IL81020A - GM-CSF protein derivatives the preparation of proteins of this type and their use - Google Patents
GM-CSF protein derivatives the preparation of proteins of this type and their useInfo
- Publication number
- IL81020A IL81020A IL8102086A IL8102086A IL81020A IL 81020 A IL81020 A IL 81020A IL 8102086 A IL8102086 A IL 8102086A IL 8102086 A IL8102086 A IL 8102086A IL 81020 A IL81020 A IL 81020A
- Authority
- IL
- Israel
- Prior art keywords
- csf
- plasmid
- sequence
- fragment
- fusion protein
- Prior art date
Links
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- 238000005755 formation reaction Methods 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- 108010049041 glutamylalanine Proteins 0.000 description 1
- 210000004524 haematopoietic cell Anatomy 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000007866 imination reaction Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 108010034529 leucyl-lysine Proteins 0.000 description 1
- 108010091798 leucylleucine Proteins 0.000 description 1
- 108010009298 lysylglutamic acid Proteins 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 108010085203 methionylmethionine Proteins 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108010070643 prolylglutamic acid Proteins 0.000 description 1
- 108010090894 prolylleucine Proteins 0.000 description 1
- 108010053725 prolylvaline Proteins 0.000 description 1
- 229940070376 protein Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 108010048818 seryl-histidine Proteins 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853545568 DE3545568A1 (de) | 1985-12-21 | 1985-12-21 | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL81020A0 IL81020A0 (en) | 1987-03-31 |
| IL81020A true IL81020A (en) | 1995-11-27 |
Family
ID=6289242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8102086A IL81020A (en) | 1985-12-21 | 1986-12-18 | GM-CSF protein derivatives the preparation of proteins of this type and their use |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0228018B1 (da) |
| JP (1) | JP2575367B2 (da) |
| KR (1) | KR940005585B1 (da) |
| AT (1) | ATE71144T1 (da) |
| AU (2) | AU601959B2 (da) |
| CA (1) | CA1341197C (da) |
| DE (2) | DE3545568A1 (da) |
| DK (1) | DK170346B1 (da) |
| ES (1) | ES2055686T3 (da) |
| FI (1) | FI91168C (da) |
| GR (1) | GR3003999T3 (da) |
| HU (1) | HU202584B (da) |
| IE (1) | IE59779B1 (da) |
| IL (1) | IL81020A (da) |
| NO (1) | NO177270C (da) |
| PT (1) | PT83972B (da) |
| ZA (1) | ZA869557B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| WO1987002060A1 (en) * | 1985-10-03 | 1987-04-09 | Biogen N.V. | Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells |
| DE3712985A1 (de) * | 1987-04-16 | 1988-11-03 | Hoechst Ag | Bifunktionelle proteine |
| US5359035A (en) * | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
| JP2583770B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | 遺伝子 |
| JPS6420097A (en) * | 1987-03-02 | 1989-01-24 | Sumitomo Chemical Co | Human granulocyte-macrophage colony stimulating factor |
| PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
| AU609128B2 (en) * | 1987-04-02 | 1991-04-26 | Amrad Operations Pty. Limited | Leukaemia-inhibitory factor |
| AU602097B2 (en) * | 1987-06-25 | 1990-09-27 | Immunex Corporation | Bovine granulocyte-macrophage colony stimulating factor |
| IL88344A (en) * | 1987-11-12 | 1994-06-24 | Schering Corp | Accelerating bone formation using a factor that accelerates colonies of granulocyte macrophages |
| GB2212159B (en) * | 1987-11-13 | 1992-01-22 | British Bio Technology | Synthetic gene for human granulocyte/macrophage colony stimulating factor. |
| JPH03503897A (ja) * | 1988-04-21 | 1991-08-29 | メドベット・サイエンス・プロプライアテリー・リミテッド | ひとｇｍ‐ｃｓｆ変異形類 |
| WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| EP0489116B1 (en) * | 1989-08-22 | 1994-04-06 | Immunex Corporation | Fusion proteins comprising gm-csf and il-3 |
| NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
| US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| US6060258A (en) * | 1995-09-28 | 2000-05-09 | Otsuka Pharmaceutical Co., Ltd. | Neutrophil chemotactic lymphokine, and method for the diagnosis of drug hypersensitive granulocytopenia using the same |
| RU2144083C1 (ru) * | 1998-03-13 | 2000-01-10 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Способ промышленного получения рекомбинантного гранулоцит-макрофаг-колониестимулирующего фактора человека |
| KR100448021B1 (ko) * | 2001-12-28 | 2004-09-08 | 크레아젠 주식회사 | 마우스 과립구 대식세포 콜로니 촉진인자 발현벡터 ｐＧＭ-ＣＳＦ로 형질전환된 대장균 및 상기 마우스 과립구 대식세포 콜로니 촉진인자의 대량생산방법 |
| CN108295087B (zh) | 2009-12-23 | 2021-01-15 | 格兰达利斯有限公司 | 弗林蛋白酶敲减和gm-csf增强的(fang)癌症疫苗 |
| SG181881A1 (en) | 2009-12-23 | 2012-07-30 | Gradalis Inc | Furin-knockdown bi-functional rna |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
| SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
| IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| AU594014B2 (en) * | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
| ES8701226A1 (es) * | 1984-07-06 | 1986-11-16 | Sandoz Ag | Procedimiento de obtencion de una proteina de factor estimu-lante de colonias (csf) en primates |
| ZA856108B (en) * | 1984-10-29 | 1986-10-29 | Immunex Corp | Cloning of human granulocyte-macrophage colony simulating factor gene |
| AU588819B2 (en) * | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| IE59581B1 (en) * | 1984-11-20 | 1994-03-09 | Schering Biotech Corp | Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity |
| WO1987002060A1 (en) * | 1985-10-03 | 1987-04-09 | Biogen N.V. | Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells |
| DE3636903A1 (de) * | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
| DE3541856A1 (de) * | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
-
1985
- 1985-12-21 DE DE19853545568 patent/DE3545568A1/de not_active Withdrawn
-
1986
- 1986-12-16 AT AT86117484T patent/ATE71144T1/de not_active IP Right Cessation
- 1986-12-16 ES ES86117484T patent/ES2055686T3/es not_active Expired - Lifetime
- 1986-12-16 EP EP86117484A patent/EP0228018B1/de not_active Expired - Lifetime
- 1986-12-16 DE DE8686117484T patent/DE3683267D1/de not_active Expired - Lifetime
- 1986-12-18 FI FI865186A patent/FI91168C/fi not_active IP Right Cessation
- 1986-12-18 IL IL8102086A patent/IL81020A/en active IP Right Grant
- 1986-12-19 IE IE333586A patent/IE59779B1/en not_active IP Right Cessation
- 1986-12-19 NO NO865191A patent/NO177270C/no unknown
- 1986-12-19 AU AU66756/86A patent/AU601959B2/en not_active Ceased
- 1986-12-19 HU HU865355A patent/HU202584B/hu not_active IP Right Cessation
- 1986-12-19 ZA ZA869557A patent/ZA869557B/xx unknown
- 1986-12-19 CA CA000525856A patent/CA1341197C/en not_active Expired - Fee Related
- 1986-12-19 DK DK619086A patent/DK170346B1/da not_active IP Right Cessation
- 1986-12-19 PT PT83972A patent/PT83972B/pt not_active IP Right Cessation
- 1986-12-20 KR KR1019860011011A patent/KR940005585B1/ko not_active Expired - Fee Related
- 1986-12-22 JP JP61306186A patent/JP2575367B2/ja not_active Expired - Lifetime
-
1990
- 1990-09-19 AU AU62683/90A patent/AU637139B2/en not_active Ceased
-
1992
- 1992-03-11 GR GR920400222T patent/GR3003999T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |