IL157657A0 - Metalloproteinase inhibitors - Google Patents

Metalloproteinase inhibitors

Info

Publication number
IL157657A0
IL157657A0 IL15765702A IL15765702A IL157657A0 IL 157657 A0 IL157657 A0 IL 157657A0 IL 15765702 A IL15765702 A IL 15765702A IL 15765702 A IL15765702 A IL 15765702A IL 157657 A0 IL157657 A0 IL 157657A0
Authority
IL
Israel
Prior art keywords
metalloproteinase inhibitors
metalloproteinase
inhibitors
Prior art date
Application number
IL15765702A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL157657A0 publication Critical patent/IL157657A0/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
IL15765702A 2001-03-15 2002-03-13 Metalloproteinase inhibitors IL157657A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100902A SE0100902D0 (sv) 2001-03-15 2001-03-15 Compounds
PCT/SE2002/000473 WO2002074748A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
IL157657A0 true IL157657A0 (en) 2004-03-28

Family

ID=20283374

Family Applications (5)

Application Number Title Priority Date Filing Date
IL15765702A IL157657A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
IL15765202A IL157652A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
IL15765602A IL157656A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
IL157652A IL157652A (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors, compositions comprising them and uses thereof for the preparation of medicaments for treating diseases or conditions mediated by metalloproteinase enzymes
IL157656A IL157656A (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for the treatment of diseases mediated by metalloproteinase enzymes

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL15765202A IL157652A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
IL15765602A IL157656A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
IL157652A IL157652A (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors, compositions comprising them and uses thereof for the preparation of medicaments for treating diseases or conditions mediated by metalloproteinase enzymes
IL157656A IL157656A (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for the treatment of diseases mediated by metalloproteinase enzymes

Country Status (32)

Country Link
US (8) US7427631B2 (cs)
EP (4) EP1370556B1 (cs)
JP (4) JP2004527515A (cs)
KR (4) KR100886315B1 (cs)
CN (5) CN100526307C (cs)
AR (2) AR035695A1 (cs)
AT (3) ATE493406T1 (cs)
AU (2) AU2002237626B2 (cs)
BR (3) BR0208104A (cs)
CA (3) CA2440630C (cs)
CY (1) CY1107525T1 (cs)
CZ (3) CZ20032499A3 (cs)
DE (3) DE60213216T2 (cs)
DK (1) DK1370556T3 (cs)
EE (3) EE05364B1 (cs)
ES (3) ES2357138T3 (cs)
HU (3) HUP0400194A3 (cs)
IL (5) IL157657A0 (cs)
IS (3) IS6943A (cs)
MX (3) MXPA03008181A (cs)
MY (2) MY136789A (cs)
NO (3) NO326087B1 (cs)
NZ (3) NZ528107A (cs)
PL (3) PL365099A1 (cs)
PT (1) PT1370556E (cs)
RU (3) RU2285695C2 (cs)
SE (1) SE0100902D0 (cs)
SI (1) SI1370556T1 (cs)
SK (3) SK287834B6 (cs)
UA (3) UA77667C2 (cs)
WO (3) WO2002074748A1 (cs)
ZA (4) ZA200306732B (cs)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
US6890915B2 (en) 2001-05-25 2005-05-10 Bristol-Myers Squibb Pharma Company Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
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CN1962641B (zh) 2012-07-04
EE200300445A (et) 2003-12-15
JP4390457B2 (ja) 2009-12-24
PL364707A1 (en) 2004-12-13
CN1509276A (zh) 2004-06-30
US20080262045A1 (en) 2008-10-23
WO2002074767A8 (en) 2004-04-22
HUP0400202A3 (en) 2004-10-28
NO20034042D0 (no) 2003-09-12
CN1962641A (zh) 2007-05-16
US7754750B2 (en) 2010-07-13
DE60238794D1 (de) 2011-02-10
KR20030082986A (ko) 2003-10-23
WO2002074767A1 (en) 2002-09-26
BR0207984A (pt) 2004-06-15
RU2293729C2 (ru) 2007-02-20
NO20034045L (no) 2003-11-10
NO20034045D0 (no) 2003-09-12
KR20080071210A (ko) 2008-08-01
JP5140058B2 (ja) 2013-02-06
CN1304377C (zh) 2007-03-14
PL364706A1 (en) 2004-12-13
MXPA03008191A (es) 2004-01-29
MXPA03008177A (es) 2003-12-12
CA2440630A1 (en) 2002-09-26
US20100273849A1 (en) 2010-10-28
PT1370556E (pt) 2006-11-30
EE05364B1 (et) 2010-12-15
HUP0400202A2 (hu) 2004-08-30
CY1107525T1 (el) 2013-03-13
US20040106659A1 (en) 2004-06-03
EP1370537A1 (en) 2003-12-17
NO20034044D0 (no) 2003-09-12
RU2003127734A (ru) 2005-03-20
US7368465B2 (en) 2008-05-06
UA77408C2 (en) 2006-12-15
ES2357138T3 (es) 2011-04-19
RU2285695C2 (ru) 2006-10-20
SK10962003A3 (sk) 2004-03-02
SK10952003A3 (sk) 2004-05-04
EP1370556B1 (en) 2006-07-19
WO2002074751A1 (en) 2002-09-26
DE60237965D1 (en) 2010-11-25
CN1509286A (zh) 2004-06-30
KR100879905B1 (ko) 2009-01-21
AU2002237626B2 (en) 2007-05-17
IS6943A (is) 2003-09-09
ATE484496T1 (de) 2010-10-15
UA78502C2 (en) 2007-04-10
CZ20032497A3 (cs) 2004-02-18
EE200300449A (et) 2003-12-15
MY136141A (en) 2008-08-29
SK287834B6 (sk) 2011-12-05
JP2004527515A (ja) 2004-09-09
DE60213216D1 (en) 2006-08-31
AR035443A1 (es) 2004-05-26
SI1370556T1 (sl) 2006-10-31
EP1370534A1 (en) 2003-12-17
ZA200306737B (en) 2004-11-29
DE60213216T2 (de) 2007-07-12
CA2440473A1 (en) 2002-09-26
US20040127528A1 (en) 2004-07-01
ZA200306734B (en) 2004-11-29
US20080306065A1 (en) 2008-12-11
NO326087B1 (no) 2008-09-15
NO327114B1 (no) 2009-04-27
US8153673B2 (en) 2012-04-10
IL157656A0 (en) 2004-03-28
BR0208104A (pt) 2004-03-02
ATE333454T1 (de) 2006-08-15
PL205315B1 (pl) 2010-04-30
NZ528107A (en) 2005-06-24
IS6942A (is) 2003-09-09
CN101602731A (zh) 2009-12-16
EP1370556A1 (en) 2003-12-17
SK287766B6 (sk) 2011-09-05
HUP0400194A3 (en) 2004-10-28
RU2288228C2 (ru) 2006-11-27
HUP0400327A2 (hu) 2005-01-28
NZ528106A (en) 2005-03-24
NZ528140A (en) 2005-02-25
HK1059932A1 (en) 2004-07-23
EP1370537B1 (en) 2010-10-13
JP2010077137A (ja) 2010-04-08
AR035695A1 (es) 2004-06-23
US20110003853A1 (en) 2011-01-06
CN1509272A (zh) 2004-06-30
CA2440473C (en) 2011-08-30
RU2003127735A (ru) 2005-03-20
CZ20032500A3 (cs) 2004-02-18

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