IL95668A - History of bile walls, processes for their preparation and use as pharmaceuticals - Google Patents

History of bile walls, processes for their preparation and use as pharmaceuticals

Info

Publication number
IL95668A
IL95668A IL9566890A IL9566890A IL95668A IL 95668 A IL95668 A IL 95668A IL 9566890 A IL9566890 A IL 9566890A IL 9566890 A IL9566890 A IL 9566890A IL 95668 A IL95668 A IL 95668A
Authority
IL
Israel
Prior art keywords
alkyl
mmol
solution
trisubstituted
mol
Prior art date
Application number
IL9566890A
Other languages
English (en)
Hebrew (he)
Other versions
IL95668A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL95668A0 publication Critical patent/IL95668A0/xx
Publication of IL95668A publication Critical patent/IL95668A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
  • Control Of Heat Treatment Processes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
IL9566890A 1989-09-14 1990-09-12 History of bile walls, processes for their preparation and use as pharmaceuticals IL95668A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3930696A DE3930696A1 (de) 1989-09-14 1989-09-14 Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
IL95668A0 IL95668A0 (en) 1991-06-30
IL95668A true IL95668A (en) 1995-03-30

Family

ID=6389405

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9566890A IL95668A (en) 1989-09-14 1990-09-12 History of bile walls, processes for their preparation and use as pharmaceuticals

Country Status (21)

Country Link
US (3) US5462933A (ja)
EP (1) EP0417725B1 (ja)
JP (3) JP2568306B2 (ja)
KR (1) KR0166962B1 (ja)
AT (1) ATE152117T1 (ja)
AU (1) AU637822B2 (ja)
CA (1) CA2025294C (ja)
CY (1) CY2112B1 (ja)
DE (2) DE3930696A1 (ja)
DK (1) DK0417725T3 (ja)
ES (1) ES2100858T3 (ja)
FI (1) FI105155B (ja)
GR (1) GR3024095T3 (ja)
HU (1) HU213395B (ja)
IE (1) IE903329A1 (ja)
IL (1) IL95668A (ja)
NO (1) NO303450B1 (ja)
NZ (1) NZ235285A (ja)
PT (1) PT95299B (ja)
TW (1) TW199097B (ja)
ZA (1) ZA907300B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU742944B2 (en) * 1998-04-08 2002-01-17 Galmed Research And Development Ltd. Fatty acid derivatives of bile acids and bile acid derivatives

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
EP0540670B1 (en) * 1990-07-26 1996-03-20 Monsanto Company Method for preparation of crosslinked polyamines
US5693769A (en) * 1991-12-13 1997-12-02 Transcell Technologies, Inc. Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
US5338837A (en) * 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
US5795870A (en) * 1991-12-13 1998-08-18 Trustees Of Princeton University Compositions and methods for cell transformation
EP0548793A3 (en) * 1991-12-20 1995-11-02 Hoechst Ag Ethylenic-unsaturated bile acid derivatives, process for their production and preliminary processes therefor
FI108451B (fi) * 1991-12-20 2002-01-31 Hoechst Ag Menetelmõ polymeeristen ja oligomeeristen sappihappojohdannaisten valmistamiseksi
IL108748A0 (en) * 1993-02-23 1994-08-26 Univ Princeton Solution and solid-phase formation of glycosidic linkages
US5639866A (en) * 1993-02-23 1997-06-17 Princeton University Single-step formation of multiple glycosidic linkages
TW289757B (ja) * 1993-05-08 1996-11-01 Hoechst Ag
TW289020B (ja) * 1993-05-08 1996-10-21 Hoechst Sktiengesellschaft
TW289021B (ja) * 1993-05-08 1996-10-21 Hoechst Ag
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US5585470A (en) * 1994-06-23 1996-12-17 Transcell Technologies, Inc. Process for the manufacture of 3-amino-substituted glycosylated bile acids
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
DE4432708A1 (de) * 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
IL142650A (en) * 1998-04-08 2007-06-03 Galmed Int Ltd Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
IL139241A0 (en) * 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
EA200100707A1 (ru) 1998-12-23 2001-12-24 Джи.Ди.Сирл Ллс Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и производных фибриновой кислоты для сердечно-сосудистых показаний
WO2000038723A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
CN1342089A (zh) 1998-12-23 2002-03-27 G.D.瑟尔有限公司 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆固醇酯转移蛋白抑制剂的组合
BR9916484A (pt) 1998-12-23 2002-01-22 Searle Llc Combinações de inibidores do transporte de ácido biliar ileal e de agentes sequestrantes de ácido biliar em indicações cardiovasculares
EP1340509A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
DE69908643T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
GB9907048D0 (en) * 1999-03-27 1999-05-19 Karobio Ab Novel glucocorticoid receptor ligands for the treatment of meta bolic disorders
GB2355009A (en) * 1999-07-30 2001-04-11 Univ Glasgow Peptides conjugated to bile acids/salts
DE60034954D1 (de) 1999-09-14 2007-07-05 Xenoport Inc Substrate und screeningverfahren für transportproteine
DE19950686B4 (de) * 1999-10-21 2006-06-29 Martin-Luther-Universität Halle-Wittenberg Multifunktionelle Spacer
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
AU2002230398A1 (en) * 2000-10-06 2002-04-29 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
US6992076B2 (en) * 2000-10-06 2006-01-31 Xenoport, Inc. Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
WO2002028411A1 (en) * 2000-10-06 2002-04-11 Xenoport, Inc. Compounds for sustained release of orally delivered drugs
US8975246B2 (en) 2001-04-17 2015-03-10 Galmed Research And Development Ltd. Bile acid or bile salt fatty acid conjugates
US7053076B2 (en) * 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
JP2005518347A (ja) 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
EP1551860B1 (en) * 2002-06-19 2006-11-22 Karo Bio Ab Glucocorticoid receptor ligands for the treatment of metabolic disorders
US7141559B2 (en) 2002-06-19 2006-11-28 Karo Bio Ab Glucocorticoid receptor ligands for the treatment of metabolic disorders
US7101912B2 (en) 2002-12-06 2006-09-05 Xenoport, Inc. Carbidopa prodrugs and derivatives, and compositions and uses thereof
JP4610345B2 (ja) * 2003-01-13 2011-01-12 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 医薬品化合物のための改善されたリンカー
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
US7205415B2 (en) * 2004-01-02 2007-04-17 Hetero Drugs, Ltd. Process for the preparation of simvastatin
US20080317767A1 (en) * 2004-04-08 2008-12-25 Tobias Braxmeier Tripartitle Raftophilic Strutures and their Use
JP4896870B2 (ja) * 2004-04-08 2012-03-14 ヤード・テヒノロギース・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 細胞膜ラフトと相互作用する構造を含む三者複合体およびその使用
WO2005113008A1 (en) * 2004-05-21 2005-12-01 Mediplex Corp. Delivery agents for enhancing mucosal absorption of therapeutic agents
ZA200610042B (en) * 2004-06-04 2008-06-25 Xenoport Inc Levodopa prodrugs, and compositions and uses thereof
US20060003976A1 (en) * 2004-06-04 2006-01-05 Yuehua Zhang Cholesterol/bile acid/bile acid derivative-modified therapeutic drug compounds
US7323585B2 (en) * 2004-06-04 2008-01-29 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
BRPI0619425A2 (pt) * 2005-12-05 2011-10-04 Xenoport Inc mesilato de pró-fármaco de levedopa, composição farmacêutica, método de preparar (2s)-2- amino-3-(3,4-diidróxi fenil) propanoato de mesilato de (2r)-2- fenil carbonilóxi propila e uso do referido composto
WO2008076458A1 (en) 2006-12-21 2008-06-26 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use
US7829592B2 (en) * 2006-12-21 2010-11-09 Xenoport, Inc. Catechol protected levodopa diester prodrugs, compositions, and methods of use
CN101367859B (zh) * 2007-08-17 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸胆汁酸偶合物及其医药用途
KR101239008B1 (ko) * 2008-03-31 2013-03-04 한양대학교 산학협력단 바일산 유도체 및 그의 응용
MX2011000847A (es) * 2008-08-06 2011-02-25 Novo Nordisk Healthcare Ag Proteinas conjugadas con eficacia prolongada in vivo.
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
CA2740017A1 (en) * 2008-10-20 2010-04-29 Xenoport, Inc. Methods of synthesizing a levodopa ester prodrug
AU2010207725B2 (en) 2009-01-22 2015-06-11 Novo Nordisk Health Care Ag Stable growth hormone compounds
CN102612376A (zh) 2009-08-06 2012-07-25 诺沃-诺迪斯克保健股份有限公司 具有延长的体内功效的生长激素
US8435562B2 (en) 2009-11-09 2013-05-07 Xenoport, Inc. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
CN103002918B (zh) 2010-01-22 2016-05-04 诺沃—诺迪斯克保健股份有限公司 体内功效延长的生长激素
MX338357B (es) 2010-01-22 2016-04-13 Novo Nordisk Healthcare Ag Compuestos estables de la hormona de crecimiento.
EP3593802A3 (en) 2010-05-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
EA201891154A1 (ru) 2011-10-28 2019-02-28 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей
SG11201401816SA (en) 2011-10-28 2014-05-29 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
MX2015013196A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett.
KR20160002773A (ko) 2013-03-15 2016-01-08 루메나 파마수티컬즈, 인코포레이티드 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제
WO2014166836A1 (en) 2013-04-05 2014-10-16 Novo Nordisk A/S Growth hormone compound formulation
CN104693264B (zh) * 2015-02-09 2016-09-21 华南理工大学 一种化合物及其制备方法和应用
CN106046101B (zh) * 2016-05-25 2018-01-05 华南理工大学 一种糖原磷酸化酶抑制剂及其制备方法和应用
JP7036805B2 (ja) 2016-05-29 2022-03-15 深▲じぇん▼市▲絵▼云生物科技有限公司 肝疾患関連バイオマーカーおよびその使用方法
CN106496300B (zh) * 2016-10-19 2018-05-18 上海博志研新药物技术有限公司 花生胆酸及其中间体的制备方法
BR112021015809A2 (pt) 2019-02-12 2022-01-18 Mirum Pharmaceuticals Inc Resposta dependente de genótipo e dose a um asbti em pacientes com deficiência de bomba de exportação de sal biliar
WO2023105494A1 (en) 2021-12-10 2023-06-15 Universidade Do Porto Cationic steroid compounds, method of obtaining thereof, formulations comprising thereof and their uses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441129A (en) * 1942-05-23 1948-05-11 Berczeller Arpad Bile acid derivatives of aryl sulfonamides
US3937815A (en) * 1975-12-05 1976-02-10 SPA--Societa Prodotti Antibiotici S.p.A. Lysozyme derivatives
FR2457302A1 (fr) * 1979-05-23 1980-12-19 Roussel Uclaf Nouveau procede de purification de l'acide ursodesoxycholique
JPS5754151A (en) * 1980-09-18 1982-03-31 Takeda Chem Ind Ltd Physiologically active substance b-52653 and its preparation
JPS57131735A (en) * 1981-02-09 1982-08-14 Takeda Chem Ind Ltd Preparation of quinones
US4418059A (en) * 1981-07-20 1983-11-29 Montefiore Medical Center Nucleoside ester compositions
US4499020A (en) * 1981-07-21 1985-02-12 Montefiore Hospital And Medical Center, Inc. Mixed anhydrides and processes thereof
FR2511007A1 (fr) * 1981-08-07 1983-02-11 Roussel Uclaf Procede de preparation de l'acide ursodesoxycholique a partir de l'acide 3a, 7b, 12a-trihydroxycholanique et produit intermediaire utilises
NL8201492A (nl) * 1982-04-07 1983-11-01 Rijksuniversiteit Werkwijze ter bereiding van een op de 4-plaats equatoriaal gesubstitueerde symmetrisch-polycycloethyleenverbinding; op de 4-plaats equatoriaal gesubstitueerde symmetrisch-polycycloethyleenverbinding alsmede een op basis van de verbinding bereid thermochemiluminescerend merkmateriaal of thermochemiluminescerend sondeermateriaal.
EP0105404A1 (en) * 1982-09-30 1984-04-18 Merck & Co. Inc. Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
JPS62175497A (ja) * 1986-01-28 1987-08-01 Wakunaga Pharmaceut Co Ltd 胆汁酸誘導体およびその製造法
US5238948A (en) * 1987-02-10 1993-08-24 Hoechst Aktiengesellschaft Pyridine-2,4- and -2,5-dicarboxylic acid derivatives and medicaments based on these compounds
ATE132496T1 (de) * 1987-07-10 1996-01-15 Hoechst Ag 3-desmethyl-mevalonsäurederivate, verfahren zu ihrer herstellung, pharmazeutische präparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte
US4968790A (en) * 1988-08-12 1990-11-06 American Cyanamid Company Antidiabetic phosphates
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
DE3931432A1 (de) * 1989-09-21 1991-04-04 Hoechst Ag Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU742944B2 (en) * 1998-04-08 2002-01-17 Galmed Research And Development Ltd. Fatty acid derivatives of bile acids and bile acid derivatives

Also Published As

Publication number Publication date
TW199097B (ja) 1993-02-01
KR0166962B1 (ko) 1999-01-15
JP2642090B2 (ja) 1997-08-20
IE903329A1 (en) 1991-04-10
ZA907300B (en) 1991-06-26
JPH0892276A (ja) 1996-04-09
FI904497A0 (fi) 1990-09-12
NO903999L (no) 1991-03-15
JPH0892277A (ja) 1996-04-09
IL95668A0 (en) 1991-06-30
FI105155B (fi) 2000-06-30
GR3024095T3 (en) 1997-10-31
CA2025294C (en) 2001-11-27
US5462933A (en) 1995-10-31
DE3930696A1 (de) 1991-03-28
CA2025294A1 (en) 1991-03-15
AU637822B2 (en) 1993-06-10
EP0417725B1 (de) 1997-04-23
US5646272A (en) 1997-07-08
ATE152117T1 (de) 1997-05-15
JP2568306B2 (ja) 1997-01-08
DK0417725T3 (da) 1997-11-03
NO303450B1 (no) 1998-07-13
CY2112B1 (en) 2002-04-26
AU6244190A (en) 1991-03-21
HU905893D0 (en) 1991-03-28
PT95299A (pt) 1991-05-22
HUT56115A (en) 1991-07-29
EP0417725A3 (en) 1992-03-18
PT95299B (pt) 1997-06-30
HU213395B (en) 1997-06-30
KR910006319A (ko) 1991-04-29
ES2100858T3 (es) 1997-07-01
US5668126A (en) 1997-09-16
NO903999D0 (no) 1990-09-13
DE59010706D1 (de) 1997-05-28
NZ235285A (en) 1993-05-26
EP0417725A2 (de) 1991-03-20
JP2642089B2 (ja) 1997-08-20
JPH03109396A (ja) 1991-05-09

Similar Documents

Publication Publication Date Title
IL95668A (en) History of bile walls, processes for their preparation and use as pharmaceuticals
KR100333149B1 (ko) 담즙산의테트라졸유도체및이를포함하는약제
US5512558A (en) Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
JP3237882B2 (ja) 胆汁酸誘導体、その製法および医薬としてのこれらの化合物の使用
KR100333151B1 (ko) 단량체성담즙산유도체
US5641767A (en) Modified bile acids process for their preparation and their use
NZ247827A (en) Bile acid derivatives with 3 or 4 steroid radicals and pharmaceutical compositions thereof
NZ260470A (en) Hypolipidemic dimeric bile acid derivatives and medicaments
EP0208446B1 (en) Fluorescent substance for use as a cell-discriminating agent
GOTO et al. Synthesis of disulfates of unconjugated and conjugated bile acids

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed