IL192277A - Pharmaceutical compounds with resistance to cea soluble, specific bivalve-specific antibodies that bind cea, nucleic acid sequences encoding the antibodies, vectors and surrogate cells containing the nucleic acids, as well as processes for their creation, uses and compatible kits - Google Patents
Pharmaceutical compounds with resistance to cea soluble, specific bivalve-specific antibodies that bind cea, nucleic acid sequences encoding the antibodies, vectors and surrogate cells containing the nucleic acids, as well as processes for their creation, uses and compatible kitsInfo
- Publication number
- IL192277A IL192277A IL192277A IL19227708A IL192277A IL 192277 A IL192277 A IL 192277A IL 192277 A IL192277 A IL 192277A IL 19227708 A IL19227708 A IL 19227708A IL 192277 A IL192277 A IL 192277A
- Authority
- IL
- Israel
- Prior art keywords
- cea
- vectors
- processes
- resistance
- acid sequences
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75196305P | 2005-12-21 | 2005-12-21 | |
| EP05028064 | 2005-12-21 | ||
| US78086106P | 2006-03-10 | 2006-03-10 | |
| PCT/EP2006/012425 WO2007071426A1 (en) | 2005-12-21 | 2006-12-21 | Pharmaceutical compositions with resistance to soluble cea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL192277A0 IL192277A0 (en) | 2008-12-29 |
| IL192277A true IL192277A (en) | 2016-08-31 |
Family
ID=40413962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL192277A IL192277A (en) | 2005-12-21 | 2008-06-18 | Pharmaceutical compounds with resistance to cea soluble, specific bivalve-specific antibodies that bind cea, nucleic acid sequences encoding the antibodies, vectors and surrogate cells containing the nucleic acids, as well as processes for their creation, uses and compatible kits |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8394926B2 (enExample) |
| EP (2) | EP1976880B1 (enExample) |
| JP (2) | JP5399712B2 (enExample) |
| KR (1) | KR101287777B1 (enExample) |
| CN (1) | CN101370827B (enExample) |
| AU (1) | AU2006328886C1 (enExample) |
| BR (1) | BRPI0620632A2 (enExample) |
| CA (1) | CA2633766C (enExample) |
| CY (1) | CY1118053T1 (enExample) |
| DK (1) | DK1976880T3 (enExample) |
| ES (1) | ES2595091T3 (enExample) |
| HR (1) | HRP20161216T1 (enExample) |
| HU (1) | HUE031151T2 (enExample) |
| IL (1) | IL192277A (enExample) |
| LT (1) | LT1976880T (enExample) |
| ME (1) | ME02581B (enExample) |
| NZ (1) | NZ569204A (enExample) |
| PL (1) | PL1976880T3 (enExample) |
| PT (1) | PT1976880T (enExample) |
| RS (1) | RS55181B1 (enExample) |
| RU (2) | RU2426743C2 (enExample) |
| SG (1) | SG193141A1 (enExample) |
| WO (1) | WO2007071426A1 (enExample) |
| ZA (1) | ZA200805400B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
| PT1976880T (pt) | 2005-12-21 | 2016-09-28 | Amgen Res Munich Gmbh | Composições farmacêuticas com resistência a cea solúvel |
| US20090226444A1 (en) * | 2005-12-21 | 2009-09-10 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
| WO2008134461A2 (en) | 2007-04-27 | 2008-11-06 | Dow Global Technologies, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| WO2009070642A1 (en) | 2007-11-28 | 2009-06-04 | Medimmune, Llc | Protein formulation |
| GB0908613D0 (en) * | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| US20130035249A1 (en) * | 2009-12-01 | 2013-02-07 | Medimmune, Llc | Methods and compositions for detecting and treating cea-expressing cancers |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| WO2013012414A1 (en) * | 2011-07-18 | 2013-01-24 | Medimmune, Llc | Dosing regimens for treatment of cea-expressing cancers |
| WO2013054320A1 (en) * | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| US9783610B2 (en) | 2012-04-27 | 2017-10-10 | The Trustees Of The University Of Pennsylvania | Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof |
| WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| EP3586874A1 (en) | 2012-08-14 | 2020-01-01 | IBC Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| US20150231241A1 (en) | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| CA3169263A1 (en) | 2012-11-13 | 2014-05-22 | Astellas Pharma Inc. | Agents for treatment of claudin expressing cancer diseases |
| HUE033369T2 (en) | 2012-11-20 | 2017-11-28 | Sanofi Sa | Anti-CEACAM5 antibodies and their applications |
| BR112015017800A2 (pt) | 2013-02-26 | 2017-11-21 | Roche Glycart Ag | moléculas de ligação ao antígeno biespecífica ativadora de célula t, polinucleotídeo, polipeptídeo, vetor, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica ativadora de célula t, composição farmacêutica e uso da molécula de ligação ao antígeno biespecífica ativadora de célula t |
| MX375359B (es) * | 2013-02-26 | 2025-03-06 | Roche Glycart Ag | Moléculas biespecíficas de unión a antígeno activadoras de células t. |
| ES2753950T3 (es) | 2013-03-15 | 2020-04-15 | Amgen Res Munich Gmbh | Moléculas de unión monocatenarias que comprenden ABP del extremo N |
| EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
| WO2015166484A1 (en) | 2014-04-27 | 2015-11-05 | Ccam Therapeutics Ltd. | Humanized antibodies against ceacam1 |
| RU2016151645A (ru) | 2014-07-01 | 2018-08-03 | Пфайзер Инк. | Биспецифические гетеродимерные диантитела и их применение |
| EP3262217A4 (en) | 2015-02-24 | 2018-07-18 | BioAtla LLC | Conditionally active biological proteins |
| CN106432502B (zh) * | 2015-08-10 | 2020-10-27 | 中山大学 | 用于治疗cea阳性表达肿瘤的双特异纳米抗体 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CA2990755A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffman-La Roche Ag | Bispecific anti-ceaxcd3 t cell activating antigen binding molecules |
| CA2997406C (en) | 2015-12-09 | 2024-05-28 | F. Hoffmann-La Roche Ag | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release |
| CN108368179B (zh) * | 2016-01-08 | 2022-08-23 | 豪夫迈·罗氏有限公司 | 使用pd-1轴结合拮抗剂和抗cea/抗cd3双特异性抗体治疗cea阳性癌症的方法 |
| WO2017208018A1 (en) | 2016-06-02 | 2017-12-07 | Immunocore Limited | Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein |
| CN107663240B (zh) * | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用 |
| JP7125400B2 (ja) | 2016-12-19 | 2022-08-24 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 標的化４－１ｂｂ（ｃｄ１３７）アゴニストとの併用療法 |
| KR20190099527A (ko) | 2017-01-03 | 2019-08-27 | 에프. 호프만-라 로슈 아게 | 항-4-1bb 클론 20h4.9를 포함하는 이중특이성 항원 결합 분자 |
| CN107056952A (zh) * | 2017-05-10 | 2017-08-18 | 常州市第人民医院 | Cea.car‑t及其制备与应用 |
| CN107058234B (zh) * | 2017-05-12 | 2019-09-13 | 常州市第一人民医院 | Car.il-33-t及其制备与应用 |
| KR102794369B1 (ko) | 2017-08-01 | 2025-04-15 | 에이비 테라퓨틱스 인코퍼레이티드 | 이중특이 항체 및 그의 용도 |
| EP3704155A2 (en) | 2017-11-01 | 2020-09-09 | F. Hoffmann-La Roche AG | Combination therapy with targeted ox40 agonists |
| EP3502140A1 (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| ES2973518T3 (es) | 2018-06-03 | 2024-06-20 | Lamkap Bio Beta Ag | Anticuerpos biespecíficos contra CEACAM5 y CD47 |
| JP2021528988A (ja) | 2018-07-04 | 2021-10-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 新規の二重特異性アゴニスト４−１ｂｂ抗原結合分子 |
| WO2020127618A1 (en) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic cd28 antigen binding molecules |
| WO2020159918A2 (en) | 2019-01-28 | 2020-08-06 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| EP3693023A1 (en) | 2019-02-11 | 2020-08-12 | Sanofi | Use of anti-ceacam5 immunoconjugates for treating lung cancer |
| CN114173823A (zh) | 2019-02-07 | 2022-03-11 | 赛诺菲 | 抗ceacam5免疫缀合物用于治疗肺癌的用途 |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| KR20220034784A (ko) | 2019-06-13 | 2022-03-18 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | 아미노벤즈아제핀 화합물, 면역접합체, 및 이의 용도 |
| CN114531878A (zh) * | 2019-06-27 | 2022-05-24 | 豪夫迈·罗氏有限公司 | 新颖icos抗体及包含它们的肿瘤靶向抗原结合分子 |
| WO2021041300A2 (en) * | 2019-08-23 | 2021-03-04 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| CA3148694A1 (en) | 2019-09-03 | 2021-03-11 | Romas Kudirka | Aminoquinoline compounds, immunoconjugates, and uses thereof |
| PE20221045A1 (es) | 2019-09-18 | 2022-06-22 | Lamkap Bio Alpha AG | Anticuerpos biespecificos contra ceacam5 y cd3 |
