IL155588A0 - Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby - Google Patents

Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby

Info

Publication number
IL155588A0
IL155588A0 IL15558803A IL15558803A IL155588A0 IL 155588 A0 IL155588 A0 IL 155588A0 IL 15558803 A IL15558803 A IL 15558803A IL 15558803 A IL15558803 A IL 15558803A IL 155588 A0 IL155588 A0 IL 155588A0
Authority
IL
Israel
Prior art keywords
expression
methods
transgenic plant
enzymatically active
plant root
Prior art date
Application number
IL15558803A
Other languages
English (en)
Original Assignee
Metabogal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabogal Ltd filed Critical Metabogal Ltd
Priority to IL15558803A priority Critical patent/IL155588A0/xx
Publication of IL155588A0 publication Critical patent/IL155588A0/xx
Priority to ES04713966T priority patent/ES2391057T3/es
Priority to SG2013021217A priority patent/SG2013021217A/en
Priority to CN2011101127063A priority patent/CN102240397A/zh
Priority to EP10012375.1A priority patent/EP2330205B1/en
Priority to KR1020117014421A priority patent/KR20110089193A/ko
Priority to EP10012373.6A priority patent/EP2343378B1/en
Priority to AU2004234635A priority patent/AU2004234635B2/en
Priority to US10/554,387 priority patent/US20060204487A1/en
Priority to DK10012376.9T priority patent/DK2333083T3/da
Priority to SI200432130T priority patent/SI2333083T1/sl
Priority to PT100123769T priority patent/PT2333083E/pt
Priority to CA2523539A priority patent/CA2523539C/en
Priority to EP04713966A priority patent/EP1618177B1/en
Priority to PCT/IL2004/000181 priority patent/WO2004096978A2/en
Priority to MXPA05011507A priority patent/MXPA05011507A/es
Priority to JP2006507577A priority patent/JP4993693B2/ja
Priority to KR1020057020434A priority patent/KR101332372B1/ko
Priority to EP10012372.8A priority patent/EP2322636B1/en
Priority to US10/784,295 priority patent/US20050032211A1/en
Priority to RU2005136874A priority patent/RU2385928C3/ru
Priority to EP10012376.9A priority patent/EP2333083B1/en
Priority to BRPI0410520A priority patent/BRPI0410520B8/pt
Priority to EP10012374A priority patent/EP2330204A1/en
Priority to ES10012376.9T priority patent/ES2446965T3/es
Priority to SG2007172737A priority patent/SG2007172737A/en
Priority to UAA200511193A priority patent/UA89944C2/ru
Priority to CN2004800179162A priority patent/CN1875111B/zh
Priority to KR1020127012693A priority patent/KR20120093964A/ko
Priority to ZA200508680A priority patent/ZA200508680B/xx
Priority to IL171561A priority patent/IL171561A/en
Priority to HK06108225.4A priority patent/HK1088041A1/xx
Priority to IL182888A priority patent/IL182888A/en
Priority to US11/790,991 priority patent/US7951557B2/en
Priority to US11/979,813 priority patent/US20090053762A1/en
Priority to US12/451,188 priority patent/US20100196345A1/en
Priority to US12/385,894 priority patent/US8790641B2/en
Priority to RU2009148012/10A priority patent/RU2535342C2/ru
Priority to US12/690,977 priority patent/US20100136673A1/en
Priority to US13/008,048 priority patent/US20110159590A1/en
Priority to US13/080,694 priority patent/US8449876B2/en
Priority to US13/080,692 priority patent/US8227230B2/en
Priority to JP2011099013A priority patent/JP2011184445A/ja
Priority to US13/555,243 priority patent/US8741620B2/en
Priority to US13/727,632 priority patent/US20130177538A1/en
Priority to CY20141100067T priority patent/CY1114893T1/el
Priority to US14/292,966 priority patent/US9220737B2/en
Priority to US14/937,939 priority patent/US20160095907A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
IL15558803A 1996-09-26 2003-04-27 Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby IL155588A0 (en)

Priority Applications (48)

Application Number Priority Date Filing Date Title
IL15558803A IL155588A0 (en) 2003-04-27 2003-04-27 Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
ES04713966T ES2391057T3 (es) 2003-04-27 2004-02-24 Glucocerebrosidasa con alto contenido y de manosa y su producción en cultivo vegetal
SG2013021217A SG2013021217A (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
CN2011101127063A CN102240397A (zh) 2003-04-27 2004-02-24 用植物培养生产高甘露糖蛋白
EP10012375.1A EP2330205B1 (en) 2003-04-27 2004-02-24 Plant cells expressing human glucocerebrosidase
KR1020117014421A KR20110089193A (ko) 2003-04-27 2004-02-24 식물 배양에서 고-만노스 단백질의 생산
EP10012373.6A EP2343378B1 (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
AU2004234635A AU2004234635B2 (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
US10/554,387 US20060204487A1 (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
DK10012376.9T DK2333083T3 (da) 2003-04-27 2004-02-24 Fremstilling af human glucocerebrosidase med højt mannoseindhold i plantekultur
SI200432130T SI2333083T1 (sl) 2003-04-27 2004-02-24 Proizvodnja človeške glukocerebrozidaze z visoko vsebnostjo manoze v rastlinski kulturi
PT100123769T PT2333083E (pt) 2003-04-27 2004-02-24 Produção de glucocerebrosidase humana com teor elevado de manose em culturas de plantas
CA2523539A CA2523539C (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
EP04713966A EP1618177B1 (en) 2003-04-27 2004-02-24 High mannose glucocerebrosidease and its production in plant culture
PCT/IL2004/000181 WO2004096978A2 (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
MXPA05011507A MXPA05011507A (es) 2003-04-27 2004-02-24 Produccion de proteinas con alto contenido de manosa en cultivo de plantas.
JP2006507577A JP4993693B2 (ja) 2003-04-27 2004-02-24 植物培養における高マンノースタンパク質の製造
KR1020057020434A KR101332372B1 (ko) 2003-04-27 2004-02-24 식물 배양에서 고-만노스 단백질의 생산
EP10012372.8A EP2322636B1 (en) 2003-04-27 2004-02-24 Alpha galactosidase attached to an ER retention signal and its production in plants.
US10/784,295 US20050032211A1 (en) 1996-09-26 2004-02-24 Cell/tissue culturing device, system and method
RU2005136874A RU2385928C3 (ru) 2003-04-27 2004-02-24 Продуцирование высокоманнозных белков в растительных культурах
EP10012376.9A EP2333083B1 (en) 2003-04-27 2004-02-24 Production of high mannose human glucocerebrosidease in plant culture
BRPI0410520A BRPI0410520B8 (pt) 2003-04-27 2004-02-24 produção de proteínas de fusão de glucocerebrosidase (gcd) glicosilada em cultura de plantas
EP10012374A EP2330204A1 (en) 2003-04-27 2004-02-24 Production of iduronate-2-sulphatase in plant culture
ES10012376.9T ES2446965T3 (es) 2003-04-27 2004-02-24 Producción de glucocerebrosidasa humana con alto contenido de manosa en cultivo vegetal
SG2007172737A SG2007172737A (en) 2003-04-27 2004-02-24 Production of high mannose proteins in plant culture
UAA200511193A UA89944C2 (ru) 2003-04-27 2004-02-24 Продуцирование высокоманнозных белков в растительных культурах
CN2004800179162A CN1875111B (zh) 2003-04-27 2004-02-24 用植物培养生产高甘露糖蛋白
KR1020127012693A KR20120093964A (ko) 2003-04-27 2004-02-24 식물 배양에서 고-만노스 단백질의 생산
ZA200508680A ZA200508680B (en) 2003-04-27 2005-10-26 Production of high mannose proteins in plant culture
IL171561A IL171561A (en) 2003-04-27 2005-10-26 Production of a human-cultured human glucose-rich ribosidase protein
HK06108225.4A HK1088041A1 (en) 2003-04-27 2006-07-25 High mannose glucocerebrosidease and its production in plant culture
IL182888A IL182888A (en) 2003-04-27 2007-04-30 The production of mano-rich plants in plant culture
US11/790,991 US7951557B2 (en) 2003-04-27 2007-04-30 Human lysosomal proteins from plant cell culture
US11/979,813 US20090053762A1 (en) 1996-09-26 2007-11-08 Cell/tissue culturing device, system and method
US12/451,188 US20100196345A1 (en) 2003-04-27 2008-04-30 Production of high mannose proteins in plant culture
US12/385,894 US8790641B2 (en) 2003-04-27 2009-04-23 Production of high mannose proteins in plant culture and therapeutic uses thereof
RU2009148012/10A RU2535342C2 (ru) 2003-04-27 2009-12-23 Продуцирование высокоманнозных белков в растительных культурах
US12/690,977 US20100136673A1 (en) 1996-09-26 2010-01-21 Cell/tissue culturing device, system and method
US13/008,048 US20110159590A1 (en) 1996-09-26 2011-01-18 Cell/tissue culturing device, system and method
US13/080,694 US8449876B2 (en) 2003-04-27 2011-04-06 Human lysosomal proteins from plant cell culture
US13/080,692 US8227230B2 (en) 2003-04-27 2011-04-06 Human lysosomal proteins from plant cell culture
JP2011099013A JP2011184445A (ja) 2003-04-27 2011-04-27 植物培養における高マンノースタンパク質の製造
US13/555,243 US8741620B2 (en) 2003-04-27 2012-07-23 Human lysosomal proteins from plant cell culture
US13/727,632 US20130177538A1 (en) 2003-04-27 2012-12-27 Human lysosomal proteins from plant cell culture
CY20141100067T CY1114893T1 (el) 2003-04-27 2014-01-24 Παραγωγη ανθρωπινης γλυκοσερεμπροσιδασης υψηλης μαννοζης σε φυτικη καλλιεργεια
US14/292,966 US9220737B2 (en) 2003-04-27 2014-06-02 Plant cell culture expressing human lysosomal proteins and uses thereof
US14/937,939 US20160095907A1 (en) 2003-04-27 2015-11-11 Plant cell culture expressing human lysosomal proteins and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL15558803A IL155588A0 (en) 2003-04-27 2003-04-27 Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby

Publications (1)

Publication Number Publication Date
IL155588A0 true IL155588A0 (en) 2003-11-23

Family

ID=32697072

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15558803A IL155588A0 (en) 1996-09-26 2003-04-27 Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
IL171561A IL171561A (en) 2003-04-27 2005-10-26 Production of a human-cultured human glucose-rich ribosidase protein
IL182888A IL182888A (en) 2003-04-27 2007-04-30 The production of mano-rich plants in plant culture

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL171561A IL171561A (en) 2003-04-27 2005-10-26 Production of a human-cultured human glucose-rich ribosidase protein
IL182888A IL182888A (en) 2003-04-27 2007-04-30 The production of mano-rich plants in plant culture

Country Status (21)

Country Link
US (1) US20060204487A1 (ko)
EP (6) EP2333083B1 (ko)
JP (2) JP4993693B2 (ko)
KR (3) KR101332372B1 (ko)
CN (2) CN1875111B (ko)
AU (1) AU2004234635B2 (ko)
BR (1) BRPI0410520B8 (ko)
CA (1) CA2523539C (ko)
CY (1) CY1114893T1 (ko)
DK (1) DK2333083T3 (ko)
ES (2) ES2391057T3 (ko)
HK (1) HK1088041A1 (ko)
IL (3) IL155588A0 (ko)
MX (1) MXPA05011507A (ko)
PT (1) PT2333083E (ko)
RU (2) RU2385928C3 (ko)
SG (2) SG2013021217A (ko)
SI (1) SI2333083T1 (ko)
UA (1) UA89944C2 (ko)
WO (1) WO2004096978A2 (ko)
ZA (1) ZA200508680B (ko)

Families Citing this family (41)

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US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
EP1866071A4 (en) * 2005-03-03 2013-04-24 Univ Indiana Res & Tech Corp PERMETHYLATION OF OLIGOSACCHARIDES
WO2007010533A2 (en) * 2005-07-18 2007-01-25 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
EP2077855B1 (en) 2006-10-31 2012-02-01 Yildiz, Dr. med., Yildiz Therapeutic use of gba2
CA2685701C (en) 2007-05-07 2019-01-15 Protalix Ltd. Large scale disposable bioreactor
JP5279089B2 (ja) * 2007-07-03 2013-09-04 出光興産株式会社 ブタ浮腫病ワクチン
WO2009024977A2 (en) 2007-08-20 2009-02-26 Protalix Ltd. Saccharide-containing protein conjugates and uses thereof
ITUD20080055A1 (it) * 2008-03-13 2009-09-14 Transactiva S R L Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali
JP5305284B2 (ja) * 2008-03-26 2013-10-02 独立行政法人産業技術総合研究所 糖化合物の質量分析法
JP2012521786A (ja) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
AU2010281403B2 (en) 2009-07-28 2016-03-10 Takeda Pharmaceutical Company Limited Compositions and methods for treating Gaucher disease
PT3482767T (pt) 2009-08-28 2021-12-29 Icahn School Med Mount Sinai Terapia de substituição enzimática com escaladas de dose para tratamento de deficência da esfingomielinase ácida
US20120230974A1 (en) 2009-11-17 2012-09-13 Protalix Ltd Alkaline alpha galactosidase for the treatment of fabry disease
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
WO2011107991A1 (en) 2010-03-02 2011-09-09 Protalix Ltd. Glucocerebrosidase multimers and uses thereof
WO2011123495A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
WO2012001641A1 (en) * 2010-06-30 2012-01-05 Actelion Pharmaceuticals Ltd Stable pharmaceutical compositions
US20130224797A1 (en) * 2010-10-15 2013-08-29 Jcr Pharmaceuticals Co., Ltd. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
EP2665814B1 (en) 2011-01-20 2017-05-17 Protalix Ltd. Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells
KR101158673B1 (ko) * 2011-06-24 2012-07-03 주식회사 지씨바이오 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법
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