IL153122A0 - Oligonucleotides for targeted alteration of a genetic sequence and methods utilizing the same - Google Patents

Oligonucleotides for targeted alteration of a genetic sequence and methods utilizing the same

Info

Publication number
IL153122A0
IL153122A0 IL15312201A IL15312201A IL153122A0 IL 153122 A0 IL153122 A0 IL 153122A0 IL 15312201 A IL15312201 A IL 15312201A IL 15312201 A IL15312201 A IL 15312201A IL 153122 A0 IL153122 A0 IL 153122A0
Authority
IL
Israel
Prior art keywords
oligonucleotides
same
genetic sequence
methods utilizing
targeted alteration
Prior art date
Application number
IL15312201A
Other languages
English (en)
Original Assignee
Univ Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Delaware filed Critical Univ Delaware
Publication of IL153122A0 publication Critical patent/IL153122A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
IL15312201A 2000-06-01 2001-06-01 Oligonucleotides for targeted alteration of a genetic sequence and methods utilizing the same IL153122A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20853800P 2000-06-01 2000-06-01
US24498900P 2000-10-30 2000-10-30
US09/818,875 US6936467B2 (en) 2000-03-27 2001-03-27 Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
PCT/US2001/017672 WO2001092512A2 (fr) 2000-06-01 2001-06-01 Modifications genomiques chromosomiques ciblees dans des plantes mettant en application des oligonucleotides monocatenaires modifies

Publications (1)

Publication Number Publication Date
IL153122A0 true IL153122A0 (en) 2003-06-24

Family

ID=27395218

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15312201A IL153122A0 (en) 2000-06-01 2001-06-01 Oligonucleotides for targeted alteration of a genetic sequence and methods utilizing the same

Country Status (6)

Country Link
US (3) US6936467B2 (fr)
EP (1) EP1297122A2 (fr)
AU (2) AU2001265277B2 (fr)
CA (1) CA2410523A1 (fr)
IL (1) IL153122A0 (fr)
WO (1) WO2001092512A2 (fr)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
OA12240A (en) * 2000-03-27 2006-05-10 Univ Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides.
WO2002026967A2 (fr) * 2000-09-25 2002-04-04 Thomas Jefferson University Correction de gene cible au moyen d'oligodesoxynucleotides monocatenaires
WO2002079495A2 (fr) 2001-03-27 2002-10-10 University Of Delaware Applications genomiques destinees a des oligonucleotides modifies
US7053195B1 (en) * 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
US20030109476A1 (en) * 2001-08-07 2003-06-12 Kmiec Eric B. Compositions and methods for the prevention and treatment of Huntington's disease
RU2004106631A (ru) 2001-08-09 2005-05-10 Нортвест Плант Бридинг Компани (Us) Растения пшеницы с повышенной устойчивостью к имидозалиновым гербицидам
BRPI0211809B1 (pt) 2001-08-09 2019-04-24 University Of Saskatchewan Método para o controle de ervas daninhas nas vizinhanças de uma planta de trigo ou triticale, método para modificar a tolerância de uma planta de trigo ou triticale a um herbicida de imidazolinona e método de produção de uma planta de trigo ou triticale transgênica tendo resistência aumentada a um herbicida de imidazolinona
US7521599B2 (en) 2001-08-09 2009-04-21 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
AU2002341905A2 (en) * 2001-09-27 2003-04-07 University Of Delaware Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration
EP1448766A2 (fr) * 2001-09-27 2004-08-25 University Of Delaware Collections de cellules eucaryotes co-isogeniques
US7468244B2 (en) 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
AU2002361069A1 (en) * 2001-12-20 2003-07-24 Japan As Represented By The President Of Okayama University Characteristic base sequences occurring in plant genes and method of utilizing the same
AU2003220119A1 (en) 2002-03-07 2003-09-22 University Of Delaware Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea
DE10221224A1 (de) * 2002-05-13 2003-12-04 Frommer Wolf Bernd Verfahren zur Herstellung einer transgenen Pflanze mit verändertem Stofftransport
PL375524A1 (en) 2002-07-10 2005-11-28 The Department Of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
AU2003282477A1 (en) * 2002-10-07 2004-05-04 Napro Bio Therapeutics, Inc. Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
EP1558767A2 (fr) * 2002-10-29 2005-08-03 BASF Plant Science GmbH Compositions et procedes permettant d'identifier des plantes presentant une meilleure tolerance aux herbicides imidazolinones
US7595177B2 (en) 2002-10-29 2009-09-29 Advanta Canada, Inc. Assay for imidazolinone resistance mutations in Brassica species
US20040198640A1 (en) * 2003-04-02 2004-10-07 Dharmacon, Inc. Stabilized polynucleotides for use in RNA interference
US20040205840A1 (en) * 2003-04-11 2004-10-14 Pioneer Hi-Bred International, Inc. Method for reducing gene expression
MXPA05012733A (es) 2003-05-28 2006-05-17 Basf Ag Plantas de trigo que tienen tolerancia incrementada a los herbicidas de imidazolinona.
