IL76872A - Luminescent metal chelate labels and means for detection - Google Patents

Luminescent metal chelate labels and means for detection

Info

Publication number
IL76872A
IL76872A IL7687285A IL7687285A IL76872A IL 76872 A IL76872 A IL 76872A IL 7687285 A IL7687285 A IL 7687285A IL 7687285 A IL7687285 A IL 7687285A IL 76872 A IL76872 A IL 76872A
Authority
IL
Israel
Prior art keywords
substance
detection
compound
ligands
labels
Prior art date
Application number
IL7687285A
Other languages
English (en)
Other versions
IL76872A0 (en
Original Assignee
Hyperion Catalysis Internat In
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperion Catalysis Internat In filed Critical Hyperion Catalysis Internat In
Publication of IL76872A0 publication Critical patent/IL76872A0/xx
Publication of IL76872A publication Critical patent/IL76872A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046Ruthenium compounds
    • C07F15/0053Ruthenium compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/002Osmium compounds
    • C07F15/0026Osmium compounds without a metal-carbon linkage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Luminescent Compositions (AREA)
  • Pyridine Compounds (AREA)
IL7687285A 1984-10-31 1985-10-29 Luminescent metal chelate labels and means for detection IL76872A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66698784A 1984-10-31 1984-10-31
US06/789,113 US5238808A (en) 1984-10-31 1985-10-24 Luminescent metal chelate labels and means for detection

Publications (2)

Publication Number Publication Date
IL76872A0 IL76872A0 (en) 1986-02-28
IL76872A true IL76872A (en) 2000-12-06

Family

ID=27099589

Family Applications (1)

Application Number Title Priority Date Filing Date
IL7687285A IL76872A (en) 1984-10-31 1985-10-29 Luminescent metal chelate labels and means for detection

Country Status (10)

Country Link
US (1) US5238808A (xx)
EP (2) EP0199804B1 (xx)
JP (4) JPH0826054B2 (xx)
AT (2) ATE230114T1 (xx)
AU (1) AU5020085A (xx)
CA (1) CA1339835C (xx)
DE (2) DE3588243T2 (xx)
HK (2) HK1007349A1 (xx)
IL (1) IL76872A (xx)
WO (1) WO1986002734A1 (xx)