| AU2020359446A1 (en) | 2019-09-30 | 2022-04-21 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
| KR20220088901A (ko) | 2019-10-25 | 2022-06-28 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | 티에노아제핀 면역접합체, 및 이의 용도 |
| TW202128765A (zh) * | 2019-11-21 | 2021-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種雙特異性抗體 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| EP4146282A1 (en) | 2020-05-08 | 2023-03-15 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
| JP2023530109A (ja) | 2020-06-11 | 2023-07-13 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を予防するための方法および組成物 |
| EP4196168A1 (en) | 2020-08-13 | 2023-06-21 | Bolt Biotherapeutics, Inc. | Pyrazoloazepine immunoconjugates, and uses thereof |
| US20220195066A1 (en) | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| US20240238430A1 (en) | 2020-12-11 | 2024-07-18 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| KR20230121772A (ko) | 2020-12-18 | 2023-08-21 | 람카프 바이오 베타 엘티디. | Ceacam5 및 cd47에 대한 이중특이적 항체 |
| CA3212907A1 (en) | 2021-03-26 | 2022-09-29 | Gary Brandt | 2-amino-4-carboxamide-benzazepine immunoconjugates, and uses thereof |
| EP4313162A1 (en) | 2021-03-26 | 2024-02-07 | Bolt Biotherapeutics, Inc. | 2-amino-4-carboxamide-benzazepine immunoconjugates, and uses thereof |
| AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
| CN119233830A (zh) | 2022-03-23 | 2024-12-31 | 新锐生物技术公司 | 用于靶向表达癌胚抗原的肿瘤的抗体缀合物 |
| US20250230256A1 (en) | 2022-06-16 | 2025-07-17 | Lamkap Bio Beta Ltd | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
| AU2024237581A1 (en) | 2023-03-14 | 2025-10-02 | Xencor, Inc. | Anti-cd28 compositions |
| WO2024261013A1 (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394448A (en) | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
| DE3856559T2 (de) | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunktionelle Proteine mit vorbestimmter Zielsetzung |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9014932D0 (en) * | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| DK0561907T3 (da) | 1990-12-05 | 1999-05-31 | Novo Nordisk As | Proteiner med ændrede epitoper og fremgangsmåder til fremstilling deraf |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5910488A (en) | 1993-06-07 | 1999-06-08 | Vical Incorporated | Plasmids suitable for gene therapy |
| CA2225460A1 (en) | 1995-06-23 | 1997-01-09 | Winston Campbell Patterson | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| AU736549B2 (en) | 1997-05-21 | 2001-08-02 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Method for the production of non-immunogenic proteins |
| EP1071752B1 (en) | 1998-04-21 | 2003-07-09 | Micromet AG | CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF |
| CA2342967A1 (en) | 1998-12-08 | 2000-06-15 | Biovation Limited | Modifying protein immunogenicity |
| AU2002233340B2 (en) | 2001-02-19 | 2008-05-22 | Merck Patent Gmbh | Artificial fusion proteins with reduced immunogenicity |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| RU2401843C2 (ru) | 2003-10-16 | 2010-10-20 | Микромет Аг | Полиспецифические деиммунизирующие cd3-связующие |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| PT1976880T (pt) | 2005-12-21 | 2016-09-28 | Amgen Res Munich Gmbh | Composições farmacêuticas com resistência a cea solúvel |
| US20090226444A1 (en) * | 2005-12-21 | 2009-09-10 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
-
2006
- 2006-12-21 PT PT68411123T patent/PT1976880T/pt unknown
- 2006-12-21 BR BRPI0620632-8A patent/BRPI0620632A2/pt active Search and Examination
- 2006-12-21 JP JP2008546272A patent/JP5399712B2/ja not_active Expired - Fee Related
- 2006-12-21 CA CA2633766A patent/CA2633766C/en not_active Expired - Fee Related
- 2006-12-21 ZA ZA200805400A patent/ZA200805400B/xx unknown
- 2006-12-21 RS RS20160791A patent/RS55181B1/sr unknown
- 2006-12-21 LT LTEP06841112.3T patent/LT1976880T/lt unknown
- 2006-12-21 EP EP06841112.3A patent/EP1976880B1/en active Active
- 2006-12-21 KR KR1020087017796A patent/KR101287777B1/ko not_active Expired - Fee Related
- 2006-12-21 DK DK06841112.3T patent/DK1976880T3/en active
- 2006-12-21 WO PCT/EP2006/012425 patent/WO2007071426A1/en not_active Ceased
- 2006-12-21 EP EP12167996A patent/EP2527370A1/en not_active Withdrawn
- 2006-12-21 CN CN200680052637.9A patent/CN101370827B/zh not_active Expired - Fee Related
- 2006-12-21 HU HUE06841112A patent/HUE031151T2/en unknown
- 2006-12-21 AU AU2006328886A patent/AU2006328886C1/en not_active Ceased
- 2006-12-21 ES ES06841112.3T patent/ES2595091T3/es active Active
- 2006-12-21 US US12/158,611 patent/US8394926B2/en active Active
- 2006-12-21 HR HRP20161216TT patent/HRP20161216T1/hr unknown
- 2006-12-21 NZ NZ569204A patent/NZ569204A/en not_active IP Right Cessation
- 2006-12-21 SG SG2013054853A patent/SG193141A1/en unknown
- 2006-12-21 RU RU2008129787/10A patent/RU2426743C2/ru not_active IP Right Cessation
- 2006-12-21 PL PL06841112T patent/PL1976880T3/pl unknown
-
2008
- 2008-06-18 IL IL192277A patent/IL192277A/en not_active IP Right Cessation
-
2010
- 2010-11-29 RU RU2010148652/10A patent/RU2573893C2/ru not_active IP Right Cessation
-
2012
- 2012-10-03 JP JP2012221161A patent/JP2013056885A/ja not_active Withdrawn
-
2013
- 2013-01-14 US US13/740,358 patent/US9695250B2/en active Active
-
2016
- 2016-09-19 US US15/269,680 patent/US9982063B2/en active Active
- 2016-09-23 CY CY20161100951T patent/CY1118053T1/el unknown
- 2016-12-21 ME MEP-2016-218A patent/ME02581B/me unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL192277A (en) | Pharmaceutical compounds with resistance to cea soluble, specific bivalve-specific antibodies that bind cea, nucleic acid sequences encoding the antibodies, vectors and surrogate cells containing the nucleic acids, as well as processes for their creation, uses and compatible kits | |
| WO2009120374A3 (en) | Methods and compositions for nucleic acid sample preparation | |
| WO2007109441A3 (en) | Polypeptides having endoglucanase activity and polynucleotides encoding same | |
| WO2007115201A8 (en) | Polypeptides having endoglucanase activity and polynucleotides encoding same | |
| WO2006074435A3 (en) | Polypeptides having cellobiohydrlase activity and polynucleotides encoding same | |
| IL198379A0 (en) | Antibodies binding sphingosine-1-phosphate, nucleic acids encoding the same, and compositions containing the same | |
| WO2009105141A3 (en) | Polypeptides having endoglucanase activity and polynucleotides encoding same | |
| IL210485A (en) | An isolated antibody or its functional protein, a process for making it, a pharmaceutical preparation containing it, and an isolated amino acid encoding an antibody or a functional protein | |
| IL202327A (en) | An isolated cyclic protein, an isolated nucleic acid encoded for this protein, a host cell containing this nucleic acid sequence and a process for making this cyclic protein | |
| ZA200707804B (en) | Cellulases,nucleic acids encoding them and methods for making and using them | |
| WO2010127304A3 (en) | Sequencing methods | |
| WO2009085935A3 (en) | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same | |
| WO2009085859A3 (en) | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same | |
| WO2009085864A3 (en) | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same | |
| EP1869174A4 (en) | LYASE ENZYMES, NUCLEIC ACIDS FOR THEIR CODING AND METHOD FOR THEIR PREPARATION AND USE | |
| WO2009019007A3 (en) | Sdf-1 binding nucleic acids and the use thereof | |
| HK1216894A1 (zh) | 多價結合蛋白組合物 | |
| EP3009454A3 (en) | Antibodies specific to cadherin-17 | |
| WO2006135684A3 (en) | Methods and kits for sense rna synthesis | |
| WO2010066411A3 (en) | Polypeptides having cellobiohydrolase ii activity | |
| WO2009034190A3 (en) | Affinity tag | |
| EP2450052A3 (en) | Dendritic cells | |
| WO2007085923A8 (en) | Novel fluorescent proteins and methods for using same | |
| WO2006047673A3 (en) | Mammalian genes involved in infection | |
| EP2647647A3 (en) | Thiopeptide precursor protein, gene encoding it and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |