IL41556A - N-carboxyalkyl triiodoisopthalic acid amides process for their manufacture and their use as x-ray shading agents - Google Patents
N-carboxyalkyl triiodoisopthalic acid amides process for their manufacture and their use as x-ray shading agentsInfo
- Publication number
- IL41556A IL41556A IL41556A IL4155673A IL41556A IL 41556 A IL41556 A IL 41556A IL 41556 A IL41556 A IL 41556A IL 4155673 A IL4155673 A IL 4155673A IL 41556 A IL41556 A IL 41556A
- Authority
- IL
- Israel
- Prior art keywords
- benzoyl
- group
- odo
- carboxy
- methyl
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title claims abstract 20
- 238000000034 method Methods 0.000 title claims abstract 10
- 150000001408 amides Chemical class 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 18
- 239000002253 acid Substances 0.000 claims abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- -1 hydroxy , methoxy, ethoxy Chemical group 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- NARVIWMVBMUEOG-UHFFFAOYSA-N prop-1-en-2-ol Chemical group CC(O)=C NARVIWMVBMUEOG-UHFFFAOYSA-N 0.000 claims 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000004292 cyclic ethers Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002798 polar solvent Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 238000002583 angiography Methods 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 1
- 238000009608 myelography Methods 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- RLZZZVKAURTHCP-UHFFFAOYSA-N phenanthrene-3,4-diol Chemical compound C1=CC=C2C3=C(O)C(O)=CC=C3C=CC2=C1 RLZZZVKAURTHCP-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 238000007487 urography Methods 0.000 claims 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 229940039231 contrast media Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2207950A DE2207950C3 (de) | 1972-02-16 | 1972-02-16 | Trijod-isophthalsäure-monoaminosäureamide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41556A0 IL41556A0 (en) | 1973-07-30 |
| IL41556A true IL41556A (en) | 1976-11-30 |
Family
ID=5836524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41556A IL41556A (en) | 1972-02-16 | 1973-02-16 | N-carboxyalkyl triiodoisopthalic acid amides process for their manufacture and their use as x-ray shading agents |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3953501A (de) |
| JP (2) | JPS5741460B2 (de) |
| AR (2) | AR209257A1 (de) |
| AT (1) | AT319464B (de) |
| AU (1) | AU474420B2 (de) |
| BE (1) | BE795555A (de) |
| CA (1) | CA987325A (de) |
| CH (2) | CH576422A5 (de) |
| CS (2) | CS182796B2 (de) |
| DD (1) | DD103890A5 (de) |
| DE (1) | DE2207950C3 (de) |
| DK (1) | DK135484C (de) |
| ES (1) | ES411117A1 (de) |
| FI (1) | FI55294C (de) |
| FR (1) | FR2181737B1 (de) |
| GB (1) | GB1428985A (de) |
| HU (1) | HU165260B (de) |
| IL (1) | IL41556A (de) |
| IT (1) | IT1048111B (de) |
| NL (1) | NL7302174A (de) |
| NO (1) | NO138168C (de) |
| SE (1) | SE410597B (de) |
| SU (2) | SU563912A3 (de) |
| YU (1) | YU36154B (de) |
| ZA (1) | ZA731089B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
| GB1488903A (en) * | 1974-05-31 | 1977-10-19 | Guerbet Sa | X-ray contrast media |
| US4314055A (en) * | 1975-09-29 | 1982-02-02 | Mallinckrodt, Inc. | 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids |
| US4307072A (en) * | 1976-03-12 | 1981-12-22 | Mallinckrodt, Inc. | N-Triiodobenzoylaminoacyl polyhydroxic amines |
| CH626873A5 (de) * | 1977-03-28 | 1981-12-15 | Bracco Ind Chimica Spa | |
| DE2852094A1 (de) * | 1978-11-30 | 1980-06-12 | Schering Ag | Neue roentgenkontrastmittel |
| DE2928417A1 (de) * | 1979-07-12 | 1981-01-29 | Schering Ag | Trijodierte basen |
| DK162045C (da) * | 1982-10-01 | 1992-02-10 | Nyegaard & Co As | Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser |
| US4584401A (en) * | 1983-10-20 | 1986-04-22 | Biophysica Foundation | Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media |
| US5866100A (en) * | 1995-12-19 | 1999-02-02 | Bracco Research S.A. | Compositions for imaging of the gastrointestinal tract |
| US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
| CN117986193A (zh) * | 2022-11-01 | 2024-05-07 | 科睿驰（深圳）医疗科技发展有限公司 | 显影化合物及其制备方法、显影栓塞材料及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA616717A (en) * | 1961-03-21 | Distelmaier Alfred | Halogenated aminoisophthalic acids | |
| DE1125587B (de) * | 1957-03-06 | 1962-03-15 | Schering Ag | Roentgenkontrastmittel |
| US3009952A (en) * | 1957-04-17 | 1961-11-21 | Sterling Drug Inc | Preparation of halogenated isophthalic acids |
| US3145197A (en) * | 1961-06-26 | 1964-08-18 | Mallinckrodt Chemical Works | 5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds |
| US3102880A (en) * | 1960-09-06 | 1963-09-03 | Mallinckrodt Chemical Works | Isophthaloylbis-amino acid compounds |
| CH467626A (de) * | 1965-03-31 | 1969-01-31 | Chemie Linz Ag | Röntgenkontrastmittel |
| FR6777M (de) * | 1967-07-10 | 1969-03-10 | ||
| IL34803A (en) * | 1969-06-27 | 1975-03-13 | Nyegaard & Co As | N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them |
-
0
- BE BE795555D patent/BE795555A/xx not_active IP Right Cessation
-
1972
- 1972-02-16 DE DE2207950A patent/DE2207950C3/de not_active Expired
- 1972-12-27 DD DD167918A patent/DD103890A5/xx unknown
-
1973
- 1973-01-05 SU SU7301873501A patent/SU563912A3/ru active
- 1973-01-26 FI FI220/73A patent/FI55294C/fi active
- 1973-01-30 ES ES411117A patent/ES411117A1/es not_active Expired
- 1973-01-30 DK DK50273A patent/DK135484C/da active
- 1973-02-01 CS CS7600002559A patent/CS182796B2/cs unknown
- 1973-02-01 CS CS7300000781A patent/CS182780B2/cs unknown
- 1973-02-05 AU AU51814/73A patent/AU474420B2/en not_active Expired
- 1973-02-05 YU YU276/73A patent/YU36154B/xx unknown
- 1973-02-09 US US05/331,110 patent/US3953501A/en not_active Expired - Lifetime
- 1973-02-12 GB GB682273A patent/GB1428985A/en not_active Expired
- 1973-02-14 AT AT130273A patent/AT319464B/de not_active IP Right Cessation
- 1973-02-15 FR FR7305347A patent/FR2181737B1/fr not_active Expired
- 1973-02-15 SE SE7302156A patent/SE410597B/sv unknown
- 1973-02-15 NO NO610/73A patent/NO138168C/no unknown
- 1973-02-15 HU HUSCHE424*1A patent/HU165260B/hu unknown
- 1973-02-16 ZA ZA731089A patent/ZA731089B/xx unknown
- 1973-02-16 IL IL41556A patent/IL41556A/en unknown
- 1973-02-16 CH CH213476A patent/CH576422A5/xx not_active IP Right Cessation
- 1973-02-16 IT IT20486/73A patent/IT1048111B/it active
- 1973-02-16 CH CH227873A patent/CH590823A5/xx not_active IP Right Cessation
- 1973-02-16 CA CA163,941A patent/CA987325A/en not_active Expired
- 1973-02-16 JP JP48019136A patent/JPS5741460B2/ja not_active Expired
- 1973-02-16 NL NL7302174A patent/NL7302174A/xx not_active Application Discontinuation
- 1973-02-16 AR AR246650A patent/AR209257A1/es active
-
1974
- 1974-01-01 AR AR253241A patent/AR207951A1/es active
- 1974-07-17 SU SU2043817A patent/SU555846A3/ru active
-
1982
- 1982-01-22 JP JP57007722A patent/JPS6059224B2/ja not_active Expired
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