Families Citing this family (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK365785A (da) * 1984-09-17 1986-03-18 Hoffmann La Roche Metalcomplexer
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5585279A (en) * 1986-01-23 1996-12-17 Davidson; Robert S. Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium
GB8601646D0 (en) * 1986-01-23 1986-02-26 Davidson R S Binding assay & reagent
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US5770459A (en) * 1986-04-30 1998-06-23 Igen International, Inc. Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence detection
US6165729A (en) * 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6881536B1 (en) * 1986-04-30 2005-04-19 Bioveris Corporation Particle based electrochemiluminescent assays
US6316607B1 (en) 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
ATE212030T1 (de) * 1986-04-30 2002-02-15 Igen Int Inc Elektrolumineszente verbindungen und zwischenprodukte zur herstellung
US6271041B1 (en) * 1986-04-30 2001-08-07 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5591581A (en) * 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
US6451225B1 (en) * 1986-04-30 2002-09-17 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
WO1988007670A2 (en) * 1987-03-27 1988-10-06 Chimerix Corporation Time-resolved fluorescence apparatus and immunoassay
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US6881589B1 (en) * 1987-04-30 2005-04-19 Bioveris Corporation Electrochemiluminescent localizable complexes for assay compositions
HU204856B (en) * 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
WO1989004302A1 (en) * 1987-11-04 1989-05-18 Igen, Inc. Electrochemiluminescent rhenium moieties and methods
SE8800613D0 (sv) * 1988-02-23 1988-02-23 Wallac Oy A novel spectrofluorometric method and compounds that are of value for the method
US5308754A (en) * 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
SE461117B (sv) * 1988-03-21 1990-01-08 Jouko J Kankare Foerfarande foer bestaemning av koncentrationen av en luminiscerande lantanid foerening
CA1325527C (en) * 1988-04-28 1993-12-28 Nicholas Leventis Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5093268A (en) * 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US6702986B1 (en) 1988-04-29 2004-03-09 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5061445A (en) * 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
CA2002083C (en) * 1988-11-03 2001-01-09 Haresh P. Shah Enhanced electrochemiluminescence
ATE161096T1 (de) * 1988-11-03 1997-12-15 Igen Inc Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels
US5068088A (en) * 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5247243A (en) * 1988-11-03 1993-09-21 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5298427A (en) * 1990-04-24 1994-03-29 The Board Of Trustees Of The University Of Arkansas Chemiluminescent detection of amino acids
IL100866A (en) * 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
ZA92804B (en) 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
FR2673183B1 (fr) * 1991-02-21 1996-09-27 Asulab Sa Complexes mono, bis ou tris (2,2'-bipyridine substituee) d'un metal choisi parmi le fer, le ruthenium, l'osmium ou le vanadium et leurs procedes de preparation .
CA2112675C (en) * 1991-07-10 2007-03-20 Richard J. Massey Methods and apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
ZA929351B (en) * 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
EP0774120B1 (de) 1994-07-25 2009-08-26 Roche Diagnostics GmbH Metallchelat-markierte peptide
US5981286A (en) * 1994-07-25 1999-11-09 Roche Diagnostics, Gmbh Hydrophilic metal complexes
AU690315B2 (en) * 1994-07-25 1998-04-23 Boehringer Mannheim Gmbh Metal complexes with charged linker
AU703344B2 (en) * 1994-08-26 1999-03-25 Igen International, Inc. Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface
US5786141A (en) * 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
FR2727415A1 (fr) * 1994-11-30 1996-05-31 Commissariat Energie Atomique Complexes du ruthenium utilisables en particulier pour determiner la topologie des proteines, et leur procede de preparation
US20010003647A1 (en) * 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US5610075A (en) * 1995-01-17 1997-03-11 Stahl-Rees; Marianne Competitive electrochemiluminescence assays for endotoxins using a ruthenium label
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
BR9607193B1 (pt) * 1995-03-10 2009-01-13 teste de eletroquimioluscÊncia multi-especÍfico de méltiplos conjuntos.
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
WO1996033411A1 (en) * 1995-04-18 1996-10-24 Igen, Inc. Electrochemiluminescence of rare earth metal chelates
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
WO1996036870A1 (en) * 1995-05-18 1996-11-21 Igen, Inc. Method for derivitizing electrodes and assay methods using such derivitized electrodes
US6099760A (en) * 1995-06-07 2000-08-08 Igen, Inc. Hydrogen peroxide based ECL
US5807978A (en) 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
CA2223027A1 (en) 1995-06-07 1996-12-19 Igen, Inc. Electrochemiluminescent enzyme immunoassay
JP3574457B2 (ja) * 1995-09-12 2004-10-06 エーザイ株式会社 電気化学発光検出方法と装置
FR2747694B1 (fr) * 1996-04-18 1998-06-05 France Etat Cathode pour la reduction de dioxyde de carbone et procede de fabrication d'une telle cathode
US20030078416A1 (en) * 1996-04-30 2003-04-24 Yitzhak Tor Substituted phenanthrolines
EP0917533A2 (en) * 1996-07-03 1999-05-26 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US5958573A (en) * 1997-02-10 1999-09-28 Quantum Energy Technologies Electroluminescent device having a structured particle electron conductor
US5976887A (en) * 1997-06-02 1999-11-02 Applied Research Associates, Inc. Electrochemiluminescence assays based on interactions with soluble metal ions and diaminoaromatic ligands
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6613583B1 (en) 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
DE19811582A1 (de) 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen
ES2180241T3 (es) 1998-05-06 2003-02-01 Roche Diagnostics Gmbh Eliminacion de interferencias causadas por factores reumaticos.
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
WO1999059578A1 (en) 1998-05-19 1999-11-25 Research Development Foundation Triterpene compositions and methods for use thereof
EP1084409B1 (en) * 1998-06-01 2004-05-12 Roche Diagnostics Corporation Method and device for electrochemical immunoassay of multiple analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
DE19828441A1 (de) * 1998-06-25 1999-12-30 Roche Diagnostics Gmbh Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren
WO2000001848A1 (fr) * 1998-07-01 2000-01-13 Hitachi, Ltd. Appareil et methode de criblage de polynucleotide
US6656471B1 (en) 1998-11-17 2003-12-02 Board Of Regents, The University Of Texas System HIV-specific T-cell induction
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US20030068635A1 (en) * 1999-02-16 2003-04-10 Boehringer Mannheim Gmbh Determination of an analyte using two labels
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
DE19933104A1 (de) * 1999-07-15 2001-01-18 Ingo Klimant Phosphoreszierende Mikro- und Nanopartikel als Referenzstandard und Phosphoreszenzmarker
AU779220B2 (en) 1999-07-26 2005-01-13 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
EP1933395B2 (en) * 1999-12-01 2019-08-07 The Trustees of Princeton University Complexes of form L2IrX
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
WO2001094951A2 (en) * 2000-06-08 2001-12-13 Board Of Regents, The University Of Texas System Inhibitors of c-reactive protein induced inflammation
AU2001277066A1 (en) * 2000-07-21 2002-02-05 University Of Maryland, Baltimore Long wavelength long lifetime luminophores
US20060148732A1 (en) * 2000-11-17 2006-07-06 Gutterman Jordan U Inhibition of NF-kappaB by triterpene compositions
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
US20020173042A1 (en) * 2001-03-16 2002-11-21 Timothy Oolman Method of tagging agricultural products
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
US7695919B2 (en) * 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
SE0102327D0 (sv) 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
US7842246B2 (en) 2001-06-29 2010-11-30 Meso Scale Technologies, Llc Assay plates, reader systems and methods for luminescence test measurements
DE60236732D1 (de) 2001-07-30 2010-07-29 Meso Scale Technologies Llc Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung
KR100454868B1 (ko) * 2001-08-01 2004-11-05 주식회사 아이센스 신규의 전기화학발광 면역분석 표지물질인 루테늄착화합물 및 그의 제조방법
WO2003023360A2 (en) * 2001-09-10 2003-03-20 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
WO2004001380A2 (en) 2002-06-20 2003-12-31 Igen International, Inc Electrochemiluminescence flow cell and flow cell components
WO2004025259A2 (en) * 2002-09-12 2004-03-25 Molecular Probes, Inc. Site-specific labeling of affinity tags in fusion proteins
