IL271993A - Viral vectors of cell lysis and their uses - Google Patents
Viral vectors of cell lysis and their usesInfo
- Publication number
- IL271993A IL271993A IL271993A IL27199320A IL271993A IL 271993 A IL271993 A IL 271993A IL 271993 A IL271993 A IL 271993A IL 27199320 A IL27199320 A IL 27199320A IL 271993 A IL271993 A IL 271993A
- Authority
- IL
- Israel
- Prior art keywords
- viral vectors
- oncolytic viral
- oncolytic
- vectors
- viral
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/763—Herpes virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16645—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16671—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16761—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537359P | 2017-07-26 | 2017-07-26 | |
| US201862686802P | 2018-06-19 | 2018-06-19 | |
| PCT/US2018/043938 WO2019023483A1 (en) | 2017-07-26 | 2018-07-26 | ONCOLYTIC VIRAL VECTORS AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL271993A true IL271993A (en) | 2020-02-27 |
Family
ID=65040409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL271993A IL271993A (en) | 2017-07-26 | 2020-01-12 | Viral vectors of cell lysis and their uses |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11612625B2 (enExample) |
| EP (1) | EP3658165A4 (enExample) |
| JP (2) | JP7249323B2 (enExample) |
| KR (1) | KR20200042904A (enExample) |
| CN (1) | CN111212656B (enExample) |
| AU (1) | AU2018306455A1 (enExample) |
| BR (1) | BR112020001559A2 (enExample) |
| CA (1) | CA3070299A1 (enExample) |
| IL (1) | IL271993A (enExample) |
| MX (1) | MX2020000993A (enExample) |
| RU (1) | RU2771110C2 (enExample) |
| SG (1) | SG11202000691XA (enExample) |
| WO (1) | WO2019023483A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2021114137A (ru) | 2016-01-27 | 2021-05-25 | Онкорус, Инк. | Онколитические вирусные векторы и их применение |
| US11612625B2 (en) | 2017-07-26 | 2023-03-28 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| CN111601890B (zh) * | 2017-12-14 | 2024-04-19 | 联合细胞Ev股份公司 | 用于治疗肾癌的包含miRNA的药物载体 |
| JP2022513639A (ja) * | 2018-11-29 | 2022-02-09 | ヴァイロジン バイオテック カナダ リミテッド | 低神経毒性ｈｓｖベクター |
| BR112021017551A2 (pt) * | 2019-03-05 | 2021-11-09 | Amgen Inc | Uso de vírus oncolíticos para o tratamento de câncer |
| CN110283794B (zh) * | 2019-05-30 | 2021-04-23 | 伍泽堂 | 重组溶瘤病毒以及制备方法、应用和药物 |
| US20220267799A1 (en) * | 2019-08-05 | 2022-08-25 | Virogin Biotech Canada Ltd | Genetically modified enterovirus vectors |
| CN111235274A (zh) * | 2020-01-18 | 2020-06-05 | 山西医科大学第一医院 | 喉鳞癌血清外泌体标志物筛选方法和外泌体来源miR-941应用 |
| ES2856232B2 (es) * | 2020-03-25 | 2023-11-24 | Fundacion Para La Investig Biomedica Del Hospital 12 De Octubre | Biomarcadores para predecir la respuesta de un sujeto a una terapia con bcg, metodos y usos basados en los mismos |
| EP4136242A4 (en) * | 2020-04-15 | 2024-05-22 | Humane Genomics | ARTIFICIAL ONCOLYTIC VIRUSES AND ASSOCIATED METHODS |
| TWI845834B (zh) * | 2020-04-23 | 2024-06-21 | 輔仁大學學校財團法人輔仁大學 | 癌症化療藥物促敏方法、其促敏劑組合物及其用途 |
| CN113583977B (zh) * | 2020-04-30 | 2025-06-06 | 杭州康万达医药科技有限公司 | 可受微小rna调控的分离的重组溶瘤痘病毒及其应用 |
| CN111494636A (zh) * | 2020-06-22 | 2020-08-07 | 中国人民解放军空军军医大学 | Mct1抑制剂的应用及含有其的药物组合物 |
| WO2022006745A1 (en) * | 2020-07-07 | 2022-01-13 | Oriengene Biotechnology Ltd | Guide rna for hsv-1 gene editing and method thereof |
| JP7539739B2 (ja) * | 2020-07-10 | 2024-08-26 | 上海米然生物科技有限公司 | 蛍光架橋型ＲＮａｓｅ Ｈ突然変異体コンジュゲート、ｍｉＲＮＡの組み合わせ及びその使用 |
| US11505607B2 (en) * | 2020-11-13 | 2022-11-22 | Binhui Biopharmaceutical Co., Ltd. | Bispecific single-chain antibody, recombinant oncolytic virus for expressing same and virus composition |
| CN116744951A (zh) * | 2020-12-25 | 2023-09-12 | 苏州系统医学研究所 | 一种包含溶瘤病毒的组合物及其在肿瘤治疗中的应用 |
| WO2022151078A1 (zh) * | 2021-01-13 | 2022-07-21 | 嘉兴允英医学检验有限公司 | 溶瘤病毒及其应用 |
| EP4298214A4 (en) * | 2021-02-23 | 2025-03-19 | Aldevron, LLC | NUCLEIC ACID VECTORS AND METHODS OF USE |
| JP2024512053A (ja) * | 2021-03-24 | 2024-03-18 | ヴァイロジン バイオテック カナダ リミテッド | 転写及び翻訳の二重調節を受ける腫瘍溶解性単純ヘルペスウイルスベクター |
| WO2023034867A1 (en) * | 2021-08-31 | 2023-03-09 | Oncorus, Inc. | Engineered oncolytic herpesviruses |
| EP4170022A1 (en) * | 2021-10-19 | 2023-04-26 | Consejo Superior De Investigaciones Científicas | Recombinant african swine fever virus and uses thereof |
| CN114010666B (zh) * | 2021-10-22 | 2024-05-07 | 上海交通大学 | 溶瘤病毒、parp抑制剂及pd-1抗体在制备抗肿瘤药物中的应用 |
| WO2023164442A2 (en) * | 2022-02-22 | 2023-08-31 | Vyro Bio Inc. | Oncolytic viruses and methods of use |
| CN117379389A (zh) * | 2022-07-12 | 2024-01-12 | 四川大学 | 血小板-溶瘤病毒复合物、其制备方法及其应用 |
| WO2024054293A1 (en) * | 2022-09-08 | 2024-03-14 | Research Institute At Nationwide Children's Hospital | Oncolytic virus combination to maximize oncolytic activity |
| KR20250124210A (ko) * | 2022-12-20 | 2025-08-19 | 얀센 바이오테크 인코포레이티드 | 종양용해성 바이러스 및 이의 용도 |
| GB2634272A (en) * | 2023-10-04 | 2025-04-09 | Averywell Ltd | Methods |
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| EP3658165A1 (en) | 2020-06-03 |
| AU2018306455A1 (en) | 2020-02-27 |
| US20230241140A1 (en) | 2023-08-03 |
| CN111212656B (zh) | 2024-10-18 |
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