DK0417725T3 - Galdesyrederivater, fremgangsmåder til deres fremstilling samt anvendelse som lægemidler. - Google Patents
Galdesyrederivater, fremgangsmåder til deres fremstilling samt anvendelse som lægemidler.Info
- Publication number
- DK0417725T3 DK0417725T3 DK90117470.6T DK90117470T DK0417725T3 DK 0417725 T3 DK0417725 T3 DK 0417725T3 DK 90117470 T DK90117470 T DK 90117470T DK 0417725 T3 DK0417725 T3 DK 0417725T3
- Authority
- DK
- Denmark
- Prior art keywords
- bile acid
- substance
- acid residue
- acid derivatives
- absorbed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
- Control Of Heat Treatment Processes (AREA)
- Lubricants (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3930696A DE3930696A1 (de) | 1989-09-14 | 1989-09-14 | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0417725T3 true DK0417725T3 (da) | 1997-11-03 |
Family
ID=6389405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90117470.6T DK0417725T3 (da) | 1989-09-14 | 1990-09-11 | Galdesyrederivater, fremgangsmåder til deres fremstilling samt anvendelse som lægemidler. |
Country Status (21)
Country | Link |
---|---|
US (3) | US5462933A (da) |
EP (1) | EP0417725B1 (da) |
JP (3) | JP2568306B2 (da) |
KR (1) | KR0166962B1 (da) |
AT (1) | ATE152117T1 (da) |
AU (1) | AU637822B2 (da) |
CA (1) | CA2025294C (da) |
CY (1) | CY2112B1 (da) |
DE (2) | DE3930696A1 (da) |
DK (1) | DK0417725T3 (da) |
ES (1) | ES2100858T3 (da) |
FI (1) | FI105155B (da) |
GR (1) | GR3024095T3 (da) |
HU (1) | HU213395B (da) |
IE (1) | IE903329A1 (da) |
IL (1) | IL95668A (da) |
NO (1) | NO303450B1 (da) |
NZ (1) | NZ235285A (da) |
PT (1) | PT95299B (da) |
TW (1) | TW199097B (da) |
ZA (1) | ZA907300B (da) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
ES2084825T3 (es) * | 1990-07-26 | 1996-05-16 | Monsanto Co | Procedimiento de preparacion de poliamidas entrecruzadas. |
US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
US5693769A (en) * | 1991-12-13 | 1997-12-02 | Transcell Technologies, Inc. | Glycosylated steroid derivatives for transport across biological membranes and process for making and using same |
US5338837A (en) * | 1991-12-13 | 1994-08-16 | The Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making same |
AU664059B2 (en) * | 1991-12-20 | 1995-11-02 | Hoechst Aktiengesellschaft | Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors |
FI108451B (fi) * | 1991-12-20 | 2002-01-31 | Hoechst Ag | Menetelmõ polymeeristen ja oligomeeristen sappihappojohdannaisten valmistamiseksi |
IL108748A0 (en) * | 1993-02-23 | 1994-08-26 | Univ Princeton | Solution and solid-phase formation of glycosidic linkages |
US5639866A (en) * | 1993-02-23 | 1997-06-17 | Princeton University | Single-step formation of multiple glycosidic linkages |
TW289021B (da) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
TW289757B (da) * | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
TW289020B (da) * | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
IT1269839B (it) * | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
US5585470A (en) * | 1994-06-23 | 1996-12-17 | Transcell Technologies, Inc. | Process for the manufacture of 3-amino-substituted glycosylated bile acids |
US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
DE4432708A1 (de) * | 1994-09-14 | 1996-03-21 | Hoechst Ag | Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
