IN2013CH05455A - - Google Patents
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- Publication number
- IN2013CH05455A IN2013CH05455A IN5455CH2013A IN2013CH05455A IN 2013CH05455 A IN2013CH05455 A IN 2013CH05455A IN 5455CH2013 A IN5455CH2013 A IN 5455CH2013A IN 2013CH05455 A IN2013CH05455 A IN 2013CH05455A
- Authority
- IN
- India
- Prior art keywords
- diastereomer
- undesired
- racemization
- recycle
- efficient
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- LDEKQSIMHVQZJK-CAQYMETFSA-N tenofovir alafenamide Chemical compound O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 LDEKQSIMHVQZJK-CAQYMETFSA-N 0.000 abstract 1
- 229960004946 tenofovir alafenamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to an efficient and economical process to recycle the undesired diastereomer of Tenofovir alafenamide to desired diastereomer by racemization of the undesired diastereomer followed by separation of the desired diastereomer from the racemic mixture.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2014/000734 WO2015079455A2 (en) | 2013-11-27 | 2014-11-27 | A recycling process for preparing tenofovir alafenamide diastereomers |
IN5455CH2013 IN2013CH05455A (en) | 2013-11-27 | 2014-11-27 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN5455CH2013 IN2013CH05455A (en) | 2013-11-27 | 2014-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013CH05455A true IN2013CH05455A (en) | 2015-08-07 |
Family
ID=53199699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN5455CH2013 IN2013CH05455A (en) | 2013-11-27 | 2014-11-27 |
Country Status (2)
Country | Link |
---|---|
IN (1) | IN2013CH05455A (en) |
WO (1) | WO2015079455A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107179355B (en) * | 2016-03-11 | 2021-08-10 | 广东东阳光药业有限公司 | Method for separating and detecting tenofovir alafenamide and related substances thereof |
CN107655987B (en) * | 2017-09-08 | 2020-11-03 | 厦门蔚扬药业有限公司 | HPLC detection method for tenofovir alafenamide and isomer thereof |
CN111239285B (en) * | 2020-02-20 | 2020-10-09 | 北京阳光诺和药物研究有限公司 | Method for detecting content of genotoxic impurities in Tenofovir alafenamide |
CN111189947B (en) * | 2020-03-30 | 2022-06-17 | 济南新科医药科技有限公司 | Analysis method for separating and detecting propane fumarate tenofovir disoproxil isomer |
CN113970612B (en) * | 2020-07-22 | 2023-08-01 | 北京四环制药有限公司 | Method for measuring related substances of propiophenone tenofovir by high performance liquid chromatography |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1291994C (en) * | 2000-07-21 | 2006-12-27 | 吉里德科学公司 | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
MX353064B (en) * | 2011-10-07 | 2017-12-19 | Gilead Sciences Inc | Methods for preparing anti-viral nucleotide analogs. |
CN104105484A (en) * | 2012-02-03 | 2014-10-15 | 吉联亚科学公司 | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
-
2014
- 2014-11-27 IN IN5455CH2013 patent/IN2013CH05455A/en unknown
- 2014-11-27 WO PCT/IN2014/000734 patent/WO2015079455A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015079455A3 (en) | 2015-08-27 |
WO2015079455A2 (en) | 2015-06-04 |
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