PT3482767T - Terapia de substituição enzimática com escaladas de dose para tratamento de deficência da esfingomielinase ácida - Google Patents
Terapia de substituição enzimática com escaladas de dose para tratamento de deficência da esfingomielinase ácidaInfo
- Publication number
- PT3482767T PT3482767T PT181993585T PT18199358T PT3482767T PT 3482767 T PT3482767 T PT 3482767T PT 181993585 T PT181993585 T PT 181993585T PT 18199358 T PT18199358 T PT 18199358T PT 3482767 T PT3482767 T PT 3482767T
- Authority
- PT
- Portugal
- Prior art keywords
- replacement therapy
- dose escalation
- enzyme replacement
- acid sphingomyelinase
- treating acid
- Prior art date
Links
- 208000034012 Acid sphingomyelinase deficiency Diseases 0.000 title 1
- 238000002641 enzyme replacement therapy Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23811309P | 2009-08-28 | 2009-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3482767T true PT3482767T (pt) | 2021-12-29 |
Family
ID=43625265
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT181993585T PT3482767T (pt) | 2009-08-28 | 2010-08-28 | Terapia de substituição enzimática com escaladas de dose para tratamento de deficência da esfingomielinase ácida |
PT10812683T PT2470199T (pt) | 2009-08-28 | 2010-08-28 | Terapia de substituição enzimática com escaladas de dose para tratamento de deficência em esfingomielinase ácida |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT10812683T PT2470199T (pt) | 2009-08-28 | 2010-08-28 | Terapia de substituição enzimática com escaladas de dose para tratamento de deficência em esfingomielinase ácida |
Country Status (26)
Country | Link |
---|---|
US (9) | US8349319B2 (pt) |
EP (3) | EP3482767B1 (pt) |
JP (7) | JP5955219B2 (pt) |
KR (5) | KR102608546B1 (pt) |
CN (3) | CN106047835A (pt) |
AU (5) | AU2010286550B2 (pt) |
BR (1) | BR112012004377A2 (pt) |
CA (1) | CA2773133A1 (pt) |
CL (1) | CL2012000495A1 (pt) |
CY (1) | CY1122128T1 (pt) |
DK (2) | DK3482767T3 (pt) |
ES (2) | ES2738859T3 (pt) |
FR (1) | FR22C1062I2 (pt) |
HR (2) | HRP20211992T1 (pt) |
HU (3) | HUE046598T2 (pt) |
IL (3) | IL300625A (pt) |
LT (2) | LT3482767T (pt) |
MX (1) | MX356873B (pt) |
NL (1) | NL301211I2 (pt) |
PL (2) | PL3482767T3 (pt) |
PT (2) | PT3482767T (pt) |
RU (3) | RU2731616C2 (pt) |
SI (2) | SI2470199T1 (pt) |
TR (1) | TR201911293T4 (pt) |
WO (1) | WO2011025996A2 (pt) |
ZA (2) | ZA201201435B (pt) |
Families Citing this family (23)
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US8889127B2 (en) | 2004-07-01 | 2014-11-18 | Icahn School Of Medicine At Mount Sinai | Targeted protein replacement for the treatment of lysosomal storage disorders |
US20080228056A1 (en) | 2007-03-13 | 2008-09-18 | Michael Blomquist | Basal rate testing using frequent blood glucose input |
US7751907B2 (en) | 2007-05-24 | 2010-07-06 | Smiths Medical Asd, Inc. | Expert system for insulin pump therapy |
US8221345B2 (en) | 2007-05-30 | 2012-07-17 | Smiths Medical Asd, Inc. | Insulin pump based expert system |
ES2635726T3 (es) | 2007-06-06 | 2017-10-04 | Genzyme Corporation | Terapia génica para enfermedades de almacenamiento lisosómico |
EP3482767B1 (en) * | 2009-08-28 | 2021-10-06 | Icahn School of Medicine at Mount Sinai | Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency |
US8882701B2 (en) | 2009-12-04 | 2014-11-11 | Smiths Medical Asd, Inc. | Advanced step therapy delivery for an ambulatory infusion pump and system |