IL123998A (en) * | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
IL142650A (en) * | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
IL139241A0 (en) * | 1998-05-13 | 2001-11-25 | Novo Nordisk As | Meiosis regulating compounds |
CZ20012342A3 (cs) | 1998-12-23 | 2001-12-12 | G. D. Searle Llc | Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny fibrové pro kardiovaskulární indikace |
IT1304501B1 (it) * | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
EP1340509A1 (en) | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
CN1338945A (zh) | 1998-12-23 | 2002-03-06 | G·D·瑟尔有限公司 | 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆汁酸螯合剂组合 |
AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
CA2356158C (en) | 1998-12-23 | 2008-09-02 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
US6569905B1 (en) | 1998-12-23 | 2003-05-27 | G.D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
HUP0201972A3 (en) | 1998-12-23 | 2005-06-28 | G D Searle Llc Chicago | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
GB9907048D0 (en) * | 1999-03-27 | 1999-05-19 | Karobio Ab | Novel glucocorticoid receptor ligands for the treatment of meta bolic disorders |
GB2355009A (en) * | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
WO2001020331A1 (en) * | 1999-09-14 | 2001-03-22 | Xenoport, Inc. | Substrates and screening methods for transport proteins |
DE19950686B4 (de) * | 1999-10-21 | 2006-06-29 | Martin-Luther-Universität Halle-Wittenberg | Multifunktionelle Spacer |
JP2003528830A (ja) | 2000-03-10 | 2003-09-30 | ファルマシア・コーポレーション | テトラヒドロベンゾチエピン類の製造方法 |
US6900192B2 (en) * | 2000-10-06 | 2005-05-31 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
EP1358200A4 (en) * | 2000-10-06 | 2005-07-20 | Xenoport Inc | COMPOUNDS DERIVED FROM GALLENIC ACID TO IMPROVE THE ORAL ABSORPTION AND SYSTEMIC BIOVERABILITY OF MEDICAMENTS |
US6992076B2 (en) * | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
US8975246B2 (en) | 2001-04-17 | 2015-03-10 | Galmed Research And Development Ltd. | Bile acid or bile salt fatty acid conjugates |
US7053076B2 (en) * | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
WO2003040127A1 (en) | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
US6852753B2 (en) | 2002-01-17 | 2005-02-08 | Pharmacia Corporation | Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
US7141559B2 (en) | 2002-06-19 | 2006-11-28 | Karo Bio Ab | Glucocorticoid receptor ligands for the treatment of metabolic disorders |
JP4611019B2 (ja) * | 2002-06-19 | 2011-01-12 | カロ バイオ エービー | 代謝異常治療のための新規な糖質コルチコイド受容体結合体 |
WO2004052841A1 (en) | 2002-12-06 | 2004-06-24 | Xenoport, Inc. | Carbidopa prodrugs and uses thereof |
AU2003303714B2 (en) * | 2003-01-13 | 2009-02-19 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
EP1699774A1 (en) * | 2004-01-02 | 2006-09-13 | Hetero Drugs Limited | A novel process for the preparation of simvastatin |
DE602005016658D1 (de) * | 2004-04-08 | 2009-10-29 | Jadolabs Gmbh | Dreigeteilte konjugate mit einer struktur, die mit zellmembran-rafts interagieren und ihre verwendung |
JP4896870B2 (ja) * | 2004-04-08 | 2012-03-14 | ヤード・テヒノロギース・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞膜ラフトと相互作用する構造を含む三者複合体およびその使用 |
WO2005113008A1 (en) * | 2004-05-21 | 2005-12-01 | Mediplex Corp. | Delivery agents for enhancing mucosal absorption of therapeutic agents |
WO2005121070A1 (en) * | 2004-06-04 | 2005-12-22 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
WO2005118612A1 (en) * | 2004-06-04 | 2005-12-15 | Sonus Pharmaceuticals, Inc. | Cholesterol/bile acid/bile acid derivative-modified therapeutic anti-cancer drugs |
WO2005121069A1 (en) * | 2004-06-04 | 2005-12-22 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
US7563821B2 (en) | 2005-12-05 | 2009-07-21 | Xenoport, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
US7709527B2 (en) * | 2006-12-21 | 2010-05-04 | Xenoport, Inc. | Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use |
WO2008079387A1 (en) * | 2006-12-21 | 2008-07-03 | Xenoport, Inc. | Catechol protected levodopa diester prodrugs, compositions, and methods of use |
CN101367859B (zh) * | 2007-08-17 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 脂肪酸胆汁酸偶合物及其医药用途 |
KR101239008B1 (ko) * | 2008-03-31 | 2013-03-04 | 한양대학교 산학협력단 | 바일산 유도체 및 그의 응용 |
US8865868B2 (en) * | 2008-08-06 | 2014-10-21 | Novo Nordisk Healthcare Ag | Conjugated proteins with prolonged in vivo efficacy |
US8399513B2 (en) * | 2008-10-20 | 2013-03-19 | Xenoport, Inc. | Levodopa prodrug mesylate hydrate |
CN102186804A (zh) * | 2008-10-20 | 2011-09-14 | 克塞诺波特公司 | 合成左旋多巴酯前药的方法 |
RU2539797C2 (ru) | 2009-01-22 | 2015-01-27 | Ново Нордиск Хелс Кеа Аг | Производное гормона роста человека с повышенной стабильностью к протеолитическому разрушению, способ получения такого производного, его применение, способ лечения и фармацевтическая композиция |
EP2461831B1 (en) | 2009-08-06 | 2018-11-21 | Novo Nordisk Health Care AG | Growth hormones with prolonged in-vivo efficacy |
WO2011056240A2 (en) | 2009-11-09 | 2011-05-12 | Xenoport, Inc. | Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use |
US9211342B2 (en) | 2010-01-22 | 2015-12-15 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds resistant to proteolytic degradation |
US9695226B2 (en) | 2010-01-22 | 2017-07-04 | Novo Nordisk Healthcare Ag | Growth hormones with prolonged in-vivo efficacy |
WO2011150286A2 (en) | 2010-05-26 | 2011-12-01 | Satiogen Pharmaceuticals,Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
AU2012328453B2 (en) | 2011-10-28 | 2017-05-04 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
CN104023727B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
US20140275090A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
CN105228615A (zh) | 2013-03-15 | 2016-01-06 | 鲁美纳医药公司 | 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂 |
US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
CN104693264B (zh) * | 2015-02-09 | 2016-09-21 | 华南理工大学 | 一种化合物及其制备方法和应用 |
CN106046101B (zh) * | 2016-05-25 | 2018-01-05 | 华南理工大学 | 一种糖原磷酸化酶抑制剂及其制备方法和应用 |
CN106496300B (zh) * | 2016-10-19 | 2018-05-18 | 上海博志研新药物技术有限公司 | 花生胆酸及其中间体的制备方法 |
WO2020167958A1 (en) | 2019-02-12 | 2020-08-20 | Mirum Pharmaceuticals, Inc. | Methods for treating cholestasis |
WO2023105494A1 (en) | 2021-12-10 | 2023-06-15 | Universidade Do Porto | Cationic steroid compounds, method of obtaining thereof, formulations comprising thereof and their uses |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2441129A (en) * | 1942-05-23 | 1948-05-11 | Berczeller Arpad | Bile acid derivatives of aryl sulfonamides |
US3937815A (en) * | 1975-12-05 | 1976-02-10 | SPA--Societa Prodotti Antibiotici S.p.A. | Lysozyme derivatives |
FR2457302A1 (fr) * | 1979-05-23 | 1980-12-19 | Roussel Uclaf | Nouveau procede de purification de l'acide ursodesoxycholique |
JPS5754151A (en) * | 1980-09-18 | 1982-03-31 | Takeda Chem Ind Ltd | Physiologically active substance b-52653 and its preparation |
JPS57131735A (en) * | 1981-02-09 | 1982-08-14 | Takeda Chem Ind Ltd | Preparation of quinones |
US4418059A (en) * | 1981-07-20 | 1983-11-29 | Montefiore Medical Center | Nucleoside ester compositions |
US4499020A (en) * | 1981-07-21 | 1985-02-12 | Montefiore Hospital And Medical Center, Inc. | Mixed anhydrides and processes thereof |
FR2511007A1 (fr) * | 1981-08-07 | 1983-02-11 | Roussel Uclaf | Procede de preparation de l'acide ursodesoxycholique a partir de l'acide 3a, 7b, 12a-trihydroxycholanique et produit intermediaire utilises |
NL8201492A (nl) * | 1982-04-07 | 1983-11-01 | Rijksuniversiteit | Werkwijze ter bereiding van een op de 4-plaats equatoriaal gesubstitueerde symmetrisch-polycycloethyleenverbinding; op de 4-plaats equatoriaal gesubstitueerde symmetrisch-polycycloethyleenverbinding alsmede een op basis van de verbinding bereid thermochemiluminescerend merkmateriaal of thermochemiluminescerend sondeermateriaal. |
EP0105404A1 (en) * | 1982-09-30 | 1984-04-18 | Merck & Co. Inc. | Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation |
DE3432094A1 (de) * | 1984-08-31 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase |
JPS62175497A (ja) * | 1986-01-28 | 1987-08-01 | Wakunaga Pharmaceut Co Ltd | 胆汁酸誘導体およびその製造法 |
US5238948A (en) * | 1987-02-10 | 1993-08-24 | Hoechst Aktiengesellschaft | Pyridine-2,4- and -2,5-dicarboxylic acid derivatives and medicaments based on these compounds |
EP0307342B1 (de) * | 1987-07-10 | 1996-01-03 | Hoechst Aktiengesellschaft | 3-Desmethyl-mevalonsäurederivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen, ihre Verwendung sowie Zwischenprodukte |
US4968790A (en) * | 1988-08-12 | 1990-11-06 | American Cyanamid Company | Antidiabetic phosphates |
DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
DE3931432A1 (de) * | 1989-09-21 | 1991-04-04 | Hoechst Ag | Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
-
1989
- 1989-09-14 DE DE3930696A patent/DE3930696A1/de not_active Withdrawn
-
1990
- 1990-09-11 EP EP90117470A patent/EP0417725B1/de not_active Expired - Lifetime
- 1990-09-11 ES ES90117470T patent/ES2100858T3/es not_active Expired - Lifetime
- 1990-09-11 AT AT90117470T patent/ATE152117T1/de not_active IP Right Cessation
- 1990-09-11 DK DK90117470.6T patent/DK0417725T3/da active
- 1990-09-11 DE DE59010706T patent/DE59010706D1/de not_active Expired - Lifetime
- 1990-09-12 IL IL9566890A patent/IL95668A/en unknown
- 1990-09-12 NZ NZ235285A patent/NZ235285A/xx unknown
- 1990-09-12 FI FI904497A patent/FI105155B/fi active IP Right Grant
- 1990-09-13 ZA ZA907300A patent/ZA907300B/xx unknown
- 1990-09-13 PT PT95299A patent/PT95299B/pt not_active IP Right Cessation
- 1990-09-13 HU HU905893A patent/HU213395B/hu unknown
- 1990-09-13 AU AU62441/90A patent/AU637822B2/en not_active Expired
- 1990-09-13 CA CA002025294A patent/CA2025294C/en not_active Expired - Lifetime
- 1990-09-13 IE IE332990A patent/IE903329A1/en not_active IP Right Cessation
- 1990-09-13 JP JP2241338A patent/JP2568306B2/ja not_active Expired - Lifetime
- 1990-09-13 NO NO903999A patent/NO303450B1/no not_active IP Right Cessation
