|
JPH0637520B2
(ja)
|
1985-07-03 |
1994-05-18 |
味の素株式会社 |
ポリペプチド
|
|
WO1987005330A1
(en)
|
1986-03-07 |
1987-09-11 |
Michel Louis Eugene Bergh |
Method for enhancing glycoprotein stability
|
|
US4973577A
(en)
|
1986-04-04 |
1990-11-27 |
The Salk Institute For Biological Studies |
FSH-releasing peptides
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5096815A
(en)
|
1989-01-06 |
1992-03-17 |
Protein Engineering Corporation |
Generation and selection of novel dna-binding proteins and polypeptides
|
|
US5198346A
(en)
|
1989-01-06 |
1993-03-30 |
Protein Engineering Corp. |
Generation and selection of novel DNA-binding proteins and polypeptides
|
|
US5078486A
(en)
|
1989-10-13 |
1992-01-07 |
Evans David W |
Self-calibrating vision test apparatus
|
|
EP0548276A4
(en)
|
1990-09-13 |
1993-12-29 |
Children's Hospital Medical Center Of Northern California |
Method for increasing red blood cell production by treatment with activin or activin-related peptides
|
|
US5208219A
(en)
|
1991-02-14 |
1993-05-04 |
Celtrix Pharmaceuticals Inc. |
Method for inducing bone growth
|
|
US5118667A
(en)
|
1991-05-03 |
1992-06-02 |
Celtrix Pharmaceuticals, Inc. |
Bone growth factors and inhibitors of bone resorption for promoting bone formation
|
|
US5885794A
(en)
|
1991-05-10 |
1999-03-23 |
The Salk Institute For Biological Studies |
Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
|
|
US6162896A
(en)
|
1991-05-10 |
2000-12-19 |
The Salk Institute For Biological Studies |
Recombinant vertebrate activin receptors
|
|
US20050186593A1
(en)
|
1991-05-10 |
2005-08-25 |
The Salk Institute For Biological Studies |
Cloning and recombinant production of CRF receptor(s)
|
|
CA2086327A1
(en)
|
1991-05-10 |
1992-11-11 |
Lawrence S. Mathews |
Cloning and recombinant production of receptor(s) of the activin/tgf- .beta. superfamily
|
|
US6287816B1
(en)
|
1991-06-25 |
2001-09-11 |
Genetics Institute, Inc. |
BMP-9 compositions
|
|
KR100255415B1
(ko)
|
1991-06-25 |
2000-05-01 |
브루스 엠. 에이센 |
비엠피-9 조성물
|
|
US6692925B1
(en)
|
1992-11-17 |
2004-02-17 |
Ludwig Institute For Cancer Research |
Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use
|
|
EP1475440A3
(en)
|
1993-01-12 |
2004-11-17 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-3
|
|
US5637480A
(en)
|
1993-05-12 |
1997-06-10 |
Genetics Institute, Inc. |
DNA molecules encoding bone morphogenetic protein-10
|
|
DE69433742T2
(de)
|
1993-05-12 |
2005-07-07 |
Genetics Institute, LLC, Cambridge |
Bmp-10 zusammensetzungen
|
|
US5677196A
(en)
|
1993-05-18 |
1997-10-14 |
University Of Utah Research Foundation |
Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
|
|
US5831050A
(en)
|
1993-06-07 |
1998-11-03 |
Creative Biomolecules, Inc. |
Morphogen cell surface receptor
|
|
AU701623B2
(en)
|
1993-10-14 |
1999-02-04 |
President And Fellows Of Harvard College |
Method of inducing and maintaining neuronal cells
|
|
US5525490A
(en)
|
1994-03-29 |
1996-06-11 |
Onyx Pharmaceuticals, Inc. |
Reverse two-hybrid method
|
|
US5658876A
(en)
|
1994-04-28 |
1997-08-19 |
The General Hospital Corporation |
Activin antagonists as novel contraceptives
|
|
WO1996001845A1
(en)
|
1994-07-08 |
1996-01-25 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-11
|
|
US5885574A
(en)
|
1994-07-26 |
1999-03-23 |
Amgen Inc. |
Antibodies which activate an erythropoietin receptor
|
|
US5545616A
(en)
|
1994-09-22 |
1996-08-13 |
Genentech, Inc. |
Method for predicting and/or preventing preterm labor
|
|
US5760010A
(en)
|
1995-01-01 |
1998-06-02 |
Klein; Ira |
Method of treating liver disorders with a macrolide antibiotic
|
|
US5814565A
(en)
|
1995-02-23 |
1998-09-29 |
University Of Utah Research Foundation |
Integrated optic waveguide immunosensor
|
|
NZ502795A
(en)
|
1995-04-11 |
2001-09-28 |
Gen Hospital Corp |
Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems
|
|
EP0771873A3
(en)
|
1995-10-27 |
1998-03-04 |
Takeda Chemical Industries, Ltd. |
Neuronal cell-specific receptor protein
|
|
GB9526131D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Recombinant chimeric receptors
|
|
US6004780A
(en)
|
1996-03-26 |
1999-12-21 |
Human Genome Sciences, Inc. |
Growth factor HTTER36
|
|
US20050244867A1
(en)
|
1996-03-26 |
2005-11-03 |
Human Genome Sciences, Inc. |
Growth factor HTTER36
|
|
PL189756B1
(pl)
|
1996-10-25 |
2005-09-30 |
Searle & Co |
Polipeptyd ludzkiego agonisty receptora erytropoetyny (EPO), sposób jego wytwarzania i zastosowanie, cząsteczka kwasu nukleinowego, kompozycja, sposób selektywnego namnażania ex vivo erytroidalnych komórek progenitorowych
|
|
US6605699B1
(en)
|
1997-01-21 |
2003-08-12 |
Human Genome Sciences, Inc. |
Galectin-11 polypeptides
|
|
US6034062A
(en)
|
1997-03-13 |
2000-03-07 |
Genetics Institute, Inc. |
Bone morphogenetic protein (BMP)-9 compositions and their uses
|
|
US6231880B1
(en)
|
1997-05-30 |
2001-05-15 |
Susan P. Perrine |
Compositions and administration of compositions for the treatment of blood disorders
|
|
ES2320603T3
(es)
|
1997-07-30 |
2009-05-25 |
Emory University |
Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos.
|
|
US6656475B1
(en)
|
1997-08-01 |
2003-12-02 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
|
|
US6891082B2
(en)
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
AU8666398A
(en)
|
1997-08-01 |
1999-02-22 |
Johns Hopkins University School Of Medicine, The |
Methods to identify growth differentiation factor (gdf) receptors
|
|
US6696260B1
(en)
|
1997-08-01 |
2004-02-24 |
The Johns Hopkins University School Of Medicine |
Methods to identify growth differentiation factor (GDF) binding proteins
|
|
US6953662B2
(en)
|
1997-08-29 |
2005-10-11 |
Human Genome Sciences, Inc. |
Follistatin-3
|
|
JP2001513982A
(ja)
|
1997-08-29 |
2001-09-11 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
フォリスタチン−３
|
|
CA2305712A1
(en)
|
1997-10-03 |
1999-04-15 |
Chugai Seiyaku Kabushiki Kaisha |
Natural humanized antibody
|
|
US6696411B1
(en)
|
1998-04-22 |
2004-02-24 |
Cornell Research Foundation, Inc. |
Canine erythropoietin gene and recombinant protein
|
|
BR9913857A
(pt)
|
1998-09-17 |
2001-06-12 |
Lilly Co Eli |
Formulações de proteìna
|
|
WO2000017350A1
(fr)
|
1998-09-22 |
2000-03-30 |
Long Yu |
Sequence codante pour un nouveau facteur de differenciation de la croissance d'origine humaine et polypeptide code par cette sequence d'adn, et methode de production correspondante
|
|
US6472179B2
(en)
|
1998-09-25 |
2002-10-29 |
Regeneron Pharmaceuticals, Inc. |
Receptor based antagonists and methods of making and using
|
|
US6548634B1
(en)
|
1998-09-30 |
2003-04-15 |
Chiron Corporation |
Synthetic peptides having FGF receptor affinity
|
|
US6238860B1
(en)
|
1998-11-05 |
2001-05-29 |
Dyax Corp. |
Binding moieties for human parvovirus B19
|
|
US6777205B1
(en)
|
1998-11-06 |
2004-08-17 |
Sterrenbeld Biotechnologie North America, Inc. |
Host cells expressing recombinant human erythropoietin
|
|
US20040009535A1
(en)
|
1998-11-27 |
2004-01-15 |
Celltech R&D, Inc. |
Compositions and methods for increasing bone mineralization
|
|
NZ513642A
(en)
|
1999-01-21 |
2004-02-27 |
Metamorphix Inc |
Growth differentiation factor inhibitors and uses therefor
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
AU777783B2
(en)
|
1999-04-19 |
2004-10-28 |
Kyowa Hakko Kogyo Co. Ltd. |
Proliferation inhibitor for androgen-independent tumor
|
|
US6468543B1
(en)
|
1999-05-03 |
2002-10-22 |
Zymogenetics, Inc. |
Methods for promoting growth of bone using ZVEGF4
|
|
SK8292002A3
(en)
|
1999-11-12 |
2002-12-03 |
Maxygen Holdings Ltd |
A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
|
|
NZ519546A
(en)
|
1999-12-15 |
2005-07-29 |
Res Dev Foundation |
Betaglycan as an inhibin receptor and uses thereof
|
|
US20030224501A1
(en)
|
2000-03-17 |
2003-12-04 |
Young Paul E. |
Bone morphogenic protein polynucleotides, polypeptides, and antibodies
|
|
JP4487376B2
(ja)
|
2000-03-31 |
2010-06-23 |
味の素株式会社 |
腎疾患治療剤
|
|
JP3967594B2
(ja)
|
2000-05-15 |
2007-08-29 |
エフ．ホフマン−ラ ロシュ アーゲー |
新しい薬剤組成物
|
|
US6627424B1
(en)
|
2000-05-26 |
2003-09-30 |
Mj Bioworks, Inc. |
Nucleic acid modifying enzymes
|
|
AU2001269709A1
(en)
|
2000-07-19 |
2002-02-05 |
Eli Lilly And Company |
Nucleic acids, vectors, host cells, polypeptides, and uses thereof
|
|
US6632180B1
(en)
|
2000-09-07 |
2003-10-14 |
John H. Laragh |
Method for evaluating and treating hypertension
|
|
DE10045591A1
(de)
|
2000-09-15 |
2002-04-04 |
Klaus Pfizenmaier |
Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine)
|
|
EP2141243A3
(en)
|
2000-10-16 |
2010-01-27 |
Brystol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7087224B2
(en)
|
2000-10-31 |
2006-08-08 |
Amgen Inc. |
Method of treating anemia by administering IL-1ra
|
|
WO2002040501A2
(en)
|
2000-11-20 |
2002-05-23 |
The Board Of Trustees Of The University Of Illinois |
Membrane scaffold proteins
|
|
US20030082233A1
(en)
|
2000-12-01 |
2003-05-01 |
Lyons Karen M. |
Method and composition for modulating bone growth
|
|
WO2002043759A2
(en)
|
2000-12-01 |
2002-06-06 |
Wyeth |
Method and composition for modulating bone growth
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
|
US20040132675A1
(en)
|
2002-02-08 |
2004-07-08 |
Calvin Kuo |
Method for treating cancer and increasing hematocrit levels
|
|
US7294472B2
(en)
|
2001-03-14 |
2007-11-13 |
Caden Biosciences |
Method for identifying modulators of G protein coupled receptor signaling
|
|
WO2002074340A1
(fr)
|
2001-03-16 |
2002-09-26 |
Takeda Chemical Industries, Ltd. |
Procede de fabrication d'une preparation a liberation continue
|
|
JP4369662B2
(ja)
|
2001-04-26 |
2009-11-25 |
アビディア インコーポレイテッド |
単量体ドメインのコンビナトリアルライブラリー
|
|
EA010594B1
(ru)
|
2001-05-24 |
2008-10-30 |
Займодженетикс, Инк. |
Слитые белки taci-иммуноглобулина
|
|
AU2001286171B2
(en)
|
2001-05-25 |
2008-01-10 |
Serono Genetics Institute S.A. |
Human CDNAs and proteins and uses thereof
|
|
AUPR638101A0
(en)
|
2001-07-13 |
2001-08-09 |
Bioa Pty Limited |
Composition and method for treatment of disease
|
|
JP3888998B2
(ja)
|
2001-07-17 |
2007-03-07 |
帝人株式会社 |
ＰＰＡＲδ活性化作用を測定することを特徴とする物質の選択方法及び薬剤
|
|
US6855344B2
(en)
|
2001-07-17 |
2005-02-15 |
Integrated Chinese Medicine Holdings, Ltd. |
Compositions and methods for prostate and kidney health and disorders, an herbal preparation
|
|
KR100453877B1
(ko)
|
2001-07-26 |
2004-10-20 |
메덱스젠 주식회사 |
연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
US6784154B2
(en)
|
2001-11-01 |
2004-08-31 |
University Of Utah Research Foundation |
Method of use of erythropoietin to treat ischemic acute renal failure
|
|
CN102526045A
(zh)
|
2001-12-06 |
2012-07-04 |
法布罗根股份有限公司 |
提高内源性红细胞生成素(epo)的方法
|
|
US20060234918A1
(en)
|
2001-12-19 |
2006-10-19 |
Voyager Pharmaceutical Corporation |
Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors
|
|
US20030144203A1
(en)
|
2001-12-19 |
2003-07-31 |
Voyager Pharmaceutical Corporation |
Methods for slowing senescence and treating and preventing diseases associated with senescence
|
|
US6998118B2
(en)
|
2001-12-21 |
2006-02-14 |
The Salk Institute For Biological Studies |
Targeted retrograde gene delivery for neuronal protection
|
|
WO2003068801A2
(en)
|
2002-02-11 |
2003-08-21 |
Genentech, Inc. |
Antibody variants with faster antigen association rates
|
|
JP4429728B2
(ja)
|
2002-02-21 |
2010-03-10 |
ワイス エルエルシー |
フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質
|
|
BR0307907A2
(pt)
|
2002-02-21 |
2011-07-05 |
Wyeth Corp |
gasp1: proteìna contendo domìnio de folistatina
|
|
US20030219846A1
(en)
|
2002-02-28 |
2003-11-27 |
Pfizer Inc. |
Assay for activity of the ActRIIB kinase
|
|
AU2003232485A1
(en)
|
2002-04-18 |
2003-10-27 |
Mtm Laboratories Ag |
Neopeptides and methods useful for detection and treatment of cancer
|
|
DE10234192B4
(de)
|
2002-07-26 |
2009-11-26 |
Epoplus Gmbh Co.Kg |
Verwendung von Erythropoetin
|
|
US20050271637A1
(en)
|
2002-08-16 |
2005-12-08 |
Bodine Peter Van N |
BMP-2 estrogen responsive element and methods of using the same
|
|
US7842691B2
(en)
|
2002-10-15 |
2010-11-30 |
Celgene Corporation |
Method for the treatment of myelodysplastic syndromes using cyclopropanecarboxylic acid {2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-OXO-2,3-dihydro-1 H-isoindol-4-yl}-amide
|
|
US7261893B2
(en)
|
2002-10-22 |
2007-08-28 |
Wyeth |
Neutralizing antibodies against GDF-8 and uses therefor
|
|
US20040223966A1
(en)
|
2002-10-25 |
2004-11-11 |
Wolfman Neil M. |
ActRIIB fusion polypeptides and uses therefor
|
|
AU2002953327A0
(en)
|
2002-12-12 |
2003-01-09 |
Monash University |
Methods of diagnosing prognosing and treating activin associated diseases and conditions
|
|
WO2004064770A2
(en)
|
2003-01-17 |
2004-08-05 |
Government Of The United States Of America As Represented By The Secretary, Department Of Health Andhuman Services |
Use of smad3 inhibitor in the treatment of fibrosis dependent on epithelial to mesenchymal transition as in the eye and kidney
|
|
EP1592416B1
(en)
|
2003-02-07 |
2009-01-07 |
ProMetic BioSciences Inc. |
Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis
|
|
WO2004086953A2
(en)
|
2003-03-26 |
2004-10-14 |
The Board Of Trustees Of The University Of Arkansas |
Method for diagnosis and treatment of bone turnover
|
|
WO2010019832A2
(en)
|
2008-08-13 |
2010-02-18 |
Designer Molecules, Inc. |
Amide-extended crosslinking compounds and methods for use thereof
|
|
US20070184052A1
(en)
|
2003-05-09 |
2007-08-09 |
Lin Herbert Y |
Soluble tgf-b type III receptor fusion proteins
|
|
JP5110877B2
(ja)
|
2003-06-02 |
2012-12-26 |
ワイス・エルエルシー |
神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用
|
|
US7381409B2
(en)
|
2003-06-16 |
2008-06-03 |
Celltech R&D, Inc. |
Antibodies specific for sclerostin and methods of screening and use therefor
|
|
US7611465B2
(en)
*
|
2003-07-15 |
2009-11-03 |
Board Of Regents, The University Of Texas System |
Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry
|
|
WO2005009460A2
(en)
|
2003-07-25 |
2005-02-03 |
Medexis, S.A. |
Pharmaceutical composition comprising activin a, alk-4 or derivatives thereof for the treatment of ophthalmic disorders or cancer
|
|
DE10335211A1
(de)
|
2003-08-01 |
2005-02-17 |
Robert Bosch Gmbh |
Kraftstoff-Einspritzvorrichtung für eine Brennkraftmaschine
|
|
US20070135336A1
(en)
|
2003-09-15 |
2007-06-14 |
De Kretser David |
Follistatin isoforms and uses thereof
|
|
US8895540B2
(en)
|
2003-11-26 |
2014-11-25 |
DePuy Synthes Products, LLC |
Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
|
|
AU2005206277B2
(en)
|
2004-01-22 |
2011-06-23 |
Merck Patent Gmbh |
Anti-cancer antibodies with reduced complement fixation
|
|
US20050197292A1
(en)
|
2004-01-30 |
2005-09-08 |
Glennda Smithson |
Compositions and methods for treating T-cell mediated pathological conditions
|
|
JP2007530055A
(ja)
|
2004-03-26 |
2007-11-01 |
アクセルロン ファーマ インコーポレーテッド |
Ｂｍｐ−３プロペプチドおよび関連する方法
|
|
WO2005097825A2
(en)
|
2004-03-31 |
2005-10-20 |
Xencor, Inc. |
Bmp-7 variants with improved properties
|
|
WO2005113590A2
(en)
|
2004-05-12 |
2005-12-01 |
Acceleron Pharma Inc. |
Bmp10 propeptides and related methods
|
|
EP1771557B1
(en)
|
2004-06-24 |
2014-12-31 |
Acceleron Pharma Inc. |
GDF3 Propeptides and Related Methods
|
|
EP3489257A1
(en)
|
2004-07-23 |
2019-05-29 |
Acceleron Pharma Inc. |
Actrii receptor polypeptides, methods and compositions
|
|
JP2008508878A
(ja)
|
2004-08-05 |
2008-03-27 |
ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア |
細胞の発生および機能に対する効果を有する分子
|
|
MX2007000976A
(es)
|
2004-08-12 |
2007-04-10 |
Wyeth Corp |
Tratamiento combinado para diabetes, obesidad y enfermedades cardiovasculares utilizando inhibidores del factor 8 de crecimiento y diferenciacion.
|
|
CA2581896C
(en)
|
2004-09-29 |
2015-11-10 |
Mount Sinai School Of Medicine Of New York University |
Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis
|
|
US7879569B2
(en)
|
2004-11-09 |
2011-02-01 |
The Trustees Of The University Of Pennsylvania |
Methods for diagnosis of myelodysplastic syndromes (MDS)
|
|
EP1824796A4
(en)
|
2004-11-16 |
2010-02-17 |
Avidia Res Inst |
PROTEIN SKELETONS AND USES THEREOF
|
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
|
US7968091B2
(en)
|
2005-02-16 |
2011-06-28 |
The General Hospital Corporation |
Methods and compositions to regulate iron metabolism
|
|
KR20080003929A
(ko)
|
2005-04-26 |
2008-01-08 |
아지노모토 가부시키가이샤 |
골수 적혈구 전구 세포 분화 촉진제
|
|
JP2007099764A
(ja)
|
2005-09-09 |
2007-04-19 |
Ajinomoto Co Inc |
血糖低下剤
|
|
EP1931697B1
(en)
|
2005-09-28 |
2010-09-15 |
ZymoGenetics, Inc. |
Il-17a and il-17f antagonists and methods of using the same
|
|
US8067562B2
(en)
|
2005-11-01 |
2011-11-29 |
Amgen Inc. |
Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
|
|
EP2781222B1
(en)
*
|
2005-11-23 |
2017-08-02 |
Acceleron Pharma, Inc. |
Activin-actriia antagonists in use for promoting bone growth
|
|
US8128933B2
(en)
|
2005-11-23 |
2012-03-06 |
Acceleron Pharma, Inc. |
Method of promoting bone growth by an anti-activin B antibody
|
|
EP1968621A2
(en)
|
2005-12-06 |
2008-09-17 |
Amgen Inc. |
Uses of myostatin antagonists
|
|
WO2007071023A1
(en)
|
2005-12-20 |
2007-06-28 |
Merck Frosst Canada Ltd. |
Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
|
|
CA2634940A1
(en)
|
2005-12-21 |
2007-07-05 |
Schering Corporation |
Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
|
|
EP1973909A2
(en)
|
2005-12-22 |
2008-10-01 |
Biogen Idec MA Inc. |
Transforming growth factor modulators
|
|
US7361512B2
(en)
|
2006-01-20 |
2008-04-22 |
Beckman Coulter, Inc. |
Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency
|
|
WO2007087505A2
(en)
|
2006-01-25 |
2007-08-02 |
Wellstat Therapeutics Corporation |
Compounds for the treatment of metabolic disorders
|
|
US20100227901A1
(en)
|
2006-02-28 |
2010-09-09 |
Wellstat Therapeutics Corporation |
Compounds for the treatment of metabolic disorders
|
|
WO2007109668A2
(en)
*
|
2006-03-20 |
2007-09-27 |
The Uab Research Foundation |
Compositions and methods for improving bone mass through modulation of novel receptors of pth and fragments thereof
|
|
AU2007238705A1
(en)
|
2006-04-14 |
2007-10-25 |
Amgen Inc. |
Agonist erythropoietin receptor antibodies
|
|
WO2007123391A1
(en)
|
2006-04-20 |
2007-11-01 |
Academisch Ziekenhuis Leiden |
Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
|
|
AU2007249827A1
(en)
|
2006-05-09 |
2007-11-22 |
Colorado State University Research Foundation |
Methods for treating blood disorders
|
|
AU2007275606B9
(en)
|
2006-07-21 |
2013-09-26 |
Lyne Laboratories, Inc. |
Liquid compositions of calcium acetate
|
|
GB0615129D0
(en)
|
2006-07-29 |
2006-09-06 |
Univ Cardiff |
Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies
|
|
WO2008030367A2
(en)
|
2006-09-01 |
2008-03-13 |
The General Hospital Corporation |
Selective myostatin inhibitors
|
|
CL2007002567A1
(es)
|
2006-09-08 |
2008-02-01 |
Amgen Inc |
Proteinas aisladas de enlace a activina a humana.
|
|
US7547781B2
(en)
|
2006-09-11 |
2009-06-16 |
Curis, Inc. |
Quinazoline based EGFR inhibitors containing a zinc binding moiety
|
|
JP5468187B2
(ja)
|
2006-09-26 |
2014-04-09 |
ポリプラスチックス株式会社 |
ポリアセタール樹脂組成物
|
|
WO2008060139A1
(en)
|
2006-11-17 |
2008-05-22 |
Erasmus University Medical Center Rotterdam |
Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein
|
|
WO2008073292A2
(en)
|
2006-12-08 |
2008-06-19 |
Caritas St. Elizabeth's Medical Center Of Boston, Inc. |
Method for protecting renal tubular epithelial cells from radiocontrast nephro parhy (rcn)
|
|
CA2672581A1
(en)
|
2006-12-14 |
2008-06-19 |
Forerunner Pharma Research Co., Ltd. |
Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same
|
|
US20100028332A1
(en)
|
2006-12-18 |
2010-02-04 |
Acceleron Pharma Inc. |
Antagonists of actriib and uses for increasing red blood cell levels
|
|
US8895016B2
(en)
*
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
|
WO2008076437A2
(en)
*
|
2006-12-18 |
2008-06-26 |
Acceleron Pharma Inc. |
Activin-actrii antagonists and uses for increasing red blood cell levels
|
|
CA2677007A1
(en)
|
2007-02-01 |
2008-08-07 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for treating or preventing breast cancer
|
|
TW201803890A
(zh)
|
2007-02-02 |
2018-02-01 |
艾瑟勒朗法瑪公司 |
衍生自ＡｃｔＲＩＩＢ的變體與其用途
|
|
EP2481415B1
(en)
|
2007-02-09 |
2019-09-11 |
Acceleron Pharma Inc. |
Pharmaceutical compositions comprising Activin-ActRIIA antagonists
|
|
US8501678B2
(en)
|
2007-03-06 |
2013-08-06 |
Atara Biotherapeutics, Inc. |
Variant activin receptor polypeptides and uses thereof
|
|
US7947646B2
(en)
|
2007-03-06 |
2011-05-24 |
Amgen Inc. |
Variant activin receptor polypeptides
|
|
US20090017019A1
(en)
|
2007-06-01 |
2009-01-15 |
Wyeth |
Methods and compositions for modulating bmp-10 activity
|
|
WO2009009059A1
(en)
|
2007-07-09 |
2009-01-15 |
Biogen Idec Ma Inc. |
Spiro compounds as antagonists of tgf-beta
|
|
TW200911237A
(en)
|
2007-08-03 |
2009-03-16 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
GB0715938D0
(en)
|
2007-08-15 |
2007-09-26 |
Vastox Plc |
Method of treatment of duchenne muscular dystrophy
|
|
WO2009025651A1
(en)
|
2007-08-17 |
2009-02-26 |
University Of Maine System Board Of Trustees |
Biologically active peptide and method of using the same
|
|
WO2009035629A1
(en)
|
2007-09-13 |
2009-03-19 |
Ludwig Institute Of Cancer Research |
Method for modifying cellular immune response by modulating activin activity
|
|
JP2010539236A
(ja)
|
2007-09-18 |
2010-12-16 |
アクセルロン ファーマ， インコーポレイテッド |
アクチビン−ＡｃｔＲＩＩａ拮抗薬およびＦＳＨ分泌を低減または阻害するための使用
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
WO2009070243A2
(en)
|
2007-11-21 |
2009-06-04 |
Amgen Inc. |
Wise binding agents and epitopes
|
|
EP2265603B1
(en)
*
|
2008-03-13 |
2014-05-07 |
The General Hospital Corporation |
Inhibitors of the bmp signaling pathway
|
|
US8814094B2
(en)
|
2008-04-04 |
2014-08-26 |
Tactair Fluid Controls, Inc. |
Locking mechanism with bi-modal actuator
|
|
WO2009137075A1
(en)
|
2008-05-06 |
2009-11-12 |
Acceleron Pharma Inc. |
Anti-activin antibodies and uses for promoting bone growth
|
|
AU2009244308A1
(en)
|
2008-05-06 |
2009-11-12 |
Joslin Diabetes Center, Inc. |
Methods and compositions for inducing brown adipogenesis
|
|
CN102083439A
(zh)
|
2008-05-30 |
2011-06-01 |
萨马保健系统有限责任公司 |
使用TGF-β受体抑制剂或活化素样激酶(ALK)5抑制剂A-83-01和SB-431542治疗眼病与伤口愈合症状的方法
|
|
CN102131822A
(zh)
*
|
2008-06-26 |
2011-07-20 |
