IL273592B2 - A multispecific antigen-binding molecule with activity that replaces the function of a cofactor for blood coagulation factor VIII (FVIII), and a pharmaceutical formulation containing the molecule as an active ingredient - Google Patents

A multispecific antigen-binding molecule with activity that replaces the function of a cofactor for blood coagulation factor VIII (FVIII), and a pharmaceutical formulation containing the molecule as an active ingredient

Info

Publication number
IL273592B2
IL273592B2 IL273592A IL27359220A IL273592B2 IL 273592 B2 IL273592 B2 IL 273592B2 IL 273592 A IL273592 A IL 273592A IL 27359220 A IL27359220 A IL 27359220A IL 273592 B2 IL273592 B2 IL 273592B2
Authority
IL
Israel
Prior art keywords
molecule
fviii
active ingredient
pharmaceutical formulation
factor viii
Prior art date
Application number
IL273592A
Other languages
English (en)
Hebrew (he)
Other versions
IL273592A (en
IL273592B1 (en
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of IL273592A publication Critical patent/IL273592A/en
Publication of IL273592B1 publication Critical patent/IL273592B1/en
Publication of IL273592B2 publication Critical patent/IL273592B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL273592A 2017-09-29 2020-03-25 A multispecific antigen-binding molecule with activity that replaces the function of a cofactor for blood coagulation factor VIII (FVIII), and a pharmaceutical formulation containing the molecule as an active ingredient IL273592B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017189647 2017-09-29
PCT/JP2018/035832 WO2019065795A1 (ja) 2017-09-29 2018-09-27 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤

Publications (3)

Publication Number Publication Date
IL273592A IL273592A (en) 2020-05-31
IL273592B1 IL273592B1 (en) 2025-07-01
IL273592B2 true IL273592B2 (en) 2025-11-01

Family

ID=65902289

Family Applications (2)

Application Number Title Priority Date Filing Date
IL273592A IL273592B2 (en) 2017-09-29 2020-03-25 A multispecific antigen-binding molecule with activity that replaces the function of a cofactor for blood coagulation factor VIII (FVIII), and a pharmaceutical formulation containing the molecule as an active ingredient
IL284913A IL284913A (en) 2017-09-29 2021-07-18 Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL284913A IL284913A (en) 2017-09-29 2021-07-18 Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient

Country Status (24)

Country Link
US (2) US10759870B2 (enExample)
EP (1) EP3690050A4 (enExample)
JP (5) JP6496095B1 (enExample)
KR (2) KR102078957B1 (enExample)
CN (2) CN118994408A (enExample)
AR (1) AR113142A1 (enExample)
AU (1) AU2018338859B2 (enExample)
BR (1) BR112020005834A2 (enExample)
CA (1) CA3071236A1 (enExample)
CL (2) CL2020000767A1 (enExample)
CO (1) CO2020003432A2 (enExample)
CR (2) CR20200158A (enExample)
EA (1) EA202090641A1 (enExample)
IL (2) IL273592B2 (enExample)
MA (1) MA50667A (enExample)
MX (1) MX2020002710A (enExample)
MY (1) MY204641A (enExample)
PE (1) PE20210005A1 (enExample)
PH (1) PH12020550162A1 (enExample)
SG (2) SG11201810270SA (enExample)
TW (3) TW201936634A (enExample)
UA (1) UA128389C2 (enExample)
WO (1) WO2019065795A1 (enExample)
ZA (1) ZA202002151B (enExample)

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TWI807362B (zh) 2010-11-30 2023-07-01 日商中外製藥股份有限公司 細胞傷害誘導治療劑
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TWI877179B (zh) * 2019-06-27 2025-03-21 德商百靈佳殷格翰國際股份有限公司 抗-angpt2抗體
JP7705406B2 (ja) * 2020-01-30 2025-07-09 ノヴォ ノルディスク アー／エス 二重特異性第ｖｉｉｉ因子模倣抗体
AU2021213606A1 (en) 2020-01-31 2022-07-21 Chugai Seiyaku Kabushiki Kaisha Method for producing composition containing polypeptide with suppressed coloring
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
EP4155405A4 (en) * 2020-05-22 2024-07-03 Chugai Seiyaku Kabushiki Kaisha Antibody for neutralizing substance having coagulation factor viii (f.viii) function-substituting activity
MX2024004117A (es) 2021-10-08 2024-04-19 Chugai Pharmaceutical Co Ltd Metodo para preparar formulacion de jeringa precargada.
AR129879A1 (es) 2022-07-08 2024-10-09 Novo Nordisk As Compuestos de isvd altamente potentes capaces de sustituir al fviii(a)
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