- 1990-09-14 TW TW079107732A patent/TW199097B/zh active
- 1990-09-14 KR KR1019900014542A patent/KR0166962B1/ko not_active IP Right Cessation
-
1994
- 1994-03-10 US US08/208,192 patent/US5462933A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/476,941 patent/US5646272A/en not_active Expired - Lifetime
- 1995-06-07 US US08/475,689 patent/US5668126A/en not_active Expired - Lifetime
- 1995-09-07 JP JP7254512A patent/JP2642090B2/ja not_active Expired - Lifetime
- 1995-09-07 JP JP7254511A patent/JP2642089B2/ja not_active Expired - Lifetime
-
1997
- 1997-07-15 GR GR970401746T patent/GR3024095T3/el unknown
-
1998
- 1998-09-29 CY CY9800029A patent/CY2112B1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0417725T3 (da) | Galdesyrederivater, fremgangsmåder til deres fremstilling samt anvendelse som lægemidler. | |
Conway et al. | Absorption and Elimination Profile of Isoproterenol III: The Metabolic Fate of dl-Isoproterenol-7-3H in the Dog | |
DE3887618D1 (de) | Polyschwefelsäureester von Bis-aldonsäureamiden und deren Derivaten, Verfahren zu ihrer Herstellung und Arzneimittel. | |
DE69630918D1 (de) | Matrix für Iontophorese | |
ZA919605B (en) | Bille acid derivatives,process for their preparation and use of these compounds as pharmaceuticals | |
DK280884D0 (da) | Galeniske praeparatformer for orale antidiabetica og fremgangsmaade til deres fremstilling | |
PT91108A (pt) | Processo para a preparacao de uma composicao farmaceutica que compreende um ingrediente activo tal como um sal do acido colico e um produto inibidor para activar a absorcao do ingrediente activo pelo corpo humano | |
ATE10626T1 (de) | N-substituierte omega-(2-oxo-imidazolin-1-yl)alkans[uren, deren salze und ester, verfahren zu deren herstellung und diese aktiven substanzen enthaltende pharmazeutische zubereitungen. | |
DE69005398D1 (de) | Topisch kosmetisch anzuwendende depolymerisierte Nukleinsäuren enthaltende Arzneizubereitungen. | |
ATE59554T1 (de) | Auf mercaptoethansulfonsaeuren basierende pharmazeutische zusammensetzungen, organische abkoemmlinge von mercaptoethansulfonsaeuren sowie verfahren zu deren herstellung. | |
ATE111525T1 (de) | Plasminogenaktivator-varianten und verfahren zu ihrer herstellung. | |
FI95569C (fi) | Menetelmä uusien orgaanisten nitraattien valmistamiseksi | |
Stimler-Gerard | Immunopharmacology of anaphylatoxin-induced bronchoconstrictor responses | |
KR900701278A (ko) | 바이러스 감염 치료용 담즙산 | |
IE50550B1 (en) | Pharmaceutical compositions of therapeutic value in the treatment of acute pulmonary edema,some shock conditions and hyperfibrinolysis | |
DE3884508D1 (de) | Cystein-derivate mit expectorans-wirkung. | |
CN1048157C (zh) | 核糖核酸与肝素复方注射剂 | |
DE3579074D1 (de) | Verminderung der toxischen wirkungen von anthrachinon-medikamenten. | |
JPS5772950A (en) | Tetrapeptide derivative, its preparation and analgesic agent | |
ATE53384T1 (de) | 3-mercapto-2-oxo-1-pyrrolidinessigsaeurederivate verfahren zur herstellung und pharmazeutische zusammensetzungen die sie enthalten. | |
JPS51123834A (en) | A medicine against the headache | |
IT1226144B (it) | Di estere fosforico dell'acido ursodeossicolico e suoi derivati, processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi. | |
TH13627EX (th) | อนุพันธ์ของเบนโซฟิวแรพและสารผสมทางเภสัชกรรม | |
TH14574A (th) | สารผสมทางเภสัชกรรม |