US7000870B2 (en) * 2002-11-07 2006-02-21 Aerion Corporation Laminar flow wing for transonic cruise
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
US7238536B1 (en) * 2004-03-22 2007-07-03 Florida State University Research Foundation, Inc. Controlled transport through multiple reversible interaction point membranes
US7514223B2 (en) * 2004-05-15 2009-04-07 Genentech, Inc. Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
WO2007040559A2 (en) * 2004-11-17 2007-04-12 Bioveris Electrochemiluminescent assay
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
JP5205062B2 (ja) * 2005-02-10 2013-06-05 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 酸化還元活性構造体およびそれを利用するデバイス
ES2675044T3 (es) * 2005-06-03 2018-07-06 Board Of Regents Of The University Of Texas System Electroquímica y quimioluminiscencia electrogenerada con un único electrodo faradaico
US20070116600A1 (en) * 2005-06-23 2007-05-24 Kochar Manish S Detection device and methods associated therewith
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
AU2007281934B2 (en) 2006-01-18 2012-11-15 University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
BRPI0708677A2 (pt) 2006-03-09 2011-06-21 Hoffmann La Roche ensaio de anticorpo antifármaco
US20080108513A1 (en) * 2006-06-01 2008-05-08 Northwestern University Cellular Arrays
US7749772B1 (en) 2006-06-29 2010-07-06 Varian, Inc. Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol
ES2428876T3 (es) 2006-09-12 2013-11-12 F. Hoffmann-La Roche Ag Ensayo de anticuerpo antifármaco
EP2522735A3 (en) * 2006-10-20 2013-02-13 Arizona Board Of Regents For And On Behalf Arizona State University Modified cyanobacteria
KR100869589B1 (ko) 2006-12-19 2008-11-21 단국대학교 산학협력단 바이오센서를 이용한 생체 물질의 정량적 측정 방법
US8158217B2 (en) 2007-01-03 2012-04-17 Applied Nanostructured Solutions, Llc CNT-infused fiber and method therefor
US8951631B2 (en) 2007-01-03 2015-02-10 Applied Nanostructured Solutions, Llc CNT-infused metal fiber materials and process therefor
US9005755B2 (en) 2007-01-03 2015-04-14 Applied Nanostructured Solutions, Llc CNS-infused carbon nanomaterials and process therefor
US8951632B2 (en) 2007-01-03 2015-02-10 Applied Nanostructured Solutions, Llc CNT-infused carbon fiber materials and process therefor
CN101617228A (zh) 2007-02-27 2009-12-30 霍夫曼-拉罗奇有限公司 用于评估针对胰岛素样生长因子ⅰ受体的抗体的抑制活性的方法
US20080300796A1 (en) 2007-05-31 2008-12-04 Lassahn Gordon D Biological analysis methods, biological analysis devices, and articles of manufacture
GB0711849D0 (en) 2007-06-19 2007-07-25 Oxford Biosensors Ltd Redox Mediators
US8227195B2 (en) 2007-12-15 2012-07-24 Hoffman-La Roche Inc. Distinguishing assay
US9383369B2 (en) 2008-03-31 2016-07-05 Barb Ariel Cohen Methods for improving fertility and selectivity for desired offspring sex in artificial insemination
WO2009146043A1 (en) * 2008-03-31 2009-12-03 Cohen B Arial Assay for semen optimization
WO2009126249A1 (en) 2008-04-11 2009-10-15 Board Of Regents Of The University Of Texas System Method and apparatus for nanoparticle electrogenerated chemiluminescence amplification
EP2626692A3 (en) 2008-05-08 2014-10-01 Board of Regents of the University of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US8264347B2 (en) 2008-06-24 2012-09-11 Trelleborg Sealing Solutions Us, Inc. Seal system in situ lifetime measurement
BRPI0920041A2 (pt) 2008-10-06 2017-06-27 Univ Chicago composições e processos relacionados às proteínas eap, emp e/ou adsa bacterianas
US8614297B2 (en) 2008-12-22 2013-12-24 Hoffmann-La Roche Inc. Anti-idiotype antibody against an antibody against the amyloid β peptide
JP5577356B2 (ja) 2009-02-17 2014-08-20 アプライド ナノストラクチャード ソリューションズ リミテッド ライアビリティー カンパニー カーボン・ナノチューブを繊維上に含んで構成された複合材料
BRPI1008131A2 (pt) 2009-02-27 2016-03-08 Applied Nanostructured Sols "crescimento de nanotubo de carbono de baixa temperatura usando método de preaquecimento de gás".
US20100224129A1 (en) 2009-03-03 2010-09-09 Lockheed Martin Corporation System and method for surface treatment and barrier coating of fibers for in situ cnt growth
BRPI1010307B1 (pt) 2009-04-03 2021-07-27 University Of Chicago Polipeptídeos variantes de proteína a (spa), composição imunogênica compreendendo os mesmos, vacina, método de produção da referida vacina, bem como uso dos referidos polipeptídeos
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
US9111658B2 (en) 2009-04-24 2015-08-18 Applied Nanostructured Solutions, Llc CNS-shielded wires
CA2758570A1 (en) 2009-04-24 2010-12-16 Applied Nanostructured Solutions, Llc Cnt-based signature control material
WO2010129234A2 (en) 2009-04-27 2010-11-11 Lockheed Martin Corporation Cnt-based resistive heating for deicing composite structures
CA2769380C (en) * 2009-07-27 2020-08-25 Meso Scale Technologies, Llc Assay apparatuses, consumables and methods
BR112012002216A2 (pt) 2009-08-03 2016-05-31 Applied Nanostructured Sols método de incorporação de nanopartículas em fibras compósitas, fibra de vidro e tapete de fibra picada ou compósito
US8969009B2 (en) 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9410965B2 (en) 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
CA2775619A1 (en) 2009-11-23 2011-05-26 Applied Nanostructured Solutions, Llc Ceramic composite materials containing carbon nanotube-infused fiber materials and methods for production thereof
CA2776752A1 (en) 2009-11-23 2011-10-13 Applied Nanostructured Solutions, Llc Cnt-tailored composite sea-based structures
CN103079805B (zh) 2009-12-14 2015-02-11 应用纳米结构方案公司 含有碳纳米管并入的纤维材料的防火复合材料和制品
US9167736B2 (en) 2010-01-15 2015-10-20 Applied Nanostructured Solutions, Llc CNT-infused fiber as a self shielding wire for enhanced power transmission line
BR112012018244A2 (pt) 2010-02-02 2016-05-03 Applied Nanostructured Sols materiais de fibra infundidos com nanotubo de carbono contendo nanotubos de carbono alinhados em paralelo, métodos para produção dos mesmos e materiais compósitos derivados dos mesmos
KR101818640B1 (ko) 2010-03-02 2018-01-15 어플라이드 나노스트럭처드 솔루션스, 엘엘씨. 카본 나노튜브 주입된 섬유를 포함하는 전기 장치 및 그의 제조 방법
JP2013521656A (ja) 2010-03-02 2013-06-10 アプライド ナノストラクチャード ソリューションズ リミテッド ライアビリティー カンパニー カーボン・ナノチューブ浸出電極材料を含む螺旋に巻き付けられた電気機器及びその生産方法並びに生産装置
JP2013523818A (ja) 2010-04-05 2013-06-17 ザ・ユニバーシティー・オブ・シカゴ 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法
US8780526B2 (en) 2010-06-15 2014-07-15 Applied Nanostructured Solutions, Llc Electrical devices containing carbon nanotube-infused fibers and methods for production thereof
ES2655701T3 (es) 2010-07-02 2018-02-21 The University Of Chicago Composiciones y métodos relacionados con variantes de la proteína A (SpA)
WO2012022774A1 (en) 2010-08-19 2012-02-23 Roche Diagnostics Gmbh An assay for measurement of antibodies binding to a therapeutic monoclonal antibody
US9017854B2 (en) 2010-08-30 2015-04-28 Applied Nanostructured Solutions, Llc Structural energy storage assemblies and methods for production thereof
US9095540B2 (en) 2010-09-09 2015-08-04 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
WO2012037042A1 (en) 2010-09-14 2012-03-22 Applied Nanostructured Solutions, Llc Glass substrates having carbon nanotubes grown thereon and methods for production thereof
EP2619133A1 (en) 2010-09-22 2013-07-31 Applied NanoStructured Solutions, LLC Carbon fiber substrates having carbon nanotubes grown thereon and processes for production thereof
AU2011305751A1 (en) 2010-09-23 2012-06-21 Applied Nanostructured Solutions, Llc CNT-infused fiber as a self shielding wire for enhanced power transmission line
EP3644058A1 (en) 2010-10-14 2020-04-29 Meso Scale Technologies, LLC Reagent storage in an assay device
WO2012154272A1 (en) 2011-02-25 2012-11-15 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
WO2012143380A1 (en) 2011-04-20 2012-10-26 F. Hoffmann-La Roche Ag Microwaves for immunohistochemical analysis
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
AR086982A1 (es) 2011-06-22 2014-02-05 Hoffmann La Roche Eliminacion de celulas diana por parte de celulas t citotoxicas especificas de virus utilizando complejos que comprenden mhc de clase i
EP2776833B1 (en) 2011-11-11 2018-09-05 Eli N. Glezer Co-binder assisted assay methods
EP2795335B1 (en) 2011-12-19 2017-09-06 F. Hoffmann-La Roche AG Method for the detection of free binding partner of a multispecific binder
EP2620764B1 (en) 2012-01-25 2015-11-04 Roche Diagniostics GmbH A luminescence method of detecting an analyte in a liquid sample and analysis system
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
US9085464B2 (en) 2012-03-07 2015-07-21 Applied Nanostructured Solutions, Llc Resistance measurement system and method of using the same
CA2862824A1 (en) 2012-03-08 2013-09-12 F. Hoffmann-La Roche Ag Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes
CN104768572B (zh) 2012-04-26 2021-08-24 芝加哥大学 葡萄球菌凝固酶抗原及其使用方法
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
CN104471397B (zh) 2012-07-13 2018-03-23 弗·哈夫曼-拉罗切有限公司 用于检测多特异性结合物的方法
SG11201504414UA (en) 2012-12-21 2015-07-30 Hoffmann La Roche Disulfide-linked multivalent mhc class i comprising multi-function proteins
EP2941633B1 (en) 2013-01-04 2024-02-28 Meso Scale Technologies, LLC Assay apparatuses, methods and reagents
CA3153763A1 (en) 2013-03-11 2014-10-09 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
EP3404116B1 (en) 2013-03-15 2022-10-19 The University of Chicago Methods and compositions related to t-cell activity
WO2014143623A1 (en) 2013-03-15 2014-09-18 The Lubrizol Corporation Heavy metal free cpvc compositions
EP2816345A1 (en) 2013-06-19 2014-12-24 Roche Diagniostics GmbH Electrochemiluminescence method of detecting an analyte in a liquid sample and analysis system
CA2913687C (en) 2013-07-04 2022-12-13 F. Hoffmann-La Roche Ag Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples
IL229525A0 (en) 2013-11-20 2014-01-30 Yeda Res & Dev Metal complexes of tris-bipyridyl and their uses in electrochromic applications
US10955412B2 (en) 2014-05-09 2021-03-23 Meso Scale Technologies, Llc. Graphene-modified electrodes
JP6695280B2 (ja) 2014-05-15 2020-05-20 メソ スケール テクノロジーズ エルエルシー 改善されたアッセイ方法
EP4015533A1 (en) 2015-10-29 2022-06-22 F. Hoffmann-La Roche AG Anti-variant fc-region antibodies and methods of use
CA3004199C (en) 2015-11-30 2024-05-07 F. Hoffmann-La Roche Ag Immunoassay for the determination of fc-region modified antibodies
BR112018010902A2 (pt) 2016-01-29 2018-11-21 Hoffmann La Roche método de eletroquimioluminescência, aparelho para executar um método de eletroquimioluminescência e produto de programa de computador
EP3662268B1 (en) 2017-08-01 2021-03-24 Roche Diagnostics GmbH Method of monitoring an operation of detection of an analyte in a liquid sample
AU2018374469B2 (en) 2017-11-29 2022-06-16 F. Hoffmann-La Roche Ag Target interference suppressed anti-drug antibody assay
EP4310184A3 (en) 2018-02-23 2024-05-01 Meso Scale Technologies, LLC. Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
EP3793715A2 (en) 2018-05-17 2021-03-24 Meso Scale Technologies, LLC Methods for isolating surface marker displaying agents
WO2020086751A1 (en) 2018-10-23 2020-04-30 Meso Scale Technologies, Llc. Methods for isolating surface marker displaying agents
JP2022515543A (ja) 2018-12-30 2022-02-18 エフ.ホフマン-ラ ロシュ アーゲー 抗ウサギcd19抗体および使用方法
SG11202106924VA (en) 2019-01-03 2021-07-29 Meso Scale Technologies Llc Compositions and methods for carrying out assay measurements
AU2020232954A1 (en) 2019-03-01 2021-09-09 Meso Scale Technologies, Llc. Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
WO2020229378A1 (en) 2019-05-13 2020-11-19 F. Hoffmann-La Roche Ag Interference-suppressed pharmacokinetic immunoassay
WO2020245377A1 (en) 2019-06-07 2020-12-10 F. Hoffmann-La Roche Ag Hybridizing all-lna oligonucleotides
WO2021136772A1 (en) 2020-01-02 2021-07-08 F. Hoffmann-La Roche Ag Method for determining the amount of a therapeutic antibody in the brain
AU2021294222A1 (en) 2020-06-16 2023-01-19 F. Hoffmann-La Roche Ag Method for determining the free antigen of an antibody in a sample
US20220018785A1 (en) 2020-07-01 2022-01-20 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
WO2022051481A2 (en) 2020-09-04 2022-03-10 Meso Scale Technologies, Llc. Methods for isolating central nervous system surface marker displaying agents
WO2022136234A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Method for detecting an analyte of interest in a sample
EP4320444A1 (en) 2021-04-09 2024-02-14 F. Hoffmann-La Roche AG Process for selecting cell clones expressing a heterologous polypeptide
WO2022231900A1 (en) 2021-04-26 2022-11-03 Meso Scale Technologies, Llc. Methods for isolating and analyzing a target analyte encapsulated by a surface marker displaying agent
CN117858905A (zh) 2021-08-19 2024-04-09 豪夫迈·罗氏有限公司 多价抗变体fc区抗体及使用方法
WO2023117325A1 (en) 2021-12-21 2023-06-29 F. Hoffmann-La Roche Ag Method for the determination of hydrolytic activity
WO2023129884A1 (en) 2021-12-30 2023-07-06 Meso Scale Technologies, Llc. Methods for electrochemiluminescence detection
WO2023156510A1 (en) 2022-02-18 2023-08-24 F. Hoffmann-La Roche Ag Method for detecting an analyte of interest in a sample
WO2023212315A2 (en) 2022-04-29 2023-11-02 Meso Scale Technologies, Llc. Methods for detecting and isolating extracellular vesicles
WO2024044622A1 (en) 2022-08-24 2024-02-29 Amgen Inc. Anti-drug antibody assays

