IL65963A - 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)propan-2-ol and salts thereof,their preparation and pharmaceutical compositions containing them - Google Patents

2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)propan-2-ol and salts thereof,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL65963A
IL65963A IL65963A IL6596382A IL65963A IL 65963 A IL65963 A IL 65963A IL 65963 A IL65963 A IL 65963A IL 6596382 A IL6596382 A IL 6596382A IL 65963 A IL65963 A IL 65963A
Authority
IL
Israel
Prior art keywords
difluorophenyl
triazol
propan
bis
salts
Prior art date
Application number
IL65963A
Other languages
English (en)
Other versions
IL65963A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27261198&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL65963(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of IL65963A0 publication Critical patent/IL65963A0/xx
Publication of IL65963A publication Critical patent/IL65963A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL65963A 1981-06-06 1982-06-03 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)propan-2-ol and salts thereof,their preparation and pharmaceutical compositions containing them IL65963A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8117379 1981-06-06
GB8131370 1981-10-17
GB8206329 1982-03-04

Publications (2)

Publication Number Publication Date
IL65963A0 IL65963A0 (en) 1982-09-30
IL65963A true IL65963A (en) 1985-02-28

Family

ID=27261198

Family Applications (1)

Application Number Title Priority Date Filing Date
IL65963A IL65963A (en) 1981-06-06 1982-06-03 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)propan-2-ol and salts thereof,their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4404216A (xx)
EP (1) EP0069442B1 (xx)
KR (1) KR850001132B1 (xx)
AU (1) AU529987B2 (xx)
CA (1) CA1181076A (xx)
DE (1) DE3262386D1 (xx)
DK (1) DK149849C (xx)
EG (1) EG17222A (xx)
ES (2) ES512882A0 (xx)
FI (1) FI71134C (xx)
GR (1) GR76491B (xx)
HK (1) HK8488A (xx)
HU (1) HU189143B (xx)
IE (1) IE53144B1 (xx)
IL (1) IL65963A (xx)
IN (1) IN158113B (xx)
LU (1) LU88329I2 (xx)
MX (1) MX7119E (xx)
MY (1) MY8800094A (xx)
NL (1) NL930061I2 (xx)
NO (2) NO156128C (xx)
NZ (1) NZ200864A (xx)
PH (1) PH18015A (xx)
PL (1) PL130909B1 (xx)
PT (1) PT75017B (xx)
SG (1) SG80887G (xx)
YU (1) YU42770B (xx)

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US4992454A (en) * 1983-03-16 1991-02-12 Pfizer Inc. Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
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IL105200A (en) * 1993-03-29 1997-03-18 Teva Pharma Regiospecific processes for the preparation of 1, 3-bis (1, 2, 4-triazol-1-yl)-propan- 2-ol derivatives
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US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
NZ270418A (en) 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
CA2139079C (en) * 1994-12-23 1996-05-28 K.S. Keshava Murthy Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof
CN1054853C (zh) * 1995-01-11 2000-07-26 上海三维制药公司 氟康唑中间体1－[2－(2,4－二氟苯基)2,3－环氧丙基]－1h－1,2,4－三氮唑及其甲磺酸盐的制备方法
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DE19617461A1 (de) 1996-05-02 1997-11-06 Bayer Ag Acylmercapto-triazolyl-Derivate
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NZ328607A (en) * 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
KR100194945B1 (ko) * 1997-01-29 1999-06-15 서치영 플루코나졸의 제조방법
GR980100028A (el) * 1998-01-15 1999-09-30 Drug Research Hellas ����� Φαρμακευτικα προιοντα για τοπικη χρηση που περιεχουν φλουκοναζολη σε συγκεντρωσεις μεταξυ 0,2% και 5%
CN1081189C (zh) * 1998-07-17 2002-03-20 国家医药管理局四川抗菌素工业研究所 唑醇类新衍生物及其制备方法和医药用途
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TWI426918B (zh) * 2007-02-12 2014-02-21 Merck Sharp & Dohme Ｉｌ-２３拮抗劑於治療感染之用途
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CN111518041A (zh) * 2020-04-24 2020-08-11 湖南复瑞生物医药技术有限责任公司 一种2’4’-二氟-2-[1-(1h-1,2,4-三唑基)]苯乙酮的制备方法
CN111454227A (zh) * 2020-05-21 2020-07-28 湖南复瑞生物医药技术有限责任公司 一种西洛他唑中间体的制备方法
CN112137972A (zh) * 2020-09-16 2020-12-29 石家庄四药有限公司 一种氟康唑片剂组合物、片剂及制备方法
KR102434209B1 (ko) * 2022-01-28 2022-08-19 전기열 천연 오일을 함유한 발모촉진 및 탈모방지용 조성물

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Publication number Priority date Publication date Assignee Title
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
YU119582A (en) 1984-12-31
DK149849B (da) 1986-10-13
AU8448482A (en) 1982-12-23
NO821886L (no) 1982-12-07
FI71134C (fi) 1986-11-24
EP0069442B1 (en) 1985-02-20
DK149849C (da) 1987-04-27
PT75017A (en) 1982-07-01
DE3262386D1 (en) 1985-03-28
ES8307794A1 (es) 1983-08-01
FI822005L (fi) 1982-12-07
NL930061I1 (nl) 1993-09-01
NO156128B (no) 1987-04-21
IE821285L (en) 1982-12-06
IN158113B (xx) 1986-09-06
NO1994019I1 (no) 1994-11-02
NO156128C (no) 1987-07-29
CA1181076A (en) 1985-01-15
IL65963A0 (en) 1982-09-30
HK8488A (en) 1988-02-05
SG80887G (en) 1988-09-16
FI71134B (fi) 1986-08-14
LU88329I2 (fr) 1994-05-04
NZ200864A (en) 1985-07-12
ES512882A0 (es) 1983-08-01
MX7119E (es) 1987-06-29
PL236740A1 (en) 1983-04-25
US4404216A (en) 1983-09-13
AU529987B2 (en) 1983-06-30
EP0069442A1 (en) 1983-01-12
MY8800094A (en) 1988-12-31
IE53144B1 (en) 1988-07-20
NL930061I2 (nl) 1993-10-01
ES8404348A1 (es) 1984-05-01
PH18015A (en) 1985-02-28
DK252282A (da) 1982-12-07
HU189143B (en) 1986-06-30
ES520794A0 (es) 1984-05-01
KR840000528A (ko) 1984-02-25
YU42770B (en) 1988-12-31
EG17222A (en) 1991-03-30
PL130909B1 (en) 1984-09-29
KR850001132B1 (ko) 1985-08-09
FI822005A0 (fi) 1982-06-04
PT75017B (en) 1985-01-07
GR76491B (xx) 1984-08-10

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