IL86632A0 - Derivatives substituted at methyl-amino nitrogen - Google Patents
Derivatives substituted at methyl-amino nitrogenInfo
- Publication number
- IL86632A0 IL86632A0 IL86632A IL8663288A IL86632A0 IL 86632 A0 IL86632 A0 IL 86632A0 IL 86632 A IL86632 A IL 86632A IL 8663288 A IL8663288 A IL 8663288A IL 86632 A0 IL86632 A0 IL 86632A0
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- amino nitrogen
- derivatives substituted
- formula
- stau
- Prior art date
Links
- RTHIZFHNBCJDNB-UHFFFAOYSA-N C[N]N Chemical compound C[N]N RTHIZFHNBCJDNB-UHFFFAOYSA-N 0.000 title 1
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 abstract 2
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH224487 | 1987-06-15 | ||
CH144088 | 1988-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL86632A0 true IL86632A0 (en) | 1988-11-30 |
Family
ID=25687663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL86632A IL86632A0 (en) | 1987-06-15 | 1988-06-06 | Derivatives substituted at methyl-amino nitrogen |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0296110B1 (fr) |
JP (1) | JP2708047B2 (fr) |
KR (1) | KR970001529B1 (fr) |
AT (1) | ATE134375T1 (fr) |
AU (1) | AU617324B2 (fr) |
CA (1) | CA1337763C (fr) |
DE (1) | DE3855015D1 (fr) |
DK (1) | DK175507B1 (fr) |
ES (1) | ES2083956T3 (fr) |
FI (1) | FI89362C (fr) |
GR (1) | GR3019064T3 (fr) |
HK (1) | HK1003788A1 (fr) |
HU (1) | HU201329B (fr) |
IE (1) | IE70523B1 (fr) |
IL (1) | IL86632A0 (fr) |
MY (1) | MY104316A (fr) |
NO (1) | NO170634C (fr) |
NZ (1) | NZ225018A (fr) |
PT (1) | PT87719B (fr) |
YU (1) | YU115488A (fr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62220196A (ja) * | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ucn―01 |
WO1989007105A1 (fr) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Derives de staurosporine |
IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
USRE36736E (en) * | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
WO1993007153A1 (fr) * | 1991-10-10 | 1993-04-15 | Schering Corporation | Derives de staurosporine 4'-(n-substituee-n-oxydee) |
EP0541486A1 (fr) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Conjugates polycycliques |
WO1993018771A1 (fr) * | 1992-03-24 | 1993-09-30 | Asahi Kasei Kogyo Kabushiki Kaisha | INHIBITEUR DE L'AGGLUTINATION PLAQUETTAIRE CONTENANT UN DERIVE DE STAUROSPORINE η-LACTAME |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
CA2123895A1 (fr) * | 1992-09-21 | 1994-03-31 | Tatsuya Tamaoki | Agent pour le traitement de la thrombocytopenie |
EP0681475B1 (fr) | 1993-01-28 | 2010-10-27 | Boston Scientific Limited | Inhibiteur therapeutique de cellules de muscles vasculaires lisses |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
WO1995002057A1 (fr) * | 1993-07-09 | 1995-01-19 | The Institute Of Cancer Research | Tyrosine kinase et ses ligands |
GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
EP0711557A1 (fr) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Base pour formulations pharmaceutiques |
US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
DK0912184T3 (da) | 1996-06-25 | 2002-11-25 | Cephalon Inc | Anvendelse af K-252a-derivat til behandlingen af perifere eller centrale nervelidelser og cytokinoverproduktion |
ES2226120T3 (es) | 1997-03-31 | 2005-03-16 | Boston Scientific Limited | Inhibidor terapeutico de celulas del musculo liso vascular. |
PT1131073E (pt) * | 1998-11-23 | 2004-03-31 | Novartis Ag | Uso de derivados de estaurosporina para o tratamento de doencas oculares neovasculares |
WO2002066019A2 (fr) | 2001-02-19 | 2002-08-29 | Novartis Ag | Traitement des cancers |
WO2002092091A1 (fr) | 2001-05-16 | 2002-11-21 | Novartis Ag | Combinaison comprenant n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine et agent chimiotherapeutique |
ATE335490T1 (de) | 2001-10-30 | 2006-09-15 | Novartis Pharma Gmbh | Staurosporin-derivate als hemmer der flt3- rezeptor-tyrosinkinase-wirkung |
US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
EP1944026B1 (fr) | 2002-05-16 | 2013-06-26 | Novartis AG | Utilisation d'agents de liaison de récepteur EDG dans un cancer |
CA2492989C (fr) * | 2002-07-23 | 2012-11-20 | Novartis Ag | Composition d'onguent ophtalmique comprenant un medicament, une base d'onguent et un agent de solubilisation/dispersion |
PE20050158A1 (es) | 2003-05-19 | 2005-05-12 | Irm Llc | Compuestos inmunosupresores y composiciones |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