CA2533119A1 (fr) * 2003-07-24 2005-02-03 Qiagen Gmbh Procede de transcription et/ou d'amplification inversee d'acides nucleiques
CA2533218C (fr) * 2003-08-05 2014-11-18 Avi Biopharma, Inc. Analogue d'oligonucleotide et methode de traitement des infections dues au flavivirus
US7825235B2 (en) 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
FR2866349B1 (fr) * 2004-02-12 2008-05-16 Biomerieux Sa Procede de diagnostic/pronostic d'une thrombose
US7432082B2 (en) 2004-03-22 2008-10-07 Basf Ag Methods and compositions for analyzing AHASL genes
WO2005094370A2 (fr) 2004-03-29 2005-10-13 The General Hospital Corporation Compositions de complexe d'oligonucleotides et procedes d'utilisation de celles-ci comme outils de modification de genes
KR101147147B1 (ko) * 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
US7355098B2 (en) 2004-06-22 2008-04-08 Saskatchewan Wheat Poo1 Brassica AHAS genes and gene alleles that provide resistance to imidazolinone herbicides
US7759479B1 (en) * 2004-09-13 2010-07-20 Isis Pharmaceuticals, Inc. Compositions and their uses directed to Gemin Genes
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US7923206B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Method of determining a cellular response to a biological agent
AR051690A1 (es) 2004-12-01 2007-01-31 Basf Agrochemical Products Bv Mutacion implicada en el aumento de la tolerancia a los herbicidas imidazolinona en las plantas
EP3581024A1 (fr) 2005-03-02 2019-12-18 Instituto Nacional de Tecnologia Agropecuaria Plantes de riz résistantes aux herbicides, polynucléotides codant pour la résistance aux herbicides, protéines à grandes sous-unités d'acétohydroxyacide synthase et procédés d'utilisation
US20110209232A1 (en) * 2005-07-01 2011-08-25 Nidera Semillas S.A. Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
EP1929036A1 (fr) * 2005-09-29 2008-06-11 Keygene N.V. Procédé et moyen d'échange ciblé de nucléotides
US20070118920A1 (en) * 2005-11-09 2007-05-24 Basf Agrochemical Products B.V. Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
WO2007073149A1 (fr) * 2005-12-22 2007-06-28 Keygene N.V. Variantes de nucleotides ameliorant les echanges de nucleotides cibles
US8288354B2 (en) 2005-12-28 2012-10-16 The Scripps Research Institute Natural antisense and non-coding RNA transcripts as drug targets
EP2069536B1 (fr) * 2006-08-01 2014-11-05 Gen-Probe Incorporated Procedes de capture de cible non specifique d'acides nucleiques
WO2008036825A2 (fr) 2006-09-22 2008-03-27 Dharmacon, Inc. Complexes d'oligonucléotides bicaténaires et procédés de silençage de gènes par interférence arn
US20080124712A1 (en) * 2006-10-26 2008-05-29 Hantash Feras M Alpha globin gene dosage assay
AU2007333258B2 (en) * 2006-12-07 2014-07-17 Kansas State University Research Foundation Acetolactate synthase herbicide resistant sorghum
UA108733C2 (uk) 2006-12-12 2015-06-10 Толерантна до гербіциду рослина соняшника
UA104843C2 (uk) * 2007-04-04 2014-03-25 Басф Плант Саєнс Гмбх Мутанти ahas
US20100115650A1 (en) * 2007-04-04 2010-05-06 Kening Yao Herbicide-Resistant Brassica Plants and Methods of Use
US10017827B2 (en) 2007-04-04 2018-07-10 Nidera S.A. Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use
EA019952B9 (ru) * 2007-04-04 2015-01-30 Басф Агрокемикэл Продактс Б.Ф. Устойчивые к гербицидам, ингибирующим ahas, растения подсолнечника с двумя различными аллелями ahasl1 и способы их применения
