CA2890217C - Activin-actrii antagonists and uses for treating bone and other disorders - Google Patents

Activin-actrii antagonists and uses for treating bone and other disorders Download PDF

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Publication number
CA2890217C
CA2890217C CA2890217A CA2890217A CA2890217C CA 2890217 C CA2890217 C CA 2890217C CA 2890217 A CA2890217 A CA 2890217A CA 2890217 A CA2890217 A CA 2890217A CA 2890217 C CA2890217 C CA 2890217C
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Canada
Prior art keywords
seq
amino acid
acid sequence
actriib
polypeptide
Prior art date
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Application number
CA2890217A
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English (en)
French (fr)
Other versions
CA2890217A1 (en
Inventor
Yifu FANG
Victor Schorr Sloan
Keith Hruska
Victoria Sung
Randall Stevens
William Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Washington University in St Louis WUSTL
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Celgene Corp
Washington University in St Louis WUSTL
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Priority to CA3120678A priority Critical patent/CA3120678A1/en
Publication of CA2890217A1 publication Critical patent/CA2890217A1/en
Application granted granted Critical
Publication of CA2890217C publication Critical patent/CA2890217C/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796Receptors; Cell surface antigens; Cell surface determinants for hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2890217A 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders Active CA2890217C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3120678A CA3120678A1 (en) 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261721898P 2012-11-02 2012-11-02
US61/721,898 2012-11-02
US201261740665P 2012-12-21 2012-12-21
US61/740,665 2012-12-21
PCT/US2013/068009 WO2014071158A1 (en) 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3120678A Division CA3120678A1 (en) 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders

Publications (2)

Publication Number Publication Date
CA2890217A1 CA2890217A1 (en) 2014-05-08
CA2890217C true CA2890217C (en) 2021-07-20

Family

ID=50628091

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2890217A Active CA2890217C (en) 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders
CA3120678A Pending CA3120678A1 (en) 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3120678A Pending CA3120678A1 (en) 2012-11-02 2013-11-01 Activin-actrii antagonists and uses for treating bone and other disorders

Country Status (15)

Country Link
US (3) US10195249B2 (enExample)
EP (3) EP2914277B1 (enExample)
JP (4) JP2016504275A (enExample)
KR (3) KR20210091358A (enExample)
CN (1) CN104936605A (enExample)
AU (3) AU2013337677B2 (enExample)
BR (1) BR112015009948B1 (enExample)
CA (2) CA2890217C (enExample)
ES (2) ES2652437T3 (enExample)
IL (2) IL238443B (enExample)
MX (2) MX366336B (enExample)
NZ (1) NZ707477A (enExample)
RU (2) RU2678117C2 (enExample)
WO (1) WO2014071158A1 (enExample)
ZA (1) ZA201503135B (enExample)

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US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
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CN101861161B (zh) 2007-09-18 2017-04-19 阿塞勒隆制药公司 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途
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CN107320718B (zh) * 2017-05-23 2020-12-11 余红 促生长激素释放激素激动剂在制备抗血管钙化药物中的应用
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US20150283209A1 (en) 2015-10-08
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