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3504052A (en) * 1964-10-06 1970-03-31 Mc Donnell Douglas Corp Organometallic polymers
US3804869A (en) * 1967-12-11 1974-04-16 Rhone Poulenc Sa Ruthenium complexes and processes for their preparation
US3530049A (en) * 1968-10-02 1970-09-22 Technic Gold and ruthenium plating baths
GB1405592A (en) * 1971-08-11 1975-09-10 Johnson Matthey Co Ltd Compounds of ruthenium
US3966556A (en) * 1972-11-06 1976-06-29 Syva Company Compounds for enzyme amplification assay methadone analogs
DE2345412C2 (de) * 1973-09-08 1983-11-03 Bomag-Menck GmbH, 5407 Boppard Zweiachsige Straßenwalze
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
JPS6015957B2 (ja) * 1976-09-08 1985-04-23 株式会社日立製作所 液晶マトリクス表示装置の駆動方法
US4220722A (en) * 1978-02-10 1980-09-02 Syva Company Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4363759A (en) * 1978-04-10 1982-12-14 Miles Laboratories, Inc. Chemiluminescent-labeled haptens and antigens
US4238395A (en) * 1978-07-24 1980-12-09 Miles Laboratories, Inc. Dimethyl 7-[ω-N-(phthalimido)alkyl]aminonaphthalene-1,2-dicarboxylates
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
SE428332B (sv) * 1979-03-08 1983-06-20 Wallac Oy Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
WO1981001883A1 (en) * 1979-12-19 1981-07-09 Electro Nucleonics Chemical luminescence amplification substrate system for immunochemistry
US4293310A (en) * 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
US4637988A (en) * 1981-07-01 1987-01-20 Eastman Kodak Company Fluorescent labels for immunoassay
US4707454A (en) * 1981-08-10 1987-11-17 Bio-Diagnostics, Inc. Fluorescent chlorophyll labeled assay reagents
EP0082636B2 (en) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Luminescent labelling materials and procedures
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
DK365785A (da) * 1984-09-17 1986-03-18 Hoffmann La Roche Metalcomplexer
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4699978A (en) * 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US4721669A (en) * 1985-01-18 1988-01-26 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents

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JPH09110890A (ja) 1997-04-28
DE3588243T2 (de) 2003-10-30
ATE104057T1 (de) 1994-04-15
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EP0199804B1 (en) 1994-04-06
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IL76872A0 (en) 1986-02-28
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ATE230114T1 (de) 2003-01-15
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