AU2004262927B2 (en) | 2003-08-08 | 2008-05-22 | Novartis Ag | Combinations comprising staurosporines |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
CN101010082A (zh) * | 2004-08-31 | 2007-08-01 | 诺瓦提斯公司 | 米哚妥林用于治疗胃肠道基质瘤的用途 |
JO2897B1 (en) * | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
KR20140012218A (ko) | 2005-11-21 | 2014-01-29 | 노파르티스 아게 | Mtor 억제제를 사용하는 신경내분비 종양 치료법 |
EP2379499B1 (fr) | 2008-12-18 | 2014-04-09 | Novartis AG | Sel chlorhydrate d'acide 1-[4-[1-((e)-4-cyclohexyl-3-trifluorométhyl-benzyloxyimino)-éthyl]-2-éthyl-benzyl]-azétidine-3-carboxylique |
CA2951479A1 (fr) | 2008-12-18 | 2010-07-15 | Novartis Ag | Sel hemifumarate d'acide 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylique |
CN102256942B (zh) | 2008-12-18 | 2013-07-24 | 诺瓦提斯公司 | 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的多晶型物 |
EP2327706A1 (fr) | 2009-11-30 | 2011-06-01 | Novartis AG | Formes polymorphiques III et IV de la N-benzoyl-staurosporine |
EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
EP2847191B1 (fr) | 2012-05-09 | 2016-06-15 | Sanofi | Dérivés de 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine substitué en tant quýinhibiteurs de la kinase |
WO2019215759A1 (fr) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | Procédé amélioré de préparation de midostaurine |
EP4058465A1 (fr) | 2019-11-14 | 2022-09-21 | Cohbar Inc. | Peptides antagonistes de cxcr4 |
IT202000004291A1 (it) * | 2020-03-02 | 2021-09-02 | Indena Spa | Processo per la purificazione di alcaloidi indolo carbazolici |
CN112812129A (zh) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | 米哚妥林的新晶型及其制备方法和用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989007105A1 (fr) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Derives de staurosporine |
-
1988
- 1988-06-06 IL IL86632A patent/IL86632A0/xx not_active IP Right Cessation
- 1988-06-09 DE DE3855015T patent/DE3855015D1/de not_active Expired - Lifetime
- 1988-06-09 ES ES88810383T patent/ES2083956T3/es not_active Expired - Lifetime
- 1988-06-09 EP EP88810383A patent/EP0296110B1/fr not_active Expired - Lifetime
- 1988-06-09 MY MYPI88000629A patent/MY104316A/en unknown
- 1988-06-09 AT AT88810383T patent/ATE134375T1/de not_active IP Right Cessation
- 1988-06-10 AU AU17571/88A patent/AU617324B2/en not_active Expired
- 1988-06-13 FI FI882808A patent/FI89362C/fi active IP Right Grant
- 1988-06-13 CA CA000569303A patent/CA1337763C/fr not_active Expired - Lifetime
- 1988-06-14 NO NO882613A patent/NO170634C/no not_active IP Right Cessation
- 1988-06-14 HU HU883048A patent/HU201329B/hu unknown
- 1988-06-14 DK DK198803248A patent/DK175507B1/da not_active IP Right Cessation
- 1988-06-14 NZ NZ225018A patent/NZ225018A/xx unknown
- 1988-06-14 YU YU01154/88A patent/YU115488A/xx unknown
- 1988-06-14 KR KR1019880007102A patent/KR970001529B1/ko not_active IP Right Cessation
- 1988-06-14 IE IE178788A patent/IE70523B1/en not_active IP Right Cessation
- 1988-06-14 PT PT87719A patent/PT87719B/pt not_active IP Right Cessation
- 1988-06-15 JP JP63145937A patent/JP2708047B2/ja not_active Expired - Lifetime
-
1996
- 1996-02-22 GR GR960400221T patent/GR3019064T3/el unknown
-
1998
- 1998-04-04 HK HK98102862A patent/HK1003788A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1003788A1 (en) | 1998-11-06 |
IE881787L (en) | 1988-12-15 |
JPS6434989A (en) | 1989-02-06 |
KR890000494A (ko) | 1989-03-15 |
NZ225018A (en) | 1990-09-26 |
DK324888D0 (da) | 1988-06-14 |
FI882808A0 (fi) | 1988-06-13 |
AU1757188A (en) | 1988-12-15 |
EP0296110A2 (fr) | 1988-12-21 |
ATE134375T1 (de) | 1996-03-15 |
NO882613L (no) | 1988-12-16 |
DE3855015D1 (de) | 1996-03-28 |
FI89362B (fi) | 1993-06-15 |
PT87719B (pt) | 1992-10-30 |
NO170634B (no) | 1992-08-03 |
FI89362C (fi) | 1993-09-27 |
PT87719A (pt) | 1988-07-01 |
AU617324B2 (en) | 1991-11-28 |
HU201329B (en) | 1990-10-28 |
EP0296110B1 (fr) | 1996-02-21 |
JP2708047B2 (ja) | 1998-02-04 |
HUT47587A (en) | 1989-03-28 |
IE70523B1 (en) | 1996-12-11 |
NO170634C (no) | 1992-11-11 |
ES2083956T3 (es) | 1996-05-01 |
MY104316A (en) | 1994-03-31 |
FI882808A (fi) | 1988-12-16 |
EP0296110A3 (fr) | 1991-02-27 |
KR970001529B1 (ko) | 1997-02-11 |
CA1337763C (fr) | 1995-12-19 |
GR3019064T3 (en) | 1996-05-31 |
DK175507B1 (da) | 2004-11-15 |
YU115488A (en) | 1989-12-31 |
NO882613D0 (no) | 1988-06-14 |
DK324888A (da) | 1988-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |