CN101367859B - 脂肪酸胆汁酸偶合物及其医药用途 - Google Patents
脂肪酸胆汁酸偶合物及其医药用途 Download PDFInfo
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- CN101367859B CN101367859B CN2007101436855A CN200710143685A CN101367859B CN 101367859 B CN101367859 B CN 101367859B CN 2007101436855 A CN2007101436855 A CN 2007101436855A CN 200710143685 A CN200710143685 A CN 200710143685A CN 101367859 B CN101367859 B CN 101367859B
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- Prior art keywords
- acid
- lysine
- compound
- bile
- cholyl
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- 231100000240 steatosis hepatitis Toxicity 0.000 claims abstract description 8
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- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims description 18
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- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (9)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101436855A CN101367859B (zh) | 2007-08-17 | 2007-08-17 | 脂肪酸胆汁酸偶合物及其医药用途 |
PCT/CN2008/001460 WO2009024022A1 (fr) | 2007-08-17 | 2008-08-13 | Conjugués acides gras-acides biliaires et leurs utilisations médicales |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2007101436855A CN101367859B (zh) | 2007-08-17 | 2007-08-17 | 脂肪酸胆汁酸偶合物及其医药用途 |
Publications (2)
Publication Number | Publication Date |
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CN101367859A CN101367859A (zh) | 2009-02-18 |
CN101367859B true CN101367859B (zh) | 2011-05-11 |
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CN2007101436855A Expired - Fee Related CN101367859B (zh) | 2007-08-17 | 2007-08-17 | 脂肪酸胆汁酸偶合物及其医药用途 |
Country Status (2)
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CN (1) | CN101367859B (zh) |
WO (1) | WO2009024022A1 (zh) |
Families Citing this family (2)
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EP3004132A4 (en) | 2013-06-06 | 2017-01-18 | Yissum, Research Development Company of the Hebrew | Bile acid-basic amino acid conjugates and uses thereof |
CN104610415B (zh) * | 2014-11-13 | 2016-05-25 | 昆明贵金属研究所 | 肝靶向铂类抗癌药物及其合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1296492A (zh) * | 1998-04-08 | 2001-05-23 | 盖尔梅德国际有限公司 | 胆汁酸和胆汁酸衍生物的脂肪酸衍生物 |
CN1908001A (zh) * | 2005-08-03 | 2007-02-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
Family Cites Families (1)
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DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
-
2007
- 2007-08-17 CN CN2007101436855A patent/CN101367859B/zh not_active Expired - Fee Related
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2008
- 2008-08-13 WO PCT/CN2008/001460 patent/WO2009024022A1/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1296492A (zh) * | 1998-04-08 | 2001-05-23 | 盖尔梅德国际有限公司 | 胆汁酸和胆汁酸衍生物的脂肪酸衍生物 |
CN1908001A (zh) * | 2005-08-03 | 2007-02-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
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WO2009024022A1 (fr) | 2009-02-26 |
CN101367859A (zh) | 2009-02-18 |
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