RU2009146054A (ru) * 2007-05-14 2011-06-20 Инсайт Дженетикс, Инк. (Us) Способы скрининга нуклеиновых кислот для выявления одиночных нуклеотидных вариаций
CN101868542A (zh) * 2007-06-22 2010-10-20 凯津公司 具有改进的经修饰的寡核苷酸的定向核苷酸交换
EA036997B1 (ru) * 2007-10-05 2021-01-25 СИБАС ЕУРОП Би.Ви. Растение и семя ярового масличного рапса brassica napus, содержащие мутированные гены синтазы ацетогидроксикислот
US7845686B2 (en) * 2007-12-17 2010-12-07 S & B Technical Products, Inc. Restrained pipe joining system for plastic pipe
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
US20130219563A1 (en) * 2008-03-18 2013-08-22 Mendel Biotechnology, Inc. Enhancement of plant yield vigor and stress tolerance
AU2014262183B2 (en) * 2008-05-06 2017-02-02 Agriculture Victoria Services Pty Ltd Herbicide resistant barley (2)
CN105284628A (zh) * 2008-05-06 2016-02-03 维多利亚农业服务控股公司 抗除草剂大麦
US20110214196A1 (en) * 2008-06-20 2011-09-01 University Of Georgia Research Foundation Development of herbicide-resistant grass species
WO2010003008A1 (fr) * 2008-07-01 2010-01-07 Arcadia Biosciences, Inc. Tomates ramollissant plus lentement après la récolte grâce à des modifications non transgéniques du gène de l’expansine
GB0816461D0 (en) * 2008-09-09 2008-10-15 Univ Manchester Biomass
KR20110094268A (ko) 2008-09-11 2011-08-23 키진 엔.브이. 진단 마커 개발 방법
ES2454978T3 (es) * 2008-09-25 2014-04-14 University Of Guelph Gen de nodulina precoz sensible a nitrógeno
PL2342331T3 (pl) * 2008-09-26 2016-05-31 Basf Agrochemical Products Bv Mutanty ahas odporne na herbicydy i sposoby ich zastosowania
EP2352830B1 (fr) 2008-10-03 2019-01-16 CuRNA, Inc. Traitement de maladies liées à l'apolipoprotéine a1 par l'inhibition d'un produit de la transcription antisens naturel de l'apolipoprotéine a1
ES2600781T3 (es) 2008-12-04 2017-02-10 Curna, Inc. Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
WO2010065792A2 (fr) 2008-12-04 2010-06-10 Curna, Inc. Traitement de maladies liées à l'érythropoïétine (epo) par inhibition d'un transcrit antisens naturel de l'epo
EP2370582B1 (fr) 2008-12-04 2017-05-10 CuRNA, Inc. Traitement de maladies liées à un gène suppresseur de tumeur par inhibition d'un transcrit antisens naturel du gène
WO2010078156A1 (fr) * 2008-12-31 2010-07-08 Sapphire Energy, Inc. Algues génétiquement modifiées résistant aux herbicides
ES2762610T3 (es) 2009-02-12 2020-05-25 Curna Inc Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
EA028985B1 (ru) 2009-02-13 2018-01-31 Икс-Чем, Инк. Способ идентификации соединений в составе библиотек, кодируемых днк
US9464287B2 (en) 2009-03-16 2016-10-11 Curna, Inc. Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2
CN102549159B (zh) 2009-03-17 2016-08-10 库尔纳公司 通过抑制针对δ样1同源物(DLK1)的天然反义转录物来治疗DLK1相关的疾病
CN102803492B (zh) 2009-05-06 2016-06-29 库尔纳公司 通过抑制针对三重四脯氨酸(ttp)的天然反义转录物来治疗ttp相关疾病
CN103223177B (zh) 2009-05-06 2016-08-10 库尔纳公司 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
CA3185821A1 (fr) 2009-05-08 2010-11-11 Curna, Inc. Traitement de maladies liees a la famille de la dystrophine par inhibition du produit antisens naturel de transcription vers la famille de la dmd
EP2432881B1 (fr) 2009-05-18 2017-11-15 CuRNA, Inc. Traitement des maladies associées aux facteurs de reprogrammation par inhibition du transcrit antisens naturel d'un facteur de reprogrammation
CA2762987A1 (fr) 2009-05-22 2010-11-25 Joseph Collard Traitement des maladies liees au facteur de transcription e3 (tfe3) et au substrat recepteur d'insuline 2 (irs2) par inhibition du transcript antisens naturel du tfe3
JP5960049B2 (ja) 2009-05-28 2016-08-02 クルナ・インコーポレーテッド 抗ウイルス遺伝子に対する天然アンチセンス転写物の抑制による抗ウイルス遺伝子関連疾患の治療
JP6128846B2 (ja) 2009-06-16 2017-05-17 クルナ・インコーポレーテッド パラオキソナーゼ（ｐｏｎ１）に対する天然アンチセンス転写物の抑制によるｐｏｎ１遺伝子関連疾患の治療
US20120171170A1 (en) 2009-06-16 2012-07-05 Opko Curna, Llc Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
EP2446036B1 (fr) 2009-06-24 2017-03-01 CuRNA, Inc. Traitement de maladies associées au récepteur de facteur nécrosant des tumeurs 2 (tnfr2) par inhibition de la transcription antisens naturelle de tnfr2
CN102482672B (zh) 2009-06-26 2016-11-09 库尔纳公司 通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病
JP2013500017A (ja) 2009-07-24 2013-01-07 カッパーアールエヌエー，インコーポレイテッド サ−チュイン（ｓｉｒｔ）への天然アンチセンス転写物の阻止によるサ−チュイン（ｓｉｒｔ）関連疾患の治療
CN102762731B (zh) 2009-08-05 2018-06-22 库尔纳公司 通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
US9044493B2 (en) 2009-08-11 2015-06-02 Curna, Inc. Treatment of Adiponectin related diseases by inhibition of natural antisense transcript to an Adiponectin
WO2011022606A2 (fr) 2009-08-21 2011-02-24 Curna, Inc. Traitement des maladies liées à « l'extrémité c de la protéine chip (protéine interagissant avec hsp70) » par inhibition du transcrit antisens naturel de chip
WO2011031482A2 (fr) 2009-08-25 2011-03-17 Curna, Inc. Traitement de maladies associées à la protéine d'activation de gtpase contenant un motif iq (iqgap), par inhibition d'un transcrit antisens naturel de iqgap
TW201113376A (en) 2009-09-01 2011-04-16 Basf Agrochemical Products Bv Herbicide-tolerant plants
US11096345B2 (en) 2009-09-01 2021-08-24 Basf Se Method for treating post-emergent rice
EP2480669B1 (fr) 2009-09-25 2017-11-08 CuRNA, Inc. Traitement de maladies associées à la filaggrine (flg) par modulation de l'expression et de l'activité de flg
US9562235B2 (en) * 2009-12-06 2017-02-07 A.B. Seeds Ltd. MicroRNA compositions and methods for enhancing plant resistance to abiotic stress
RU2639550C2 (ru) 2009-12-16 2017-12-21 Курна, Инк. Лечение заболеваний, связанных с сайт-1 мембраносвязанной пептидазой транскрипционных факторов (mbtps1), путем ингибирования природного антисмыслового транскрипта к mbtps1
KR101891352B1 (ko) 2009-12-23 2018-08-24 큐알엔에이, 인크. 간세포 성장 인자(ｈｇｆ)에 대한 천연 안티센스 전사체의 억제에 의한 ｈｇｆ 관련 질환의 치료
CN102781480B (zh) 2009-12-23 2018-07-27 库尔纳公司 通过抑制解偶联蛋白2(ucp2)的天然反义转录物而治疗ucp2相关疾病
CN102918154B (zh) * 2009-12-24 2016-02-17 独立行政法人农业生物资源研究所 控制植物深根特征的基因Dro1及其应用
CA2785173A1 (fr) 2009-12-29 2011-07-28 Curna, Inc. Traitement de maladies liees au facteur respiratoire nucleaire 1 (nrf1) par l'inhibition du produit de transcription antisens naturel de nrf1
WO2011090741A2 (fr) 2009-12-29 2011-07-28 Opko Curna, Llc Traitement de maladies liées à la protéine tumorale 63 (p63) par l'inhibition du produit de transcription antisens naturel de p63
US20120289583A1 (en) 2009-12-31 2012-11-15 Curna, Inc. Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
US8946181B2 (en) 2010-01-04 2015-02-03 Curna, Inc. Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8
US20110167517A1 (en) * 2010-01-06 2011-07-07 Pioneer Hi-Bred International, Inc. Identification of diurnal rhythms in photosynthetic and non-photsynthetic tissues from zea mays and use in improving crop plants
EP2521785B1 (fr) 2010-01-06 2022-03-09 CuRNA, Inc. Inhibition de la transcription antisens naturelle du gène de développement du pancrea pour l'utilisation dans le traitement des maladies du développement du pancréa
US9200277B2 (en) 2010-01-11 2015-12-01 Curna, Inc. Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG
CA2786568A1 (fr) 2010-01-25 2011-07-28 Curna, Inc. Traitement de maladies liees a la rnase h1 par l'inhibition du produit de transcription naturel antisens de la rnase h1
JP5976548B2 (ja) 2010-02-22 2016-08-23 カッパーアールエヌエー，インコーポレイテッド Ｐｙｃｒ１に対する天然アンチセンス転写物の阻害によるピロリン−５−カルボン酸レダクターゼ１（ｐｙｃｒ１）関連疾患の治療
DE102010013166B4 (de) * 2010-03-27 2012-08-09 Technische Universität Kaiserslautern Verfahren zur Erhöhung des Samenertrages sowie Förderung des Wachstums von Pflanzen
CA2795145C (fr) 2010-04-02 2019-01-22 Curna, Inc. Traitement de maladies liees au facteur de stimulation des colonies 3 (csf3) par inhibition du produit de la transcription antisens naturel en csf3
CA2795281A1 (fr) 2010-04-09 2011-10-13 Curna, Inc. Traitement des maladies associees au facteur de croissance du fibroblaste 21 (fgf21) par l'inhibition d'un produit de la transcription antisens naturel de fgf21
RU2693462C2 (ru) 2010-05-03 2019-07-03 Курна, Инк. Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt)
TWI531370B (zh) 2010-05-14 2016-05-01 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
JP5917497B2 (ja) 2010-05-26 2016-05-18 カッパーアールエヌエー，インコーポレイテッド メチオニンスルホキシドレダクターゼａ（ｍｓｒａ）に対する天然アンチセンス転写物の阻害によるｍｓｒａ関連疾患の治療
RU2585229C2 (ru) 2010-05-26 2016-05-27 Курна, Инк. Лечение заболеваний, связанных с атональным гомологом 1 (атон1), путем ингибирования природного антисмыслового транскрипта гена атон1
DK2585596T3 (da) 2010-06-23 2021-04-06 Curna Inc Behandling af spændingsreguleret natriumkanal-alpha-underenhed (scna)-relaterede sygdomme ved inhibering af naturligt antisense-transkript til scna
JP5998131B2 (ja) 2010-07-14 2016-09-28 カッパーアールエヌエー，インコーポレイテッド Ｄｉｓｃｓｌａｒｇｅｈｏｍｏｌｏｇ（ｄｌｇ）ｄｌｇ１への天然アンチセンス転写物の阻害によるｄｌｇ関連疾患の治療
US20120122223A1 (en) * 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) * 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
WO2012028993A2 (fr) * 2010-08-30 2012-03-08 Evogene Ltd. Polynucléotides et polypeptides isolés, et procédés les utilisant pour augmenter l'efficacité d'utilisation de l'azote, le rendement, la vitesse de croissance, la vigueur, la biomasse, la teneur d'huile, et/ou la tolérance aux stress abiotiques
WO2012031203A2 (fr) * 2010-09-02 2012-03-08 Donald Danforth Plant Science Center Réduction d'une détérioration physiologique après récolte
EP2625274B1 (fr) 2010-10-06 2017-07-19 CuRNA, Inc. Traitement de maladies liées à la sialidase 4 (neu4) par inhibition du transcrit anti-sens endogène de neu4
US9222088B2 (en) 2010-10-22 2015-12-29 Curna, Inc. Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
US10000752B2 (en) 2010-11-18 2018-06-19 Curna, Inc. Antagonat compositions and methods of use
RU2608493C2 (ru) 2010-11-23 2017-01-18 Курна, Инк. Лечение заболеваний, связанных с nanog, путем ингибирования природного антисмыслового транскрипта nanog
CA2819431C (fr) 2010-12-02 2021-09-28 Keygene N.V. Alteration ciblee d'adn avec des oligonucleotides.
DK2857512T3 (en) 2010-12-02 2016-10-03 Keygene Nv Targeted DNA change
GB201020737D0 (en) * 2010-12-08 2011-01-19 Univ Leuven Kath Anti-oxidative stress agents
KR102085133B1 (ko) * 2010-12-16 2020-03-05 바스프 아그로 비.브이. 제초제에 대한 내성이 증가된 식물
AR085394A1 (es) * 2011-02-25 2013-09-25 Univ Nac De La Plata Unlp Proteasa de plantas
AR085832A1 (es) * 2011-03-31 2013-10-30 Shanghai Inst Biol Sciences Metodos de ingenieria genetica para aumentar el rendimiento de las plantas
MX354195B (es) 2011-05-03 2018-02-16 Evogene Ltd Polipeptidos y polinucleotidos aislados y metodos para su uso, para aumentar el rendimiento, la biomasa, el indice de crecimiento, el vigor, el contenido de aceite, la tolerancia al estrés abiotico de las plantas y la eficiencia en el uso de nitrogeno.
CN102775481B (zh) * 2011-05-10 2014-04-02 中国农业大学 耐旱相关蛋白dt1及其编码基因和应用
US20140223604A1 (en) * 2011-05-13 2014-08-07 Andy Pereira Crop plants with improved water use efficiency and grain yield and methods of making them
EP2710128A4 (fr) * 2011-05-20 2015-05-06 Frontier Agri Science Inc Plantes ayant une résistance au stress abiotique accrue
KR101328112B1 (ko) * 2011-05-27 2013-11-08 연세대학교 산학협력단 비생물학적 스트레스 내성 관련 유전자 및 형질전환 식물체
CA2837521A1 (fr) * 2011-06-02 2012-06-12 Board Of Regents, The University Of Texas System Regulation des ouvertures stomatiques par des apyrases et des nucleotides extracellulaires
TWI678375B (zh) 2011-06-09 2019-12-01 可娜公司 藉由抑制共濟蛋白（ｆｒａｔａｘｉｎ，ｆｘｎ）之天然反股轉錄本治療ｆｘｎ相關疾病
EP2723162A4 (fr) * 2011-06-23 2014-12-17 Basf Plant Science Co Gmbh Plantes ayant des caractères liés au rendement améliorés et procédé de fabrication de ces plantes
CN103874486A (zh) 2011-09-06 2014-06-18 库尔纳公司 用小分子治疗与电压门控钠通道的α亚基(SCNxA)相关的疾病
MX360438B (es) 2011-09-07 2018-11-01 X Chem Inc Metodos para etiquetar bibliotecas codificadas por adn.
US11149282B2 (en) * 2011-10-03 2021-10-19 University Of Kentucky Research Foundation Systems and methods for the production of linear and branched-chain hydrocarbons
WO2013052755A1 (fr) * 2011-10-06 2013-04-11 University Of Wyoming Procédé de récolte d'organismes unicellulaires photosynthétiques par flottation induite génétiquement
BR112014010546B1 (pt) * 2011-11-02 2021-04-13 Ceres, Inc Método de aumento do rendimento de planta em solo contendo níveis elevados de al3+, método de aumento da tolerância de uma planta
CA2854327A1 (fr) * 2011-11-02 2013-05-10 University Of North Texas Plantes regulees par mtnip a dimension et biomasse significativement ameliorees
CA2855995A1 (fr) * 2011-11-16 2013-05-23 The State Of Queensland Acting Through The Department Of Agriculture, Fisheries And Forestry Vegetaux tolerants a la secheresse produits par modification du locus stay-green stgx
US20140322717A1 (en) * 2011-11-18 2014-10-30 The Trustees Of Columbia University In The City Of New York Selective amplification and detection of mutant gene alleles
US20140359899A1 (en) * 2011-12-08 2014-12-04 Carnegie Institution Of Washington Sucrose Transporters and Methods of Generating Pathogen-Resistant Plants
PL2791325T3 (pl) 2011-12-16 2018-08-31 Basf Agrochemical Products, B.V. Sposoby i kompozycje do analizy genów ahasl w pszenicy
HUE040179T2 (hu) 2012-03-15 2019-02-28 Curna Inc Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
WO2013168181A1 (fr) * 2012-05-07 2013-11-14 Niranjan Chakraborty Polynucléotide codant la protéine catlp1, et ses utilisations
US10041087B2 (en) * 2012-06-19 2018-08-07 BASF Agro B.V. Plants having increased tolerance to herbicides
AR091489A1 (es) 2012-06-19 2015-02-11 Basf Se Plantas que tienen una mayor tolerancia a herbicidas inhibidores de la protoporfirinogeno oxidasa (ppo)
JP5828302B2 (ja) * 2012-06-21 2015-12-02 トヨタ自動車株式会社 サトウキビ花成制御技術
EA201992285A1 (ru) 2012-07-13 2020-05-31 Икс-Чем, Инк. Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
KR101494499B1 (ko) * 2012-09-13 2015-02-24 포항공과대학교 산학협력단 Ａｂｉ３단백질을 코딩하는 유전자를 포함하는 식물체의 개화 조절용 조성물
US9441241B2 (en) * 2013-02-05 2016-09-13 Clemson University Methods and compositions for transgenic plants with enhanced resistance to biotic and abiotic stress
US9957520B2 (en) 2013-03-13 2018-05-01 The Board Of Trustees Of The University Of Arkansas Methods of increasing resistance of crop plants to heat stress and selecting crop plants with increased resistance to heat stress
US9523097B2 (en) * 2013-03-15 2016-12-20 The United States Of America, As Represented By The Secretary Of Agriculture Engineering rubber production in plants
UA120033C2 (uk) 2013-03-15 2019-09-25 Сібас Юс Ллс Спосіб підвищення ефективності спрямованої модифікації генів із застосуванням опосередкованої олігонуклеотидами репарації генів
EP3033419A4 (fr) 2013-08-12 2017-07-05 BASF Agro B.V. Plantes ayant une tolérance accrue à des herbicides (ppo)
CA2920590C (fr) 2013-08-12 2023-12-05 BASF Agro B.V. Plantes presentant une tolerance accrue a des herbicides
KR101564748B1 (ko) * 2013-10-24 2015-11-02 연세대학교 산학협력단 건조 스트레스 저항성 관련 유전자 및 형질전환 식물체
US20150247161A1 (en) * 2013-12-24 2015-09-03 National Institute Of Plant Genome Research METHOD OF PRODUCING STRESS TOLERANT PLANTS OVER-EXPRESSING OsAlba1
AU2014370930B2 (en) * 2013-12-27 2018-03-15 National Agriculture And Food Research Organization Transgenic plant and method for producing sugar-containing exudate by using transgenic plant
US20150184193A1 (en) * 2013-12-30 2015-07-02 Dow Agrosciences Llc Trait stacking strategy for corn introgression
US10072066B2 (en) 2014-02-03 2018-09-11 Sangamo Therapeutics, Inc. Methods and compositions for treatment of a beta thalessemia
DE102014005337A1 (de) * 2014-04-11 2015-10-15 Friedrich-Alexander-Universität Erlangen-Nürnberg Tonoplastidäre Protonen/Zucker-Antiporter-Proteine und deren Verwendung zur Erhöhung der Saccharosekonzentration eines Saccharosespeicherorgans von Pflanzen
US20150315250A1 (en) * 2014-05-02 2015-11-05 Academia Sinica Transgenic plants with increased trace element contents and methods for producing the same
JP6719174B2 (ja) * 2015-02-23 2020-07-08 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557989B2 (ja) * 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557990B2 (ja) * 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6641702B2 (ja) * 2015-02-23 2020-02-05 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6586693B2 (ja) * 2015-06-30 2019-10-09 住友ゴム工業株式会社 ポリイソプレノイドの製造方法、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
CN109477106B (zh) 2015-07-10 2022-10-04 Ionis制药公司 二酰基甘油酰基转移酶2(dgat2)的调节剂
CN105543239B (zh) * 2016-01-22 2018-12-28 南京农业大学 一种小麦抗赤霉病基因Tafhb1及其应用
EP4023228A1 (fr) 2016-05-06 2022-07-06 Tod M. Woolf Oligonucleotides d'édition de génome sans nucléases programmables
BR112019006765B1 (pt) * 2016-10-04 2023-09-26 Membrane Protective Technologies, Inc Método para congelar células e tecidos
US10913952B2 (en) * 2016-10-26 2021-02-09 Salk Institute For Biological Studies Environmental stress response transcriptional regulatory network
WO2018092072A1 (fr) * 2016-11-16 2018-05-24 Cellectis Méthodes de modification de la teneur en acides aminés de plantes par décalages du cadre de lecture
EP3568470B1 (fr) * 2017-01-10 2022-07-06 Christiana Care Health Services, Inc. Procédés de mutagenèse dirigée in vitro faisant appel à des technologies d'édition de gènes
WO2018144180A1 (fr) * 2017-01-31 2018-08-09 Ricetec, Inc. Effets d'une pluralité de mutations pour améliorer la résistance/tolérance du riz aux herbicides
CN108396072B (zh) * 2018-03-21 2021-04-30 新疆维吾尔自治区药物研究所 一种快速鉴别毛菊苣与菊苣的方法
WO2020140146A1 (fr) * 2019-01-02 2020-07-09 Linnaeus Plant Sciences Inc. Plantes de camelina sativa résistantes aux herbicides et polypeptides variants d'acétohydroxyacide synthase de cameline
CN110100732A (zh) * 2019-05-27 2019-08-09 东北林业大学 一种龙葵离体快速繁殖方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US119570A (en) * 1871-10-03 Improvement in coopers crozes and howels
US193334A (en) * 1877-07-24 Improvement in show-cases
US163849A (en) * 1875-06-01 Improvement in grading apparatus
US217377A (en) * 1879-07-08 hislop
US51270A (en) * 1865-11-28 Improvement in children s bedclothes-retainers
US4459355A (en) * 1982-07-12 1984-07-10 International Paper Company Method for transforming plant cells
DK175922B1 (da) * 1985-08-07 2005-07-04 Monsanto Technology Llc Glyphosat-resistente planter
US5422251A (en) * 1986-11-26 1995-06-06 Princeton University Triple-stranded nucleic acids
US5312910A (en) * 1987-05-26 1994-05-17 Monsanto Company Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthase
US5955363A (en) * 1990-01-03 1999-09-21 Promega Corporation Vector for in vitro mutagenesis and use thereof
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5792903A (en) * 1993-10-25 1998-08-11 Yissum Research Development Company Of Hebrew University Of Jerusalem Lycopene cyclase gene
EP0733059B1 (fr) 1993-12-09 2000-09-13 Thomas Jefferson University Composes et procedes pour realiser des mutations dirigees sur le site dans des cellules eucaryotes
GB9408717D0 (en) * 1994-05-03 1994-06-22 Biotech & Biolog Scien Res DNA sequences
US5882941A (en) * 1994-05-04 1999-03-16 Massachusette Institute Of Technology Programmable genotoxic agents and uses therefor
CA2194960C (fr) * 1994-07-15 1999-09-21 Kevin J. Scanlon Clivage de l'arnm de la 5.alpha.-reductase
US5912340A (en) 1995-10-04 1999-06-15 Epoch Pharmaceuticals, Inc. Selective binding complementary oligonucleotides
US5905185A (en) * 1995-11-30 1999-05-18 Ppl Therapeutics Protein C production in non-human transgenic mammals
US5731181A (en) 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US5810222A (en) * 1996-09-27 1998-09-22 Shoemaker; Randy R. Holster with handgun detent means
KR20010022652A (ko) * 1997-08-05 2001-03-26 키메라젠, 인크. 식물에서 국소적인 유전자변형을 유발하기 위한 혼성 이중나선올리고뉴클레오티드의 용도
NZ503765A (en) 1997-09-12 2002-04-26 Exiqon As Bi-cyclic and tri-cyclic nucleotide analogues
AU1526199A (en) * 1997-11-18 1999-06-07 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
US6010907A (en) * 1998-05-12 2000-01-04 Kimeragen, Inc. Eukaryotic use of non-chimeric mutational vectors
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
WO2000056748A1 (fr) 1999-03-18 2000-09-28 Exiqon A/S Analogues de xylo-lna
CA2372085C (fr) 1999-05-04 2009-10-27 Exiqon A/S Analogues de l-ribo-lna
US6271360B1 (en) 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) * 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
OA12240A (en) * 2000-03-27 2006-05-10 Univ Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides.
US6387699B1 (en) * 2000-09-08 2002-05-14 Isis Pharmaceuticals, Inc. Antisense inhibition of A20 expression
WO2002026967A2 (fr) 2000-09-25 2002-04-04 Thomas Jefferson University Correction de gene cible au moyen d'oligodesoxynucleotides monocatenaires
US6982169B2 (en) * 2001-01-15 2006-01-03 Morphotek, Inc. Chemical inhibitors of mismatch repair

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