IL278423A - - Google Patents
Info
- Publication number
- IL278423A IL278423A IL27842320A IL27842320A IL278423A IL 278423 A IL278423 A IL 278423A IL 27842320 A IL27842320 A IL 27842320A IL 27842320 A IL27842320 A IL 27842320A IL 278423 A IL278423 A IL 278423A
- Authority
- IL
- Israel
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562121025P | 2015-02-26 | 2015-02-26 | |
| US201562133721P | 2015-03-16 | 2015-03-16 | |
| US201562160291P | 2015-05-12 | 2015-05-12 | |
| US201562215394P | 2015-09-08 | 2015-09-08 | |
| US201562254424P | 2015-11-12 | 2015-11-12 | |
| PCT/US2016/019120 WO2016137985A1 (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL278423A true IL278423A (https=) | 2020-12-31 |
| IL278423B1 IL278423B1 (en) | 2023-12-01 |
| IL278423B2 IL278423B2 (en) | 2024-04-01 |
Family
ID=55588542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL278423A IL278423B2 (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| IL254131A IL254131B (en) | 2015-02-26 | 2017-08-24 | Fidi-1 / Fidi-AL1 inhibitors for cancer treatment |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254131A IL254131B (en) | 2015-02-26 | 2017-08-24 | Fidi-1 / Fidi-AL1 inhibitors for cancer treatment |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10800846B2 (https=) |
| EP (2) | EP3262073A1 (https=) |
| JP (3) | JP6885869B2 (https=) |
| KR (1) | KR20170132171A (https=) |
| CN (2) | CN107405401B (https=) |
| AU (3) | AU2016222928B2 (https=) |
| BR (1) | BR112017018234A2 (https=) |
| CA (1) | CA2977767C (https=) |
| IL (2) | IL278423B2 (https=) |
| MX (2) | MX393976B (https=) |
| NZ (1) | NZ733854A (https=) |
| RU (1) | RU2714233C2 (https=) |
| SG (2) | SG11201706918YA (https=) |
| TW (2) | TWI755791B (https=) |
| WO (1) | WO2016137985A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| NZ733854A (en) | 2015-02-26 | 2022-07-01 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| PH12017501857B1 (en) | 2015-06-16 | 2024-01-17 | Merck Patent Gmbh | Pd-l1 antagonist combination treatments |
| KR102055396B1 (ko) | 2015-08-11 | 2019-12-12 | 우시 바이올로직스 (케이만) 인코포레이티드 | 신규한 항-pd-1 항체 |
| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| SI3386541T1 (sl) | 2015-12-07 | 2020-11-30 | Merck Patent Gbmh | Vodna farmacevtska formulacija, ki vsebuje protitelo proti PD-1 avelumab |
| AU2017269675A1 (en) * | 2016-05-26 | 2019-01-17 | Merck Patent Gmbh | PD-1 / PD-L1 inhibitors for cancer treatment |
| US11369618B2 (en) | 2016-06-17 | 2022-06-28 | The Trustees Of The University Of Pennsylvania | Compounds, compositions and methods for prevention and/or treatment of cancer |
| AU2017328309B2 (en) * | 2016-09-14 | 2020-10-15 | Beijing Hanmi Pharm. Co., Ltd. | Antibody specifically binding to PD-1 and functional fragment thereof |
| KR20190062515A (ko) * | 2016-10-06 | 2019-06-05 | 화이자 인코포레이티드 | 암의 치료를 위한 아벨루맙의 투약 용법 |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| JP7106538B2 (ja) | 2016-12-07 | 2022-07-26 | アジェナス インコーポレイテッド | 抗体およびその使用方法 |
| SG11201907211TA (en) * | 2017-02-16 | 2019-09-27 | Medimmune Llc | Anti-pd-l1 antibody treatment of bladder cancer |
| EP3372615A1 (en) | 2017-03-06 | 2018-09-12 | Merck Patent GmbH | Composition comprising avelumab |
| SG11201908091QA (en) | 2017-03-06 | 2019-10-30 | Merck Patent Gmbh | Aqueous anti-pd-l1 antibody formulation |
| SG10202110707UA (en) * | 2017-03-30 | 2021-11-29 | Merck Patent Gmbh | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| KR20200071097A (ko) * | 2017-10-13 | 2020-06-18 | 메르크 파텐트 게엠베하 | Parp 억제제 및 pd-1 축 결합 길항제의 조합 |
| WO2019118855A1 (en) * | 2017-12-14 | 2019-06-20 | The Trustees Of The University Of Pennsylvania | Compounds and compositions for prevention and/or treatment of cancer |
| JP2021514379A (ja) | 2018-02-21 | 2021-06-10 | ファイブ プライム セラピューティクス， インコーポレイテッド | Ｂ７−ｈ４抗体製剤 |
| CN119899267A (zh) * | 2018-03-22 | 2025-04-29 | 赛因格先进生物技术弗朗哥塞尔瓦托有限责任公司 | 拮抗性pd-1、pd-l1和lag-3结合蛋白 |
| EP3806842A4 (en) * | 2018-06-13 | 2022-03-16 | Merck Patent GmbH | Treatment of stage iii nsclc and mitigation of pathological conditions associated with the treatment |
| WO2020064971A1 (en) * | 2018-09-26 | 2020-04-02 | Merck Patent Gmbh | Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer |
| WO2020081497A1 (en) * | 2018-10-15 | 2020-04-23 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| BR112021007448A2 (pt) * | 2018-11-14 | 2021-10-26 | Bayer Aktiengesellschaft | Combinação farmacêutica de anticorpos anti-ceacam6 e anti-pd-1 ou anti-pd-l1 para o tratamento de câncer |
| US11851490B2 (en) | 2019-08-15 | 2023-12-26 | Northwestern University | Methods and compositions for treating, inhibiting, and/or preventing heterotopic ossification |
| US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
| MX2022008216A (es) * | 2020-01-02 | 2022-08-04 | Merck Sharp & Dohme Llc | Tratamiento de cancer en combinacion usando un antagonista de pd-1, un antagonista de ilt4 y lenvatinib o sales del mismo. |
| WO2022048775A1 (en) * | 2020-09-04 | 2022-03-10 | Pharma Mar, S.A. | Combination of lurbinectedin and immune checkpoint inhibitor |
| WO2023154799A1 (en) | 2022-02-14 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy for treating cancer |
| TW202404634A (zh) * | 2022-04-05 | 2024-02-01 | 美商安進公司 | 胃癌的治療 |
| WO2024137442A1 (en) | 2022-12-21 | 2024-06-27 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
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2016
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- 2016-02-23 CN CN201680012312.1A patent/CN107405401B/zh not_active Expired - Fee Related
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- 2016-02-23 EP EP16711389.3A patent/EP3262073A1/en not_active Withdrawn
- 2016-02-23 KR KR1020177026975A patent/KR20170132171A/ko not_active Ceased
- 2016-02-23 US US15/553,437 patent/US10800846B2/en active Active
- 2016-02-23 CN CN202011179277.7A patent/CN112263677A/zh active Pending
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2017
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2020
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- 2020-08-05 US US16/985,805 patent/US20200362040A1/en not_active Abandoned
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2021
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- 2021-06-29 JP JP2021107909A patent/JP2021178822A/ja active Pending