IN2013CH05455A - - Google Patents
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- Publication number
- IN2013CH05455A IN2013CH05455A IN5455CH2013A IN2013CH05455A IN 2013CH05455 A IN2013CH05455 A IN 2013CH05455A IN 5455CH2013 A IN5455CH2013 A IN 5455CH2013A IN 2013CH05455 A IN2013CH05455 A IN 2013CH05455A
- Authority
- IN
- India
- Prior art keywords
- diastereomer
- undesired
- racemization
- recycle
- efficient
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- LDEKQSIMHVQZJK-CAQYMETFSA-N tenofovir alafenamide Chemical compound O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 LDEKQSIMHVQZJK-CAQYMETFSA-N 0.000 abstract 1
- 229960004946 tenofovir alafenamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2014/000734 WO2015079455A2 (en) | 2013-11-27 | 2014-11-27 | A recycling process for preparing tenofovir alafenamide diastereomers |
| IN5455CH2013 IN2013CH05455A (enExample) | 2013-11-27 | 2014-11-27 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5455CH2013 IN2013CH05455A (enExample) | 2013-11-27 | 2014-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013CH05455A true IN2013CH05455A (enExample) | 2015-08-07 |
Family
ID=53199699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN5455CH2013 IN2013CH05455A (enExample) | 2013-11-27 | 2014-11-27 |
Country Status (2)
| Country | Link |
|---|---|
| IN (1) | IN2013CH05455A (enExample) |
| WO (1) | WO2015079455A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107179355B (zh) * | 2016-03-11 | 2021-08-10 | 广东东阳光药业有限公司 | 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法 |
| CN107655987B (zh) * | 2017-09-08 | 2020-11-03 | 厦门蔚扬药业有限公司 | 一种替诺福韦艾拉酚胺及其异构体的hplc检测方法 |
| CN111239285B (zh) * | 2020-02-20 | 2020-10-09 | 北京阳光诺和药物研究有限公司 | 一种替诺呋韦艾拉酚胺中基因毒性杂质的含量检测方法 |
| CN111189947B (zh) * | 2020-03-30 | 2022-06-17 | 济南新科医药科技有限公司 | 一种分离检测富马酸丙酚替诺福韦异构体的分析方法 |
| CN113970612B (zh) * | 2020-07-22 | 2023-08-01 | 北京四环制药有限公司 | 一种高效液相色谱法测定丙酚替诺福韦有关物质的方法 |
| CN114137092B (zh) * | 2020-09-03 | 2025-02-11 | 北京四环制药有限公司 | 一种测定丙酚替诺福韦异构体的方法 |
| CN113075307B (zh) * | 2021-03-08 | 2025-03-11 | 瑞阳制药股份有限公司 | 富马酸丙酚替诺福韦异构体的检测方法 |
| CN116609445B (zh) * | 2022-12-01 | 2025-12-16 | 上海医药工业研究院有限公司 | 无环核苷膦酸酯类化合物及其制备方法、分析方法和应用 |
| CN118883741A (zh) * | 2024-07-05 | 2024-11-01 | 福建广生堂药业股份有限公司 | 一种富马酸丙酚替诺福韦及其对映异构体的分离检测方法及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20030047B1 (hr) * | 2000-07-21 | 2016-02-26 | Gilead Sciences, Inc. | Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava |
| ES2661705T3 (es) * | 2011-10-07 | 2018-04-03 | Gilead Sciences, Inc. | Métodos para la preparación de análogos de nucleótidos antivirales |
| WO2013116730A1 (en) * | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
-
2014
- 2014-11-27 IN IN5455CH2013 patent/IN2013CH05455A/en unknown
- 2014-11-27 WO PCT/IN2014/000734 patent/WO2015079455A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015079455A3 (en) | 2015-08-27 |
| WO2015079455A2 (en) | 2015-06-04 |
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