IL164804A0 - Methods and compositions for diagnosing and monitoring transplant rejection - Google Patents

Methods and compositions for diagnosing and monitoring transplant rejection

Info

Publication number
IL164804A0
IL164804A0 IL16480403A IL16480403A IL164804A0 IL 164804 A0 IL164804 A0 IL 164804A0 IL 16480403 A IL16480403 A IL 16480403A IL 16480403 A IL16480403 A IL 16480403A IL 164804 A0 IL164804 A0 IL 164804A0
Authority
IL
Israel
Prior art keywords
diagnosing
compositions
methods
transplant rejection
monitoring transplant
Prior art date
Application number
IL16480403A
Other languages
English (en)
Original Assignee
Expression Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/131,831 external-priority patent/US7026121B1/en
Application filed by Expression Diagnostics Inc filed Critical Expression Diagnostics Inc
Publication of IL164804A0 publication Critical patent/IL164804A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/24Immunology or allergic disorders
    • G01N2800/245Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL16480403A 2002-04-24 2003-04-24 Methods and compositions for diagnosing and monitoring transplant rejection IL164804A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/131,831 US7026121B1 (en) 2001-06-08 2002-04-24 Methods and compositions for diagnosing and monitoring transplant rejection
US10/325,899 US7235358B2 (en) 2001-06-08 2002-12-20 Methods and compositions for diagnosing and monitoring transplant rejection
PCT/US2003/012946 WO2004042346A2 (en) 2002-04-24 2003-04-24 Methods and compositions for diagnosing and monitoring transplant rejection

Publications (1)

Publication Number Publication Date
IL164804A0 true IL164804A0 (en) 2005-12-18

Family

ID=32314283

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16480403A IL164804A0 (en) 2002-04-24 2003-04-24 Methods and compositions for diagnosing and monitoring transplant rejection

Country Status (7)

Country Link
US (3) US7235358B2 (xx)
EP (4) EP2292786B1 (xx)
JP (2) JP2005536230A (xx)
AU (1) AU2003299465B2 (xx)
CA (1) CA2483481C (xx)
IL (1) IL164804A0 (xx)
WO (1) WO2004042346A2 (xx)

Families Citing this family (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
WO2003023007A2 (en) 2001-09-07 2003-03-20 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39
US7405292B2 (en) * 2002-02-19 2008-07-29 The Children's Hospital Of Philadelphia Cellular genes regulated by HIV-1 infection and methods of use thereof
FR2836573A1 (fr) * 2002-02-27 2003-08-29 France Telecom Representation informatique d'une structure de donnees arborescente et methodes de codage/decodage associees
AT412678B (de) * 2002-09-30 2005-05-25 Gerhard Dr Kranner Verfahren zur rechnergestützten erstellung von prognosen für operative systeme sowie system zur erstellung von prognosen für operative systeme
EP1559725A4 (en) * 2002-10-04 2005-12-14 Mitsubishi Pharma Corp ANTIBODY WITH ANTIGENIC RECOGNITION
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
KR101438983B1 (ko) 2003-11-06 2014-09-05 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
WO2005054503A2 (en) * 2003-12-03 2005-06-16 Novartis Ag Biomarkers for graft rejection
CA2957704A1 (en) 2004-01-21 2005-08-04 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
EP1723428A2 (en) * 2004-02-19 2006-11-22 Yale University Corporation Identification of cancer protein biomarkers using proteomic techniques
EP1753463A2 (en) 2004-06-01 2007-02-21 Genentech, Inc. Antibody drug conjugates and methods
CN101068574B (zh) * 2004-07-20 2012-07-18 伊索格尼斯股份有限公司 与自身抗原有关的自身免疫和疾病的特异性抑制
EP1621550A1 (en) * 2004-07-29 2006-02-01 Dompé S.P.A. Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
EP1802321A4 (en) * 2004-09-03 2009-12-02 Dana Farber Cancer Inst Inc COMPOSITIONS AND METHODS FOR MODULATING PGC-1-ALPHA FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND DISORDERS
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
RU2412947C2 (ru) 2004-09-23 2011-02-27 Дженентек, Инк. Антитела, сконструированные на основе цистеинов, и их конъюгаты
ITFI20040243A1 (it) * 2004-11-25 2005-02-25 Paola Romagnani Metodo diagnostico per la previsione di rigetto di organo trapiantato
US20060194238A1 (en) * 2005-02-28 2006-08-31 Norman Latov Peripheral neuropathy diagnosis
US20060194237A1 (en) * 2005-02-28 2006-08-31 Norman Latov Method for diagnosing peripheral neuropathy
USRE46843E1 (en) 2005-03-14 2018-05-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
CA2601623C (en) 2005-03-14 2018-10-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
EP1885889A4 (en) * 2005-05-11 2010-01-20 Expression Diagnostics Inc METHOD FOR MONITORING THE OPERATING STATUS OF TRANSPLANTS OVER GENLISTS
US20060269948A1 (en) * 2005-05-16 2006-11-30 Halloran Philip F Tissue rejection
CN101268373A (zh) * 2005-05-17 2008-09-17 塞尔艾克特制药有限公司 作为检测早期免疫激活的标记物的tirc7
AU2007309726A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
BRPI0710240A2 (pt) * 2006-04-20 2011-08-09 Glaxo Group Ltd composto, uso de um composto, método para o tratamento de um paciente humano ou animal com uma condição ou doença, composição farmacêutica, combinação, e, processo para a preparação de um composto
US20080057503A1 (en) 2006-04-24 2008-03-06 Genentech, Inc. Methods and compositions for detecting autoimmune disorders
WO2007124578A1 (en) 2006-04-27 2007-11-08 Universite De Montreal Assessment and reduction of risk of graft-versus-host disease
WO2007127458A2 (en) * 2006-04-28 2007-11-08 Nsabp Foundation, Inc. Methods of whole genome or microarray expression profiling using nucleic acids
GB0611405D0 (en) * 2006-06-09 2006-07-19 Univ Belfast FKBP-L: A novel inhibitor of angiogenesis
EP1872787A1 (en) * 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008140484A2 (en) * 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
EP1947463A1 (en) * 2007-01-16 2008-07-23 Roche Diagnostics GmbH Collection of liquid analytical samples for clinical analytical purpose
WO2008137500A2 (en) * 2007-05-01 2008-11-13 The Brigham And Women's Hospital Immunosuppression with antibody against itm2a
US8600135B2 (en) * 2007-06-28 2013-12-03 Mayo Foundation For Medical Education And Research System and method for automatically generating sample points from a series of medical images and identifying a significant region
WO2009003198A1 (en) * 2007-06-28 2008-12-31 Mayo Foundation For Medical Education And Research System and method for automatically detecting change in a series of medical images of a subject over time
EP2190379B1 (en) 2007-08-23 2016-06-15 Direct Flow Medical, Inc. Translumenally implantable heart valve with formed in place support
ES2663662T3 (es) 2008-01-18 2018-04-16 President And Fellows Of Harvard College Métodos para detectar distintivos de enfermedades o afecciones en fluidos corporales
US8215329B2 (en) * 2008-02-01 2012-07-10 Woodward, Inc. Digital closed loop proportional hydraulic pressure controller
US20110008795A1 (en) * 2008-02-28 2011-01-13 Sysmex Corporation Marker for detection of il-17-producing helper t-cell, and method for detection of il-17-producing helper t-cell
KR20110009095A (ko) 2008-03-03 2011-01-27 더 유니버시티 오브 마이애미 동종 이계 암 세포-기반 면역 요법
EP2103689A1 (en) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
CA2720863A1 (en) * 2008-04-09 2009-10-15 The University Of British Columbia Methods of diagnosing acute cardiac allograft rejection
CA2724179A1 (en) * 2008-05-15 2009-11-19 Topigen Pharmaceuticals Inc. Oligonucleotides for treating inflammation and neoplastic cell proliferation
WO2010000320A1 (en) * 2008-07-03 2010-01-07 Institut D'investigations Biomediques August Pi I Sunyer (Idibaps) In vitro diagnosis/prognosis method and kit for assessment of tolerance in liver transplantation
WO2010010951A1 (ja) * 2008-07-24 2010-01-28 Kuroda Masahiko 子宮内膜症関連疾患の指標mRNAの発現の検出方法およびそれに用いるプローブ
US8285719B1 (en) 2008-08-08 2012-10-09 The Research Foundation Of State University Of New York System and method for probabilistic relational clustering
WO2010021696A1 (en) 2008-08-18 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
CN105067819B (zh) * 2008-08-28 2018-05-22 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
CN102187219B (zh) * 2008-08-29 2015-08-05 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
WO2010033722A2 (en) 2008-09-17 2010-03-25 Isogenis, Inc. Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof
EP2347260A4 (en) * 2008-10-21 2012-09-26 Astute Medical Inc METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
EP3974836A1 (en) 2008-10-21 2022-03-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BRPI0922021A2 (pt) 2008-11-10 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal
MX2011005379A (es) * 2008-11-22 2011-06-09 Astute Medical Inc Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal.
WO2010083121A1 (en) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
TWI387750B (zh) * 2009-02-10 2013-03-01 Nat Defense Medical Ct Biomarker and detection method for detecting kidney disease
US20110045468A1 (en) * 2009-03-02 2011-02-24 Richard Robison Polynucleotides for the identification and quantification of group a streptococcus nucleic acids
EP2406402B1 (en) 2009-03-13 2018-05-16 Cornell University Method to assess human allograft status from microrna expression levels
BRPI1010693A2 (pt) 2009-06-15 2019-07-16 Cardiodx Inc métodos implementados por computador para marcar e/ou pontuar uma primeira amostra obtida a partir de um sujeito, meios de armazenamento legível em computador de armazenamento de código de programa executável e métodos, sistema e kits de predição de cad em um sujeito
AU2010268690B2 (en) 2009-07-03 2011-11-10 Avipep Pty Ltd Immuno-conjugates and methods for producing them
US9752191B2 (en) * 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
ES2356217B1 (es) * 2009-08-04 2012-02-13 Universidad De Salamanca Método para la detección de daño renal.
KR20120061863A (ko) 2009-08-07 2012-06-13 아스튜트 메디컬 인코포레이티드 신장 손상 및 신부전증의 진단과 예후를 위한 방법 및 조성물
US20110065136A1 (en) * 2009-08-07 2011-03-17 Rules-Based Medicine, Inc. Methods and Devices for Detecting Glomerulonephritis and Associated Disorders
NZ598876A (en) * 2009-09-02 2014-07-25 Accugen Pty Ltd Improved nucleic acid quantitation method
EP2475391B1 (en) 2009-09-09 2018-09-12 Centrose, LLC Extracellular targeted drug conjugates
GB2488289A (en) 2009-11-06 2012-08-22 Univ Leland Stanford Junior Non-invasive diagnosis of graft rejection in organ transplant patients
EP2496942B1 (en) 2009-11-07 2017-03-22 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20110125791A1 (en) * 2009-11-25 2011-05-26 Microsoft Corporation Query classification using search result tag ratios
EP3185013B1 (en) 2009-12-02 2019-10-09 The Board of Trustees of the Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
MX342967B (es) 2009-12-20 2016-10-19 Astute Medical Inc Metodos y composiciones para la diagnosis y prognosis de lesion renal y falla renal.
AU2010336029B2 (en) 2009-12-23 2011-10-13 Avipep Pty Ltd Immuno-conjugates and methods for producing them 2
CN102791885B (zh) * 2010-02-05 2015-09-09 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
AU2011213685B2 (en) * 2010-02-05 2014-10-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ701807A (en) 2010-02-26 2015-05-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9746479B2 (en) 2010-03-09 2017-08-29 Cornell University Methods and compositions to predict and detect acute rejection
US9535075B2 (en) 2010-03-25 2017-01-03 The Board Of Trustees Of The Leland Stanford Junior University Protein and gene biomarkers for rejection of organ transplants
WO2011130598A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
CN114246952A (zh) 2010-06-08 2022-03-29 基因泰克公司 半胱氨酸改造的抗体和偶联物
WO2011158667A1 (ja) * 2010-06-16 2011-12-22 国立大学法人浜松医科大学 大腸腫瘍の検出方法
EP2585827A4 (en) 2010-06-23 2013-12-04 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
EP2585825B1 (en) 2010-06-23 2018-01-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
SG187582A1 (en) * 2010-07-23 2013-03-28 Harvard College Methods of detecting diseases or conditions using phagocytic cells
EP2596116A4 (en) 2010-07-23 2014-03-19 Harvard College METHODS FOR DETECTION OF AUTOIMMUNE OR IMMUNE-RELATED DISEASES / PATHOLOGIES
US20130203624A1 (en) 2010-07-23 2013-08-08 President And Fellows Of Harvard College Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions
EP2437192A1 (en) * 2010-09-16 2012-04-04 Roche Diagnostics GmbH Relative quantification analysis of multi-parametric PCR experiments
JP6069209B2 (ja) 2010-11-12 2017-02-01 ジェンティウム ソシエタ ア レスポンサビリタ リミタータ 移植片対宿主病(gvhd)の予防および/または治療に使用するためのデフィブロタイド
CN103313990B (zh) 2010-11-17 2016-07-20 基因泰克公司 丙氨酰美登醇抗体偶联物
EP2658994B1 (en) 2010-12-28 2017-07-19 Qiagen Hamburg GmbH Oligonucleotide probe for the detection of adenovirus
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US8962261B2 (en) 2011-04-06 2015-02-24 The Board Of Trustees Of The Leland Stanford Junior University Autoantibody biomarkers for IGA nephropathy
CN103619877B (zh) 2011-04-21 2018-01-02 加文医学研究所 修饰的可变结构域分子及其产生和使用方法b
MX2013013054A (es) 2011-05-12 2014-02-20 Genentech Inc Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura.
DK2750713T3 (en) 2011-10-14 2015-12-21 Medimmune Ltd PYRROLOBENZODIAZEPINS AND CONJUGATES THEREOF
ES2734494T3 (es) 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US20150142460A1 (en) * 2012-05-24 2015-05-21 Allegheny-Singer Research Institute Method and system for ordering and arranging a data set for a severity and heterogeneity approach to preventing events including a disease stratification scheme
CN104619857A (zh) 2012-06-22 2015-05-13 真蒂奥姆有限公司 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法
WO2014037811A2 (en) 2012-09-07 2014-03-13 The Governors Of The University Of Alberta Methods and compositions for diagnosis of inflammatory liver disease
RU2506592C1 (ru) * 2012-10-11 2014-02-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ выбора тактики хирургического лечения больных с периимплантным воспалением в области крупных суставов
WO2014057119A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP2906251B1 (en) 2012-10-12 2017-09-27 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
PT2906253T (pt) 2012-10-12 2018-11-05 Medimmune Ltd Conjugados de anticorpo anti-psma de pirrolobenzodiazepina
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
US9931414B2 (en) 2012-10-12 2018-04-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
RS53818B1 (en) 2012-10-12 2015-06-30 Spirogen Sàrl PIROLOBENZODIAZEPINI I NJIHOVI conjugated
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
JP6527466B2 (ja) 2012-12-21 2019-06-05 メドイミューン・リミテッドMedImmune Limited 増殖性疾患および自己免疫疾患の治療に使用するための非対称ピロロベンゾジアゼピンニ量体
WO2014096368A1 (en) 2012-12-21 2014-06-26 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
JP6681195B2 (ja) 2013-01-17 2020-04-15 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
US9758828B2 (en) 2013-01-31 2017-09-12 Cornell University Methods to detect, treat and prevent acute cellular rejection in kidney allografts
WO2014121133A2 (en) * 2013-02-03 2014-08-07 Genelex Corporation Systems and methods for quantification and presentation of medical risk arising from unknown factors
NZ771629A (en) 2013-03-09 2022-12-23 Harry Stylli Methods of detecting cancer
JP6340019B2 (ja) 2013-03-13 2018-06-06 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピン及びそのコンジュゲート
BR112015023333A8 (pt) 2013-03-13 2018-04-17 Medimmune Ltd pirrolbenzodiazepinas e conjugados dos mesmos
EA027910B1 (ru) 2013-03-13 2017-09-29 Медимьюн Лимитед Пирролобензодиазепины и их конъюгаты
EP2983804A4 (en) 2013-03-15 2017-03-01 Moderna Therapeutics, Inc. Ion exchange purification of mrna
EP2971165A4 (en) 2013-03-15 2016-11-23 Moderna Therapeutics Inc DISSOLUTION OF DNA FRAGMENTS IN MRNA MANUFACTURING METHODS
US11377470B2 (en) 2013-03-15 2022-07-05 Modernatx, Inc. Ribonucleic acid purification
WO2014145203A2 (en) * 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Systems and methods for characterization of multiple sclerosis
EP2971033B8 (en) 2013-03-15 2019-07-10 ModernaTX, Inc. Manufacturing methods for production of rna transcripts
US20140371078A1 (en) * 2013-06-17 2014-12-18 Verinata Health, Inc. Method for determining copy number variations in sex chromosomes
SI3019619T1 (sl) 2013-07-11 2021-12-31 Modernatx, Inc. Sestave, ki zajemajo sintetične polinukleotide, ki kodirajo proteine, pozvezane s crispr, in sintetične sgrna, ter metode uporabe
EA201690195A1 (ru) 2013-08-12 2016-05-31 Дженентек, Инк. Конъюгатные соединения антитело-лекарство на основе димера 1-(хлорметил)-2,3-дигидро-1h-бензо[e]индола и способы применения и лечения
US10385088B2 (en) 2013-10-02 2019-08-20 Modernatx, Inc. Polynucleotide molecules and uses thereof
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
CN106687965B (zh) * 2013-11-13 2019-10-01 凡弗3基因组有限公司 用于传送并且预处理测序数据的系统和方法
MX2016007578A (es) 2013-12-16 2016-10-03 Genentech Inc Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento.
CN107106700B (zh) 2013-12-16 2020-10-30 基因泰克公司 肽模拟化合物及其抗体-药物缀合物
RU2689388C1 (ru) 2013-12-16 2019-05-28 Дженентек, Инк. Пептидомиметические соединения и их конъюгаты антител с лекарственными средствами
US9982301B2 (en) 2014-01-07 2018-05-29 Cornell University Urine mRNA profile and acute dysfunction of kidney allograft
KR20160142390A (ko) 2014-04-09 2016-12-12 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 면역평가 및 이식거부의 예측을 위한 단백질 바이오마커
US10394828B1 (en) * 2014-04-25 2019-08-27 Emory University Methods, systems and computer readable storage media for generating quantifiable genomic information and results
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
WO2015196128A2 (en) 2014-06-19 2015-12-23 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
JP2017522028A (ja) 2014-07-16 2017-08-10 モデルナティエックス インコーポレイテッドModernaTX,Inc. 環状ポリヌクレオチド
TWI703214B (zh) * 2014-07-31 2020-09-01 中央研究院 具拮抗pd-1功能的適體分子於癌症治療相關之應用
CN106794064B (zh) 2014-08-15 2019-08-27 成都赛拉诺医疗科技有限公司 假体植入物输送装置
CN106687141A (zh) 2014-09-10 2017-05-17 麦迪穆有限责任公司 吡咯并苯并二氮杂卓及其缀合物
CN106714844B (zh) 2014-09-12 2022-08-05 基因泰克公司 蒽环类二硫化物中间体、抗体-药物缀合物和方法
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3388449A3 (en) 2014-09-12 2018-10-24 F. Hoffmann-La Roche AG Cysteine engineered antibodies and conjugates
EP3235820A1 (en) 2014-09-17 2017-10-25 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
US10417225B2 (en) 2015-09-18 2019-09-17 Splunk Inc. Entity detail monitoring console
JP6878287B2 (ja) 2014-11-25 2021-05-26 アーデーセー セラピューティクス ソシエテ アノニム ピロロベンゾジアゼピン−抗体コンジュゲート
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
CA2969689A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
WO2016118852A1 (en) * 2015-01-23 2016-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of eomesodermin to determine risk of allograft rejection
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
US10989716B2 (en) 2015-05-01 2021-04-27 The University Of British Columbia Biomarkers for the detection of acute rejection in heart transplantation
ES2908449T3 (es) 2015-09-17 2022-04-29 Modernatx Inc Polinucleótidos que contienen una región de cola estabilizadora
WO2017049286A1 (en) 2015-09-17 2017-03-23 Moderna Therapeutics, Inc. Polynucleotides containing a morpholino linker
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
EP4273551A3 (en) 2016-03-25 2024-01-17 F. Hoffmann-La Roche AG Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック, インコーポレイテッド Protac抗体コンジュゲート及び使用方法
US20170370906A1 (en) 2016-05-27 2017-12-28 Genentech, Inc. Bioanalytical analysis of site-specific antibody drug conjugates
EP3466444A4 (en) * 2016-06-02 2019-12-11 Riken ADJUVANT COMPOSITION AND USE THEREOF
EP3464280B1 (en) 2016-06-06 2021-10-06 F. Hoffmann-La Roche AG Silvestrol antibody-drug conjugates and methods of use
WO2017214203A1 (en) 2016-06-06 2017-12-14 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
CN109689111B (zh) 2016-08-11 2024-04-05 基因泰克公司 吡咯并苯并二氮杂䓬前药及其抗体缀合物
EP3522933B1 (en) 2016-10-05 2021-12-15 F. Hoffmann-La Roche AG Methods for preparing antibody drug conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
US20180166170A1 (en) * 2016-12-12 2018-06-14 Konstantinos Theofilatos Generalized computational framework and system for integrative prediction of biomarkers
WO2018117011A1 (ja) 2016-12-19 2018-06-28 国立大学法人大阪大学 インビトロでのIgM型メモリーB細胞分化培養系を用いた臓器移植後抗体関連型拒絶反応の早期診断法
CA3047683C (en) 2017-02-08 2020-03-10 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
KR102700956B1 (ko) 2017-02-28 2024-09-03 사노피 치료적 rna
ES2953595T3 (es) 2017-03-01 2023-11-14 Hoffmann La Roche Procedimientos diagnósticos y terapéuticos para el cáncer
DK3612537T3 (da) 2017-04-18 2022-08-08 Medimmune Ltd Pyrrolobenzodiazepinkonjugater
PL3612234T3 (pl) 2017-04-20 2024-09-02 Adc Therapeutics Sa Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
CN111065638B (zh) 2017-08-18 2021-04-09 麦迪穆有限责任公司 吡咯并苯并二氮杂䓬缀合物
US10301319B2 (en) 2017-09-20 2019-05-28 Ph Pharma Co., Ltd. Thailanstatin analogs
US11106442B1 (en) 2017-09-23 2021-08-31 Splunk Inc. Information technology networked entity monitoring with metric selection prior to deployment
US11093518B1 (en) 2017-09-23 2021-08-17 Splunk Inc. Information technology networked entity monitoring with dynamic metric and threshold selection
US11159397B2 (en) 2017-09-25 2021-10-26 Splunk Inc. Lower-tier application deployment for higher-tier system data monitoring
CN107967938A (zh) * 2017-11-21 2018-04-27 成都天奥电子股份有限公司 一种心脏病患者定位监护管理系统
WO2019107673A1 (ko) * 2017-11-29 2019-06-06 서울대학교병원 Abo 혈액형 부적합 이식시의 항체-매개성 거부반응의 모니터링을 위한 바이오마커
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
US12089930B2 (en) 2018-03-05 2024-09-17 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3814532A1 (fr) * 2018-06-29 2021-05-05 bioMérieux Procédé pour déterminer in vitro ou ex vivo le statut immunitaire d'un individu
FR3085689A1 (fr) * 2018-09-12 2020-03-13 Biomerieux Procede pour determiner in vitro ou ex vivo le statut immunitaire d'un individu
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
CN113056287A (zh) 2018-10-24 2021-06-29 豪夫迈·罗氏有限公司 缀合的化学降解诱导剂及使用方法
CN113227119A (zh) 2018-12-10 2021-08-06 基因泰克公司 用于与含Fc的蛋白质进行位点特异性缀合的光交联肽
US11099975B2 (en) 2019-01-24 2021-08-24 International Business Machines Corporation Test space analysis across multiple combinatoric models
US11263116B2 (en) 2019-01-24 2022-03-01 International Business Machines Corporation Champion test case generation
US11106567B2 (en) 2019-01-24 2021-08-31 International Business Machines Corporation Combinatoric set completion through unique test case generation
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
EP3736570A1 (en) * 2019-05-09 2020-11-11 Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León Method for the diagnosis, sub-classification and prognosis of acute kidney injury by detecting cct7
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
US11232020B2 (en) 2019-06-13 2022-01-25 International Business Machines Corporation Fault detection using breakpoint value-based fingerprints of failing regression test cases
US11422924B2 (en) 2019-06-13 2022-08-23 International Business Machines Corporation Customizable test set selection using code flow trees
US10970195B2 (en) * 2019-06-13 2021-04-06 International Business Machines Corporation Reduction of test infrastructure
AU2020365937A1 (en) * 2019-10-15 2022-04-28 The Regents Of The University Of California Transplanted cell protection via Fc sequestration
CN110923356B (zh) * 2019-12-30 2022-08-12 广西大学 一种水稻抗稻瘿蚊主效基因Gm5的分子标记引物及其标记方法和应用
DE102020205364B4 (de) * 2020-04-28 2022-01-20 Universität Rostock Verfahren zur Überwachung des Verlaufs einer Kardiomyozyten-Transplantation und Methode zur Bestimmung, ob ein Proband für einer Kardiomyozyten-Transplantation geeignet ist
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
US11676072B1 (en) 2021-01-29 2023-06-13 Splunk Inc. Interface for incorporating user feedback into training of clustering model
CN113435168B (zh) * 2021-06-10 2024-03-22 上海美吉生物医药科技有限公司 胶图自动编辑方法、系统、终端及介质
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof
WO2024220546A2 (en) 2023-04-17 2024-10-24 Peak Bio, Inc. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates

Family Cites Families (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981481A (en) 1974-12-06 1999-11-09 The Johns Hopkins University Human C3b/C4b receptor (CR1)
US5212071A (en) 1988-04-01 1993-05-18 The Johns Hopkins University Nucleic acids encoding a human C3b/C4b receptor (CR1)
US4350593A (en) 1977-12-19 1982-09-21 Becton, Dickinson And Company Assembly, compositions and method for separating blood
US4190535A (en) 1978-02-27 1980-02-26 Corning Glass Works Means for separating lymphocytes and monocytes from anticoagulated blood
US4215051A (en) * 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4762780A (en) 1984-04-17 1988-08-09 The Regents Of The University Of California Method and composition for screening and diagnosing "HCMV"
US4582789A (en) 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4751001A (en) 1984-09-24 1988-06-14 Becton Dickinson And Company Blood partitioning apparatus
US4818418A (en) 1984-09-24 1989-04-04 Becton Dickinson And Company Blood partitioning method
US5264351A (en) 1984-11-05 1993-11-23 The Board Of Regents For The University Of Oklahoma Monoclonal antibodies against autoimmune RNA proteins
US5053134A (en) 1984-12-04 1991-10-01 Becton Dickinson And Company Lymphocyte collection tube
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US6197563B1 (en) 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE217102T1 (de) 1985-08-28 1987-10-15 Yeda Research And Development Co., Ltd., Rehovot Interferon-induziertes (2'-5')-oligo-a-synthetase-gen, mrna, cdna und enzyme mit (2'-5')-oligo-a-synthetase-aktivitaet.
US5011684A (en) 1985-09-05 1991-04-30 Beth Israel Hospital Association Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance
US4789630A (en) 1985-10-04 1988-12-06 Cetus Corporation Ionic compounds containing the cationic meriquinone of a benzidine
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5795762A (en) 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5352600A (en) 1986-08-22 1994-10-04 Hoffmann-La Roche Inc. Purified thermostable enzyme
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5455170A (en) 1986-08-22 1995-10-03 Hoffmann-La Roche Inc. Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5374553A (en) 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
US5693517A (en) 1987-06-17 1997-12-02 Roche Molecular Systems, Inc. Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5561058A (en) 1986-08-22 1996-10-01 Hoffmann-La Roche Inc. Methods for coupled high temperatures reverse transcription and polymerase chain reactions
US5407800A (en) 1986-08-22 1995-04-18 Hoffmann-La Roche Inc. Reverse transcription with Thermus thermophilus polymerase
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5466591A (en) 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5405774A (en) 1986-08-22 1995-04-11 Hoffmann-La Roche Inc. DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
CA1297431C (en) 1987-04-24 1992-03-17 F. Hoffmann-La Roche Ag Process for the isolation of nucleic acids
US5063162A (en) 1987-04-24 1991-11-05 Hoffmann-La Roche Inc. Process for isolating nucleic acids utilizing protease digestion
US4908318A (en) 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5120525A (en) 1988-03-29 1992-06-09 Immunomedics, Inc. Radiolabeled antibody cytotoxic therapy of cancer
US5693760A (en) 1988-04-14 1997-12-02 Incyte Pharmaceuticals, Inc. Method of causing selective immunosuppression using HL-60 related lectins
US5142033A (en) 1988-09-23 1992-08-25 Hoffmann-La Roche Inc. Structure-independent DNA amplification by the polymerase chain reaction
US5075216A (en) 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5091310A (en) 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5389512A (en) 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5340720A (en) 1989-11-29 1994-08-23 University Of Kansas Methods of diagnosing and monitoring rheumatic diseases
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
WO1991012342A1 (en) 1990-02-16 1991-08-22 F. Hoffmann-La Roche Ag Improvements in the specificity and convenience of the polymerase chain reaction
US5344755A (en) 1990-04-21 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals
US5350683A (en) * 1990-06-05 1994-09-27 Immunex Corporation DNA encoding type II interleukin-1 receptors
US5130423A (en) 1990-07-13 1992-07-14 Microprobe Corporation Non-corrosive compositions and methods useful for the extraction of nucleic acids
AU665338B2 (en) 1990-07-24 1996-01-04 F. Hoffmann-La Roche Ag The reduction of non-specific amplification during (in vitro) nucleic acid amplification using modified nucleic acid bases
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP0550696B1 (en) 1990-09-28 2000-11-22 F. Hoffmann-La Roche Ag Purified thermostable nucleic acid polymerase enzyme from thermosipho africanus
DE4034036C2 (de) 1990-10-26 1994-03-03 Diagen Inst Molekularbio Vorrichtung und Verfahren zur Isolierung von Nukleinsäuren aus Zellsuspensionen
ATE126599T1 (de) 1991-01-22 1995-09-15 Akzo Nobel Nv Verfahren zur bestimmung von anti-rns- antikörpern.
EP0585257A4 (en) 1991-03-28 1995-02-22 Univ Minnesota DNA AND AMINO ACID SEQUENCE SPECIFIC TO NATURAL K KILLER CELLS.
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DK0519338T3 (da) 1991-06-20 1996-10-28 Hoffmann La Roche Forbedrede fremgangsmåder til nukleinsyreamplifikation
US5445940A (en) 1991-08-28 1995-08-29 Brigham & Women's Hospital Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease
WO1993006864A1 (en) * 1991-10-01 1993-04-15 The General Hospital Corporation Preventing allograft rejection with antibodies to adhesion molecules
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
ES2082256T3 (es) 1992-03-23 1996-03-16 Hoffmann La Roche Metodo de deteccion del adn.
WO1993025713A1 (en) 1992-06-17 1993-12-23 Arch Development Corporation Compositions and methods for detecting gene rearrangements and translocations
GB2268935B (en) 1992-06-24 1996-10-23 Nat Heart & Lung Inst Diagnosis of rejection of transplanted organs
DK0590327T3 (da) 1992-09-11 2003-07-28 Hoffmann La Roche Påvisning af nukleinsyrer i blod
US5565339A (en) 1992-10-08 1996-10-15 Hoffmann-La Roche Inc. Compositions and methods for inhibiting dimerization of primers during storage of polymerase chain reaction reagents
US5420039A (en) * 1992-12-31 1995-05-30 Cem Corporation Control of continuous microwave digestion process
AU6230594A (en) 1993-02-01 1994-08-29 University Of Iowa Research Foundation, The Quartenary amine surfactants and methods of using same in isolation of rna
US6403304B1 (en) 1993-04-06 2002-06-11 Forsyth Dental Infirmary For Children Human osteoclast-specific and -related DNA sequences
US5491086A (en) 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5459037A (en) 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
AU1513495A (en) 1993-12-14 1995-07-03 University Of Pittsburgh Systemic gene treatment of connective tissue diseases
DK145393D0 (da) 1993-12-23 1993-12-23 Stig Haunsoe Proteinmarkoerer til forudsigelse af akut allotransplantatafstoedning
US5811284A (en) 1993-12-29 1998-09-22 Schering Corporation Nucleic acids encoding kp43 protein and antigenic fragments thereof
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US6190872B1 (en) 1994-05-06 2001-02-20 Gus J. Slotman Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5658744A (en) 1994-07-22 1997-08-19 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying patients having an altered immune status
US6010847A (en) 1994-08-18 2000-01-04 Akzo Nobel N.V. Oligonucleotides that can be used in the amplification and detection of CMV nucleic acid
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5571673A (en) 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5506145A (en) * 1994-12-02 1996-04-09 Bull; Brian S. Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements
US5834248A (en) 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US6066322A (en) 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
US5707807A (en) 1995-03-28 1998-01-13 Research Development Corporation Of Japan Molecular indexing for expressed gene analysis
US6251597B1 (en) 1996-03-29 2001-06-26 Millennium Pharmaceuticals, Inc. Methods for detecting fohy030
US5569583A (en) 1995-04-25 1996-10-29 Health Research Inc. Rapid and sensitive detection of cytomegalovirus
US5635365A (en) 1995-08-07 1997-06-03 Emory University Noninvasive diagnosis for allograft rejection
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5665551A (en) 1995-09-13 1997-09-09 Roche Molecular Systems, Inc. Purified nucleic acid encoding a thermostable pyrophosphatase
US5750345A (en) * 1995-10-31 1998-05-12 Evanston Hospital Corporation Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
US5973137A (en) 1996-02-13 1999-10-26 Gentra Systems, Inc. Low pH RNA isolation reagents, method, and kit
EP0904277A4 (en) 1996-02-16 2003-01-22 Millennium Pharm Inc COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CARDIOVASCULAR DISEASES
US6099823A (en) 1996-02-16 2000-08-08 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
CZ293215B6 (cs) 1996-08-06 2004-03-17 F. Hoffmann-La Roche Ag Rekombinantní tepelně stálá DNA polymeráza, způsob její přípravy a prostředek, který ji obsahuje
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
US6274312B1 (en) 1996-12-11 2001-08-14 Schering Corporation Intracellular regulatory molecules; related reagents
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
ES2230631T3 (es) 1997-03-20 2005-05-01 F. Hoffmann-La Roche Ag Cebadores modificados.
US6190857B1 (en) 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
US5958688A (en) 1997-04-28 1999-09-28 The Trustees Of The University Of Pennsylvania Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US6010853A (en) 1997-05-29 2000-01-04 Dana-Farber Cancer Institute Siva genes, novel genes involved in CD27-mediated apoptosis
US6228628B1 (en) 1997-07-09 2001-05-08 Roche Molecular Systems Mutant chimeric DNA polymerase
WO1999010536A1 (en) 1997-08-22 1999-03-04 Yale University A process to study changes in gene expression in granulocytic cells
US20030104371A1 (en) * 1997-09-24 2003-06-05 Strom Terry B. Methods of evaluating transplant rejection
US6187534B1 (en) 1997-09-24 2001-02-13 Cornell Research Foundation, Inc. Methods of evaluating transplant rejection
JP2001521753A (ja) 1997-10-31 2001-11-13 アフィメトリックス インコーポレイテッド 成人臓器及び胎児臓器中の発現プロフィール
US6248528B1 (en) 1998-04-06 2001-06-19 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6218122B1 (en) 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
CA2340884A1 (en) * 1998-08-25 2000-03-02 Human Genome Sciences, Inc. 49 human secreted proteins
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US6248527B1 (en) 1998-10-21 2001-06-19 Millennium Pharmaceuticals, Inc. Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E
US6203987B1 (en) * 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
WO2000028090A2 (en) 1998-11-12 2000-05-18 Nyxis, Inc. Diagnostic assay for cancer
US6177254B1 (en) 1998-12-15 2001-01-23 Jerome Bernard Rattner Nucleolus autoantigenic marker for systemic lupus erthyematosus
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US6150121A (en) 1999-02-16 2000-11-21 Wisconsin Alumni Research Foundation Assessing immunological state of transplant recipients
US6280941B1 (en) 1999-03-29 2001-08-28 Cedars-Sinai Medical Center Genetic marker test for lupus
JP2004507202A (ja) * 1999-03-31 2004-03-11 キュラジェン コーポレイション ポリペプチドをコードするオープンリーディングフレームを含む核酸;「orfx」
US6242185B1 (en) 1999-04-01 2001-06-05 Incyte Genomics, Inc. Purified nucleic acid encoding transcription factor regulatory protein
US6162604A (en) 1999-04-01 2000-12-19 Jacob; Chaim O. Methods for determining genetic predisposition to autoimmune diseases by genotyping apoptotic genes
US6245526B1 (en) 1999-05-26 2001-06-12 Incyte Pharmaceuticals, Inc. Lipid metabolism transcription factor
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
US6168933B1 (en) 1999-06-08 2001-01-02 Incyte Pharmaceuticals, Inc. Phospholipid transfer protein
JP2004528526A (ja) 1999-06-28 2004-09-16 ソース・プリシジョン・メディシン・インク 較正された遺伝子発現プロファイルを使用する生物学的状態又は作用因子を特徴付けするシステム及び方法
US6245527B1 (en) 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
AU7072700A (en) * 1999-08-23 2001-03-19 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
US6225093B1 (en) 1999-09-07 2001-05-01 Decode Genetics Ehf. Detection of C4A deletion by long range PCR
WO2001038585A2 (en) * 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
GB9928136D0 (en) 1999-11-29 2000-01-26 Rose Marlene L Organ rejection and associated conditions
WO2001047944A2 (en) 1999-12-28 2001-07-05 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
AU3095801A (en) 2000-01-31 2001-08-07 Human Genome Sciences Inc Nucleic acids, proteins, and antibodies
US20030139327A9 (en) 2000-01-31 2003-07-24 Rosen Craig A. Nucleic acids, proteins, and antibodies
CA2393002A1 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
AU2001233114A1 (en) 2000-02-04 2001-08-14 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
WO2001060860A2 (en) 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
WO2001071005A2 (en) 2000-03-24 2001-09-27 Micromet Ag Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex
US6900015B2 (en) 2000-04-24 2005-05-31 Beth Israel Deaconess Medical Center, Inc. Measurement of protective genes in allograft rejection
DE10021834A1 (de) 2000-05-06 2001-11-15 Lynx Therapeutics Gmbh mRNA Moleküle zur Verwendung als Indikatoren für den Aktivierungs- und Funktionszustand von T-Lymphozyten
AU6158501A (en) 2000-05-12 2001-11-26 Beth Israel Hospital Compositions and methods for achieving immune suppression
WO2002000677A1 (en) 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2002002807A2 (en) 2000-06-30 2002-01-10 Epigenomics Ag Diagnosis of diseases associated with cell signalling
WO2002028999A2 (en) 2000-10-03 2002-04-11 Gene Logic, Inc. Gene expression profiles in granulocytic cells
EP1334113A4 (en) 2000-10-20 2007-08-08 Expression Diagnostics Inc EVALUATION OF LEUCOCYTAIRE EXPRESSION LEVEL
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
WO2002103320A2 (en) * 2001-06-18 2002-12-27 Rosetta Inpharmatics, Inc. Diagnosis and prognosis of breast cancer patients
WO2003004612A2 (en) * 2001-07-02 2003-01-16 Yale University Inhibitor of t cell activation
EP1451340B1 (en) * 2001-11-09 2014-01-08 Life Technologies Corporation Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
BR0214571A (pt) * 2001-11-29 2006-05-30 Therakos Inc métodos para pré-tratar um indivìduo com fotoférese extracorporal e/ou células apoptóticas
US20040072181A1 (en) * 2002-01-22 2004-04-15 Whitehead Alexander Steven Methods for determining drug responsiveness
DE10234524A1 (de) * 2002-07-24 2004-02-12 Oligene Gmbh Nukleinsäurearray
US7118865B2 (en) 2002-08-16 2006-10-10 Regents Of The University Of Minnesota Methods for diagnosing severe systemic lupus erythematosus
CA2528162A1 (en) 2003-06-04 2004-12-16 The Government Of The United States As Represented By The Secretary Of T He Department Of Health And Human Services, Centers For Disease Control Pni microarray and uses
US20050281815A1 (en) * 2004-02-26 2005-12-22 Dani Eshel CD40 splice variants and their uses
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
EP1885889A4 (en) * 2005-05-11 2010-01-20 Expression Diagnostics Inc METHOD FOR MONITORING THE OPERATING STATUS OF TRANSPLANTS OVER GENLISTS
AU2007309726A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders

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