IL233874A0 - Combination therapy including tenofovir alfenamide mipomarate and cobicistat for use in the treatment of viral infections - Google Patents
Combination therapy including tenofovir alfenamide mipomarate and cobicistat for use in the treatment of viral infectionsInfo
- Publication number
- IL233874A0 IL233874A0 IL233874A IL23387414A IL233874A0 IL 233874 A0 IL233874 A0 IL 233874A0 IL 233874 A IL233874 A IL 233874A IL 23387414 A IL23387414 A IL 23387414A IL 233874 A0 IL233874 A0 IL 233874A0
- Authority
- IL
- Israel
- Prior art keywords
- cobicistat
- treatment
- combination therapy
- viral infections
- tenofovir alafenamide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594894P | 2012-02-03 | 2012-02-03 | |
| US201261618411P | 2012-03-30 | 2012-03-30 | |
| US201261624676P | 2012-04-16 | 2012-04-16 | |
| US201261692392P | 2012-08-23 | 2012-08-23 | |
| US201261737493P | 2012-12-14 | 2012-12-14 | |
| PCT/US2013/024438 WO2013116720A1 (en) | 2012-02-03 | 2013-02-01 | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL233874A0 true IL233874A0 (en) | 2014-09-30 |
Family
ID=47722563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL233874A IL233874A0 (en) | 2012-02-03 | 2014-07-30 | Combination therapy including tenofovir alfenamide mipomarate and cobicistat for use in the treatment of viral infections |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150105350A1 (enExample) |
| EP (1) | EP2809323A1 (enExample) |
| JP (1) | JP6059255B2 (enExample) |
| KR (1) | KR20140119177A (enExample) |
| CN (1) | CN104105484A (enExample) |
| AU (3) | AU2013204727A1 (enExample) |
| BR (1) | BR112014018918A8 (enExample) |
| CA (1) | CA2863662A1 (enExample) |
| EA (1) | EA026138B1 (enExample) |
| HK (2) | HK1202801A1 (enExample) |
| IL (1) | IL233874A0 (enExample) |
| MD (1) | MD20140091A2 (enExample) |
| MX (1) | MX2014009172A (enExample) |
| NZ (1) | NZ629896A (enExample) |
| WO (2) | WO2013116730A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4403221A3 (en) | 2007-02-23 | 2024-10-09 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| AU2009333559B2 (en) | 2008-12-09 | 2015-03-12 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| CN110343135A (zh) † | 2011-08-16 | 2019-10-18 | 吉利德科学公司 | 替诺福韦艾拉酚胺(tenofovir alafenamide)半反丁烯二酸盐 |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| HK1220390A1 (zh) * | 2013-08-29 | 2017-05-05 | Teva Pharmaceutical Industries Ltd. | 包括恩曲他滨，替诺福韦，达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂 |
| IN2013CH05455A (enExample) * | 2013-11-27 | 2015-08-07 | Laurus Labs Private Ltd | |
| WO2015120057A1 (en) * | 2014-02-05 | 2015-08-13 | Gilead Sciences, Inc. | Pharmaceutical combinations against co-infection with hiv and tuberculosis |
| EP3129009A1 (en) * | 2014-04-08 | 2017-02-15 | Teva Pharmaceutical Industries Ltd | Unit dosage form comprising emtricitabine, tenofovir, darunavir and ritonavir |
| WO2015161781A1 (zh) * | 2014-04-21 | 2015-10-29 | 四川海思科制药有限公司 | 一种核苷类似物及其中间体的制备方法 |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| TWI733652B (zh) * | 2014-07-11 | 2021-07-21 | 美商基利科學股份有限公司 | 用於治療ＨＩＶ之ｔｏｌｌ樣受體調節劑 |
| JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｏｌｌ様受容体モジュレーターの固体形態 |
| CN105237571B (zh) * | 2014-11-28 | 2018-03-09 | 成都苑东生物制药股份有限公司 | 9‑[(r)‑2‑[[(s)‑[[(s)‑1‑(异丙氧基羰基)乙基]氨基]苯氧基氧膦基]甲氧基]丙基]腺嘌呤的盐 |
| EP3226973A4 (en) * | 2014-12-04 | 2018-05-30 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| IL296496B2 (en) | 2014-12-26 | 2024-10-01 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| EP3240793A1 (en) * | 2015-01-03 | 2017-11-08 | Mylan Laboratories Ltd. | Processes for the preparation of amorphous tenofovir alafenamide hemifumarate and a premix thereof |
| US10835496B2 (en) | 2015-04-21 | 2020-11-17 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| CN104817593B (zh) * | 2015-04-27 | 2016-11-16 | 广州同隽医药科技有限公司 | 半富马酸替诺福韦艾拉酚胺关键中间体的合成工艺 |
| CA2921336A1 (en) * | 2015-06-30 | 2016-12-30 | Gilead Sciences, Inc. | Pharmaceutical formulations |
| EA201792592A1 (ru) * | 2015-06-30 | 2018-06-29 | Джилид Сайэнс, Инк. | Фармацевтические препараты, содержащие тенофовир и эмтрицитабин |
| US9598459B2 (en) | 2015-08-03 | 2017-03-21 | Pop Test Oncology Llc | Pharmaceutical compositions and methods |
| CN105153231A (zh) * | 2015-08-28 | 2015-12-16 | 浙江车头制药股份有限公司 | 一种一苯基pmpa的制备方法 |
| SI3346995T1 (sl) * | 2015-11-09 | 2019-11-29 | Gilead Sciences Inc | Terapevtski sestavek za zdravljenje virusa človeške imunske pomanjkljivosti |
| EP3413913B1 (en) * | 2016-02-12 | 2021-11-24 | Cipla Limited | Pharmaceutical compositions comprising an anti-retroviral drug and a pharmacokinetic enhancer |
| CN107179355B (zh) * | 2016-03-11 | 2021-08-10 | 广东东阳光药业有限公司 | 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法 |
| EP3503895B1 (en) * | 2016-08-25 | 2021-09-15 | Merck Sharp & Dohme Corp. | Antiviral prodrugs of tenofovir |
| CN108070003A (zh) * | 2016-12-02 | 2018-05-25 | 上海博志研新药物技术有限公司 | 替诺福韦艾拉酚胺半反丁烯二酸盐晶型及制备方法和应用 |
| RU2659388C1 (ru) | 2017-02-28 | 2018-07-02 | Васильевич Иващенко Александр | Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение |
| RU2647576C1 (ru) * | 2017-02-28 | 2018-03-16 | Васильевич Иващенко Александр | Циклобутил (S)-2-[[[(R)-2-(6-аминопурин-9-ил)-1-метил-этокси]метил-фенокси-фосфорил]амино]-пропаноаты, способ их получения и применения |
| CN106928277A (zh) * | 2017-03-16 | 2017-07-07 | 江苏诚信药业有限公司 | 一种替诺福韦艾拉酚胺合成的工艺方法 |
| EP3600332B1 (en) | 2017-03-20 | 2023-12-13 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hiv post-exposure prophylaxis |
| AU2018255954B2 (en) * | 2017-04-18 | 2024-04-04 | Cipla Limited | Combination therapy for use in treating retroviral infections |
| RU2659693C1 (ru) * | 2017-06-30 | 2018-07-03 | Общество с ограниченной ответственностью "Изварино Фарма" | Фармацевтическая композиция, обладающая активностью против ВИЧ-инфекции |
| US20190151307A1 (en) * | 2017-10-24 | 2019-05-23 | Gilead Sciences, Inc. | Methods of treating patients co-infected with a virus and tuberculosis |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CN110305163A (zh) * | 2018-03-27 | 2019-10-08 | 北京济美堂医药研究有限公司 | 替诺福韦艾拉酚胺半富马酸盐的制备方法 |
| CN108484672A (zh) * | 2018-05-23 | 2018-09-04 | 中国药科大学制药有限公司 | 磷丙替诺福韦的手性拆分方法 |
| CN109081853A (zh) * | 2018-09-03 | 2018-12-25 | 南京正大天晴制药有限公司 | 一种磷丙替诺福韦有关物质的制备方法 |
| KR20220011685A (ko) | 2019-05-22 | 2022-01-28 | 길리애드 사이언시즈, 인코포레이티드 | Tlr7 조절 화합물과 hiv 백신의 조합 |
| WO2020258211A1 (en) * | 2019-06-28 | 2020-12-30 | Anhui Ronghang Biotech Development Co., Ltd. | Compositions and methods for treatment of hepatitis b virus infection |
| CA3146263A1 (en) | 2019-07-19 | 2021-01-28 | Jose Gerardo Garcia Lerma | Hiv pre-exposure prophylaxis |
| CN111606949A (zh) * | 2020-03-13 | 2020-09-01 | 浙江车头制药股份有限公司 | 一种磷丙替诺福韦杂质的制备方法 |
| CN111303209A (zh) * | 2020-03-21 | 2020-06-19 | 石家庄龙泽制药股份有限公司 | 一种丙酚替诺福韦降解杂质的制备方法 |
| US20240009214A1 (en) * | 2020-12-02 | 2024-01-11 | Cipla Limited | Method of Treating Viral Infection |
| EP4680243A1 (en) | 2023-03-17 | 2026-01-21 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Methods for treatment of age-related macular degeneration |
| EP4640214A1 (en) * | 2024-03-28 | 2025-10-29 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A tablet comprising tenofovir alafenamide monofumarate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB453061A (en) | 1935-03-23 | 1936-09-04 | Charles Howard Twigg | Improvements in and relating to gas heated geysers and water heaters |
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| CN1291994C (zh) | 2000-07-21 | 2006-12-27 | 吉里德科学公司 | 核苷酸膦酸酯类似物前药及其筛选和制备方法 |
| DE10153078A1 (de) | 2001-10-30 | 2003-05-22 | Degussa | Verwendung von Granulaten auf Basis von pyrogen hergestelltem Siliciumdioxid in pharmazeutischen Zusammensetzungen |
| EA015145B1 (ru) | 2003-01-14 | 2011-06-30 | Джилид Сайэнс, Инк. | Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции |
| EP4403221A3 (en) * | 2007-02-23 | 2024-10-09 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| KR20100041798A (ko) | 2007-06-29 | 2010-04-22 | 한국화학연구원 | 신규 ｈｉｖ 역전사효소 억제제 |
| CN102307573B (zh) * | 2009-02-06 | 2013-09-11 | 吉里德科学公司 | 用于联合治疗的片剂 |
| CN110343135A (zh) * | 2011-08-16 | 2019-10-18 | 吉利德科学公司 | 替诺福韦艾拉酚胺(tenofovir alafenamide)半反丁烯二酸盐 |
-
2013
- 2013-02-01 MD MDA20140091A patent/MD20140091A2/ro not_active Application Discontinuation
- 2013-02-01 JP JP2014555783A patent/JP6059255B2/ja active Active
- 2013-02-01 HK HK15103394.9A patent/HK1202801A1/xx unknown
- 2013-02-01 CN CN201380007670.XA patent/CN104105484A/zh active Pending
- 2013-02-01 KR KR20147024291A patent/KR20140119177A/ko not_active Withdrawn
- 2013-02-01 BR BR112014018918A patent/BR112014018918A8/pt not_active IP Right Cessation
- 2013-02-01 WO PCT/US2013/024451 patent/WO2013116730A1/en not_active Ceased
- 2013-02-01 HK HK15105031.3A patent/HK1204914A1/xx unknown
- 2013-02-01 CA CA 2863662 patent/CA2863662A1/en not_active Abandoned
- 2013-02-01 MX MX2014009172A patent/MX2014009172A/es unknown
- 2013-02-01 NZ NZ629896A patent/NZ629896A/en unknown
- 2013-02-01 AU AU2013204727A patent/AU2013204727A1/en not_active Abandoned
- 2013-02-01 WO PCT/US2013/024438 patent/WO2013116720A1/en not_active Ceased
- 2013-02-01 EA EA201491287A patent/EA026138B1/ru unknown
- 2013-02-01 AU AU2013204731A patent/AU2013204731C1/en active Active
- 2013-02-01 EP EP13704863.3A patent/EP2809323A1/en not_active Withdrawn
- 2013-02-01 US US14/376,116 patent/US20150105350A1/en not_active Abandoned
-
2014
- 2014-07-30 IL IL233874A patent/IL233874A0/en unknown
-
2016
- 2016-06-02 AU AU2016203666A patent/AU2016203666A1/en not_active Abandoned
- 2016-10-03 US US15/284,105 patent/US20170056423A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014009172A (es) | 2014-08-27 |
| US20150105350A1 (en) | 2015-04-16 |
| EA201491287A1 (ru) | 2015-04-30 |
| MD20140091A2 (ro) | 2015-01-31 |
| US20170056423A1 (en) | 2017-03-02 |
| JP6059255B2 (ja) | 2017-01-11 |
| WO2013116730A1 (en) | 2013-08-08 |
| AU2013204727A1 (en) | 2013-08-22 |
| EP2809323A1 (en) | 2014-12-10 |
| AU2013204731B2 (en) | 2016-03-03 |
| BR112014018918A8 (pt) | 2017-07-11 |
| BR112014018918A2 (enExample) | 2017-06-20 |
| AU2013204731C1 (en) | 2017-08-31 |
| JP2015505565A (ja) | 2015-02-23 |
| WO2013116720A1 (en) | 2013-08-08 |
| AU2016203666A1 (en) | 2016-06-23 |
| HK1204914A1 (en) | 2015-12-11 |
| HK1202801A1 (en) | 2015-10-09 |
| KR20140119177A (ko) | 2014-10-08 |
| CN104105484A (zh) | 2014-10-15 |
| CA2863662A1 (en) | 2013-08-08 |
| NZ629896A (en) | 2016-03-31 |
| AU2013204731A1 (en) | 2013-08-22 |
| EA026138B1 (ru) | 2017-03-31 |
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