IL90844A0 - Process and intermediates for the synthesis of levodopa - Google Patents

Process and intermediates for the synthesis of levodopa

Info

Publication number
IL90844A0
IL90844A0 IL90844A IL9084489A IL90844A0 IL 90844 A0 IL90844 A0 IL 90844A0 IL 90844 A IL90844 A IL 90844A IL 9084489 A IL9084489 A IL 9084489A IL 90844 A0 IL90844 A0 IL 90844A0
Authority
IL
Israel
Prior art keywords
levodopa
intermediates
synthesis
Prior art date
Application number
IL90844A
Other languages
English (en)
Original Assignee
Mini Ricerca Scient Tecnolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mini Ricerca Scient Tecnolog filed Critical Mini Ricerca Scient Tecnolog
Publication of IL90844A0 publication Critical patent/IL90844A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL90844A 1988-07-12 1989-07-03 Process and intermediates for the synthesis of levodopa IL90844A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821322A IT1226902B (it) 1988-07-12 1988-07-12 Processo per la sintesi del levodopa

Publications (1)

Publication Number Publication Date
IL90844A0 true IL90844A0 (en) 1990-02-09

Family

ID=11180092

Family Applications (1)

Application Number Title Priority Date Filing Date
IL90844A IL90844A0 (en) 1988-07-12 1989-07-03 Process and intermediates for the synthesis of levodopa

Country Status (23)

Country Link
US (1) US4962223A (hu)
EP (1) EP0357565B1 (hu)
JP (1) JP2507069B2 (hu)
KR (1) KR960004185B1 (hu)
AR (1) AR248267A1 (hu)
AT (1) ATE111439T1 (hu)
AU (1) AU615083B2 (hu)
CA (1) CA1338672C (hu)
DD (1) DD284674A5 (hu)
DE (1) DE68918207T2 (hu)
DK (1) DK172106B1 (hu)
ES (1) ES2063837T3 (hu)
FI (1) FI101534B (hu)
HU (1) HU203318B (hu)
IE (1) IE65956B1 (hu)
IL (1) IL90844A0 (hu)
IT (1) IT1226902B (hu)
NO (1) NO174293C (hu)
NZ (1) NZ229910A (hu)
PL (1) PL160103B1 (hu)
PT (1) PT91144B (hu)
YU (1) YU47907B (hu)
ZA (1) ZA895255B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
IT1226903B (it) * 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog Processo per la sintesi di aminoacidi otticamente attivi
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
JP3634207B2 (ja) * 1999-09-14 2005-03-30 独立行政法人科学技術振興機構 光学活性なα−アミノニトリル並びにα−アミノ酸類の製造方法
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
US20040180086A1 (en) * 2002-10-11 2004-09-16 Zebunnissa Ramtoola Gastro-retentive levodopa delivery form
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
WO2004069146A2 (en) * 2003-02-07 2004-08-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-dopa amide derivatives and uses thereof
WO2007093450A2 (en) 2006-02-17 2007-08-23 Birds Pharma Gmbh Berolina Innovative Research & Development Services Deuterated catecholamine derivatives and medicaments comprising said compounds
EP4299128A3 (en) 2014-03-13 2024-04-17 Neuroderm Ltd. Dopa decarboxylase inhibitor compositions
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
MX2021003730A (es) 2018-09-28 2021-06-18 Univ Griffith Agentes y métodos para modular la actividad patógena.
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA504449A (en) * 1954-07-20 C. Britton Edgar Alpha-amino-beta-alkoxy-butyronitriles and method of making same
BE638485A (hu) * 1962-10-11
US3845076A (en) * 1971-04-20 1974-10-29 Sagami Chem Res Method of preparing aldehydes
JPS4920305A (hu) * 1972-06-21 1974-02-22
HU165026B (hu) * 1972-08-11 1974-06-28
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
IL59048A (en) * 1979-12-27 1984-01-31 Plantex Ltd Process for the preparation of alpha-amino-3-phenyl-propionitriles and novel benzylidene amino acetonitriles as intermediates therefor
DE3002543A1 (de) * 1980-01-25 1981-07-30 Basf Ag, 6700 Ludwigshafen 4-tert.-butoxyphenylglycinnitril sowie verfahren zur herstellung von d-(-)- und l-(+)-4-hydroxyphenylglycin
JPS56115749A (en) * 1980-02-18 1981-09-11 Sagami Chem Res Center Dopa derivative
JPS61275253A (ja) * 1985-05-30 1986-12-05 Nippon Kayaku Co Ltd ３−（３，４−ジヒドロキシフエニル）−２−メチルアラニンの製造法
FR2614626B1 (fr) * 1987-04-30 1989-07-21 Ranoux Claude Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal

Also Published As

Publication number Publication date
DE68918207T2 (de) 1995-05-11
IT8821322A0 (it) 1988-07-12
IE892227L (en) 1990-01-12
ZA895255B (en) 1990-04-25
JP2507069B2 (ja) 1996-06-12
HU203318B (en) 1991-07-29
PT91144A (pt) 1990-02-08
HUT51596A (en) 1990-05-28
ATE111439T1 (de) 1994-09-15
NO174293B (no) 1994-01-03
NO174293C (no) 1994-04-13
AU615083B2 (en) 1991-09-19
IE65956B1 (en) 1995-11-29
AR248267A1 (es) 1995-07-12
KR900001641A (ko) 1990-02-27
YU139989A (en) 1990-12-31
EP0357565B1 (en) 1994-09-14
FI893368A (fi) 1990-01-13
US4962223A (en) 1990-10-09
NZ229910A (en) 1991-04-26
PT91144B (pt) 1995-01-31
FI101534B1 (fi) 1998-07-15
IT1226902B (it) 1991-02-21
NO892861D0 (no) 1989-07-11
CA1338672C (en) 1996-10-22
KR960004185B1 (ko) 1996-03-27
YU47907B (sh) 1996-05-20
DK172106B1 (da) 1997-10-27
JPH02231457A (ja) 1990-09-13
DD284674A5 (de) 1990-11-21
FI101534B (fi) 1998-07-15
NO892861L (no) 1990-01-15
PL160103B1 (pl) 1993-02-26
DE68918207D1 (de) 1994-10-20
FI893368A0 (fi) 1989-07-11
ES2063837T3 (es) 1995-01-16
EP0357565A2 (en) 1990-03-07
DK342489A (da) 1990-01-13
EP0357565A3 (en) 1991-09-25
AU3805789A (en) 1990-01-25
DK342489D0 (da) 1989-07-11

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Legal Events

Date Code Title Description
KB Patent renewed
RH1 Patent not in force