IL97867A0 IL97867A0 (en) | 1992-06-21 |
IL97867A true IL97867A (en) | 1995-11-27 |
Family
ID=10674534
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11103091A IL111030A (en) | 1990-04-17 | 1991-04-16 | Phenyl-alkyl alcohol esters are converted to position 2 |
IL11102991A IL111029A (en) | 1990-04-17 | 1991-04-16 | Esters of 4-hydroxyalkyl-indoline-2-helium |
IL11102891A IL111028A (en) | 1990-04-17 | 1991-04-16 | 4-Hydroxyalkyl- Indole-2-Onim |
IL9786791A IL97867A (en) | 1990-04-17 | 1991-04-16 | Process for making indolones and intermediates used in it |
IL11102894A IL111028A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
IL11102994A IL111029A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
IL11103094A IL111030A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11103091A IL111030A (en) | 1990-04-17 | 1991-04-16 | Phenyl-alkyl alcohol esters are converted to position 2 |
IL11102991A IL111029A (en) | 1990-04-17 | 1991-04-16 | Esters of 4-hydroxyalkyl-indoline-2-helium |
IL11102891A IL111028A (en) | 1990-04-17 | 1991-04-16 | 4-Hydroxyalkyl- Indole-2-Onim |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11102894A IL111028A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
IL11102994A IL111029A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
IL11103094A IL111030A0 (en) | 1990-04-17 | 1994-09-22 | Intermediates to indolones |
Country Status (29)
Country | Link |
---|---|
US (1) | US5336781A (fr) |
EP (1) | EP0526529B1 (fr) |
JP (2) | JP2788548B2 (fr) |
KR (1) | KR0180215B1 (fr) |
CN (1) | CN1027892C (fr) |
AP (1) | AP184A (fr) |
AT (1) | ATE144251T1 (fr) |
AU (2) | AU640006B2 (fr) |
CA (1) | CA2080221C (fr) |
CY (1) | CY1981A (fr) |
DE (1) | DE69122753T2 (fr) |
DK (1) | DK0526529T3 (fr) |
ES (1) | ES2094812T3 (fr) |
FI (1) | FI101148B (fr) |
GB (1) | GB9008605D0 (fr) |
GR (1) | GR3022261T3 (fr) |
HK (1) | HK3097A (fr) |
HU (1) | HU214822B (fr) |
IE (1) | IE911262A1 (fr) |
IL (7) | IL111030A (fr) |
MA (1) | MA22133A1 (fr) |
MY (1) | MY109628A (fr) |
NO (2) | NO178396C (fr) |
NZ (1) | NZ237819A (fr) |
PL (1) | PL166736B1 (fr) |
PT (1) | PT97375B (fr) |
SA (1) | SA91110352B1 (fr) |
WO (1) | WO1991016306A1 (fr) |
ZA (1) | ZA912782B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
DE69131775T2 (de) * | 1990-09-28 | 2000-04-20 | Smithkline Beecham Corp. | Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin |
GB9300309D0 (en) * | 1993-01-08 | 1993-03-03 | Smithkline Beecham Plc | Process |
US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
WO2005074387A2 (fr) * | 2003-12-30 | 2005-08-18 | Sun Pharmaceutical Industries Limited | Nouvelles formes cristallines d'hydrochlorure de 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone |
US7378439B2 (en) * | 2004-01-20 | 2008-05-27 | Usv, Ltd. | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride |
WO2005105741A1 (fr) * | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Hydrochlorure de 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone sensiblement pur |
WO2005080333A1 (fr) * | 2004-02-19 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Processus de purification de ropinirole |
US20070254941A1 (en) * | 2006-04-21 | 2007-11-01 | Glenmark Pharmaceuticals Limited | Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation |
CN103130704B (zh) * | 2013-03-11 | 2019-03-22 | 上海奥博生物医药技术有限公司 | 一种制备4-(2-羟乙基)-1,3-二氢-2h-吲哚-2-酮的新方法 |
CN103145604A (zh) * | 2013-03-19 | 2013-06-12 | 上海奥博生物医药技术有限公司 | 一种制备罗匹尼罗关键中间体的方法 |
CN105418482A (zh) * | 2015-11-23 | 2016-03-23 | 东南大学 | 一种改进的盐酸罗匹尼罗的制备方法 |
CN108440376B (zh) * | 2018-05-08 | 2020-06-05 | 中国科学院成都生物研究所 | 一种盐酸罗匹尼罗的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1154976A (en) * | 1967-02-21 | 1969-06-11 | Pfizer Ltd | N-Phenyl Indoline Derivatives |
JPS53101333A (en) * | 1977-02-14 | 1978-09-04 | Sagami Chem Res Center | 3-acyloxymethyl-3,4:5,6-diepoxycyclohexane-1,2-diol and |
IT1171624B (it) * | 1980-11-12 | 1987-06-10 | Thomae Gmbh Dr K | Indolinoni dotati di proprieta' farmaceutiche e procedimento per la loro produzione |
US4588790A (en) * | 1982-03-24 | 1986-05-13 | Union Carbide Corporation | Method for fluidized bed polymerization |
US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
US4593033A (en) * | 1985-04-24 | 1986-06-03 | Merck & Co., Inc. | Substituted indeno[2,1-c] pyridines useful as calcium channel blockers |
GB8712073D0 (en) * | 1987-05-21 | 1987-06-24 | Smith Kline French Lab | Medicament |
GB8714371D0 (en) * | 1987-06-19 | 1987-07-22 | Smith Kline French Lab | Process |
FR2635104B1 (fr) * | 1988-08-03 | 1992-04-30 | Synthelabo | Derives d'indolone, leur preparation et leur application en therapeutique |
GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
-
1990
- 1990-04-17 GB GB909008605A patent/GB9008605D0/en active Pending
-
1991
- 1991-04-09 MY MYPI91000591A patent/MY109628A/en unknown
- 1991-04-15 KR KR1019920702578A patent/KR0180215B1/ko not_active IP Right Cessation
- 1991-04-15 DK DK91908508.4T patent/DK0526529T3/da active
- 1991-04-15 AU AU76562/91A patent/AU640006B2/en not_active Expired
- 1991-04-15 ES ES91908508T patent/ES2094812T3/es not_active Expired - Lifetime
- 1991-04-15 AT AT91908508T patent/ATE144251T1/de not_active IP Right Cessation
- 1991-04-15 NZ NZ237819A patent/NZ237819A/xx unknown
- 1991-04-15 DE DE69122753T patent/DE69122753T2/de not_active Expired - Lifetime
- 1991-04-15 PL PL91296387A patent/PL166736B1/pl unknown
- 1991-04-15 US US07/934,492 patent/US5336781A/en not_active Expired - Lifetime
- 1991-04-15 EP EP91908508A patent/EP0526529B1/fr not_active Expired - Lifetime
- 1991-04-15 MA MA22402A patent/MA22133A1/fr unknown
- 1991-04-15 JP JP3507509A patent/JP2788548B2/ja not_active Expired - Lifetime
- 1991-04-15 CA CA002080221A patent/CA2080221C/fr not_active Expired - Lifetime
- 1991-04-15 ZA ZA912782A patent/ZA912782B/xx unknown
- 1991-04-15 WO PCT/GB1991/000587 patent/WO1991016306A1/fr active IP Right Grant
- 1991-04-15 HU HU9203261A patent/HU214822B/hu unknown
- 1991-04-16 IL IL11103091A patent/IL111030A/en not_active IP Right Cessation
- 1991-04-16 IL IL11102991A patent/IL111029A/en not_active IP Right Cessation
- 1991-04-16 IL IL11102891A patent/IL111028A/en not_active IP Right Cessation
- 1991-04-16 IL IL9786791A patent/IL97867A/en not_active IP Right Cessation
- 1991-04-16 CN CN91102564A patent/CN1027892C/zh not_active Expired - Lifetime
- 1991-04-16 PT PT97375A patent/PT97375B/pt not_active IP Right Cessation
- 1991-04-16 IE IE126291A patent/IE911262A1/en not_active IP Right Cessation
- 1991-04-16 AP APAP/P/1991/000251A patent/AP184A/en active
- 1991-05-13 SA SA91110352A patent/SA91110352B1/ar unknown
-
1992
- 1992-10-15 FI FI924674A patent/FI101148B/fi active
- 1992-10-16 NO NO924028A patent/NO178396C/no not_active IP Right Cessation
-
1993
- 1993-04-01 AU AU35669/93A patent/AU646771B2/en not_active Expired
-
1994
- 1994-09-22 IL IL11102894A patent/IL111028A0/xx unknown
- 1994-09-22 IL IL11102994A patent/IL111029A0/xx unknown
- 1994-09-22 IL IL11103094A patent/IL111030A0/xx unknown
-
1997
- 1997-01-02 HK HK3097A patent/HK3097A/xx not_active IP Right Cessation
- 1997-01-09 GR GR970400030T patent/GR3022261T3/el unknown
- 1997-09-05 CY CY198197A patent/CY1981A/xx unknown
-
1998
- 1998-02-19 JP JP10037427A patent/JP3044013B2/ja not_active Expired - Lifetime
-
1999
- 1999-06-18 NO NO1999012C patent/NO1999012I1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |