FR22C1062I1 - Thérapie de remplacement enzymatique d'escalade de doses pour le traitement du déficit en sphingomyélinase acide - Google Patents

Thérapie de remplacement enzymatique d'escalade de doses pour le traitement du déficit en sphingomyélinase acide

Info

Publication number
FR22C1062I1
FR22C1062I1 FR22C1062C FR22C1062C FR22C1062I1 FR 22C1062 I1 FR22C1062 I1 FR 22C1062I1 FR 22C1062 C FR22C1062 C FR 22C1062C FR 22C1062 C FR22C1062 C FR 22C1062C FR 22C1062 I1 FR22C1062 I1 FR 22C1062I1
Authority
FR
France
Prior art keywords
enzy
treatment
replacement therapy
dose escalation
acid sphingomyelinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1062C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Icahn School of Medicine at Mount Sinai
Original Assignee
Genzyme Corp
Icahn School of Medicine at Mount Sinai
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43625265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR22C1062(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp, Icahn School of Medicine at Mount Sinai filed Critical Genzyme Corp
Publication of FR22C1062I1 publication Critical patent/FR22C1062I1/fr
Application granted granted Critical
Publication of FR22C1062I2 publication Critical patent/FR22C1062I2/fr
Active legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Dermatology (AREA)
FR22C1062C 2009-08-28 2022-12-15 Thérapie de remplacement enzymatique d'escalade de doses pour le traitement du déficit en sphingomyélinase acide Active FR22C1062I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23811309P 2009-08-28 2009-08-28
EP10812683.0A EP2470199B1 (fr) 2009-08-28 2010-08-28 Thérapie de substitution enzymatique à doses croissantes permettant de traiter un déficit en sphingomyélinase acide
PCT/US2010/047057 WO2011025996A2 (fr) 2009-08-28 2010-08-28 Thérapie de substitution enzymatique à doses croissantes permettant de traiter un déficit en sphingomyélinase acide

Publications (2)

Publication Number Publication Date
FR22C1062I1 true FR22C1062I1 (fr) 2023-02-03
FR22C1062I2 FR22C1062I2 (fr) 2023-12-29

Family

ID=43625265

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1062C Active FR22C1062I2 (fr) 2009-08-28 2022-12-15 Thérapie de remplacement enzymatique d'escalade de doses pour le traitement du déficit en sphingomyélinase acide

Country Status (26)

Country Link
US (9) US8349319B2 (fr)
EP (3) EP2470199B1 (fr)
JP (7) JP5955219B2 (fr)
KR (5) KR20230164773A (fr)
CN (3) CN105999238A (fr)
AU (5) AU2010286550B2 (fr)
BR (1) BR112012004377A2 (fr)
CA (1) CA2773133A1 (fr)
CL (1) CL2012000495A1 (fr)
CY (1) CY1122128T1 (fr)
DK (2) DK2470199T3 (fr)
ES (2) ES2902229T3 (fr)
FR (1) FR22C1062I2 (fr)
HR (2) HRP20211992T1 (fr)
HU (3) HUE046598T2 (fr)
IL (3) IL300625A (fr)
LT (2) LT2470199T (fr)
MX (1) MX356873B (fr)
NL (1) NL301211I2 (fr)
PL (2) PL2470199T3 (fr)
PT (2) PT2470199T (fr)
RU (3) RU2731616C2 (fr)
SI (2) SI2470199T1 (fr)
TR (1) TR201911293T4 (fr)
WO (1) WO2011025996A2 (fr)
ZA (2) ZA201201435B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006007560A2 (fr) 2004-07-01 2006-01-19 University Of Pennsylvania Remplacement de proteines ciblees pour le traitement de maladies lysosomales
US20080228056A1 (en) 2007-03-13 2008-09-18 Michael Blomquist Basal rate testing using frequent blood glucose input
US7751907B2 (en) 2007-05-24 2010-07-06 Smiths Medical Asd, Inc. Expert system for insulin pump therapy
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system
EP2158322B1 (fr) 2007-06-06 2017-05-03 Genzyme Corporation Thérapie génique pour les maladies de stockage lysosomal
KR20230164773A (ko) * 2009-08-28 2023-12-04 이칸 스쿨 오브 메디슨 엣 마운트 시나이 산성 스핑고미엘리나제 결핍을 치료하기 위한 투여량 단계적 증가 효소 대체 요법
US8882701B2 (en) 2009-12-04 2014-11-11 Smiths Medical Asd, Inc. Advanced step therapy delivery for an ambulatory infusion pump and system
CA2798812A1 (fr) 2010-05-21 2011-11-24 Ohmx Corporation Detection du cancer par dosage de l'activite enzymatique du psa
TWI546301B (zh) 2011-03-18 2016-08-21 健臻公司 葡萄糖神經醯胺合成酶抑制劑
US10350277B2 (en) 2011-09-07 2019-07-16 Icahn School Of Medicine At Mount Sinai Ceramidase and cell differentiation
DK2780716T3 (da) * 2011-11-15 2019-10-14 Centogene Ag Fremgangsmåde til diagnose af Niemann-Pick sygdom
PT2854910T (pt) 2012-06-01 2020-05-06 Yeda Res & Dev Níveis de ceramida no tratamento e prevenção de infeções
JOP20130273B1 (ar) 2012-09-11 2021-08-17 Genzyme Corp مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
ES2739811T3 (es) * 2013-03-14 2020-02-04 Icahn School Med Mount Sinai Composiciones terapéuticas de ceramidasa ácida y métodos de fabricación y uso de ellas
JO3713B1 (ar) 2013-03-15 2021-01-31 Genzyme Corp أشكال ملح (s)-كوينوكليدين-3-يل(2-(2-(4-فلوروفينيل)ثيازول-4-يل)بروبان-2-يل)كارباميت
WO2014183873A1 (fr) * 2013-05-14 2014-11-20 Centogene Ag Procédé pour le diagnostic de la maladie de niemann-pick
SG11201509622WA (en) * 2013-06-07 2015-12-30 Genzyme Corp Marker for acid sphingomyelinase disorders and uses thereof
JP6984854B2 (ja) * 2015-10-08 2021-12-22 国立大学法人千葉大学 ニーマン・ピック病ｃ型を予防または治療するための医薬組成物
US10569016B2 (en) 2015-12-29 2020-02-25 Tandem Diabetes Care, Inc. System and method for switching between closed loop and open loop control of an ambulatory infusion pump
MX2020002106A (es) * 2017-08-24 2020-07-14 Sanofi Sa Tratamiento de afecciones oseas anormales en pacientes con deficiencia de esfingomielinasa acida.
JP2021500857A (ja) 2017-10-02 2021-01-14 デナリ セラピューティクス インコーポレイテッドＤｅｎａｌｉ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 酵素補充療法用酵素を含む融合タンパク質
UY38238A (es) 2018-05-25 2019-12-31 Genzyme Corp Composiciones farmacéuticas para el tratamiento de la deficiencia de esfingomielinasa ácida
EP4185267A1 (fr) 2020-07-24 2023-05-31 Genzyme Corporation Compositions pharmaceutiques comprenant du venglustat

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039388A (en) 1976-06-04 1977-08-02 The United States Of America As Represented By The Government Diagnostic test for Niemann-Pick disease
US4082781A (en) 1976-06-04 1978-04-04 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide
IL74761A0 (en) 1984-04-13 1985-06-30 Hughes Howard Med Inst Human phenylalanine hydroxylase cdna clones,their production and their use in diagnosing classical phenylketonuria
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4863195A (en) * 1987-10-02 1989-09-05 Capozzola Carl A Identification tag
US5047335A (en) 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
US5549892A (en) 1988-12-23 1996-08-27 Genzyme Corporation Enhanced in vivo uptake of glucocerebrosidase
US5773278A (en) 1991-05-03 1998-06-30 Mount Sinai Medical Center Acid sphingomyelinase gene
US6034298A (en) 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
US5612487A (en) 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
US5484719A (en) 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5716614A (en) 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
AU7071196A (en) 1995-09-14 1997-04-01 Croptech Development Corporation Production of lysosomal enzymes in plant-based expression systems
JP2820106B2 (ja) 1996-02-29 1998-11-05 日本電気株式会社 トラヒックシェーパ装置
US20050032211A1 (en) 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
EP1230257A4 (fr) 1998-12-23 2003-08-13 Thompson Boyce Plant Res Expression des antigenes de surface de l'hepatite b immunogenes dans les plantes transgeniques
US6642038B1 (en) 1999-09-14 2003-11-04 Genzyme Glycobiology Research Institute, Inc. GlcNAc phosphotransferase of the lysosomal targeting pathway
WO2001071014A2 (fr) 2000-03-17 2001-09-27 Boyce Thompson Institute For Plant Research, Inc. Expression d'acetylcholinesterase de recombinaison humaine dans des plantes transgeniques
US20020095135A1 (en) * 2000-06-19 2002-07-18 David Meeker Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
WO2002018539A2 (fr) 2000-08-25 2002-03-07 Lysometrix Corporation Procede permettant d'analyser l'activite des enzymes lysosomales
US7001994B2 (en) * 2001-01-18 2006-02-21 Genzyme Corporation Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
IL158623A0 (en) 2001-04-30 2004-05-12 Symbiontics Inc Subcellular targeting of therapeutic proteins
IES20011101A2 (en) * 2001-12-21 2003-06-25 Japkinstill Services Ltd A Bi-directional Messaging System
US7658916B2 (en) 2002-04-05 2010-02-09 Genzyme Corporation Methods of enhancing lysosomal storage disease therapy by modulation of cell surface receptor density
US7585518B2 (en) 2002-11-19 2009-09-08 Kimberly-Clark Worldwide, Inc. Products and methods for maintaining or increasing ceramide levels in skin
US7388079B2 (en) 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
BRPI0411291A (pt) * 2003-06-12 2006-08-01 Genzyme Corp esfingomielinase acida humana modificada tendo atividade aumentada e métodos para a fabricação da mesma
US20050026823A1 (en) * 2003-06-20 2005-02-03 Biomarin Pharmaceutical Inc. Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
US7442372B2 (en) * 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
CN1897957A (zh) 2003-11-25 2007-01-17 纽约大学西奈山医学院 尼曼－皮克病的基于陪伴分子的治疗
DE602005021379D1 (de) 2004-10-13 2010-07-01 Protalix Ltd System und verfahren zur produktion von antikörpern in der pflanzenzellkultur
US7615224B2 (en) 2004-12-02 2009-11-10 Women's And Children's Hospital Multiplex-bead complex for determination of lysosomal storage disorders
EP1960534A4 (fr) 2005-12-15 2009-03-25 Univ New York State Res Found Methodes enzymatiques permettant de mesurer la sphingomyeline et la phosphatidylcholine dans le plasma et le tissu
AR059089A1 (es) * 2006-01-20 2008-03-12 Genzyme Corp Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal
US10265412B2 (en) 2006-02-06 2019-04-23 Ramot At Tel-Aviv University Ltd. Enzyme replacement therapy for treating lysosomal storage diseases
ES2697502T3 (es) * 2006-02-09 2019-01-24 Genzyme Corp Administración intraventricular lenta
JP2009526526A (ja) 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー， インコーポレイテッド インフルエンザ抗原、ワクチン組成物、および関連する方法
JP5302189B2 (ja) 2007-04-27 2013-10-02 長瀬産業株式会社 スフィンゴミエリナーゼ
US20110237538A1 (en) 2008-08-06 2011-09-29 Summit Corporation Plc Treatment of lysosomal storage disorders and other proteostatic diseases
EP4212541A1 (fr) 2008-12-16 2023-07-19 Genzyme Corporation Conjugués oligosaccharide-protéine et ses produits intermédiaires
KR20230164773A (ko) * 2009-08-28 2023-12-04 이칸 스쿨 오브 메디슨 엣 마운트 시나이 산성 스핑고미엘리나제 결핍을 치료하기 위한 투여량 단계적 증가 효소 대체 요법
ES2664844T3 (es) * 2011-06-20 2018-04-23 Mount Sinai School Of Medicine Tratamiento dirigido contra TNF para las mucopolisacaridosis y otros trastornos lisosómicos

Also Published As

Publication number Publication date
BR112012004377A2 (pt) 2017-12-12
CL2012000495A1 (es) 2014-02-07
EP2470199A4 (fr) 2013-03-27
ES2738859T3 (es) 2020-01-27
AU2010286550A1 (en) 2012-03-15
TR201911293T4 (tr) 2019-08-21
HUE046598T2 (hu) 2020-03-30
AU2018204156A1 (en) 2018-06-28
KR20120081077A (ko) 2012-07-18
US20180055916A1 (en) 2018-03-01
US20160120957A1 (en) 2016-05-05
FR22C1062I2 (fr) 2023-12-29
AU2010286550B2 (en) 2016-05-19
IL218324A0 (en) 2012-04-30
US20110052559A1 (en) 2011-03-03
DK3482767T3 (da) 2021-12-20
IL266915B2 (en) 2023-07-01
SI2470199T1 (sl) 2019-11-29
LT3482767T (lt) 2022-01-10
KR20210107153A (ko) 2021-08-31
ZA201601362B (en) 2017-05-31
ZA201201435B (en) 2020-05-27
AU2016216625A1 (en) 2016-09-15
HRP20211992T1 (hr) 2022-04-01
EP2470199B1 (fr) 2019-05-22
JP2016153408A (ja) 2016-08-25
CN106047835A (zh) 2016-10-26
PT2470199T (pt) 2019-08-07
US20130078231A1 (en) 2013-03-28
DK2470199T3 (da) 2019-08-05
ES2902229T3 (es) 2022-03-25
US20210077593A1 (en) 2021-03-18
US8658162B2 (en) 2014-02-25
IL266915A (en) 2019-07-31
CA2773133A1 (fr) 2011-03-03
WO2011025996A9 (fr) 2011-08-25
RU2020128994A (ru) 2022-03-02
PL3482767T3 (pl) 2022-02-14
KR20220104271A (ko) 2022-07-26
JP6952810B2 (ja) 2021-10-20
JP2020090513A (ja) 2020-06-11
RU2569744C2 (ru) 2015-11-27
MX2012002449A (es) 2012-03-14
CN105999238A (zh) 2016-10-12
NL301211I2 (nl) 2023-02-02
JP2018076322A (ja) 2018-05-17
PL2470199T3 (pl) 2019-11-29
JP2024026214A (ja) 2024-02-28
IL218324B (en) 2019-05-30
RU2015145255A (ru) 2019-01-11
AU2020256322B2 (en) 2024-02-29
US20190151419A1 (en) 2019-05-23
MX356873B (es) 2018-06-18
HRP20191385T1 (hr) 2019-11-01
KR20230164773A (ko) 2023-12-04
US9655954B2 (en) 2017-05-23
JP2013502933A (ja) 2013-01-31
US9114139B2 (en) 2015-08-25
HUE057440T2 (hu) 2022-05-28
JP2022003065A (ja) 2022-01-11
NL301211I1 (nl) 2022-12-28
EP2470199A2 (fr) 2012-07-04
WO2011025996A3 (fr) 2012-03-15
AU2020256322A1 (en) 2020-11-12
JP7167281B2 (ja) 2022-11-08
SI3482767T1 (sl) 2022-03-31
KR102094253B1 (ko) 2020-03-31
RU2731616C2 (ru) 2020-09-07
HUS2200050I1 (hu) 2022-12-28
US20140335070A1 (en) 2014-11-13
EP3482767B1 (fr) 2021-10-06
JP6251307B2 (ja) 2017-12-20
WO2011025996A2 (fr) 2011-03-03
AU2018204156B2 (en) 2020-07-16
US8349319B2 (en) 2013-01-08
KR102608551B1 (ko) 2023-12-04
JP5955219B2 (ja) 2016-07-20
JP7395693B2 (ja) 2023-12-11
RU2012111823A (ru) 2013-10-10
US8709408B2 (en) 2014-04-29
PT3482767T (pt) 2021-12-29
JP2023012499A (ja) 2023-01-25
EP3482767A1 (fr) 2019-05-15
US20220305091A1 (en) 2022-09-29
LT2470199T (lt) 2019-10-10
KR20200034828A (ko) 2020-03-31
KR102608546B1 (ko) 2023-12-04
US20130078230A1 (en) 2013-03-28
IL266915B1 (en) 2023-03-01
CY1122128T1 (el) 2020-11-25
RU2015145255A3 (fr) 2019-08-12
CN102596232A (zh) 2012-07-18
AU2016216625B2 (en) 2018-07-05
IL300625A (en) 2023-04-01
US10188705B2 (en) 2019-01-29
AU2024201085A1 (en) 2024-03-07
EP3998078A1 (fr) 2022-05-18

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