阿塞勒隆制药公司 |
进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法
|
|
KR20110031951A
(ko)
*
|
2008-06-26 |
2011-03-29 |
악셀레론 파마 인코포레이티드 |
액티빈-ａｃｔｒｉｉａ의 길항물질 및 적혈구 수준을 증가시키기 위한 이들의 용도
|
|
TWI626945B
(zh)
|
2008-08-14 |
2018-06-21 |
艾瑟勒朗法瑪公司 |
使用ｇｄｆ阱以增加紅血球水平
|
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
WO2010059861A1
(en)
|
2008-11-20 |
2010-05-27 |
University Of Southern California |
Compositions and methods to modulate hair growth
|
|
NZ627111A
(en)
|
2008-11-26 |
2015-10-30 |
Amgen Inc |
Variants of activin iib receptor polypeptides and uses thereof
|
|
AU2010204985A1
(en)
|
2009-01-13 |
2011-08-04 |
Acceleron Pharma Inc. |
Methods for increasing adiponectin
|
|
BRPI1008815A2
(pt)
*
|
2009-02-05 |
2018-02-14 |
Digna Biotech, S.L |
composições farmacêuticas compreendendo peptídeos inibidores de tgf-beta1
|
|
US8110355B2
(en)
|
2009-02-20 |
2012-02-07 |
GenRemedy, LLC |
Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis
|
|
JP2012524073A
(ja)
|
2009-04-17 |
2012-10-11 |
スムマ ヘルス システムズ エルエルシー |
眼球瘢痕化を抑制するための形質転換成長因子−β受容体阻害剤の使用
|
|
CA2993053A1
(en)
|
2009-04-27 |
2010-11-04 |
Novartis Ag |
Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
|
|
JP5912078B2
(ja)
|
2009-06-08 |
2016-04-27 |
アクセルロン ファーマ， インコーポレイテッド |
熱発生性脂肪細胞を増加させるための方法
|
|
EP3290439B1
(en)
|
2009-06-12 |
2020-09-02 |
Acceleron Pharma Inc. |
Truncated actriib-fc fusion proteins
|
|
CN102655872B
(zh)
|
2009-08-13 |
2016-01-20 |
阿塞勒隆制药公司 |
Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
|
|
JP6211767B2
(ja)
|
2009-09-09 |
2017-10-11 |
アクセルロン ファーマ， インコーポレイテッド |
ＡｃｔＲＩＩｂアンタゴニストならびにその投薬および使用
|
|
WO2011056896A1
(en)
|
2009-11-03 |
2011-05-12 |
Acceleron Pharma Inc. |
Methods for treating fatty liver disease
|
|
EP3332796A1
(en)
|
2009-11-17 |
2018-06-13 |
Acceleron Pharma Inc. |
Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
|
|
WO2012027065A2
(en)
|
2010-08-27 |
2012-03-01 |
Celgene Corporation |
Combination therapy for treatment of disease
|
|
US8580922B2
(en)
|
2011-03-04 |
2013-11-12 |
Shire Human Genetic Therapies, Inc. |
Peptide linkers for polypeptide compositions and methods for using same
|
|
DK2726099T3
(en)
|
2011-07-01 |
2018-11-05 |
Novartis Ag |
Method of treating metabolic disorders
|
|
KR20140084211A
(ko)
|
2011-10-17 |
2014-07-04 |
악셀레론 파마 인코포레이티드 |
효과가 없는 적혈구생성 치료를 위한 방법 및 조성물
|
|
US8765385B2
(en)
|
2011-10-27 |
2014-07-01 |
Ravindra Kumar |
Method of detection of neutralizing anti-actriib antibodies
|
|
WO2013063536A1
(en)
|
2011-10-27 |
2013-05-02 |
Acceleron Pharma, Inc. |
Actriib binding agents and uses thereof
|
|
EP2771017A4
(en)
|
2011-10-28 |
2015-04-01 |
Paranta Biosciences Ltd |
METHOD FOR THE TREATMENT OF SLIP SEED SECRETION
|
|
BR112014015003A2
(pt)
|
2011-12-19 |
2019-09-24 |
Amgen Inc |
composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral
|
|
EP2830642B1
(en)
|
2012-03-30 |
2019-08-28 |
Shire Human Genetic Therapies, Inc. |
Subcutaneous administration of iduronate- 2-sulfatase
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
EP3521310A1
(en)
|
2012-06-14 |
2019-08-07 |
The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center |
Use of blocking agents of bone morphogenic protein (bmp) signaling for the treatment of neuroinflammatory and neurodegenerative diseases
|
|
CN104411720B
(zh)
|
2012-07-02 |
2018-05-11 |
协和发酵麒麟株式会社 |
以抗bmp9抗体作为有效成分的、对肾性贫血、癌性贫血等贫血的治疗剂
|
|
CA2889286A1
(en)
|
2012-10-24 |
2014-05-01 |
Celgene Corporation |
