CY1118053T1 - Φαρμακευτικες συνθεσεις με ανθεκτικοτητα σε διαλυτο cea - Google Patents
Φαρμακευτικες συνθεσεις με ανθεκτικοτητα σε διαλυτο ceaInfo
- Publication number
- CY1118053T1 CY1118053T1 CY20161100951T CY161100951T CY1118053T1 CY 1118053 T1 CY1118053 T1 CY 1118053T1 CY 20161100951 T CY20161100951 T CY 20161100951T CY 161100951 T CY161100951 T CY 161100951T CY 1118053 T1 CY1118053 T1 CY 1118053T1
- Authority
- CY
- Cyprus
- Prior art keywords
- human
- resolution
- cea
- antibody
- medicinal compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75196305P | 2005-12-21 | 2005-12-21 | |
| EP05028064 | 2005-12-21 | ||
| US78086106P | 2006-03-10 | 2006-03-10 | |
| EP06841112.3A EP1976880B1 (en) | 2005-12-21 | 2006-12-21 | Pharmaceutical compositions with resistance to soluble cea |
| PCT/EP2006/012425 WO2007071426A1 (en) | 2005-12-21 | 2006-12-21 | Pharmaceutical compositions with resistance to soluble cea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118053T1 true CY1118053T1 (el) | 2017-06-28 |
Family
ID=40413962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100951T CY1118053T1 (el) | 2005-12-21 | 2016-09-23 | Φαρμακευτικες συνθεσεις με ανθεκτικοτητα σε διαλυτο cea |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8394926B2 (enExample) |
| EP (2) | EP1976880B1 (enExample) |
| JP (2) | JP5399712B2 (enExample) |
| KR (1) | KR101287777B1 (enExample) |
| CN (1) | CN101370827B (enExample) |
| AU (1) | AU2006328886C1 (enExample) |
| BR (1) | BRPI0620632A2 (enExample) |
| CA (1) | CA2633766C (enExample) |
| CY (1) | CY1118053T1 (enExample) |
| DK (1) | DK1976880T3 (enExample) |
| ES (1) | ES2595091T3 (enExample) |
| HR (1) | HRP20161216T1 (enExample) |
| HU (1) | HUE031151T2 (enExample) |
| IL (1) | IL192277A (enExample) |
| LT (1) | LT1976880T (enExample) |
| ME (1) | ME02581B (enExample) |
| NZ (1) | NZ569204A (enExample) |
| PL (1) | PL1976880T3 (enExample) |
| PT (1) | PT1976880T (enExample) |
| RS (1) | RS55181B1 (enExample) |
| RU (2) | RU2426743C2 (enExample) |
| SG (1) | SG193141A1 (enExample) |
| WO (1) | WO2007071426A1 (enExample) |
| ZA (1) | ZA200805400B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| AU2005269527B2 (en) | 2004-07-26 | 2011-12-01 | Pfenex Inc. | Process for improved protein expression by strain engineering |
| CA2633756C (en) * | 2005-12-21 | 2015-11-24 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
| ES2595091T3 (es) * | 2005-12-21 | 2016-12-27 | Amgen Research (Munich) Gmbh | Composiciones farmacéuticas con resistencia a CEA soluble |
| EP2615172A1 (en) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| WO2009070642A1 (en) | 2007-11-28 | 2009-06-04 | Medimmune, Llc | Protein formulation |
| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| US20130035249A1 (en) * | 2009-12-01 | 2013-02-07 | Medimmune, Llc | Methods and compositions for detecting and treating cea-expressing cancers |
| EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
| US20140242081A1 (en) * | 2011-07-18 | 2014-08-28 | Micromet Ag | Dosing regimens for treatment of cea-expressing cancers |
| WO2013054320A1 (en) * | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| WO2013162748A1 (en) * | 2012-04-27 | 2013-10-31 | The Trustees Of The University Of Pennsylvania | Anti-tumor endothelial marker-1 (tem1) antibody variants and uses thereof |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| US9315567B2 (en) | 2012-08-14 | 2016-04-19 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| US20150231241A1 (en) | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| BR112015010740B1 (pt) | 2012-11-13 | 2024-01-30 | Biontech Ag | Agentes para tratamento de doenças cancerosas expressando claudina |
| AR093557A1 (es) | 2012-11-20 | 2015-06-10 | Sanofi Sa | Anticuerpos anti-ceacam5 y usos de estos |
| EA031214B1 (ru) | 2013-02-26 | 2018-12-28 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
| WO2014131694A1 (en) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| DK2970449T3 (da) | 2013-03-15 | 2019-11-25 | Amgen Res Munich Gmbh | Enkeltkædede bindingsmolekyler, der omfatter n-terminal abp |
| EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| CA2946262C (en) | 2014-04-27 | 2022-07-26 | Ccam Biotherapeutics Ltd. | Humanized antibodies against ceacam1 |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
| PE20170286A1 (es) | 2014-07-01 | 2017-03-30 | Pfizer | Diacuerpos heterodimericos biespecificos y sus usos |
| EP3262217A4 (en) | 2015-02-24 | 2018-07-18 | BioAtla LLC | Conditionally active biological proteins |
| CN106432502B (zh) * | 2015-08-10 | 2020-10-27 | 中山大学 | 用于治疗cea阳性表达肿瘤的双特异纳米抗体 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| MA43025A (fr) | 2015-10-02 | 2021-05-26 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t anti-ceaxcd3 |
| PL3387015T3 (pl) | 2015-12-09 | 2022-02-14 | F. Hoffmann-La Roche Ag | Przeciwciało anty-CD20 typu II do ograniczania tworzenia przeciwciał przeciwlekowych |
| JP6949030B2 (ja) | 2016-01-08 | 2021-10-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｐｄ−１軸結合アンタゴニスト及び抗ｃｅａ／抗ｃｄ３二重特異性抗体を用いたｃｅａ陽性がんの治療方法 |
| SI3464380T1 (sl) | 2016-06-02 | 2025-03-31 | Immunocore Limited | Režim doziranja za gp100-specifični tcr - anti-cd3 scfv fuzijski protein |
| CN107663240B (zh) * | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用 |
| MX2019006955A (es) | 2016-12-19 | 2019-08-01 | Hoffmann La Roche | Terapia de combinacion con agonistas de 4-1bb orientados (cd137). |
| BR112019013189A2 (pt) | 2017-01-03 | 2019-12-10 | Hoffmann La Roche | moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa |
| CN107056952A (zh) * | 2017-05-10 | 2017-08-18 | 常州市第人民医院 | Cea.car‑t及其制备与应用 |
| CN107058234B (zh) * | 2017-05-12 | 2019-09-13 | 常州市第一人民医院 | Car.il-33-t及其制备与应用 |
| KR20250052490A (ko) | 2017-08-01 | 2025-04-18 | 에이비 테라퓨틱스 인코퍼레이티드 | 이중특이적 항체 및 그의 용도 |
| CN111315781A (zh) | 2017-11-01 | 2020-06-19 | 豪夫迈·罗氏有限公司 | 用靶向性ox40激动剂的组合疗法 |
| EP3502140A1 (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| CA3102398A1 (en) | 2018-06-03 | 2019-12-12 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
| JP2021528988A (ja) | 2018-07-04 | 2021-10-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 新規の二重特異性アゴニスト４−１ｂｂ抗原結合分子 |
| MY198034A (en) | 2018-12-21 | 2023-07-27 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
| EP3917579A4 (en) | 2019-01-28 | 2023-03-29 | AB Therapeutics, Inc. | SPECIFIC ANTIBODIES AND USES THEREOF |
| EP3693023A1 (en) | 2019-02-11 | 2020-08-12 | Sanofi | Use of anti-ceacam5 immunoconjugates for treating lung cancer |
| WO2020161214A1 (en) | 2019-02-07 | 2020-08-13 | Sanofi | Use of anti-ceacam5 immunoconjugates for treating lung cancer |
| KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| EP3983082A1 (en) | 2019-06-13 | 2022-04-20 | Bolt Biotherapeutics, Inc. | Aminobenzazepine compounds, immunoconjugates, and uses thereof |
| JP7354306B2 (ja) * | 2019-06-27 | 2023-10-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 新規ｉｃｏｓ抗体及びそれらを含む腫瘍標的化抗原結合分子 |
| WO2021041300A2 (en) * | 2019-08-23 | 2021-03-04 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| CN114630684A (zh) | 2019-09-03 | 2022-06-14 | 博尔特生物治疗药物有限公司 | 氨基喹啉化合物、免疫缀合物及其用途 |
| BR112022004995A2 (pt) | 2019-09-18 | 2022-06-21 | Lamkap Bio Alpha AG | Anticorpos biespecíficos contra ceacam5 e cd3 |
| MX2022003740A (es) | 2019-09-30 | 2022-05-02 | Bolt Biotherapeutics Inc | Inmunoconjugados de aminobenzazepina unidos a amida y usos de estos. |
| EP4048315B1 (en) | 2019-10-25 | 2025-03-12 | Bolt Biotherapeutics, Inc. | Thienoazepine immunoconjugates, and uses thereof |
| TW202128765A (zh) * | 2019-11-21 | 2021-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種雙特異性抗體 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| WO2021226440A1 (en) | 2020-05-08 | 2021-11-11 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
| AU2021287998A1 (en) | 2020-06-11 | 2023-02-02 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| IL300316A (en) | 2020-08-13 | 2023-04-01 | Bolt Biotherapeutics Inc | Immune conjugates of pyrazolozapines and their uses |
| EP4259210A2 (en) | 2020-12-11 | 2023-10-18 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| US20220195066A1 (en) | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| HRP20240213T1 (hr) | 2020-12-18 | 2024-04-26 | Lamkap Bio Beta Ag | Bispecifična antitijela protiv ceacam5 i cd47 |
| WO2022204536A1 (en) | 2021-03-26 | 2022-09-29 | Bolt Biotherapeutics, Inc. | 2-amino-4-carboxamide-benzazepine immunoconjugates, and uses thereof |
| WO2022204528A1 (en) | 2021-03-26 | 2022-09-29 | Bolt Biotherapeutics, Inc. | 2-amino-4-carboxamide-benzazepine immunoconjugates, and uses thereof |
| AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
| JP2025510678A (ja) | 2022-03-23 | 2025-04-15 | シンアフィックス ビー．ブイ． | カルシノエンビロニック抗原を発現する腫瘍を標的化するための抗体コンジュゲート |
| AU2023291779A1 (en) | 2022-06-16 | 2024-10-17 | Lamkap Bio Beta Ltd | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
| US20250043001A1 (en) | 2023-03-14 | 2025-02-06 | Xencor, Inc. | Anti-cd28 compositions |
| AU2024311339A1 (en) | 2023-06-21 | 2026-01-08 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394448A (en) | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
| AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9014932D0 (en) * | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| KR100237968B1 (ko) | 1990-12-05 | 2000-01-15 | 한센 핀 베네드 | 변화된 에피토프를 지닌 단백질 및 그 제조방법 |
| AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
| EP0702722B1 (en) | 1993-06-07 | 2005-08-03 | Vical Incorporated | Plasmids suitable for gene therapy |
| JPH11509088A (ja) | 1995-06-23 | 1999-08-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 血管内皮増殖因子受容体をコードする遺伝子の転写調節 |
| DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
| NZ507381A (en) | 1998-04-21 | 2003-12-19 | Micromet Ag | CD19xCD3 specific polypeptides and uses thereof |
| EP1051432B1 (en) | 1998-12-08 | 2007-01-24 | Biovation Limited | Method for reducing immunogenicity of proteins |
| PL362324A1 (en) | 2001-02-19 | 2004-10-18 | Merck Patent Gmbh | Artificial fusion proteins with reduced immunogenicity |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| US7820166B2 (en) * | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| HRP20110187T1 (hr) | 2003-10-16 | 2011-04-30 | Micromet Ag | Multispecifične deimunizirane tvari koje vežu cd3 |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| ES2595091T3 (es) | 2005-12-21 | 2016-12-27 | Amgen Research (Munich) Gmbh | Composiciones farmacéuticas con resistencia a CEA soluble |
| CA2633756C (en) * | 2005-12-21 | 2015-11-24 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
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2006
- 2006-12-21 ES ES06841112.3T patent/ES2595091T3/es active Active
- 2006-12-21 NZ NZ569204A patent/NZ569204A/en not_active IP Right Cessation
- 2006-12-21 US US12/158,611 patent/US8394926B2/en active Active
- 2006-12-21 EP EP06841112.3A patent/EP1976880B1/en active Active
- 2006-12-21 EP EP12167996A patent/EP2527370A1/en not_active Withdrawn
- 2006-12-21 RU RU2008129787/10A patent/RU2426743C2/ru not_active IP Right Cessation
- 2006-12-21 ZA ZA200805400A patent/ZA200805400B/xx unknown
- 2006-12-21 CA CA2633766A patent/CA2633766C/en not_active Expired - Fee Related
- 2006-12-21 HR HRP20161216TT patent/HRP20161216T1/hr unknown
- 2006-12-21 AU AU2006328886A patent/AU2006328886C1/en not_active Ceased
- 2006-12-21 RS RS20160791A patent/RS55181B1/sr unknown
- 2006-12-21 PL PL06841112T patent/PL1976880T3/pl unknown
- 2006-12-21 DK DK06841112.3T patent/DK1976880T3/en active
- 2006-12-21 CN CN200680052637.9A patent/CN101370827B/zh not_active Expired - Fee Related
- 2006-12-21 HU HUE06841112A patent/HUE031151T2/en unknown
- 2006-12-21 KR KR1020087017796A patent/KR101287777B1/ko not_active Expired - Fee Related
- 2006-12-21 BR BRPI0620632-8A patent/BRPI0620632A2/pt active Search and Examination
- 2006-12-21 JP JP2008546272A patent/JP5399712B2/ja not_active Expired - Fee Related
- 2006-12-21 SG SG2013054853A patent/SG193141A1/en unknown
- 2006-12-21 WO PCT/EP2006/012425 patent/WO2007071426A1/en not_active Ceased
- 2006-12-21 PT PT68411123T patent/PT1976880T/pt unknown
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- 2016-09-23 CY CY20161100951T patent/CY1118053T1/el unknown
- 2016-12-21 ME MEP-2016-218A patent/ME02581B/me unknown
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