US20120034638A1 (en) | 2010-05-21 | 2012-02-09 | Michael Ahrens | Electrochemical assay for the detection of enzymatically active PSA |
PT2685986T (pt) | 2011-03-18 | 2020-03-05 | Genzyme Corp | Inibidor de glicosilceramida-sintase |
LT2753346T (lt) | 2011-09-07 | 2020-08-10 | Mount Sinai School Of Medicine | Ceramidazė ir ląstelių diferenciacija |
EP2780716B1 (en) | 2011-11-15 | 2019-07-31 | Centogene AG | Method for the diagnosis of niemann-pick disease |
ES2897825T3 (es) | 2012-06-01 | 2022-03-02 | Icahn School Med Mount Sinai | Niveles de ceramida en el tratamiento y prevención de infecciones |
MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
EP2968479B1 (en) | 2013-03-14 | 2019-07-17 | Icahn School of Medicine at Mount Sinai | Therapeutic acid ceramidase compositions and methods of making and using them |
JO3713B1 (ar) | 2013-03-15 | 2021-01-31 | Genzyme Corp | أشكال ملح (s)-كوينوكليدين-3-يل(2-(2-(4-فلوروفينيل)ثيازول-4-يل)بروبان-2-يل)كارباميت |
TR201906195T4 (tr) * | 2013-05-14 | 2019-05-21 | Centogene Ag | Niemann pıck hastalığının teşhisi için metot. |
IL284102B2 (en) * | 2013-06-07 | 2023-04-01 | Genzyme Corp | A marker for disorders of acid sphingomyelinase and its uses |
JP6984854B2 (ja) * | 2015-10-08 | 2021-12-22 | 国立大学法人千葉大学 | ニーマン・ピック病c型を予防または治療するための医薬組成物 |
US10569016B2 (en) | 2015-12-29 | 2020-02-25 | Tandem Diabetes Care, Inc. | System and method for switching between closed loop and open loop control of an ambulatory infusion pump |
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MA50746A (fr) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc | Protéines de fusion comprenant des enzymes d'enzymothérapie substitutive |
UY38238A (es) | 2018-05-25 | 2019-12-31 | Genzyme Corp | Composiciones farmacéuticas para el tratamiento de la deficiencia de esfingomielinasa ácida |
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2010
- 2010-08-28 EP EP18199358.5A patent/EP3482767B1/en active Active
- 2010-08-28 BR BR112012004377A patent/BR112012004377A2/pt not_active Application Discontinuation
- 2010-08-28 CN CN201610403228.4A patent/CN106047835A/zh active Pending
- 2010-08-28 CN CN201610404696.3A patent/CN105999238A/zh active Pending
- 2010-08-28 SI SI201031915T patent/SI2470199T1/sl unknown
- 2010-08-28 KR KR1020217026374A patent/KR102608546B1/ko active IP Right Grant
- 2010-08-28 KR KR1020127005293A patent/KR102094253B1/ko active IP Right Grant
- 2010-08-28 DK DK18199358.5T patent/DK3482767T3/da active
- 2010-08-28 PT PT181993585T patent/PT3482767T/pt unknown
- 2010-08-28 LT LTEP18199358.5T patent/LT3482767T/lt unknown
- 2010-08-28 AU AU2010286550A patent/AU2010286550B2/en active Active
- 2010-08-28 ES ES10812683T patent/ES2738859T3/es active Active
- 2010-08-28 HR HRP20211992TT patent/HRP20211992T1/hr unknown
- 2010-08-28 RU RU2015145255A patent/RU2731616C2/ru active
- 2010-08-28 WO PCT/US2010/047057 patent/WO2011025996A2/en active Application Filing
- 2010-08-28 US US12/870,790 patent/US8349319B2/en active Active
- 2010-08-28 SI SI201032100T patent/SI3482767T1/sl unknown
- 2010-08-28 EP EP10812683.0A patent/EP2470199B1/en active Active
- 2010-08-28 MX MX2012002449A patent/MX356873B/es active IP Right Grant
- 2010-08-28 ES ES18199358T patent/ES2902229T3/es active Active
- 2010-08-28 RU RU2012111823/15A patent/RU2569744C2/ru active
- 2010-08-28 TR TR2019/11293T patent/TR201911293T4/tr unknown
- 2010-08-28 HU HUE10812683A patent/HUE046598T2/hu unknown
- 2010-08-28 KR KR1020227023712A patent/KR102608551B1/ko active IP Right Grant
- 2010-08-28 KR KR1020237040891A patent/KR20230164773A/ko active Application Filing
- 2010-08-28 IL IL300625A patent/IL300625A/en unknown
- 2010-08-28 HU HUE18199358A patent/HUE057440T2/hu unknown
- 2010-08-28 PT PT10812683T patent/PT2470199T/pt unknown
- 2010-08-28 KR KR1020207008342A patent/KR20200034828A/ko not_active IP Right Cessation
- 2010-08-28 LT LTEP10812683.0T patent/LT2470199T/lt unknown
- 2010-08-28 PL PL18199358T patent/PL3482767T3/pl unknown
- 2010-08-28 CA CA2773133A patent/CA2773133A1/en active Pending
- 2010-08-28 PL PL10812683T patent/PL2470199T3/pl unknown
- 2010-08-28 CN CN2010800439108A patent/CN102596232A/zh active Pending
- 2010-08-28 EP EP21200695.1A patent/EP3998078A1/en active Pending
- 2010-08-28 JP JP2012527054A patent/JP5955219B2/ja active Active
- 2010-08-28 DK DK10812683.0T patent/DK2470199T3/da active
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2012
- 2012-02-26 IL IL218324A patent/IL218324B/en active IP Right Grant
- 2012-02-27 CL CL2012000495A patent/CL2012000495A1/es unknown
- 2012-02-27 ZA ZA2012/01435A patent/ZA201201435B/en unknown
- 2012-11-16 US US13/679,583 patent/US8658162B2/en active Active
- 2012-11-16 US US13/679,623 patent/US8709408B2/en active Active
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2014
- 2014-01-16 US US14/156,894 patent/US9114139B2/en active Active
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2015
- 2015-07-08 US US14/793,838 patent/US9655954B2/en active Active
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2016
- 2016-02-26 ZA ZA2016/01362A patent/ZA201601362B/en unknown
- 2016-03-03 JP JP2016041242A patent/JP6251307B2/ja active Active
- 2016-08-17 AU AU2016216625A patent/AU2016216625B2/en active Active
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2017
- 2017-04-12 US US15/485,604 patent/US10188705B2/en active Active
- 2017-11-24 JP JP2017226255A patent/JP2018076322A/ja active Pending
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2018
- 2018-06-12 AU AU2018204156A patent/AU2018204156B2/en active Active
- 2018-12-04 US US16/209,336 patent/US20190151419A1/en not_active Abandoned
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2019
- 2019-05-27 IL IL266915A patent/IL266915B2/en unknown
- 2019-07-29 CY CY20191100808T patent/CY1122128T1/el unknown
- 2019-07-31 HR HRP20191385 patent/HRP20191385T1/hr unknown
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2020
- 2020-01-17 JP JP2020005901A patent/JP6952810B2/ja active Active
- 2020-05-26 US US16/883,407 patent/US20210077593A1/en not_active Abandoned
- 2020-09-02 RU RU2020128994A patent/RU2020128994A/ru unknown
- 2020-10-13 AU AU2020256322A patent/AU2020256322B2/en active Active
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2021
- 2021-09-28 JP JP2021157902A patent/JP7167281B2/ja active Active
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2022
- 2022-02-18 US US17/675,474 patent/US20220305091A1/en active Pending
- 2022-10-26 JP JP2022171242A patent/JP7395693B2/ja active Active
- 2022-12-08 HU HUS2200050C patent/HUS2200050I1/hu unknown
- 2022-12-15 FR FR22C1062C patent/FR22C1062I2/fr active Active
- 2022-12-20 NL NL301211C patent/NL301211I2/nl unknown
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2023
- 2023-11-29 JP JP2023201609A patent/JP2024026214A/ja active Pending
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2024
- 2024-02-20 AU AU2024201085A patent/AU2024201085A1/en active Pending
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