Methods for treating anemia
|
|
EP2912462B1
(en)
|
2012-10-24 |
2019-08-07 |
Celgene Corporation |
Biomarker for use in treating anemia
|
|
WO2014064292A1
(en)
|
2012-10-26 |
2014-05-01 |
Universite Pierre Et Marie Curie (Paris 6) |
A method for preventing or treating atrial fibrillation
|
|
US10195249B2
(en)
|
2012-11-02 |
2019-02-05 |
Celgene Corporation |
Activin-ActRII antagonists and uses for treating bone and other disorders
|
|
KR102467714B1
(ko)
|
2012-11-08 |
2022-11-16 |
클리어사이드 바이오메디컬, 인코포레이드 |
인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치
|
|
CN103047581B
(zh)
|
2012-12-04 |
2015-04-01 |
京东方科技集团股份有限公司 |
背光模组及具有该背光模组的显示装置
|
|
WO2014093531A1
(en)
|
2012-12-11 |
2014-06-19 |
Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center |
Modulation of myofiber repair by anti-myostatin in strategies with stem cells
|
|
US20140220033A1
(en)
|
2013-02-01 |
2014-08-07 |
Santa Maria Biotherapeutics, Inc. |
Administration of an Anti-Activin-A Compound to a Subject
|
|
TW201920262A
(zh)
|
2013-07-30 |
2019-06-01 |
美商再生元醫藥公司 |
抗活化素ａ之抗體及其用途
|
|
CA2918300A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Methods of treating sporadic inclusion body myositis
|
|
JP2017505428A
(ja)
|
2013-12-16 |
2017-02-16 |
パランタ バイオサイエンス リミテッド |
診断及び治療の方法
|
|
US20160333418A1
(en)
|
2014-01-14 |
2016-11-17 |
Santa Maria Biotherapeutics, Inc. |
Activin Inhibitor Response Prediction and Uses for Treatment
|
|
JP2017510622A
(ja)
|
2014-01-27 |
2017-04-13 |
ノバルティス アーゲー |
筋萎縮を予測するバイオマーカー、方法および使用
|
|
EP3119418B1
(en)
|
2014-03-21 |
2022-02-23 |
Acceleron Pharma Inc. |
Composition for use in a method of treating or preventing anemia by inhibiting activin b and gdf11
|
|
US10260068B2
(en)
|
2014-03-31 |
2019-04-16 |
Sumitomo Dainippon Pharma Co., Ltd. |
Prophylactic agent and therapeutic agent for fibrodysplasia ossificans progressiva
|
|
BR112016024319B1
(pt)
|
2014-04-18 |
2024-01-23 |
Acceleron Pharma Inc |
USO DE UMA COMPOSIÇÃO COMPREENDENDO UM ANTAGONISTA DE ActRII PARA A FABRICAÇÃO DE UM MEDICAMENTO PARA TRATAR OU PREVINIR UMA COMPLICAÇÃO DE ANEMIA FALCIFORME
|
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
|
MA40008A
(fr)
|
2014-06-13 |
2021-05-05 |
Acceleron Pharma Inc |
Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
|
|
PE20170471A1
(es)
|
2014-06-13 |
2017-05-14 |
Santa Maria Biotherapeutics Inc |
Polipeptidos receptores formulados y metodos relacionados
|
|
MA41052A
(fr)
|
2014-10-09 |
2017-08-15 |
Celgene Corp |
Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
|
|
TWI730949B
(zh)
|
2014-12-03 |
2021-06-21 |
美商西建公司 |
活化素-ａｃｔｒｉｉ拮抗劑及治療貧血之用途
|
|
MA41119A
(fr)
|
2014-12-03 |
2017-10-10 |
Acceleron Pharma Inc |
Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
|
|
JP6976859B2
(ja)
|
2015-05-13 |
2021-12-08 |
セルジーン コーポレイション |
ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療
|
|
EP3298034A4
(en)
|
2015-05-20 |
2019-02-13 |
Celgene Corporation |
IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS
|
|
CN116327952A
(zh)
|
2015-08-04 |
2023-06-27 |
阿塞勒隆制药公司 |
用于治疗骨髓增生性病症的方法
|
|
EP3370754B1
(en)
|
2015-11-04 |
2026-04-29 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating ineffective erythropoiesis
|
|
CA3005975A1
(en)
|
2015-11-23 |
2017-06-01 |
Acceleron Pharma Inc. |
Methods for treating eye disorders
|
|
HUE067225T2
(hu)
|
2016-07-27 |
2024-10-28 |
Acceleron Pharma Inc |
Mielofibrózis kezelésére szolgáló készítmények
|